Tissue-specific concentration changes of estrone and estradiol during spontaneous and ACTH-induced parturition in sheep.

abstract：:Using labelled microspheres, the effect of norepinephrine (NE) infusions (15 microgram and 30 microgram/min) on coronary blood flow and its intramyocardial distribution during ischemia was studied. The results reported here show that in the ischemic myocardium, the ratio of endocardial to epicardial flow was 0.67. Thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Dumont L,Lelorier J

更新日期：1977-08-01 00:00:00

abstract：:Excitation-contraction coupling in crab muscle fibers was studied in voltage-clamp conditions. Extracellular calcium is essential for the mechanical activity. Two calcium influxes induced by membrane depolarization contribute to tension development: one is the inward calcium current responsible for the phasic tension,...

journal_title：Canadian journal of physiology and pharmacology

authors： Mounier Y,Goblet C

更新日期：1987-04-01 00:00:00

abstract：:Steady state glucose kinetics were measured in 19 premature and 16 full-term piglets. Bodyweight, plasma glucose concentration, total body glucose turnover rate, and glucose pool size were not significantly different between the two groups. This suggests that the premature piglet is capable of maintaining glucose home...

journal_title：Canadian journal of physiology and pharmacology

authors： Flecknell PA,Wootton R,John M,Royston JP

更新日期：1981-10-01 00:00:00

abstract：:Clonidine was administered to isolated guinea pig right atria in order to characterize its chronotropic activity and its interaction with other chronotropic agents at the postjunctional level. Clonidine either had no significant effect (10(-7)--10(-4) M) or decreased (10(-3) M) atrial rate. Pretreatment of the atria w...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodgers RL,Tenner TE Jr,Laher IE,McNeill JH

更新日期：1980-01-01 00:00:00

abstract：:Although dual endothelin receptor antagonists (ERAs) show great promise for treating various conditions, their propensity to induce liver injury limits their clinical usage. Inflammation and fibrosis are important processes in liver responses to injury and it has been suggested that they and dual ERA-induced liver inj...

journal_title：Canadian journal of physiology and pharmacology

authors： Ryanto GRT,Yorifuji K,Ikeda K,Emoto N

更新日期：2020-09-01 00:00:00

abstract：:Uroporphyrinogen decarboxylase (UROG-D) activity in the 10,000g supernatant of 17-day-old chick embryo liver homogenates was determined by measuring the conversion of pentacarboxylporphyrinogen I to coproporphyrinogen I. The optimum pH of the enzyme was found to be approximately 6.0 and enzyme activity was found to be...

journal_title：Canadian journal of physiology and pharmacology

authors： James CA,Marks GS

更新日期：1989-03-01 00:00:00

abstract：:A knowledge of the mechanical properties of valve tissue is a necessary prerequisite for a better understanding of valvular behavior and design of prosthetic heart valves. Elastic response of chordae tendineae under strain rates of 0.05 cm min(-1)(6.25% min(-1)) to 12.7 cm min(-1)(1600% min(-1)) were obtained by the a...

journal_title：Canadian journal of physiology and pharmacology

authors： Lim KO,Boughner DR

更新日期：1975-06-01 00:00:00

abstract：:The contractile recoverability of isolated portal veins made hypodynamic by removal of glucose from the perfusion medium by diverse exogenous substrates was studied. It was found that glucose, mannose, pyruvate, lactate, acetate, and butyrate readily restored contraction. The effects of anoxia and metabolic inhibitors...

journal_title：Canadian journal of physiology and pharmacology

authors： Cremer-Lacuara MG,Lacuara JL,Fiol de Cuneo M,Ruiz RD

更新日期：1980-06-01 00:00:00

abstract：:The effects of beta-adrenergic blocking agents, timolol and atenolol (1-1000 microM), were studied on rat heart sarcolemmal ATPase and Ca2+ binding activities. Timolol, unlike atenolol, increased both Ca2+-stimulated ATPase and ATP-dependent Ca2+ binding; the maximal effects were seen at 1 microM concentration of timo...

journal_title：Canadian journal of physiology and pharmacology

authors： Dzurba A,Ganguly PK,Beamish RE,Dhalla NS

更新日期：1983-03-01 00:00:00

abstract：:This study aimed to investigate the anti-depressant effect of hesperidin (Hsp) in streptozotocin (STZ)-induced diabetic rats. Additionally, the effect of Hsp on hyperglycaemia, oxidative stress, inflammation, brain-derived neurotrophic factor (BDNF), and brain monoamines in diabetic rats was also assessed. The Wistar ...

