Differences in the altered energy metabolism of hemorrhagic shock and hypoxemia.

abstract：:Vanadium (V) as sodium orthovanadate induces an increase in lipid peroxidation in the kidneys after a single subcutaneous or intraperitoneal injection to rats or mice. The rate of malondialdehyde (MDA) formation, an index of lipid peroxidation, by kidney homogenates increased by more than 100% 1 h after injection. Chr...

journal_title：Canadian journal of physiology and pharmacology

authors： Donaldson J,Hemming R,LaBella F

更新日期：1985-03-01 00:00:00

abstract：:Cerebrocrast is a novel lipophilic dihydropyridine derivative with potential neuroprotective and antidiabetic properties. We have analyzed its interaction with L-type (CaV1.2b) and T-type (CaV3.1) calcium channels using a whole-cell patch clamp in HEK 293 cells. Cerebrocrast inhibited current flux through both CaV1.2b...

journal_title：Canadian journal of physiology and pharmacology

authors： Drígelová M,Tarabová B,Duburs G,Lacinová L

更新日期：2009-11-01 00:00:00

abstract：:The world-wide increase in cancer incidence imposes a corresponding significant increase in the use of chemotherapeutic agents. Nephrotoxicity is a side effect frequently encountered with cyclophosphamide (CP), which is also well-known to cause acute and chronic lung toxicities. The current study focuses on the evalua...

journal_title：Canadian journal of physiology and pharmacology

authors： Said E,Elkashef WF,Abdelaziz RR

更新日期：2016-04-01 00:00:00

abstract：:Heme oxygenase (HO) has a central role in cellular antioxidant defences and vascular protection, and it may mediate pleiotropic actions of drugs used in cardiovascular therapy. We investigated whether long-term use of statins upregulates HO activity and increases carbon monoxide (CO) and bilirubin levels in vivo. Adul...

journal_title：Canadian journal of physiology and pharmacology

authors： Muchova L,Wong RJ,Hsu M,Morioka I,Vitek L,Zelenka J,Schröder H,Stevenson DK

更新日期：2007-08-01 00:00:00

abstract：:Previous studies have demonstrated that abdominal irradiation alters intestinal uptake of nutrients. The purpose of this study was to determine the effect of an orally administered synthetic prostaglandin E2, enprostil, given on three occasions shortly prior to a single exposure to 600 cGy external abdominal irradiati...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson AB,Keelan M,Clandinin MT,Tavernini M,Lam T,Walker K,Cheeseman CI

更新日期：1989-10-01 00:00:00

abstract：:Rhus tripartitum D.C., Anacardiaceae, has traditionally been used in Tunisia against many illnesses. The present study investigates, for the first time, the protective effects of the methanol extract of Rhus tripartitum fruit (MERT) against CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicty in Wistar rats...

journal_title：Canadian journal of physiology and pharmacology

authors： Tlili N,Feriani A,Allagui MS,Saadoui E,Khaldi A,Nasri N

更新日期：2016-08-01 00:00:00

abstract：:We studied the in vitro effect of corticosterone on insulin binding, uptake of 2-deoxy-D-glucose, glycolysis, and glycogenesis in the soleus and extensor digitorum longus (EDL) of Swiss-Webster mice. In each experiment, one muscle (soleus/EDL) was incubated with corticosterone (0.1, 1, 50, and 100 micrograms/mL) and t...

journal_title：Canadian journal of physiology and pharmacology

authors： Tan MH,Bonen A

更新日期：1985-09-01 00:00:00

abstract：:Cardiac injury and loss of cardiomyocytes is a causative as well as a resultant condition of cardiovascular disorders, which are the leading cause of death throughout the world. This loss of cardiomyocytes cannot be completely addressed through the currently available drugs being administered, which mainly function on...

journal_title：Canadian journal of physiology and pharmacology

authors： Padda J,Sequiera GL,Sareen N,Dhingra S

更新日期：2015-10-01 00:00:00

abstract：:The response pattern of the isolated longitudinal muscle of the rabbit ileum to adenosine-5'-alpha, beta-methylenediphosphonate (APCP) was found to differ from that caused by adenosine or ATP in that the rapid initial phase of relaxation is absent and that at doses above 10 muM a secondary increase of contractile acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Frew R,McKenzie SG,Bär HP,Hutchison KJ

更新日期：1976-08-01 00:00:00

abstract：:Neuropeptide Y (NPY(1-36)), a sympathetic cotransmitter and neurohormone, has pleiotropic activities ranging from the control of obesity to anxiolysis and cardiovascular function. Its actions are mediated by multiple Gi/o-coupled receptors (Y1-Y5) and modulated by dipeptidyl peptidase IV (DPPIV/cd26), which inactivate...

