Angiotensin II receptors' modulation of calcium homeostasis in human vascular endothelial cells.

abstract：:Bicuculline methochloride (BMC), applied by microiontophoresis, tends to depolarize spinal motoneurons and lower their input resistance. With approximately equal iontophoretic currents of gamma-aminobutyric acid (GABA) and BMC, there is an almost equal chance of observing no change, a potentiation, or a depression of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Puil E,Werman R

更新日期：1977-06-01 00:00:00

abstract：:In order to understand the mechanisms of exercise intolerance and muscle fatigue, which are commonly observed in congestive heart failure, we studied sarcoplasmic reticulum (SR) Ca(2+)-transport in the hind-leg skeletal muscle of rats subjected to myocardial infarction (MI). Sham-operated animals were used for compari...

journal_title：Canadian journal of physiology and pharmacology

authors： Shah KR,Ganguly PK,Netticadan T,Arneja AS,Dhalla NS

更新日期：2004-07-01 00:00:00

abstract：:The development of cardiac hypertrophy was examined in rats given ethanol in a nutritionally adequate, liquid diet mixture, by intubation, in severely intoxicating doses at 8-h intervals for up to 96 h, alone or in combination with prazosin. Other groups of rats received isocalorically paired quantities of maltose-dex...

journal_title：Canadian journal of physiology and pharmacology

authors： Adams MA,Hirst M

更新日期：1989-03-01 00:00:00

abstract：:The present experiments were designed to evaluate vascular reactivity to angiotensin II in rats with experimental cirrhosis of the liver (induced with CCl4 and phenobarbital) before ascites appearance. The systemic pressor response to angiotensin II in conscious animals and the contractile effect of angiotensin II in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Villamediana LM,García-Villalón AL,Caramelo C,López-Novoa JM

更新日期：1989-12-01 00:00:00

abstract：:The role that thromboxane A2 plays in contractions induced by leukotriene D4 in guinea-pig isolated lung parenchyma was investigated under equilibrium conditions. Lung tissue generated thromboxane A2 and prostacyclin spontaneously as evidenced by the slow accumulation of their biologically inactive metabolites, thromb...

journal_title：Canadian journal of physiology and pharmacology

authors： Giembycz MA,Rodger IW

更新日期：1987-07-01 00:00:00

abstract：:Several laboratories have reported ligand binding studies using radioactive histamine H1 antagonists to label the H1 receptors in mammalian brain. We have extended these studies to a detailed examination of the binding of [3H]mepyramine to monkey brain and have shown that the distribution is similar to that in man, wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Bielkiewicz B,Cook DA

更新日期：1985-06-01 00:00:00

abstract：:A variety of porphyrinogenic xenobiotics cause mechanism-based inactivation of a number of rat hepatic cytochrome P450 isozymes. As a result, a mixture of four N-alkylprotoporphyin IX (N-alkylPP) regioisomers, with ferrochelatase-inhibitory properties, are formed. This study was designed to determine whether all four ...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamee JP,Kobus SM,Marks GS

更新日期：1996-08-01 00:00:00

abstract：:A hydroperoxide compound structurally related to acetylsalicylic acid, 3-hydroperoxy-3-methylphthalide, inhibits both the first and second phases of adenosine diphosphate induced, biphasic, human platelet aggregation. This occurs over the same concentration range (0.05-0.5 mM) that acetylsalicylic acid inhibits second...

journal_title：Canadian journal of physiology and pharmacology

authors： Killackey JJ,Killackey BA,Cerskus I,Philp RB

更新日期：1984-03-01 00:00:00

abstract：:We compared the determinants of spontaneous activity in explanted neonatal (2-day-old) rat ventricle cells and in reaggregates derived from 15-day-old chick embryos. We studied the beating rate with an optical recording method and the underlying electrical activity with glass microelectrodes using the K current blocke...

journal_title：Canadian journal of physiology and pharmacology

authors： Schanne OF,Boutin L,Derosiers J

更新日期：1989-07-01 00:00:00

abstract：:Cardiac adenosine receptors are coupled to adenylate cyclase inhibition. In the guinea pig heart, the relative agonist potencies observed for adenylate cyclase inhibition were R-N6-phenylisopropyladenosine (R-PIA) = N6-cyclohexyladenosine greater than 5'-N-ethylcarboxamidoadenosine much greater than S-PIA. In both atr...

