Changes in skeletal muscle SR Ca2+ pump in congestive heart failure due to myocardial infarction are prevented by angiotensin II blockade.

abstract：:Allicin, the active substance of garlic, exerts a broad spectrum of pharmacological activities and is considered to have potential therapeutic applications. The present study was designed to investigate the possible beneficial effects of allicin against oxidative stress, inflammation, and endothelial dysfunction in hy...

journal_title：Canadian journal of physiology and pharmacology

authors： El-Sheakh AR,Ghoneim HA,Suddek GM,Ammar ESM

更新日期：2016-02-01 00:00:00

abstract：:We examined the interaction of smooth muscle myosin with alpha-actin and beta-actin isoforms during the contraction of A7r5 smooth muscle cells and rat aortic smooth muscle. The techniques of confocal microscopy and fluorescence resonance energy transfer (FRET) analysis were utilized in examining A7r5 cells and rat ao...

journal_title：Canadian journal of physiology and pharmacology

authors： Black J,Dykes A,Thatcher S,Brown D,Bryda EC,Wright GL

更新日期：2009-05-01 00:00:00

abstract：:Diamine oxidase activity was measured in the intestinal mucosa, lymph, and in the serum of rats, to determine whether histamine, a substrate of diamine oxidase, liberates this enzyme from its mucosal storage site(s). Histamine induced a sharp rise in intestinal lymph flow, lymph protein, and lymph diamine oxidase, las...

journal_title：Canadian journal of physiology and pharmacology

authors： Wollin A,Navert H

更新日期：1983-04-01 00:00:00

abstract：:Phosphofructokinase activity was measured in the sciatic nerve of streptozotocin-induced diabetic and nondiabetic rats. Average steady-state phosphofructokinase activity was obtained from three consecutive segments of the mid-femoral region in the left sciatic nerve in both diabetic (4 and 24 weeks) and nondiabetic, a...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilgour RD,Gardiner K,Gardiner PF

更新日期：1990-10-01 00:00:00

abstract：:The purpose of this study was to elucidate the mechanism whereby a potassium infusion led to an elevation in the urine minus blood (ohm-B) PCO2 difference in alkaline urine of the rabbit. Rabbits given 9alpha-fluorohydrocortisone 16 h prior to study had a significantly high olm-B PCO2 than control rabbits. However, th...

journal_title：Canadian journal of physiology and pharmacology

authors： Robson WL,Halperin ML,Stinebaugh BJ,Goldstein MB

更新日期：1981-03-01 00:00:00

abstract：:The contractile recoverability of isolated portal veins made hypodynamic by removal of glucose from the perfusion medium by diverse exogenous substrates was studied. It was found that glucose, mannose, pyruvate, lactate, acetate, and butyrate readily restored contraction. The effects of anoxia and metabolic inhibitors...

journal_title：Canadian journal of physiology and pharmacology

authors： Cremer-Lacuara MG,Lacuara JL,Fiol de Cuneo M,Ruiz RD

更新日期：1980-06-01 00:00:00

abstract：:The effect of hemorrhagic shock, hypoxemia, and anoxia on the levels of adenine and pyridine nucleotides of liver and kidney was assessed. ATP levels in liver and kidney of animals in shock or animals subjected to 7 min of anoxia decreased by 85 and 73%, respectively. Under hypoxic conditions (arterial PO2 AT 18 MMHg)...

journal_title：Canadian journal of physiology and pharmacology

authors： Chaudry IH,Sayeed MM,Baue AE

更新日期：1976-10-01 00:00:00

abstract：:Extracellular spikes were recorded from cell bodies of sympathetic preganglionic neurones in spinal segments T1-T3 of the cat. Each neurone was identified by its antidromic response to electrical stimulation of the sympathetic chain and was found in histological sections to lie within the intermediolateral nucleus. Ph...

journal_title：Canadian journal of physiology and pharmacology

authors： Backman SB,Henry JL

更新日期：1984-09-01 00:00:00

abstract：:Experiments were carried out in pigs to investigate the relationship between concentration of intestinal calcium-binding protein (CaBP) and the presence of rickets. Pigs made rachitic by a diet deficient in calcium and in vitamin D had concentrations of intestinal CaBP no less than values obtained on control pigs. The...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrison JE,Hitchman AJ,Brown RG

更新日期：1975-02-01 00:00:00

abstract：:In Western societies, the incidence of diet-related diseases is progressively increasing due to greater availability of hypercaloric food and a sedentary lifestyle. Obesity, diabetes, atherosclerosis, and neurodegeneration are major diet-related pathologies that share a common pathogenic denominator of low-grade infla...

