Prostaglandin E1 increases myocardial contractility in the conscious dog.

abstract：:Rats fed a polychlorinated biphenyl (PCB) mixture in a high- or low-iodine diet (HID or LID respectively) for 15 days had thyroid enlargement, low serum thyroxine (T4), and high serum thyrotropin concentrations. Although binding of thyroid hormones to serum proteins was reduced in PCB-fed animals, the free T4 index (r...

journal_title：Canadian journal of physiology and pharmacology

authors： Bastomsky CH

更新日期：1977-04-01 00:00:00

abstract：:Over the last 2 decades, mi(cro)RNAs have emerged as one of the key regulators of metabolic homeostasis. Most of the studies have highlighted that, in the cytoplasm, miRNAs directly bind to the 3'-UTR (untranslated region) of a mRNA. Conventional RNA-induced silencing complex (RISC) formation results in the post-trans...

journal_title：Canadian journal of physiology and pharmacology

authors： Baradan R,Hollander JM,Das S

更新日期：2017-10-01 00:00:00

abstract：:To determine the effects of chronic hyperinsulinemia on glucagon release, rats were made hyperinsulinemic for 14 days by supplementation of drinking water with sucrose (10%; sucrose-fed) to increase endogenous release or by implantation of osmotic minipumps (subcutaneous, s.c.; or intraperitoneal, i.p.) to deliver exo...

journal_title：Canadian journal of physiology and pharmacology

authors： Brubaker PL,Kazumi T,Hirano T,Vranic M,Steiner G

更新日期：1991-03-01 00:00:00

abstract：:Garlic is a commonly used spice in folk medicine that can exert adverse health effects when given at a high dose. Grape seed and skin extract (GSSE) exhibits a variety of beneficial effects even at a high dose. In the present study we evaluated the toxicity of high-dose garlic treatment on liver and the protective eff...

journal_title：Canadian journal of physiology and pharmacology

authors： Hamlaoui-Gasmi S,Mokni M,Limam N,N'guessan P,Carrier A,Limam F,Amri M,Aouani E,Marzouki L

更新日期：2012-05-01 00:00:00

abstract：:Altered sympathetic nervous activity has been linked to the development and persistence of obesity, partly relating to overfeeding. Binding of the selective, positron-emitting phosphodiesterase-4 (PDE4) inhibitor (R)-[11C]rolipram provides a direct index of the cAMP-hydrolyzing enzyme PDE4. This study examines progres...

journal_title：Canadian journal of physiology and pharmacology

authors： Greene M,Thackeray JT,Kenk M,Thorn SL,Bevilacqua L,Harper ME,Beanlands RS,Dasilva JN

更新日期：2009-03-01 00:00:00

abstract：:A variety of porphyrinogenic xenobiotics cause mechanism-based inactivation of a number of rat hepatic cytochrome P450 isozymes. As a result, a mixture of four N-alkylprotoporphyin IX (N-alkylPP) regioisomers, with ferrochelatase-inhibitory properties, are formed. This study was designed to determine whether all four ...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamee JP,Kobus SM,Marks GS

更新日期：1996-08-01 00:00:00

abstract：:While conducting studies on the prevention of mortality from acute iron intoxication in rats, diazepam, given to prevent animal suffering, was observed to be associated with reduced mortality in a limited number of animals. The objective was to assess whether diazepam reduces mortality following acute iron intoxicatio...

journal_title：Canadian journal of physiology and pharmacology

authors： Fassos FF,Berkovitch M,Daneman N,Koren L,Cameron R,Klein J,Falcitelli C,St Louis P,Daneman R,Koren G

更新日期：1998-09-01 00:00:00

abstract：:In Western societies, the incidence of diet-related diseases is progressively increasing due to greater availability of hypercaloric food and a sedentary lifestyle. Obesity, diabetes, atherosclerosis, and neurodegeneration are major diet-related pathologies that share a common pathogenic denominator of low-grade infla...

journal_title：Canadian journal of physiology and pharmacology

authors： Magrone T,Perez de Heredia F,Jirillo E,Morabito G,Marcos A,Serafini M

更新日期：2013-06-01 00:00:00

abstract：:The purpose of this study was to characterize the biological activity of the synthetic rat growth hormone releasing factor analogue rGRF(1-29)NH2 and to compare its action on growth hormone (GH) release to that of authentic rGRF(1-43)OH. We first compared the concentration-response characteristics of the two peptides ...

journal_title：Canadian journal of physiology and pharmacology

authors： Kraicer J,French MB,Lussier BT,Moor BC,Brazlan P

更新日期：1991-02-01 00:00:00

abstract：:Mechanisms leading to ifosfamide (IF)-induced renal damage have not been fully elucidated. Recent work suggests that localized renal tubular metabolism of IF and the production of the nephrotoxic chloroacetaldehyde may lead to nephrotoxicity. Presently no pharmacological method to reduce IF nephrotoxicity has been ide...