journal_title：Canadian journal of physiology and pharmacology

authors： Leung E,Woodcock EA

更新日期：1986-12-01 00:00:00

abstract：:The potential of nickel chloride to prevent streptozotocin-induced hyperglycemia was tested in rats in vivo. To induce diabetes, streptozotocin (100 mg/kg body weight) was injected as a single dose. Streptozotocin treatment resulted in a significant decrease in plasma insulin and ceruloplasmin, and pancreatic Cu, prot...

journal_title：Canadian journal of physiology and pharmacology

authors： Novelli EL,Rodrigues NL,Ribas BO

更新日期：1988-05-01 00:00:00

abstract：:N,N-Diethyl-2-(1-pyridyl)ethylamine (E-2-P) produced 59 +/- 7% of the maximal response to histamine in guinea pig ileal longitudinal smooth muscle and antagonized the responses of this tissue to histamine. The estimated binding constant of E-2-P for the histamine receptor predicted a binding curve nearly coincident wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Kenakin TP,Cook DA

更新日期：1980-11-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) was reported to induce mast cell proliferation and aggravate allergic reactions through activation of mouse double minute 2 (MDM2). We aimed to ascertain that β-sitosterol (SI), which is one of the several phytosterols found mostly in foods, would regulate TSLP-induced mast cell pro...

journal_title：Canadian journal of physiology and pharmacology

authors： Han NR,Kim HM,Jeong HJ

更新日期：2015-11-01 00:00:00

abstract：:Neuropeptide Y (NPY(1-36)), a sympathetic cotransmitter and neurohormone, has pleiotropic activities ranging from the control of obesity to anxiolysis and cardiovascular function. Its actions are mediated by multiple Gi/o-coupled receptors (Y1-Y5) and modulated by dipeptidyl peptidase IV (DPPIV/cd26), which inactivate...

journal_title：Canadian journal of physiology and pharmacology

authors： Zukowska Z,Pons J,Lee EW,Li L

更新日期：2003-02-01 00:00:00

abstract：:Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of phentolamine, a nonse...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhou K,Kumar U,Yuen VG,McNeill JH

更新日期：2012-08-01 00:00:00

abstract：:The natural history of the disease of the dilated strain Bio TO-2 of cardiomyopathic hamsters (CMH) is not totally characterized. We investigated its hemodynamic and histomorphometric characteristics at 140, 180, 220, 260, and 300 days of age. Forty CMH and 40 controls were investigated (8 at each stage). Mean arteria...

journal_title：Canadian journal of physiology and pharmacology

authors： Goineau S,Pape D,Guillo P,Ramée MP,Bellissant E

更新日期：2001-04-01 00:00:00

abstract：:Various researchers have hypothesized that the thickening of the vascular wall plays an important role in the maintenance of hypertension. Such an alteration can increase the vascular resistance by exerting two effects. A thickened vascular wall could occlude the lumen of the blood vessel and (or) cause the artery to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee RM,Smeda JS

更新日期：1985-04-01 00:00:00

abstract：:The effect of adrenaline on the membrane transport of 3-methylglucose was studied in perifused isolated rat left atria that had been fully arrested. In this preparation a high concentration of adrenaline stimulated and a low one decreased sugar transport. The stimulatory effect was strongly inhibited by the beta-adren...

journal_title：Canadian journal of physiology and pharmacology

authors： Bihler I,Sawh PC

更新日期：1976-10-01 00:00:00

abstract：:It has been proposed that medullary washout secondary to increased blood flow will limit maximal urine osmolality and reabsorption of salt and water from the inner medullary collecting duct. We have tested this prediction. The function of the inner medullary collecting duct was examined by microcatheterization. Acetyl...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA,Sonnenberg H

更新日期：1987-12-01 00:00:00

abstract：:In Sprague-Dawley rats, we attempted to develop an experimental model to stimulate the cardiac sympathetic nerve. After transverse thoracotomy under anesthesia, a miniature, bipolar electrode was placed on the right ansa subclavia and it was stimulated electrically. The nerve stimulation at 2, 4, and 8.3 Hz (2 ms in d...

journal_title：Canadian journal of physiology and pharmacology

authors： Masuda Y,Matsuoka H

更新日期：1997-02-01 00:00:00

abstract：:Puerarin (Pur), an isoflavonoid extracted from the dried roots of Pueraria lobata, has been reported to be useful in the treatment of various diseases. This study was designed to evaluate the anti-apoptotic and anti-inflammatory activities of Pur against 3-nitropropionic acid (3-NP) induced neurotoxicity. For 5 consec...