journal_title：Canadian journal of physiology and pharmacology

authors： Zukowska Z,Pons J,Lee EW,Li L

更新日期：2003-02-01 00:00:00

abstract：:In this study, we examined the effect of hydrogen peroxide on the accumulation of various mRNAs encoding heat shock proteins (hsps) and proto-oncogenes in Xenopus A6 kidney epithelial cells. Hydrogen peroxide treatment enhanced the accumulation of hsp90, hsp70, hsp30, c-jun, c-fos, and actin mRNAs with distinct tempor...

journal_title：Canadian journal of physiology and pharmacology

authors： Muller M,Gauley J,Heikkila JJ

更新日期：2004-07-01 00:00:00

abstract：:We describe postsynaptic Ca2+ signals that subserve induction of two forms of neuronal plasticity, long-term potentiation (LTP) and long-term depression (LTD), in rat hippocampal neurons. The common induction protocol for LTP, a 1-s, 50-Hz tetanus, generates Ca2+ increases of about 50-Hz in dendritic spines of CA1 neu...

journal_title：Canadian journal of physiology and pharmacology

authors： Connor JA,Petrozzino J,Pozzo-Miller LD,Otani S

更新日期：1999-09-01 00:00:00

abstract：:This study developed an animal model of gestational obesity and prediabetes in Sprague Dawley rats using 35% sucrose supplementation (SS). Postprandially, insulin stimulates glucose uptake and nutrient partitioning via insulin-dependent as well as Hepatic Insulin Sensitizing Substance (HISS)-dependent action. HISS is ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lovat NEJ,Legare DJ,Lautt WW

更新日期：2020-10-16 00:00:00

abstract：:The hemodynamic effects of the combination of clonidine and propranolol were studied in conscious rats with portal hypertension owing to secondary biliary cirrhosis. Pressure and blood flow measurements (radioactive microsphere method) were performed in three groups of eight rats before and after drug administration. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Roulot D,Gaudin C,Braillon A,Sekiyama T,Bacq Y,Lebrec D

更新日期：1989-10-01 00:00:00

abstract：:1. To examine whether different local anesthetics act on different or similar sites in the nerve membrane, the effects of combinations of lipid-soluble anesthetics and tetrodotoxin (TTX) were studied on the compound action potential of the frog sciatic nerve. 2. The nerve-blocking potency of TTX was potentiated 5-fold...

journal_title：Canadian journal of physiology and pharmacology

authors： Staiman AL,Seeman P

更新日期：1975-08-01 00:00:00

abstract：:The area postrema (AP) is one of the circumventricular organs of the brain and as such it is highly vascular and lacks the normal blood-brain barrier. Anatomical tracing studies have demonstrated afferent projections to AP originating from the paraventricular nucleus, lateral parabrachial nucleus (l-PBN), nucleus trac...

journal_title：Canadian journal of physiology and pharmacology

authors： Ferguson AV

更新日期：1991-07-01 00:00:00

abstract：:The 3,5-pyrazolidinedione (3,5-P) drugs, phenylbutazone and sulfinpyrazone, have been reported to bind to receptors for the chemotactic peptide, f-Met-Leu-Phe, and to behave as functional antagonists of f-Met-Leu-Phe in human and rabbit neutrophils. To explore the structure-activity relationship of this family of drug...

journal_title：Canadian journal of physiology and pharmacology

authors： Levesque L,Gaudreault RC,Marceau F

更新日期：1991-03-01 00:00:00

abstract：:The airway smooth muscle from asthmatic airways produces increased amounts and an altered composition of extracellular matrix proteins. The extracellular matrix can in turn influence the phenotype and function of airway smooth muscle cells, affecting the biochemical, geometric, and mechanical properties of the airway ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tran T,Halayko AJ

更新日期：2007-07-01 00:00:00

abstract：:Several experimental data document an activation of the mitogen-activated protein kinases Erk1 and Erk2 by bradykinin (BK), an agonist of the kinin B2 receptor (B2R). In contrast, other reports showed an inhibitory modulation of mitogenesis by BK. Therefore, we explored in the isolated glomeruli the effect of B2R acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Cellier E,Duchêne J,Pécher C,Alric C,Bascands JL,Schanstra JP,Girolami JP

更新日期：2002-04-01 00:00:00

abstract：:This review updates our current knowledge on the regulation of Na+/H+ exchanger, Na+,K+,Cl- cotransporter, Na+,Pi cotransporter, and Na+,K+ pump in isolated epithelial cells from mammalian kidney by protein kinase C (PKC). In cells derived from different tubule segments, an activator of PKC, 4beta-phorbol 12-myristate...

