Lipoprotein lipase activity is stimulated by insulin and dexamethasone in cardiomyocytes from diabetic rats.

abstract：:The aim of this study was to identify the key genes involved in the cardiac hypertrophy (CH) induced by pressure overload. mRNA microarray data sets GSE5500 and GSE18801 were downloaded from the Gene Expression Omnibus database, and differentially expressed genes (DEGs) were screened using the Limma package; then, fun...

journal_title：Canadian journal of physiology and pharmacology

authors： Gao J,Li Y,Wang T,Shi Z,Zhang Y,Liu S,Wen P,Ma C

更新日期：2018-08-01 00:00:00

abstract：:The distribution of atrial natriuretic factor (ANF) binding sites in Wistar rat tissues, as well as tissues from other species was studied. Using autoradiography of slide mounted tissue sections incubated with 125I-labelled ANF, high densities of binding sites were found in the renal glomeruli and papilla, aortic smoo...

journal_title：Canadian journal of physiology and pharmacology

authors： von Schroeder HP,Nishimura E,McIntosh CH,Buchan AM,Wilson N,Ledsome JR

更新日期：1985-11-01 00:00:00

abstract：:Pioglitazone (Pio) and swimming exercise (SE) are insulin sensitisers. This investigation was suggested because of the significant side effects associated with Pio treatment in metabolic syndrome (MetS). This study was, therefore, designed to investigate the preventive role of Pio treatment and SE in terms of efficien...

journal_title：Canadian journal of physiology and pharmacology

authors： Sakr HF,Al-Hashem FH,El-Naby WM,Alkhateeb MA,Zaki MS,Refaey HM,Morsy MD

更新日期：2014-02-01 00:00:00

abstract：:We compared the determinants of spontaneous activity in explanted neonatal (2-day-old) rat ventricle cells and in reaggregates derived from 15-day-old chick embryos. We studied the beating rate with an optical recording method and the underlying electrical activity with glass microelectrodes using the K current blocke...

journal_title：Canadian journal of physiology and pharmacology

authors： Schanne OF,Boutin L,Derosiers J

更新日期：1989-07-01 00:00:00

abstract：:A brief burst of electrical stimuli delivered to the vagus nerve during the cardiac cycle elicits a triphasic cardiac chronotropic response. The cardiac cycle length initially increases, then briefly decreases, and subsequently increases again. We studied the effects of a calcium channel blocking agent, verapamil, on ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wallick DW,Stuesse SL,Valencic F,Fratianne RB

更新日期：1986-07-01 00:00:00

abstract：:There are important differences in pain arising from deep tissues in comparison to cutaneous pain. These differences can be partially explained by the unique organization of nociceptive systems activated by stimulation of muscle, joint, or viscera. Recent evidence also indicates that stimulation of deep tissues can pr...

journal_title：Canadian journal of physiology and pharmacology

authors： Dubner R

更新日期：1991-05-01 00:00:00

abstract：:A semisynthetic chemical compound, demethyldiisoeugenol, concentration dependently inhibited platelet aggregation and ATP release stimulated by thrombin (0.1 U/mL), platelet-activating factor (2 ng/mL), arachidonic acid (100 microM), collagen (10 micrograms/mL), and U46619 (1 microM) in rabbit washed platelets. The IC...

journal_title：Canadian journal of physiology and pharmacology

authors： Liao CH,Ko FN,Kuo YH,Teng CM

更新日期：1996-10-01 00:00:00

abstract：:We previously reported that calpain, the Ca2+-sensitive cysteine protease, gets involved in atherogenesis. This study aimed to investigate the effects of calpain inhibitor I (CAI, 5 mg/kg per day) with or without NG-nitro-l-arginine-methyl ester (l-NAME) (100 mg/kg per day), the inhibitor of nitric oxide synthase (NOS...

journal_title：Canadian journal of physiology and pharmacology

authors： Yu L,Yin M,Yang X,Lu M,Tang F,Wang H

更新日期：2018-01-01 00:00:00

abstract：:Heparin was introduced into the stomach or duodenum of mice separately in doses of ca. 250 mg/kg. A slight anticoagulant effect in the systemic circulation was detected in whole blood clotting times and factor X inhibition. In contrast to most drugs, more heparin was absorbed from the stomach than from the intestine. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sue TK,Jaques LB,Yuen E

更新日期：1976-08-01 00:00:00

abstract：:The effects of modulators of Ca-ATPase and alkaline phosphatase (AP) activity on placental calcium and phosphorus transfer were studied using the in situ perfused guinea pig placenta. The diuretics ethacrynic acid and furosemide had no significant effect on placental calcium and phosphorus transfer when injected into ...

