Abstract:
:Several laboratories have reported ligand binding studies using radioactive histamine H1 antagonists to label the H1 receptors in mammalian brain. We have extended these studies to a detailed examination of the binding of [3H]mepyramine to monkey brain and have shown that the distribution is similar to that in man, with specific binding sites being concentrated in the frontal cortex with relatively low binding to the pons and basal ganglia. The binding shows a single saturable component with a KD of about 1 nM and a Hill plot slope close to unity. These observations are the same for all structures tested. Comparison with data from other laboratories suggests that in this species, the histamine receptor is the same as that in peripheral tissues. From Ki values for various ligands and comparison of KD estimates in other species, the receptor seems to be essentially identical to the H1 receptor in central and peripheral tissues of the guinea pig and also to that in human brain. The rat and possibly the dog have minor differences from the monkey in terms of KD values for [3H]mepyramine binding.
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Bielkiewicz B,Cook DAdoi
10.1139/y85-125subject
Has Abstractpub_date
1985-06-01 00:00:00pages
756-9issue
6eissn
0008-4212issn
1205-7541journal_volume
63pub_type
杂志文章abstract::Resveratrol, a polyphenol compound with anti-inflammatory properties, has been previously evaluated for its beneficial effects in several ulcerative colitis models. However, the current study elucidates the effect of resveratrol on adhesion molecules, as well as its antioxidant efficacy in a trinitrobenzene sulfonic a...
journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1986-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-08-01 00:00:00
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doi:10.1139/y02-062
更新日期:2002-05-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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doi:10.1139/y86-053
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pub_type: 杂志文章,评审
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更新日期:2005-07-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 临床试验,杂志文章
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更新日期:1994-03-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:2002-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1976-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,评审
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更新日期:1992-04-01 00:00:00
abstract::Clonidine was administered to isolated guinea pig right atria in order to characterize its chronotropic activity and its interaction with other chronotropic agents at the postjunctional level. Clonidine either had no significant effect (10(-7)--10(-4) M) or decreased (10(-3) M) atrial rate. Pretreatment of the atria w...
journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00