Changes in skeletal muscle SR Ca2+ pump in congestive heart failure due to myocardial infarction are prevented by angiotensin II blockade.

abstract：:The epicardial coronary venous pressure in 16 dogs was compared with coronary arterial pressure as well as aortic, intraventricular, and intramyocardial pressures. Partial aortic occlusion augmented intraventricular (IVP), intramyocardial (IMP), aortic (AP), and coronary arterial pressures. Peripheral coronary venous ...

journal_title：Canadian journal of physiology and pharmacology

authors： Klassen GA,Armour JA

更新日期：1983-03-01 00:00:00

abstract：:In the present study we characterized the receptor(s) that mediates non-adrenergic non-cholinergic (NANC) contractions of isolated guinea pig cervical trachea, using CP-99,994, a selective neurokinin (NK1) receptor antagonist, and SR-48,968, a selective neurokinin (NK2) receptor antagonist. The activity of these two a...

journal_title：Canadian journal of physiology and pharmacology

authors： Charette L,Foulon D,Rodger IW,Jones TR

更新日期：1994-02-01 00:00:00

abstract：:Immature female quails were treated for 6 days with estradiol benzoate at daily 0.01-, 0.02-, 0.01-, and 1-mg dosages. At the end of treatment, bile outflow, biliary cholesterol (CST), and bile acid (BA) secretory rates and liver, bile, and serum CST and BA levels were determined. Some quails were used to measure the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Laugier C,Pageaux JF,Duperray B,Pacheco H,Brard E

更新日期：1979-04-01 00:00:00

abstract：:Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of phentolamine, a nonse...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhou K,Kumar U,Yuen VG,McNeill JH

更新日期：2012-08-01 00:00:00

abstract：:Although amiodarone is a highly efficacious antidysrhythmic agent, the drug produces numerous adverse effects. The most critical of these is pulmonary toxicity because of the potential for mortality. This review examines the experimental model systems used to study amiodarone toxicity, summarizes the current state of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Massey TE,Leeder RG,Rafeiro E,Brien JF

更新日期：1995-12-01 00:00:00

abstract：:Changes in metabolic characteristics of the liver and jejunal epithelia as a result of feeding the beta-agonist albuterol to chickens for 3 and 6 weeks were studied. Feeding albuterol resulted in a change in weights of the liver and small intestines. Chickens fed albuterol for 6 weeks had greater levels of plasma none...

journal_title：Canadian journal of physiology and pharmacology

authors： Rompala RE,Darre MJ

更新日期：1989-05-01 00:00:00

abstract：:Wave speed (c) must be known to separate forward- and backward-going waves during wave-intensity analysis, which measures the energy transported by the waves in the circulation. c is related to elastance; the present study was performed to measure right ventricular (RV) c during the cardiac cycle and to compare c with...

journal_title：Canadian journal of physiology and pharmacology

authors： Sun Y,Wang JJ,Belenkie I,Tyberg JV

更新日期：2006-08-01 00:00:00

abstract：:Neonatal hyperthyroidism (NH) in the rat is associated with permanent reductions in serum thyroxine (T4), triiodothyronine (T3), and thyroid-stimulating hormone (TSH) concentrations in the adult, changes suggestive of a hypothyroid state. In the adult NH rat, the thyrotroph appears to be more sensitive to the feedback...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker P

更新日期：1985-09-01 00:00:00

abstract：:Rats fed a polychlorinated biphenyl (PCB) mixture in a high- or low-iodine diet (HID or LID respectively) for 15 days had thyroid enlargement, low serum thyroxine (T4), and high serum thyrotropin concentrations. Although binding of thyroid hormones to serum proteins was reduced in PCB-fed animals, the free T4 index (r...

journal_title：Canadian journal of physiology and pharmacology

authors： Bastomsky CH

更新日期：1977-04-01 00:00:00

abstract：:The purpose of this study was to investigate whether Ca2+ -Mg2+ ATPase in the distal tubule (where calcium transport is active, against a gradient, and hormone dependent) presents some characteristics different from those observed in the proximal tubule, and whether these characteristics are likely to shed light on th...

journal_title：Canadian journal of physiology and pharmacology

authors： Brunette MG,Blouin S,Chan M

更新日期：1987-10-01 00:00:00

abstract：:This study was designed to investigate whether and how triiodothyronine (T3) affects renal function in an experimental model of chronic kidney disease. Twenty-four female rats were divided into the following groups: sham-operated control group (n = 8), 5/6 nephrectomized group (Nx, n = 8), and 5/6 nephrectomized group...

