Vicenin-2 and scolymoside inhibit high-glucose-induced vascular inflammation in vitro and in vivo.

abstract：:Cold ischemia--warm reperfusion (CI/WR) injury of liver transplantation involves hepatocyte cell death, the nature and underlying mechanisms of which remain unclear. Isolated hepatocytes and isolated perfused livers were used to determine the prevalence of necrosis and apoptosis as well as mitochondrial dysfunction. I...

journal_title：Canadian journal of physiology and pharmacology

authors： Duval M,Plin C,Elimadi A,Vallerand D,Tillement JP,Morin D,Haddad PS

更新日期：2006-05-01 00:00:00

abstract：:Spironolactone is a diuretic steroid which is capable of blocking the binding of aldosterone to its cytosol receptor at the distal convoluted tubule. In addition, it has been shown that spironolactone is a strong inhibitor of steroidogenesis. More recently, new aldosterone antagonists have been discovered. Some of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Netchitailo P,Perroteau I,Delarue C,Leboulenger F,Capron MH,Vaudry H

更新日期：1983-01-01 00:00:00

abstract：:Cyclophosphamide (CP) is an antineoplastic drug that induces kidney damage via producing oxidative stress. Carvacrol (CAR) has antioxidative effect and we postulated that it can be protective against CP-induced nephrotoxicity. Six groups (n = 7) of rats (control, 100 mg/kg CP, CP+5 mg/kg CAR, CP+10 mg/kg CAR, 5 mg/kg ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gunes S,Ayhanci A,Sahinturk V,Altay DU,Uyar R

更新日期：2017-07-01 00:00:00

abstract：:Taurine status and pregnancy outcome were assessed in rats fed low dietary taurine and varying doses of guanidinoethyl sulfonate (GES), a structural analogue of taurine. Female Sprague-Dawley rats (225-270 g) were mated overnight and assigned to one of four groups from day 0 to 20 of gestation. Taurine-deficient anima...

journal_title：Canadian journal of physiology and pharmacology

authors： Gottschall-Pass KT,Gorecki DK,Paterson PG

更新日期：1995-08-01 00:00:00

abstract：:The effect of isoproterenol on mean right and left atrial pressures (RAP, LAP) and dimensions (RAD, LAD), and plasma immunoreactive atrial natriuretic factor (IR-ANF) was investigated in anesthetized rabbits. Infusion of isoproterenol (10 micrograms.kg-1.min-1 for 10 min) significantly increased plasma IR-ANF and hear...

journal_title：Canadian journal of physiology and pharmacology

authors： King KA,Wong A,Ledsome JR

更新日期：1991-04-01 00:00:00

abstract：:The level of circulating triacylglycerols is determined by the balance between their delivery into the plasma and their removal from it. Plasma triacylglycerols are derived either from dietary fat as chylomicrons or from endogenous hepatic synthesis as very low density lipoproteins. Their removal occurs through the ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Herzberg GR

更新日期：1991-11-01 00:00:00

abstract：:Our studies are guided by the novel hypothesis that protein tyrosine phosphorylation is an important mechanism for regulating contraction of smooth muscle. Several lines of evidence are reviewed which suggest that enhanced tyrosine phosphorylation participates in mechanisms that regulate cytosolic Ca2+ and Ca2+ sensit...

journal_title：Canadian journal of physiology and pharmacology

authors： Di Salvo J,Pfitzer G,Semenchuk LA

更新日期：1994-11-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs are widely used for the treatment of osteoarthritis and rheumatoid arthritis, but their ability to cause gastrointestinal bleeding is a significant limitation to this use. A better understanding of the pathogenesis of gastric and intestinal injury induced by these agents will permi...

journal_title：Canadian journal of physiology and pharmacology

authors： Wallace JL

更新日期：1994-12-01 00:00:00

abstract：:Pathogenic mechanisms for essential hypertension are unclear despite striking efforts from numerous research teams over several decades. Increased production of reactive oxygen species (ROS) has been associated with the development of hypertension and the role of ROS in hypertension has been well documented in recent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang T,Wu L

更新日期：2006-12-01 00:00:00

abstract：:Studies are scant on the effects of short-term carvedilol treatment as an adjuvant to angiotensin-converting enzyme (ACE) inhibitor in patients with left ventricular (LV) systolic dysfunction. The objective of this study was to find the effects of short-term treatment of carvedilol on patients with ischemic LV systoli...

journal_title：Canadian journal of physiology and pharmacology

authors： Gandhi PS,Goyal RK,Jain AR,Mallya BS,Gupta VM,Shah DS,Trivedi BR,Shastri NA,Mehta CB,Jain KA,Bhavasar NS,Shah UJ