journal_title：Canadian journal of physiology and pharmacology

authors： Magrone T,Perez de Heredia F,Jirillo E,Morabito G,Marcos A,Serafini M

更新日期：2013-06-01 00:00:00

abstract：:New methods for chronic instrumentation of the newborn piglet are described, which allow continuous monitoring of not only pressures in the pulmonary artery and aorta but also in the left and right atria, pulmonary vein, as well as main branch pulmonary artery flows. Changes in pulmonary vascular tone to short-acting ...

journal_title：Canadian journal of physiology and pharmacology

authors： Coe JY,Olley PM,Hamilton F,Vanhelder T,Coceani F

更新日期：1987-05-01 00:00:00

abstract：:Studies were conducted to determine whether Na-K ATPase or a second species of digitalis receptors in canine cardiac sarcolemma membrane preparations is associated with the positive inotropic action of nontoxic concentrations of ouabain. [3H]ouabain association and dissociation experiments using highly enriched sarcol...

journal_title：Canadian journal of physiology and pharmacology

authors： Kurobane I,Nandi DL,Okita GT

更新日期：1985-05-01 00:00:00

abstract：:Diabetes increases the risk and severity of cognitive impairment, especially after ischemic stroke. It is also known that the activation of the endothelin (ET) system is associated with cognitive impairment and microglia around the periinfarct area produce ET-1. However, little is known about the effect of ET-1 on mic...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdul Y,Jamil S,He L,Li W,Ergul A

更新日期：2020-09-01 00:00:00

abstract：:Pertussis toxin (PTX) is a heterohexameric protein, which is divided into subunits A and B. The A-subunit (protomer) possesses adenine diphosphate (ADP) ribosyltransferase activity, and the B-oligomer confers cell surface binding specificity on the toxin. By virtue of the ADP-ribosylation activity in the A-subunit, PT...

journal_title：Canadian journal of physiology and pharmacology

authors： Wong WS,Rosoff PM

更新日期：1996-05-01 00:00:00

abstract：:This review updates our current knowledge on the regulation of Na+/H+ exchanger, Na+,K+,Cl- cotransporter, Na+,Pi cotransporter, and Na+,K+ pump in isolated epithelial cells from mammalian kidney by protein kinase C (PKC). In cells derived from different tubule segments, an activator of PKC, 4beta-phorbol 12-myristate...

journal_title：Canadian journal of physiology and pharmacology

authors： Gagnon F,Hamet P,Orlov SN

更新日期：1999-05-01 00:00:00

abstract：:Initially the impetus to develop iron (Fe) chelators for clinical use was based upon the need for a drug to treat Fe-overload diseases such as beta-thalassemia. However, it has become clear that Fe chelators may be useful for the treatment of a wide variety of disease states, including cancer, malaria, and free radica...

journal_title：Canadian journal of physiology and pharmacology

authors： Richardson DR

更新日期：1997-10-01 00:00:00

abstract：:Guanine nucleotide binding proteins (G proteins) are largely grouped into three classes: heterotrimeric G proteins, ras-like or small molecular weight GTP binding proteins, and others like Gh. In the heart G proteins transduce signals from a variety of membrane receptors to generate diverse effects on contractility, h...

journal_title：Canadian journal of physiology and pharmacology

authors： Zolk O,Kouchi I,Schnabel P,Böhm M

更新日期：2000-03-01 00:00:00

abstract：:Several studies have utilized the spontaneously hypertensive (SHR) diabetic rat to document the synergistic deleterious consequences of diabetes and hypertension on various organ systems. However, whether these effects are due entirely to the overlapping pathological states or partially result from a greater susceptib...

journal_title：Canadian journal of physiology and pharmacology

authors： Jian K,Fok E,Cam MC,Sambandam N,Yao J,Rodrigues B

更新日期：1996-11-01 00:00:00

abstract：:The experiment examined biological responses produced by combined sequential exposure to low-level tritium contamination, followed by challenging irradiation with fast neutrons. Modifications of endogenous antioxidant potential of different organs in rats were discussed in relation to tissue radiosensitivity. Rats pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Petcu I,Moisol N,Savu D,Constantinescu B

更新日期：2002-07-01 00:00:00

abstract：:Ten minutes after KCl-depolarization of rat myometrial strips, at which time the muscles were in a state of sustained contracture, tissue levels of adenosine 3',5'-cyclic monophosphate (cyclic AMP) were increased by approximately 40% over relaxed controls, and levels of guanosine 3',5'-cyclic monophosphate (cyclic GMP...