journal_title：Canadian journal of physiology and pharmacology

authors： Aleksa K,Halachmi N,Ito S,Koren G

更新日期：2005-06-01 00:00:00

abstract：:Muscle pain and poor sleep commonly occur together. Whether pain induces poor sleep or vice versa is difficult to know. Muscle pain is also observed in the presence of some types of dyskinesia or movement disorders. The interaction between sleep, movement disorders, and some musculoskeletal pain appears to be complex ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavigne GJ,Velly-Miguel AM,Montplaisir J

更新日期：1991-05-01 00:00:00

abstract：:A new approach for the purification of rat mesenteric arterial bed (MAB) elastase-2 has been developed using the chromogenic substrates N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide and N-succinyl-Ala-Ala-Pro-Leu-p-nitroanilide to monitor the enzymatic activity during various stages of purification. The purified enzyme wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Santos CF,Greene AS,Salgado MC,Oliveira EB

更新日期：2004-11-01 00:00:00

abstract：:Although there are many studies reporting correlations between relative body weight and blood pressure, the correlations are generally of low order. Furthermore, these observational studies provide, at best, circumstantial evidence concerning the effect of weight reduction on elevated blood pressure. After outlining k...

journal_title：Canadian journal of physiology and pharmacology

authors： Haynes RB

更新日期：1986-06-01 00:00:00

abstract：:In order to understand the mechanisms of exercise intolerance and muscle fatigue, which are commonly observed in congestive heart failure, we studied sarcoplasmic reticulum (SR) Ca(2+)-transport in the hind-leg skeletal muscle of rats subjected to myocardial infarction (MI). Sham-operated animals were used for compari...

journal_title：Canadian journal of physiology and pharmacology

authors： Shah KR,Ganguly PK,Netticadan T,Arneja AS,Dhalla NS

更新日期：2004-07-01 00:00:00

abstract：:Norethandrolone (NE) and other androgenic steroids have been shown to be renotropic in various species and have also been reported to have salutary effects in patients with diminished renal function. Renal cortical slices prepared from rats pretreated with NE showed an increased capability to concentrate p-aminohippur...

journal_title：Canadian journal of physiology and pharmacology

authors： Watrous WM,Lacombe R,Brodeur J

更新日期：1975-10-01 00:00:00

abstract：:Gripp-Heel is a homeopathic preparation frequently used in the treatment of respiratory viral infections such as various types of influenza and the common cold. The antiviral activity of Gripp-Heel was studied in vitro on human pathogenic enveloped and nonenveloped RNA and DNA viruses. Before the antiviral assays, in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Glatthaar-Saalmüller B

更新日期：2007-11-01 00:00:00

abstract：:Oxidative stress plays a vital role in the pathogenesis of neurodegenerative diseases. Chikusetsu saponin V (CsV), the most abundant member of saponins from Panax japonicus (SPJ), has attracted increasing attention for its potential to treat neurodegenerative diseases. However, the mechanisms are unclear. Our study in...

journal_title：Canadian journal of physiology and pharmacology

authors： Wan J,Deng L,Zhang C,Yuan Q,Liu J,Dun Y,Zhou Z,Zhao H,Liu C,Yuan D,Wang T

更新日期：2016-09-01 00:00:00

abstract：:Using a time-lapse cinephotomicrographic technique, the locomotory paths taken by lymphocytes have been shown to satisfy the requirements for a continuous-time Markov chain analysis consisting of four directional states defined by the four quadrants of a Cartesian plane and state 0 in which the cells are stationary. T...

journal_title：Canadian journal of physiology and pharmacology

authors： Noble PB,Boyarsky A,Bentley KC

更新日期：1979-01-01 00:00:00

abstract：:Magnesium probably protects brain tissue against the effects of cerebral ischemia, brain injury and stroke through its actions as a calcium antagonist and inhibitor of excitatory amino acids. The effects of magnesium sulfate on cerebrovascular permeability to a dye, Evans blue, were studied during insulin-induced hypo...

journal_title：Canadian journal of physiology and pharmacology

authors： Kaya M,Küçük M,Kalayci RB,Cimen V,Gürses C,Elmas I,Arican N

更新日期：2001-09-01 00:00:00

abstract：:The goal of conformal radiotherapy is to concentrate the dose in a well-defined volume by avoiding the neighbouring healthy structures. This technique requires powerful treatment planning software and a rigorous control of estimated dosimetry. The usual dosimetric tools are not adapted to visualize and validate comple...

