In situ study of the sarcoplasmic reticulum function in control and mdx mouse diaphragm muscle.

abstract：:Norethandrolone (NE) and other androgenic steroids have been shown to be renotropic in various species and have also been reported to have salutary effects in patients with diminished renal function. Renal cortical slices prepared from rats pretreated with NE showed an increased capability to concentrate p-aminohippur...

journal_title：Canadian journal of physiology and pharmacology

authors： Watrous WM,Lacombe R,Brodeur J

更新日期：1975-10-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) has physiological roles in the absence of exposure to exogenous ligands, and mediates adaptive and toxic responses to the environmental pollutant 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD). A readily metabolized AHR agonist, 3-methylcholanthrene, disrupts the expression of mouse he...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee C,Riddick DS

更新日期：2012-10-01 00:00:00

abstract：:Apoptotic pathways in breast cancer cells are frequently altered, reducing the efficiency of radiotherapy. Conjugated linoleic acid (CLA), known to trigger apoptosis, was tested as radiosensitizer in breast cancer cells MCF-7 and MDA-MB-231. The CLA-mix, made up of the isomers CLA-9cis 11trans and CLA-10trans 12cis, w...

journal_title：Canadian journal of physiology and pharmacology

authors： Drouin G,Douillette A,Lacasse P,Paquette B

更新日期：2004-02-01 00:00:00

abstract：:Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against high mobility group box 1 (HMGB1)-mediated septi...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee W,Yoon EK,Kim KM,Park DH,Bae JS

更新日期：2015-08-01 00:00:00

abstract：:To clarify the beneficial effects of cilnidipine, an L- and N-type calcium channel blocker, which were clinically observed against diastolic dysfunction in hypertrophied hearts of hypertensive patients, we investigated the effects of cilnidipine on cardiac remodeling and enhanced gene expression in stroke-prone, spont...

journal_title：Canadian journal of physiology and pharmacology

authors： Takemori K,Ishida H,Dote K,Yamamoto K,Ito H

更新日期：2005-08-01 00:00:00

abstract：:The enhancement of the response of an isolated strip of lactating mouse mammary gland to oxytocin, resulting from dilution of the Tyrode solution in which oxytocin is administered, is due to the effects of hypotonicity per se and not to changes in concentration of any of the ions in the bathing solution. Inhibition of...

journal_title：Canadian journal of physiology and pharmacology

authors： Ferrier BM

更新日期：1979-03-01 00:00:00

abstract：:Sulforaphane, a natural isothiocyanate, demonstrates cardioprotection associated with its capacity to stimulate endogenous antioxidants and to inhibit inflammation. The aim of this study was to investigate whether sulforaphane is capable of attenuating oxidative stress and inflammatory responses through the TLR4/MyD88...

journal_title：Canadian journal of physiology and pharmacology

authors： Bonetto JH,Fernandes RO,Seolin BG,Müller DD,Teixeira RB,Araujo AS,Vassallo D,Schenkel PC,Belló-Klein A

更新日期：2016-05-01 00:00:00

abstract：:Patients with Crohn's disease (CD) have higher risk for osteoporosis following decreased level of osteocalcin. We hypothesize that active inflammation following Mycobacterium avium subsp. paratuberculosis (MAP) infection results in elevation of undercarboxylated osteocalcin (ucOC) and downregulation of active osteocal...

journal_title：Canadian journal of physiology and pharmacology

authors： Naser A,Qasem A,Naser SA

更新日期：2018-07-01 00:00:00

abstract：:The objective of this study was to explore the action of angiotensin II (AII) on cardiac contractility and cyclic AMP (cAMP) generation by forskolin and isoproterenol in the hypertrophic myocardium of the salt-sensitive Dahl rat. Inbred Dahl S and Dahl R rats that had been on a diet supplemented with 6% NaCl were stud...

journal_title：Canadian journal of physiology and pharmacology

authors： Sunga PS,Rabkin SW

更新日期：1994-06-01 00:00:00

abstract：:The tau mutation in the golden (Syrian) hamster is a single gene mutation that drastically affects the speed of the circadian clock, in such a way that homozygous mutants have an endogenous circadian period of 20 h (compared with 24 h for wild-type hamsters). While studying the circadian system of tau-mutant hamsters ...