journal_title：Canadian journal of physiology and pharmacology

authors： El Agaty SM

更新日期：2018-06-01 00:00:00

abstract：:Changes in estrogen production are considered important in the sequence of events leading to parturition. We sought tissue-specific changes in the concentration of unconjugated estrone (E1) and estradiol (E2) in intrauterine fetal (amnion, chorion) and maternal (endometrium, myometrium) tissues during normal pregnancy...

journal_title：Canadian journal of physiology and pharmacology

authors： Power SG,Challis JR

更新日期：1987-02-01 00:00:00

abstract：:Calcium antagonists may reduce propensity to ventricular fibrillation, by altering the balance between coronary blood flow and metabolic demand, and thus may substantially prolong time to occurrence of fibrillations. This delay in the onset of fibrillation should be sufficient to prevent sudden death in the case of tr...

journal_title：Canadian journal of physiology and pharmacology

authors： Timour Q,Aupetit JF,Freysz M,Frassati D,Faucon G

更新日期：1996-12-01 00:00:00

abstract：:The combined and separate effects of exercise training and bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight postmenopausal women were randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength training (3 d/week) and r...

journal_title：Canadian journal of physiology and pharmacology

authors： Chilibeck PD,Davison KS,Whiting SJ,Suzuki Y,Janzen CL,Peloso P

更新日期：2002-10-01 00:00:00

abstract：:Angiotensin II (ANG II) causes a systemic pressor effect when injected into the cerebral ventricles. In the rat fourth ventricle, the effective doses for the ANG II pressor effect are over 100 times larger than in the systemic circulation. Considering the discrepancy of doses, the possibility that ANG II may reach the...

journal_title：Canadian journal of physiology and pharmacology

authors： Pesquero JB,Fior-Chadi DR,Yu YG,Merjan AJ,Lindsey CJ,Paiva AC

更新日期：2002-05-01 00:00:00

abstract：:Spironolactone is a diuretic steroid which is capable of blocking the binding of aldosterone to its cytosol receptor at the distal convoluted tubule. In addition, it has been shown that spironolactone is a strong inhibitor of steroidogenesis. More recently, new aldosterone antagonists have been discovered. Some of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Netchitailo P,Perroteau I,Delarue C,Leboulenger F,Capron MH,Vaudry H

更新日期：1983-01-01 00:00:00

abstract：:Perfusion of isolated rat hearts with Na-free medium resulted in an immediate increase in contractile force followed by a decline and complete loss of contractile force within 25 s. The recovery of the contractile force upon reperfusion was only partial if the duration of Na-free perfusions was 10 min or longer. Ca bi...

journal_title：Canadian journal of physiology and pharmacology

authors： Dhalla NS,Lee SL,Singal PK,Yates JC,Panagia V

更新日期：1980-12-01 00:00:00

abstract：:A brief burst of electrical stimuli delivered to the vagus nerve during the cardiac cycle elicits a triphasic cardiac chronotropic response. The cardiac cycle length initially increases, then briefly decreases, and subsequently increases again. We studied the effects of a calcium channel blocking agent, verapamil, on ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wallick DW,Stuesse SL,Valencic F,Fratianne RB

更新日期：1986-07-01 00:00:00

abstract：:MicroRNA-146a (miR-146a) is reportedly implicated in the pathogenesis of ischemia-reperfusion (I/R) injury; however, its role in cerebral I/R injury is unclear and requires further investigation. In this study, cerebral I/R injury was established in mice via middle cerebral artery occlusion, and the expression of miR-...

journal_title：Canadian journal of physiology and pharmacology

authors： Chu B,Zhou Y,Zhai H,Li L,Sun L,Li Y

更新日期：2018-06-01 00:00:00

abstract：:The hemodynamic effects of the combination of clonidine and propranolol were studied in conscious rats with portal hypertension owing to secondary biliary cirrhosis. Pressure and blood flow measurements (radioactive microsphere method) were performed in three groups of eight rats before and after drug administration. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Roulot D,Gaudin C,Braillon A,Sekiyama T,Bacq Y,Lebrec D