journal_title：Canadian journal of physiology and pharmacology

authors： Gibon D,Bourel P,Castelain B,Marchandise X,Rousseau J

更新日期：2001-02-01 00:00:00

abstract：:Using radioligand binding techniques, the effect of reserpine pretreatment on ventricular adrenergic receptors from guinea pig was studied. [3H]Prazosin and [3H]dihydroalprenolol were used to label alpha 1- and beta-adrenergic receptors, respectively. Administration of 2.5 mg/kg reserpine for 2 days caused a significa...

journal_title：Canadian journal of physiology and pharmacology

authors： Latifpour J,McNeill JH

更新日期：1984-01-01 00:00:00

abstract：:Diabetes with vascular complication needs strict interventions to retard possible serious complications. This research estimated the possible interaction of rosiglitazone (RGN) with losartan (Los) in diabetic rats. Male Sprague-Dawley rats were randomly divided into nondiabetic rats, diabetic rats, and diabetic rats t...

journal_title：Canadian journal of physiology and pharmacology

authors： Ateyya H,Nader MA,El-Sherbeeny NA

更新日期：2018-03-01 00:00:00

abstract：:Angiotensin exerts numerous contractile and secretory effects by activating specific receptors. Recent pharmacological findings obtained with this peptide in various laboratories are analyzed, using the order of potency of agonists and the affinity of competitive antagonists as criteria for the classification of recep...

journal_title：Canadian journal of physiology and pharmacology

authors： Regoli D

更新日期：1979-02-01 00:00:00

abstract：:Serotonin has been shown to alter the intestinal transport of ions and intestinal motility. These effects may interfere with each other, modulating the whole physiology of the intestine. We have previously shown that serotonin also alters the transport of nutrients. Thus, the aims of the present work were to determine...

journal_title：Canadian journal of physiology and pharmacology

authors： Salvador MT,Murillo MD,Rodríguez-Yoldi MC,Alcalde AI,Mesonero JE,Rodríguez-Yoldi MJ

更新日期：2000-05-01 00:00:00

abstract：:The tau mutation in the golden (Syrian) hamster is a single gene mutation that drastically affects the speed of the circadian clock, in such a way that homozygous mutants have an endogenous circadian period of 20 h (compared with 24 h for wild-type hamsters). While studying the circadian system of tau-mutant hamsters ...

journal_title：Canadian journal of physiology and pharmacology

authors： Refinetti R

更新日期：2014-01-01 00:00:00

abstract：:Hereditary muscular hypertrophy is a character that has been selected in several animal species for industrial meat production. The selection of this character in cattle produces animals of exceptional commercial value but ones with a lower aerobic capacity than that of conventional cattle. The purpose of this work wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Amory H,McEntee K,Linden AS,Desmecht DJ,Beduin JM,D'Orio V,Lekeux PM

更新日期：1993-12-01 00:00:00

abstract：:In anesthetized dogs, 60-min occlusions of either the proximal (n = 14), distal (n = 8) left circumflex (LCX), or left anterior descending (LAD, n = 10) arteries were followed by reperfusion. Coronary sinus and aortic norepinephrine and epinephrine plasma concentrations were measured. The ventricular arrhythmias were ...

journal_title：Canadian journal of physiology and pharmacology

authors： Godin D,Campeau N,Nadeau R,Cardinal R,de Champlain J

更新日期：1985-09-01 00:00:00

abstract：:We recently reported that the two-chain form of human high molecular weight kininogen (HKa) inhibits angiogenesis by inducing endothelial cell apoptosis (Zhang et al. 2000). This property appears to be primarily conferred by HKa domain 5 (HKa D5). In this manuscript, we further characterize the activity of these polyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang JC,Qi X,Juarez J,Plunkett M,Donaté F,Sakthivel R,Mazar AP,McCrae KR

更新日期：2002-02-01 00:00:00

abstract：:The influence of variation in the extracellular concentrations of Na+, Mg2+, and Ca2+ in the depolarizing medium on isoproterenol-induced increases in cAMP levels and relaxation was studied in rat uterus. Isoproterenol (10(-8) M) failed to increase cAMP levels in the high-K+ medium containing no Na+. When 80 mM Na+ wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Meisheri KD,McNeill JH

更新日期：1979-10-01 00:00:00

abstract：:Metformin, the first medication that is often prescribed for the treatment of Type-2 Diabetes Mellitus (T2DM), was recently found to be neuroprotective. To study the mechanism underlying the neuroprotective effect of metformin, we pre-treated primary spinal cord neurons with 50 µM or 100 µM µM metformin for 2 hours pr...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang G,Chen S,Shao Z,Li Y,Wang W,Mao L,Li J,Mei X

更新日期：2020-11-17 00:00:00