journal_title：Canadian journal of physiology and pharmacology

authors： McKercher HG,Derewlany LO,Radde IC

更新日期：1983-11-01 00:00:00

abstract：:The placental transfer of indomethacin was studied in the rabbit at 30 days of gestation and in the sheep between 120 and 135 days of gestation. Plasma concentrations of indomethacin reached a maximum of 13.7 +/- 1.6 and 10.9 +/- 1.5 microgram/mL in the doe and fetuses, respectively, at 1 h following a maternal subcut...

journal_title：Canadian journal of physiology and pharmacology

authors： Harris WH,Van Petten GR

更新日期：1981-04-01 00:00:00

abstract：:The hypothesis was examined that phenoxybenzamine enhances both the overflow of noradrenaline and the mechanical response in guinea pig vas deferens by blockade of presynaptic inhibitory receptors located on adrenergic nerve terminals which serve a negative-feedback function. Preparations were stimulated with a consta...

journal_title：Canadian journal of physiology and pharmacology

authors： Kalsner S

更新日期：1979-07-01 00:00:00

abstract：:In older Aplysia, the central nervous system (CNS) (abdominal ganglion) exerts suppressive and facilitatory control over the peripheral nervous system (PNS) which initially mediates the gill withdrawal reflex and its subsequent habituation evoked by tactile stimulation of the siphon. In young animals, both the suppres...

journal_title：Canadian journal of physiology and pharmacology

authors： Lukowiak K

更新日期：1979-09-01 00:00:00

abstract：:The goal of the present study was to assess the effects of a restricted feeding schedule (RFS) on postischemic contractile recovery in relation to triacylglycerol (TAG), glycogen, and ATP content. Glucose-6-phosphate dehydrogenase (G6PDH) activity, reduced/oxidized glutathione ratio (GSH/GSSG), and thiobarbituric acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Jaitovich MM,Varela A,Sbarbati C,Hermann R,Torresín ME,Savino EA,Marina Prendes MG

更新日期：2010-10-01 00:00:00

abstract：:In using pharmacologic stimuli, force-velocity (FV) curves are usually obtained by the method of quick release (QR) and redevelopment of shortening at peak tetanic tension; the advantage of the method being that the active state is at maximum. However, the QR may itself reduce the intensity of the active state and res...

journal_title：Canadian journal of physiology and pharmacology

authors： Stephens NL

更新日期：1985-01-01 00:00:00

abstract：:This report reviews the research and mentoring career of Richard B. Stein (1940-). In 1962, he completed a B.S. degree in physics at the Massachusetts Institute of Technology, USA, and thereafter an M.A. (1964), Ph.D. (1966), and postdoctoral training (1966-68) at the University of Oxford, UK. He subsequently assumed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuart DG

更新日期：2004-08-01 00:00:00

abstract：:Hypertrophic scar (HS) results from abnormal wound healing, accompanied by excessive hypercellularity, migration and extracellular matrix (ECM) deposition. Autophagy dysregulation plays crucial roles during HS formation. The overexpressed p75 neurotrophin receptor (p75NTR) in injured skin tissue after wound healing be...

journal_title：Canadian journal of physiology and pharmacology

authors： Shi W,Wu Y,Bian D

更新日期：2020-07-29 00:00:00

abstract：:The effect of a novel antianginal agent, molsidomine (N-ethoxycarbonyl-3-morpholinosydnonimine) (SIN-10) and its metabolites, 3-morpholinosydnonimine (SIN-1) and N-nitroso-N-morpholinoaminoacetonitrile (SIN-1A) on isolated dog blood vessels were investigated. SIN-1 and SIN-1A elicited a concentration-dependent relaxat...

journal_title：Canadian journal of physiology and pharmacology

authors： Muramatsu I,Fujii K,Sakakibara Y,Fujiwara M

更新日期：1983-09-01 00:00:00

abstract：:The anticonvulsant activity of delta9-tetrahydrocannabinol (delta9-THC) has been determined against seizures induced in epileptic chickens by intermittent photic stimulation (IPS) and in epileptic and nonepileptic chickens by Metrazol. Intravenous administration of the drug reduced both the severity and incidence of s...

journal_title：Canadian journal of physiology and pharmacology

authors： Johnson DD,McNeill JR,Crawford RD,Wilcox WC

更新日期：1975-12-01 00:00:00

abstract：:Glucose utilization and insulin and growth hormone responses were evaluated in eight obese women by three rapid intravenous glucose tolerance tests (IVGTT): during a control period, and after 1 and 3 weeks of a 750 kcal/day protein-lipid diet (1 kcal = 4.1855 kJ). Weight loss averaged 454 g/day during the 1st week and...