journal_title：Canadian journal of physiology and pharmacology

authors： Diamond J,Holmes TG

更新日期：1975-12-01 00:00:00

abstract：:The precise neurobiological mechanisms of tramadol abuse underlying the cognitive function are still unknown. The aim of the present study was to examine the possible effects of intra-CA1 injections of N-methyl-d-aspartate (NMDA), a glutamate NMDA receptor (NMDAR) agonist, and d,l-2-amino-5-phosphonopentanoic acid (DL...

journal_title：Canadian journal of physiology and pharmacology

authors： Jafari-Sabet M,Mofidi H,Attarian-Khosroshahi MS

更新日期：2018-01-01 00:00:00

abstract：:The threshold for electrically induced ventricular fibrillation was determined in anesthetized open-chest dogs, before and after blockade of atrioventricular (A-V) conduction. Without exception, the threshold was significantly elevated after creation of the block. The precise mechanism of this effect is not known at t...

journal_title：Canadian journal of physiology and pharmacology

authors： Reynolds AK,Dresel PE

更新日期：1983-09-01 00:00:00

abstract：:The effect of various doses of i.p. injection of the adenosine receptor agonist (R)-phenylisopropyladenosine (R-PIA), ranging from nanomolar to micromolar concentrations, on plasma levels of free fatty acids, glucose, insulin, glucagon, ACTH, and corticosterone was examined in 200-g male rats. At the lowest dose of R-...

journal_title：Canadian journal of physiology and pharmacology

authors： LeBlanc J,Soucy J

更新日期：1994-02-01 00:00:00

abstract：:Transactivation of epidermal growth factor receptor (EGFR) is a well-documented mechanism by which vasoactive peptides and H2O2 elicit their cellular responses. However, a role for the insulin-like growth factor type-1 receptor (IGF-1R) transactivation in mediating the effects of angiotensin II (Ang II) and H2O2 in va...

journal_title：Canadian journal of physiology and pharmacology

authors： Azar ZM,Mehdi MZ,Srivastava AK

更新日期：2007-01-01 00:00:00

abstract：:Both surface pH (pHs) and intracellular pH (pHi) were measured using single- and double-barreled pH-sensitive microelectrodes in isolated sheep cardiac Purkinje strands, rabbit and cat papillary muscle, and mouse and rat soleus muscle. Superfusion of the preparations with a relatively low buffered solution (containing...

journal_title：Canadian journal of physiology and pharmacology

authors： de Hemptinne A,Marrannes R,Vanheel B

更新日期：1987-05-01 00:00:00

abstract：:We tested the effects of inhibiting the carbonic anhydrase activity of rat soleus and extensor digitorum longus muscles on the isometric contractile properties and the resistance to fatigue. SOL and EDL muscles from female rats were incubated in vitro in the presence of methazolamide, a specific inhibitor of carbonic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Côté C,Tremblay D,Riverin H,Frémont P,Rogers PA

更新日期：1989-06-01 00:00:00

abstract：:Two principles suffice to model the large-scale geometry of normal human coronary arterial networks. The first principle states that artery diameters are set to minimize the power required to distribute blood through the network. The second principle states that arterial tree geometries are set to globally minimize th...

journal_title：Canadian journal of physiology and pharmacology

authors： Changizi MA,Cherniak C

更新日期：2000-08-01 00:00:00

abstract：:Microwaves may exert adverse biological effects on the cardiovascular system at the integrated system and cellular levels. However, the mechanism underlying such effects remains poorly understood. Here, we report a previously uncharacterized mechanism through which microwaves damage myocardial cells. Rats were treated...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhu W,Cui Y,Feng X,Li Y,Zhang W,Xu J,Wang H,Lv S

更新日期：2016-08-01 00:00:00

abstract：:Acute dose--response studies were conducted to determine if ethosuximide had anticonvulsant activity against seizures evoked by stroboscopic stimulation of epileptic fowl and to correlate the observed effects with the concentration of the drug in the plasma. Ethosuximide, in doses that produced mean plasma concentrati...

journal_title：Canadian journal of physiology and pharmacology

authors： Davis HL,Johnson DD,Crawford RD

更新日期：1978-10-01 00:00:00

abstract：:Both gonadotropin-releasing hormone (GnRH) and prostaglandin F2 alpha (PGF2 alpha) can inhibit cAMP and progesterone production in the corpus luteum; however, their mechanism of action is not known. GnRH or PGF2 alpha causes a rapid and marked increase of labelling of phosphatidylinositol (PI) and phosphatidic acid (P...

journal_title：Canadian journal of physiology and pharmacology

authors： Leung PC

更新日期：1985-03-01 00:00:00