Abstract：
:A brief burst of electrical stimuli delivered to the vagus nerve during the cardiac cycle elicits a triphasic cardiac chronotropic response. The cardiac cycle length initially increases, then briefly decreases, and subsequently increases again. We studied the effects of a calcium channel blocking agent, verapamil, on these responses to vagal stimulation during sinoatrial nodal rhythm in anesthetized, open-chest dogs. Verapamil increased the basal cardiac cycle length only slightly; however, the primary cardioinhibition was accentuated approximately 40% (from 396 to 555 ms) by verapamil. Neither the acceleratory phase of this triphasic response nor the secondary cardioinhibition was significantly affected by verapamil. These results indicate that verapamil potentiates the initial action of acetylcholine at the sinoatrial node when the vagus is activated with brief stimuli.
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Wallick DW,Stuesse SL,Valencic F,Fratianne RBdoi
10.1139/y86-164subject
Has Abstractpub_date
1986-07-01 00:00:00pages
954-7issue
7eissn
0008-4212issn
1205-7541journal_volume
64pub_type
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journal_title：Canadian journal of physiology and pharmacology
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：1985-06-01 00:00:00
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pub_type： 杂志文章,评审
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