journal_title：Canadian journal of physiology and pharmacology

authors： Reid D,Rasio E

更新日期：1982-03-01 00:00:00

abstract：:The purpose of the present work was to study the rate of basal luteinizing hormone (LH) glycosylation, discriminating the co-translational (proximal) and the post-translational (distal) glycosylation. The experiments were performed to determine the temporal relationship between the biosynthesis of the peptide chains (...

journal_title：Canadian journal of physiology and pharmacology

authors： Pérez GT,Apfelbaum ME

更新日期：1997-07-01 00:00:00

abstract：:The effects of isoproterenol and forskolin on tension, cyclic AMP levels, and cyclic AMP dependent protein kinase activity were compared in helical strips of bovine coronary artery. Elevation of cyclic AMP and activation of the protein kinase appeared to be well correlated with relaxation of potassium-contracted arter...

journal_title：Canadian journal of physiology and pharmacology

authors： Vegesna RV,Diamond J

更新日期：1984-09-01 00:00:00

abstract：:The most commonly observed effect of beta-blockade on cardiovascular function has been a reduction in heart rate both at rest and during exercise. The body attempts to compensate by increasing stroke volume and (or) increasing the extraction of O2 from the blood to maintain O2 delivery to the muscle. This paper examin...

journal_title：Canadian journal of physiology and pharmacology

authors： Hughson RL,Kowalchuk JM

更新日期：1991-02-01 00:00:00

abstract：:Anti-mitogenic agents currently used to prevent restenosis in drug-eluting stents delay re-endothelialization. Delayed re-endothelialization is now considered as the main cause of late stent thrombosis with drug-eluting stents, which emphasizes the need for new treatments. We have shown that systemic insulin treatment...

journal_title：Canadian journal of physiology and pharmacology

authors： Chiang S,Breen DM,Guo J,Mori Y,Giacca A

更新日期：2013-12-01 00:00:00

abstract：:Physical activity promotes metabolic adaptations that improve body functionality and contribute to the prevention of some diseases. With respect to energy and fat balance, physical activity facilitates the equilibrium between energy intake and expenditure as well as between fat intake and fat oxidation. When combined ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tremblay A,Therrien F

更新日期：2006-02-01 00:00:00

abstract：:There is now evidence for the involvement of four beta-adrenoceptor populations in the regulation of cardiac function by catecholamines. Beta1- and beta2-adrenoceptor stimulation classically produces an increase in contractility. A fourth beta-adrenoceptor, as yet uncloned and designated provisionally as a beta4-adren...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier C,Leblais V,Moniotte S,Langin D,Balligand JL

更新日期：2000-09-01 00:00:00

abstract：:Doxepin binds to intact astrocytes in primary cultures. The binding is competitively displaceable by excess cold doxepin and it is pronounced (Bmax = 27 nmol/mg protein) but the affinity is rather low (KD = 30 microM). The binding is inhibited by other antidepressants (amitriptyline, desipramine, tranylcypromine, ipri...

journal_title：Canadian journal of physiology and pharmacology

authors： Hertz L,Richardson JS,Mukerji S

更新日期：1980-12-01 00:00:00

abstract：:Selected topics on the roles of sarcoplasmic reticulum (SR) in the control of vascular smooth muscle (VSM) tone are briefly reviewed with particular reference to the regulation of cytosolic concentration of free calcium ions, [Ca2+]i. Although morphological evidence and subcellular membrane studies indicate a relative...

journal_title：Canadian journal of physiology and pharmacology

authors： Daniel EE,van Breemen C,Schilling WP,Kwan CY

更新日期：1995-05-01 00:00:00

abstract：:In vivo fatty acid synthesis and the pathways of glycerol-3-phosphate (G3P) production were investigated in brown adipose tissue (BAT) from rats fed a cafeteria diet for 3 weeks. In spite of BAT activation, the diet promoted an increase in the carcass fatty acid content. Plasma insulin levels were markedly increased i...

journal_title：Canadian journal of physiology and pharmacology

authors： Chaves VE,Frasson D,Martins-Santos ME,Navegantes LC,Galban VD,Garófalo MA,Kettelhut IC,Migliorini RH

更新日期：2008-07-01 00:00:00

abstract：:Cyclic AMP formation from ATP was stimulated by unpurified and partially purified soluble hepatic guanylate cyclase in the presence of nitric oxide (NO) or compounds containing a nitroso moiety such as nitroprusside, N-methyl-N-nitro-N-nitrosoguanidine (MNNG), nitrosyl ferroheme, and S-nitrosothiols. Cyclic AMP format...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamara DB,Kadowitz PJ,Hyman AL,Ignarro LJ

更新日期：1980-12-01 00:00:00