journal_title：Canadian journal of physiology and pharmacology

authors： Refinetti R

更新日期：2014-01-01 00:00:00

abstract：:The effects of localized distension of the pulmonary vein - left atrial junctions on plasma arginine vasopressin (AVP) have been examined in chloralose anaesthetized dogs. Pulmonary vein distension caused an increase in heart rate and a decrease in plasma AVP concentration. Cooling the vagosympathetic nerves to 10 deg...

journal_title：Canadian journal of physiology and pharmacology

authors： Wilson N,Ledsome JR

更新日期：1983-08-01 00:00:00

abstract：:The ontogenic study of the hepatic biotransformation enzymes revealed the early development of both oxidative and conjugative enzymes in male chickens ranging in age from 3 to 12 weeks. Although the rate of microsomal cytochrome P450 reactions progressively increased during the first 9 weeks, it decreased thereafter. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Coulet M,Eeckhoutte C,Galtier P

更新日期：1996-01-01 00:00:00

abstract：:Immunocytochemistry, radioimmunoassay, chromatography, and biological assay using a rabbit isolated duodenal muscle strip preparation were used in attempting to characterize motilin from the rat small intestine. Several different antisera and monoclonal antibodies directed against natural porcine motilin were used. A ...

journal_title：Canadian journal of physiology and pharmacology

authors： Vogel LB,Brown JC

更新日期：1990-08-01 00:00:00

abstract：:The change in plasma and blood cell pools of L-glutamine during a single pass through the kidney was studied in dogs and rats. It was shown that the glutamine content of blood cells does not change following one passage through the renal vascular bed in normal or acidotic dogs. Furthermore, an infusion of L-glutamine ...

journal_title：Canadian journal of physiology and pharmacology

authors： Vinay P,Khoury N,Soowamber M,Gougoux A

更新日期：1985-07-01 00:00:00

abstract：:A brief summary is given of some of the key points of the individual contributions at this International Brain Research Organization satellite meeting, presenting up-to-date, expert knowledge of energy metabolism, ionic turnover, and cell swelling at the cellular level of the mammalian central nervous system. On the b...

journal_title：Canadian journal of physiology and pharmacology

authors： Hertz L,Code WE,Sykova E

更新日期：1992-01-01 00:00:00

abstract：:In this study, we examined the effect of hydrogen peroxide on the accumulation of various mRNAs encoding heat shock proteins (hsps) and proto-oncogenes in Xenopus A6 kidney epithelial cells. Hydrogen peroxide treatment enhanced the accumulation of hsp90, hsp70, hsp30, c-jun, c-fos, and actin mRNAs with distinct tempor...

journal_title：Canadian journal of physiology and pharmacology

authors： Muller M,Gauley J,Heikkila JJ

更新日期：2004-07-01 00:00:00

abstract：:Simple and complex cells of visual areas of cats may be reliably classified according to the modulatory index (MI) of their responses. This investigation is aimed at analysing the MI in area 18 when a small region (about 200-400 microm in diameter) of area 17 was inactivated with a microinjection of GABA, in anestheti...

journal_title：Canadian journal of physiology and pharmacology

authors： Chabli A,Fortin S,Shumikhina S,Molotchinikoff S

更新日期：1999-03-01 00:00:00

abstract：:The mesenteric vascular bed preparation of control and pinealectomized (PX) male Wistar rats was used to examine vascular reactivity to two concentrations each of norepinephrine, serotonin, angiotensin, and potassium. Vasoconstrictor responses to 50- and 100-ng injections of norepinephrine and 0.5- and 1.0-microgram i...

journal_title：Canadian journal of physiology and pharmacology

authors： Cunnane SC,Manku MS,Oka M,Horrobin DF

更新日期：1980-03-01 00:00:00

abstract：:Calcium antagonists may reduce propensity to ventricular fibrillation, by altering the balance between coronary blood flow and metabolic demand, and thus may substantially prolong time to occurrence of fibrillations. This delay in the onset of fibrillation should be sufficient to prevent sudden death in the case of tr...