journal_title：Canadian journal of physiology and pharmacology

authors： Mahdy HM,Mohamed MR,Emam MA,Karim AM,Abdel-Naim AB,Khalifa AE

更新日期：2014-03-01 00:00:00

abstract：:Doxorubicin treatment causes delayed development of cardiotoxicity. Whether the doxorubicin-induced impairment of cardiac functions reverses or progresses with time after the cessation of the treatment was examined. The rats were injected with doxorubicin (2.5 mg/kg, i.v., once a week for 3 weeks) and sacrificed at 1 ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chugun A,Temma K,Oyamada T,Suzuki N,Kamiya Y,Hara Y,Sasaki T,Kondo H,Akera T

更新日期：2000-04-01 00:00:00

abstract：:In anesthetized rats micropuncture and microcatheterization were used to collect tubular fluid from end proximal and distal tubules and from the outer medullary collecting duct. Urine was collected at the papilla tip. Samples were taken from the same sites before and after intravenous injection of atrial tissue extrac...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Cupples WA,de Bold AJ,Veress AT

更新日期：1982-09-01 00:00:00

abstract：:A variety of neural factors can influence reproductive hormone secretion by neuromodulatory actions within the hypothalamus or neuroendocrine actions within the anterior pituitary gland. Passive immunoneutralization and antagonist administration protocols have suggested physiological roles for a number of these factor...

journal_title：Canadian journal of physiology and pharmacology

authors： Samson WK,Alexander BD,Skala KD,Huang FL,Fulton RJ

更新日期：1992-05-01 00:00:00

abstract：:Type 1 diabetes mellitus reduces lipoprotein lipase (LPL) activity in the heart. The diabetic phenotype of decreased LPL activity in freshly isolated cardiomyocytes persisted after overnight culture (16 h). Total cellular LPL activity was 311+/-56 nmol oleate released x h(-1) x mg(-1) cell protein in diabetic cultured...

journal_title：Canadian journal of physiology and pharmacology

authors： Ewart HS,Carroll R,Severson DL

更新日期：1999-08-01 00:00:00

abstract：:Glucosamine sulfate is a dietary supplement that is marketed as a treatment for osteoarthritis. Recent evidence from animal and cell culture models have suggested that glucosamine treatment can promote the misfolding of proteins and the activation of the unfolded protein response (UPR). We investigated whether glucosa...

journal_title：Canadian journal of physiology and pharmacology

authors： McAlpine CS,Beriault DR,Behdinan T,Shi Y,Werstuck GH

更新日期：2014-04-01 00:00:00

abstract：:Female rats subjected to 48 h of water deprivation drank more than similarly deprived males. There was no sexual difference in the dipsogenic responses to intracellular dehydration produced by intravenous hypertonic NaCl but females drank considerably more than males in response to the extracellular stimuli of hyperon...

journal_title：Canadian journal of physiology and pharmacology

authors： Kaufman S

更新日期：1980-10-01 00:00:00

abstract：:Alterations in electrical conductivity between smooth muscle cells (SMCs) can alter the spread and effectiveness of electromechanical SMC contraction. We attempted to determine whether alterations in pressure-dependent constriction (PDC) occurring in relation to stroke development within the middle cerebral arteries (...

journal_title：Canadian journal of physiology and pharmacology

authors： Smeda JS,King SR

更新日期：1998-02-01 00:00:00

abstract：:The airway smooth muscle from asthmatic airways produces increased amounts and an altered composition of extracellular matrix proteins. The extracellular matrix can in turn influence the phenotype and function of airway smooth muscle cells, affecting the biochemical, geometric, and mechanical properties of the airway ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tran T,Halayko AJ

更新日期：2007-07-01 00:00:00

abstract：:The effect of pinaverium was electrophysiologically characterized and compared with the established L-type calcium channel blockers diltiazem, D600, and nitrendipine on canine colonic circular smooth muscle. Effects were studied on the electrical activity of the smooth muscle cells, in particular the spontaneously occ...

journal_title：Canadian journal of physiology and pharmacology

authors： Malysz J,Farraway LA,Christen MO,Huizinga JD

更新日期：1997-08-01 00:00:00