更新日期：2007-02-01 00:00:00

abstract：:In rats anesthetized with alpha-chloralose, doses of 0.1, 0.5, and 1 g/kg of ethanol produced an upward shift of baroreflex curves constructed by plotting the heart rate response against mean arterial pressure following evoked rises in mean arterial pressures by phenylephrine or angiotensin II. Whereas the upward shif...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Rahman AR,Russ R,Strickland JA,Wooles WR

更新日期：1987-05-01 00:00:00

abstract：:Single crab (Callinectes danae) fibers were equilibrated with isotonic, high KCl solutions and were subsequently returned to the control saline. This caused marked swelling of the T tubules. Fibers treated with 100 mM KCl had a 2.5-mV residual depolarization, a 50% decrease in effective membrane resistance (Reff) and ...

journal_title：Canadian journal of physiology and pharmacology

authors： Leal-Cardoso JH,Suarez-Kurtz G

更新日期：1985-07-01 00:00:00

abstract：:The pharmacological characteristics of postjunctional alpha-adrenoceptors in isolated canine internal carotid arteries were investigated by the use of selective agonists and antagonists for alpha 1- and alpha 2-adrenoceptors. Norepinephrine, phenylephrine, and xylazine caused concentration-dependent contractions in th...

journal_title：Canadian journal of physiology and pharmacology

authors： Kawai Y,Kobayashi S,Ohhashi T

更新日期：1988-05-01 00:00:00

abstract：:Using conventional intracellular microelectrode techniques, the membrane potential (Em) of vascular smooth muscle cells in isolated segments of thoracic rat aorta was measured. The influence of exogenous and of endothelium-derived nitric oxide on the Em was assessed, and the involvement of glibenclamide-sensitive chan...

journal_title：Canadian journal of physiology and pharmacology

authors： Vanheel B,Van de Voorde J

更新日期：1997-12-01 00:00:00

abstract：:The rat atrium contains a potent natriuretic factor which appears to inhibit the sodium reabsorption in the collecting tubules of the kidneys. We examined the effects of the injection of partially purified atrial natriuretic factor (ANF) and synthetic ANF (8-33) into rats with simultaneous infusions of dextrose or apr...

journal_title：Canadian journal of physiology and pharmacology

authors： Thibault G,Garcia R,Cantin M,Genest J

更新日期：1984-06-01 00:00:00

abstract：:Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach d...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Salama RB,Coceani F,Olley PM

更新日期：1984-04-01 00:00:00

abstract：:The effect of hemorrhagic shock, hypoxemia, and anoxia on the levels of adenine and pyridine nucleotides of liver and kidney was assessed. ATP levels in liver and kidney of animals in shock or animals subjected to 7 min of anoxia decreased by 85 and 73%, respectively. Under hypoxic conditions (arterial PO2 AT 18 MMHg)...

journal_title：Canadian journal of physiology and pharmacology

authors： Chaudry IH,Sayeed MM,Baue AE

更新日期：1976-10-01 00:00:00

abstract：:Endothelin 1 (ET-1) is a potent vasoconstrictor implicated in the control of blood pressure and renal function. Its effects can be modulated by nitric oxide (NO), which inhibits ET-1 production and action. Recently, we reported that ET-1 production can also be modulated by angiotensin II (AngII) in vivo. To investigat...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Amours M,Lebel M,Grose JH,Larivière R

更新日期：1999-01-01 00:00:00

abstract：:The mesangial cell is a contractile secreting cell found in a key position in the renal glomerulus. Several kidney and systemic diseases are associated with dysfunctions of the mesangial cells. We compared the effect of bradykinin (BK; B2 agonist) and des-Arg9-bradykinin (DBK; B1 agonist) on intracellular calcium mobi...

journal_title：Canadian journal of physiology and pharmacology

authors： Girolami JP,Ouardani M,Bascands JL,Pécher C,Bompart G,Leung-Tack J

更新日期：1995-07-01 00:00:00

abstract：:Neuronal factors co-released with neurotransmitters may play an important role in synapse development and function. Calcitonin gene related peptide (CGRP) and adenosine 5'-triphosphate (ATP), two principal neuromodulators present in the motor nerve terminals, were studied for their roles and mechanisms during early de...

journal_title：Canadian journal of physiology and pharmacology

authors： Lu B,Fu WM

更新日期：1995-07-01 00:00:00

abstract：:Aspirin consumption has been reported to be able to reduce colorectal cancer risk in humans and in animal models of colon carcinogenesis. Although the mechanism involved in such an effect is not yet clear, both prostaglandin-dependent and -independent effects have been proposed. Using HT-29 Glc(-/+)cells, which origin...