journal_title：Canadian journal of physiology and pharmacology

authors： Gagnon F,Hamet P,Orlov SN

更新日期：1999-05-01 00:00:00

abstract：:Single crab (Callinectes danae) fibers were equilibrated with isotonic, high KCl solutions and were subsequently returned to the control saline. This caused marked swelling of the T tubules. Fibers treated with 100 mM KCl had a 2.5-mV residual depolarization, a 50% decrease in effective membrane resistance (Reff) and ...

journal_title：Canadian journal of physiology and pharmacology

authors： Leal-Cardoso JH,Suarez-Kurtz G

更新日期：1985-07-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease resulting in the formation of the atherosclerotic plaque. Plaque formation starts with the inflammation in fatty streaks and progresses through atheroma, atheromatous plaque, and fibroatheroma leading to development of stable plaque. Hypercholesterolemia, dyslipidemia,...

journal_title：Canadian journal of physiology and pharmacology

authors： Rai V,Agrawal DK

更新日期：2017-10-01 00:00:00

abstract：:Complexes of vanadyl(IV) with 4 monosaccharides and 5 disaccharides were tested in 2 osteoblast-like cell lines (MC3T3E1 and UMR106). Many complexes caused stimulation of UMR106 proliferation (120% basal) in the range of 2.5 to 25 micromol/L. In the nontransformed osteoblasts, some vanadyl-saccharide complexes stimula...

journal_title：Canadian journal of physiology and pharmacology

authors： Barrio DA,Cattáneo ER,Apezteguía MC,Etcheverry SB

更新日期：2006-07-01 00:00:00

abstract：:H2S is an important gasotransmitter with a vasorelaxant property. The modulation of endogenous H2S generation from different tissues and the functional consequence of this modulation are not clear. In the present study, the production of H2S from vascular tissues as well as the liver and ileum of rats was measured. Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhao W,Ndisang JF,Wang R

更新日期：2003-09-01 00:00:00

abstract：:Connexin43 has been recognized as forming gap junctions in Leydig cells. However, previous work has shown that mouse Leydig cells lacking this connexin do not suffer any limitation of their ability to produce testosterone when stimulated with luteinizing hormone. The objective of this study was to identify additional ...

journal_title：Canadian journal of physiology and pharmacology

authors： Li D,Sekhon P,Barr KJ,Márquez-Rosado L,Lampe PD,Kidder GM

更新日期：2013-02-01 00:00:00

abstract：:Several studies have utilized the spontaneously hypertensive (SHR) diabetic rat to document the synergistic deleterious consequences of diabetes and hypertension on various organ systems. However, whether these effects are due entirely to the overlapping pathological states or partially result from a greater susceptib...

journal_title：Canadian journal of physiology and pharmacology

authors： Jian K,Fok E,Cam MC,Sambandam N,Yao J,Rodrigues B

更新日期：1996-11-01 00:00:00

abstract：:Prolongation of bradykinin half-life following kininase inhibition has been proposed as the reason for the potentiation of kinin effects. We have reassessed this assumption by using three different isolated smooth muscle preparations and simultaneously studying the inhibition of kininase activity and the potentiation ...

journal_title：Canadian journal of physiology and pharmacology

authors： Schaffel R,Rodrigues MS,Assreuy J

更新日期：1991-07-01 00:00:00

abstract：:Our studies are guided by the novel hypothesis that protein tyrosine phosphorylation is an important mechanism for regulating contraction of smooth muscle. Several lines of evidence are reviewed which suggest that enhanced tyrosine phosphorylation participates in mechanisms that regulate cytosolic Ca2+ and Ca2+ sensit...

journal_title：Canadian journal of physiology and pharmacology

authors： Di Salvo J,Pfitzer G,Semenchuk LA

更新日期：1994-11-01 00:00:00

abstract：:A brief burst of electrical stimuli delivered to the vagus nerve during the cardiac cycle elicits a triphasic cardiac chronotropic response. The cardiac cycle length initially increases, then briefly decreases, and subsequently increases again. We studied the effects of a calcium channel blocking agent, verapamil, on ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wallick DW,Stuesse SL,Valencic F,Fratianne RB

更新日期：1986-07-01 00:00:00

abstract：:The validity of a Hodgkin-Huxley type voltage-dependent inactivation of slow inward Ca current (Isi) was tested in frog heart using a computer simulation. The time course of Isi was calculated during the development of a frog atrial action potential (AP). With a time constant of inactivation (tauf) of 55 ms at a membr...

journal_title：Canadian journal of physiology and pharmacology

authors： Fischmeister R,Horackova M

更新日期：1982-09-01 00:00:00