journal_title：Canadian journal of physiology and pharmacology

authors： El-Marasy SA,Abdallah HM,El-Shenawy SM,El-Khatib AS,El-Shabrawy OA,Kenawy SA

更新日期：2014-11-01 00:00:00

abstract：:Lectins, known to recognize endothelial cell adhesion molecules, have been shown to release endothelium-derived relaxing factor (EDRF) from blood vessels. We investigated the effects of different leukocyte-type cells to determine if these cells, by interacting with the endothelium, could release EDRF from the circumfl...

journal_title：Canadian journal of physiology and pharmacology

authors： Kleha JF,Devesly P,Johns A

更新日期：1995-03-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) calcium handling in diaphragm was compared between mdx mice (7-8 weeks old) and age-matched controls. The total SR Ca2+ load was released from the SR by rapidly cooling muscle bundles from 22 to -1 degree C. The plateau amplitude of the rapid cooling contracture (RCC) was considered as an i...

journal_title：Canadian journal of physiology and pharmacology

authors： Khammari A,Péréon Y,Baudet S,Noireaud J

更新日期：1998-12-01 00:00:00

abstract：:Previous work suggested that sulfhydryl groups and disulfide bridges have important functions in opioid binding to the delta opioid receptor. The question regarding which cysteines are essential for ligand binding was approached by replacement of cysteine residues in the cloned delta opioid receptor using site-directe...

journal_title：Canadian journal of physiology and pharmacology

authors： Ehrlich GK,Andria ML,Zheng X,Kieffer B,Gioannini TL,Hiller JM,Rosenkranz JE,Veksler BM,Zukin RS,Simon EJ

更新日期：1998-03-01 00:00:00

abstract：:The present experiments were designed to evaluate vascular reactivity to angiotensin II in rats with experimental cirrhosis of the liver (induced with CCl4 and phenobarbital) before ascites appearance. The systemic pressor response to angiotensin II in conscious animals and the contractile effect of angiotensin II in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Villamediana LM,García-Villalón AL,Caramelo C,López-Novoa JM

更新日期：1989-12-01 00:00:00

abstract：:Microelectrode and mechanical studies were performed with isolated guinea pig myocardium (right ventricular free walls and papillary muscles) to examine the effects of platelet-activating factor (PAF) and lysophosphatidylcholine (LPC). Low concentrations of PAF (10(-8) to 10(-6) M, a range equivalent to the blood conc...

journal_title：Canadian journal of physiology and pharmacology

authors： Shigenobu K,Mori T,Kamata K,Kasuya Y

更新日期：1989-06-01 00:00:00

abstract：:The effects of some components of ischemia on the oscillatory (Vos) and nonoscillatory (V(ex)) potentials and respective currents (Ios and Iex), as well as their mechanisms, were studied in guinea pig isolated ventricular myocytes by means of a single-microelectrode, discontinuous voltage clamp method. Repetitive acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Liu QY,Vassalle M

更新日期：1994-04-01 00:00:00

abstract：:After myocardial infarction, the hemodynamics under basal conditions might appear to be unaltered, which makes it difficult to identify cardiac dysfunction by the usual approaches. Thus, we tested the response to sudden afterload stress in infarcted rats with apparently normal ejection function. Control (CT) and infar...

journal_title：Canadian journal of physiology and pharmacology

authors： dos Santos L,Antonio EL,Souza AF,Tucci PJ

更新日期：2010-07-01 00:00:00

abstract：:The epicardial coronary venous pressure in 16 dogs was compared with coronary arterial pressure as well as aortic, intraventricular, and intramyocardial pressures. Partial aortic occlusion augmented intraventricular (IVP), intramyocardial (IMP), aortic (AP), and coronary arterial pressures. Peripheral coronary venous ...

journal_title：Canadian journal of physiology and pharmacology

authors： Klassen GA,Armour JA

更新日期：1983-03-01 00:00:00

abstract：:Calcineurin was isolated from bovine cerebrum extracts by sequential chromatography on Affi-Gel blue and calmodulin affinity columns. Calcineurin so isolated was approximately 90% pure and was composed of equimolar amounts of subunit A (Mr = 61 000-63 000) and subunit B (Mr = 15 000-17 000) when examined by sodium dod...

journal_title：Canadian journal of physiology and pharmacology

authors： Gupta RC,Khandelwal RL,Sulakhe PV

更新日期：1985-08-01 00:00:00

abstract：:Two natriuretic peptides, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), are found principally in the heart. In preliminary experiments with mouse kidney cells or slices, we found mouse BNP1-45 much more potent than ANP1-28 in causing elevations of cGMP (>50-fold). The guanylyl cyclase-A (GC-A)...