journal_title：Canadian journal of physiology and pharmacology

authors： Eklou-Kalonji E,Andriamihaja M,Reinaud P,Mayeur C,Camous S,Robert V,Charpigny G,Blachier F

更新日期：2003-05-01 00:00:00

abstract：:Patients with Crohn's disease (CD) have higher risk for osteoporosis following decreased level of osteocalcin. We hypothesize that active inflammation following Mycobacterium avium subsp. paratuberculosis (MAP) infection results in elevation of undercarboxylated osteocalcin (ucOC) and downregulation of active osteocal...

journal_title：Canadian journal of physiology and pharmacology

authors： Naser A,Qasem A,Naser SA

更新日期：2018-07-01 00:00:00

abstract：:We compared the determinants of spontaneous activity in explanted neonatal (2-day-old) rat ventricle cells and in reaggregates derived from 15-day-old chick embryos. We studied the beating rate with an optical recording method and the underlying electrical activity with glass microelectrodes using the K current blocke...

journal_title：Canadian journal of physiology and pharmacology

authors： Schanne OF,Boutin L,Derosiers J

更新日期：1989-07-01 00:00:00

abstract：:The metabolic effect of intravenous infusion of ammonium chloride (60 mumol/(kg body weight.min] was compared in five sheep before and after adrenal denervation. Adrenal denervation completely abolished the hyperglycemic effect of ammonium chloride, diminished the rise of pyruvate and lactate concentration, and failed...

journal_title：Canadian journal of physiology and pharmacology

authors： Wiechetek M,Podgurniak P,Zabielski R,Podgurniak M

更新日期：1989-09-01 00:00:00

abstract：:Vanadium (V) as sodium orthovanadate induces an increase in lipid peroxidation in the kidneys after a single subcutaneous or intraperitoneal injection to rats or mice. The rate of malondialdehyde (MDA) formation, an index of lipid peroxidation, by kidney homogenates increased by more than 100% 1 h after injection. Chr...

journal_title：Canadian journal of physiology and pharmacology

authors： Donaldson J,Hemming R,LaBella F

更新日期：1985-03-01 00:00:00

abstract：:Metaiodobenzylguanidine, which is used in the diagnosis and treatment of pheochromocytoma, produced 50% inhibition of monoamine oxidase at a concentration of 8 X 10(-6) M in vitro. These results suggest that a careful study of the structure of a new radiodiagnostic agent should be done to anticipate and prepare for po...

journal_title：Canadian journal of physiology and pharmacology

authors： Burba JV

更新日期：1985-02-01 00:00:00

abstract：:In recent decades, the complexity of the endothelium and its major role in maintaining or altering blood vessel architecture are being revealed. In contrast, the vascular smooth muscle cell previously received the most attention. I suggest support of the hypothesis that the endothelium is the key to vascular disease. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Todd ME

更新日期：1992-04-01 00:00:00

abstract：:Cardiac dysfunction due to ischemia-reperfusion (I/R) is associated with marked changes in membrane function and subsequent Ca2+-handling abnormalities in cardiomyocytes. The membrane abnormalities in hearts subjected to I/R arise primarily from oxidative stress as a consequence of increased formation of reactive oxyg...

journal_title：Canadian journal of physiology and pharmacology

authors： Tappia PS,Asemu G,Rodriguez-Leyva D

更新日期：2010-03-01 00:00:00

abstract：:Our purpose was to determine the effect of eight different combinations of contraction intensity, duration, and rest on the rate of fatigue in vastus lateralis muscle. A single combination consisted of contractions at 30 or 70% maximal voluntary contraction (MVC), held for 3 or 7 s with 3- or 7-s rest intervals. Contr...

journal_title：Canadian journal of physiology and pharmacology

authors： Dolmage T,Cafarelli E

更新日期：1991-10-01 00:00:00

abstract：:Previous work suggested that sulfhydryl groups and disulfide bridges have important functions in opioid binding to the delta opioid receptor. The question regarding which cysteines are essential for ligand binding was approached by replacement of cysteine residues in the cloned delta opioid receptor using site-directe...

journal_title：Canadian journal of physiology and pharmacology

authors： Ehrlich GK,Andria ML,Zheng X,Kieffer B,Gioannini TL,Hiller JM,Rosenkranz JE,Veksler BM,Zukin RS,Simon EJ

更新日期：1998-03-01 00:00:00