更新日期：1989-10-01 00:00:00

abstract：:The effects of forskolin, Ro 20-1724, rolipram, and 3-isobutyl-1-methylxanthine (IBMX) on morphine-evoked release of adenosine from dorsal spinal cord synaptosomes were evaluated to examine the potential involvement of cyclic AMP in this action of morphine. Ro 20-1724 (1-100 microM), rolipram (1-100 microM), and forsk...

journal_title：Canadian journal of physiology and pharmacology

authors： Nicholson D,White TD,Sawynok J

更新日期：1991-06-01 00:00:00

abstract：:The mammalian daily (circadian) clock is located in the suprachiasmatic nuclei of the hypothalamus. Clock function can be detected by the measurement of the circadian change in spontaneous firing rate of suprachiasmatic nuclei cells in a brain slice preparation in vitro. We investigated the effects of neuropeptide Y o...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrington ME,Schak KM

更新日期：2000-02-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs are widely used for the treatment of osteoarthritis and rheumatoid arthritis, but their ability to cause gastrointestinal bleeding is a significant limitation to this use. A better understanding of the pathogenesis of gastric and intestinal injury induced by these agents will permi...

journal_title：Canadian journal of physiology and pharmacology

authors： Wallace JL

更新日期：1994-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most life-threatening cancers. The present study was designed to chronologically analyze the HCC chemically induced by diethylnitrosamine (DEN) in male Wistar rats during a 27-week period. DEN was given to rats in drinking water (100 mg/L) to induce HCC. In the present stud...

journal_title：Canadian journal of physiology and pharmacology

authors： Fathy AH,Bashandy MA,Bashandy SAE,Mansour AM,Elsadek B

更新日期：2017-12-01 00:00:00

abstract：:Double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of K+, Na+, and Cl- (aKi, aNai, aCli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex. In sympathetic neurones, carbachol and gamma-aminobutyric acid (GABA) p...

journal_title：Canadian journal of physiology and pharmacology

authors： Grafe P,Ballanyi K

更新日期：1987-05-01 00:00:00

abstract：:The release of endothelium-derived relaxing factor (EDRF), prostacyclin (PGI2), and endothelin-1 (ET-1) was measured from endothelial cells (EC) cultured from either bovine vena cava (BVCEC) or bovine aorta (BAEC). EDRF release was determined by using the superfusion bioassay technique, whereas ET-1 and PGI2 were meas...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Orleans-Juste P,Mitchell JA,Wood EG,Hecker M,Vane JR

更新日期：1992-05-01 00:00:00

abstract：:Although mitochondrial transcription factor A (TFAM) is a protective component of mitochondrial DNA and a regulator of calcium and reactive oxygen species (ROS) production, the mechanism remains unclear. In heart failure, TFAM is significantly decreased and cardiomyocyte instability ensues. TFAM inhibits nuclear facto...

journal_title：Canadian journal of physiology and pharmacology

authors： Kunkel GH,Chaturvedi P,Thelian N,Nair R,Tyagi SC

更新日期：2018-02-01 00:00:00

abstract：:Hepatotoxicity and nephrotoxicity are important drawbacks of cisplatin. The objective of this study is to evaluate the ability of ambroxol in 2 different doses (35 and 70 mg/kg, i.p.) to protect liver and kidney from damage induced by a single dose of cisplatin (10 mg/kg, i.p.) in comparison with N-acetylcysteine (250...

journal_title：Canadian journal of physiology and pharmacology

authors： Bishr A,Sallam N,Nour El-Din M,Awad AS,Kenawy SA

更新日期：2019-01-01 00:00:00

abstract：:Angiotensin II (ANG II) and vasopressin (AVP) are two powerful vasoconstrictors, and atrial natriuretic peptide (ANP) is a potent vasorelaxant. The changes in the density or affinity of binding sites for these agents that may alter target organ responsiveness in hypertension are reviewed. ANG II binding in mesenteric ...

journal_title：Canadian journal of physiology and pharmacology

authors： Schiffrin EL

更新日期：1989-09-01 00:00:00

abstract：:The precise role of microglia in stroke and cerebral ischemia has been the subject of debate for a number of years. Microglia are capable of synthesizing numerous soluble and membrane-bound biomolecules, some known to be neuroprotective, some neurotoxic, whereas others have less definitive bioactivities. The molecular...

journal_title：Canadian journal of physiology and pharmacology

authors： Lai AY,Todd KG

更新日期：2006-01-01 00:00:00