journal_title：Canadian journal of physiology and pharmacology

authors： Kishimoto I,Hamra FK,Garbers DL

更新日期：2001-08-01 00:00:00

abstract：:High buffer cardioplegia may provide protection against ischemic damage by reducing the extent of intracellular acidosis. Secondary cardioplegia may improve postischemic recovery by restoration of high energy phosphates, ionic gradients, and intracellular pH. To test these hypotheses, pig hearts were arrested with hig...

journal_title：Canadian journal of physiology and pharmacology

authors： Tian GH,Mainwood GW,Biro GP,Smith KE,Butler KW,Lawrence D,Deslauriers R

更新日期：1991-11-01 00:00:00

abstract：:The role of nitric oxide (NO) on the vasorelaxant effect of atrial natriuretic peptide (ANP) on the basal tone of rabbit aortic rings conditioned to angiotensin II (Ang II) was studied. ANP aortic relaxation and nitrite release were measured in the presence and absence of endothelium and a NO-synthase inhibitor. Ang I...

journal_title：Canadian journal of physiology and pharmacology

authors： Romano L,Coviello A,Jerez S,Peral de Bruno M

更新日期：2002-10-01 00:00:00

abstract：:The site of exercise-induced muscle fatigue is suggested to be the muscle membrane, which includes the sarcolemma and T-tubule membrane; the excitability of the membrane is dependent on the membrane potential. Significant potassium flux from the intracellular space of contracting muscle may decrease the membrane poten...

journal_title：Canadian journal of physiology and pharmacology

authors： Sjøgaard G

更新日期：1991-02-01 00:00:00

abstract：:The present study was designed to evaluate the role of endothelial NO in the hemodynamics and vascular changes that occur in heart failure following myocardial infarction in rats. Left ventricular systolic pressure (LVSP), mean blood pressure (MBP), aortic morphology (media thickness) and reactivity were evaluated in ...

journal_title：Canadian journal of physiology and pharmacology

authors： da Cunha V,Stefanon I,Mill JG

更新日期：2004-06-01 00:00:00

abstract：:The postprandial release of immunoreactive insulin, glucagon, gastrin, somatostatin, pancreatic polypeptide (PP), and gastric inhibitory polypeptide (GIP) was studied in parallel with the absorption of sugars and amino acids in conscious pigs. Six pigs fitted with permanent catheters in the portal vein and arterial bl...

journal_title：Canadian journal of physiology and pharmacology

authors： Rérat A,Chayvialle JA,Kandé J,Vaissade P,Vaugelade P,Bourrier T

更新日期：1985-12-01 00:00:00

abstract：:Mechanisms leading to ifosfamide (IF)-induced renal damage have not been fully elucidated. Recent work suggests that localized renal tubular metabolism of IF and the production of the nephrotoxic chloroacetaldehyde may lead to nephrotoxicity. Presently no pharmacological method to reduce IF nephrotoxicity has been ide...

journal_title：Canadian journal of physiology and pharmacology

authors： Aleksa K,Halachmi N,Ito S,Koren G

更新日期：2005-06-01 00:00:00

abstract：:Vascular smooth muscle tone is regulated primarily by the sarcoplasmic free Ca2+ concentration, which determines the level of myosin phosphorylation. Stimulation of the muscle results in an increase in free [Ca2+], whereupon Ca2+ binds to calmodulin, inducing a conformational change enabling calmodulin to interact wit...

journal_title：Canadian journal of physiology and pharmacology

authors： Walsh MP

更新日期：1994-08-01 00:00:00

abstract：:Electrophysiological studies were performed on slowly adapting cells of the crayfish (Astacus astacus) stretch receptor to examine some aspects of the operation of the sodium pump. Intracellular sodium activity (aiNa) and pH (pHi) were measured with liquid ion exchanger microelectrodes and the effects of NH3/NH+4 were...

journal_title：Canadian journal of physiology and pharmacology

authors： Moser H

更新日期：1987-02-01 00:00:00

abstract：:The present study was undertaken to determine the beta-receptor subtype responsible for the enhanced anaphylactic histamine release from bovine leukocytes produced by isoprenaline. The selective beta 1 antagonist practolol competitively inhibited the enhancement of histamine release produced by isoprenaline. The selec...

journal_title：Canadian journal of physiology and pharmacology

authors： Perron R,Eyre P

更新日期：1982-07-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and CNTF analogs were reported to have hepatoprotective effect and ameliorate hepatic steatosis in db/db or high-fat-diet-fed mice. Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate h...

journal_title：Canadian journal of physiology and pharmacology

authors： Cui MX,Jiang JF,Min GN,Han W,Wu YJ

更新日期：2017-05-01 00:00:00