journal_title：Canadian journal of physiology and pharmacology

authors： Timour Q,Aupetit JF,Freysz M,Frassati D,Faucon G

更新日期：1996-12-01 00:00:00

abstract：:The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle. Ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Stammers AN,Susser SE,Hamm NC,Hlynsky MW,Kimber DE,Kehler DS,Duhamel TA

更新日期：2015-10-01 00:00:00

abstract：:Microelectrode and mechanical studies were performed with isolated guinea pig myocardium (right ventricular free walls and papillary muscles) to examine the effects of platelet-activating factor (PAF) and lysophosphatidylcholine (LPC). Low concentrations of PAF (10(-8) to 10(-6) M, a range equivalent to the blood conc...

journal_title：Canadian journal of physiology and pharmacology

authors： Shigenobu K,Mori T,Kamata K,Kasuya Y

更新日期：1989-06-01 00:00:00

abstract：:Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach d...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Salama RB,Coceani F,Olley PM

更新日期：1984-04-01 00:00:00

abstract：:Our purpose was to determine the effect of eight different combinations of contraction intensity, duration, and rest on the rate of fatigue in vastus lateralis muscle. A single combination consisted of contractions at 30 or 70% maximal voluntary contraction (MVC), held for 3 or 7 s with 3- or 7-s rest intervals. Contr...

journal_title：Canadian journal of physiology and pharmacology

authors： Dolmage T,Cafarelli E

更新日期：1991-10-01 00:00:00

abstract：:In the wake of demographic change in Western countries, atrial fibrillation has reached an epidemiological scale, yet current strategies for drug treatment of the arrhythmia lack sufficient efficacy and safety. In search of novel medications, atrial-selective drugs that specifically target atrial over other cardiac fu...

journal_title：Canadian journal of physiology and pharmacology

authors： Ravens U

更新日期：2017-11-01 00:00:00

abstract：:In cultures of rat granulosa cells, luteinizing hormone-releasing hormone (LHRH) increases 32P incorporation into both phosphatidylinositol (PI) and phosphatidic acid (PA). After 20 min, the level of radioactivity was three- to four-fold (p less than 0.01) above control in the PI and PA fractions, respectively. The st...

journal_title：Canadian journal of physiology and pharmacology

authors： Minegishi T,Leung PC

更新日期：1985-04-01 00:00:00

abstract：:In using pharmacologic stimuli, force-velocity (FV) curves are usually obtained by the method of quick release (QR) and redevelopment of shortening at peak tetanic tension; the advantage of the method being that the active state is at maximum. However, the QR may itself reduce the intensity of the active state and res...

journal_title：Canadian journal of physiology and pharmacology

authors： Stephens NL

更新日期：1985-01-01 00:00:00

abstract：:The effects of haloperidol, an antipsychotic butyrophenone, on excitability and action potential production in frog's sartorius muscle fibers were studied. This drug produced a local-anestheticlike effect which developed slowly over 1 to 5 h with lower concentrations (2.7 to 5.3 X 10(-6 M) but was completely reversed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Durham HD,Frank GB,Marwaha J

更新日期：1977-06-01 00:00:00

abstract：:Systolic blood pressure was measured weekly in conscious and in anesthetized female Sprague-Dawley (SD) and Wistar-Furth (W/Fu) rats following adrenal enucleation, unilateral nephrectomy, and the imposition of a high salt intake. SD rats quickly developed adrenal-regeneration hypertension (ARH) which progressed rapidl...

journal_title：Canadian journal of physiology and pharmacology

authors： Hall CE,Nasseth D

更新日期：1978-12-01 00:00:00

abstract：:The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normo...

journal_title：Canadian journal of physiology and pharmacology

authors： Salahuddin M,Jalalpure SS,Gadge NB

更新日期：2010-02-01 00:00:00

abstract：:Using a time-lapse cinephotomicrographic technique, the locomotory paths taken by lymphocytes have been shown to satisfy the requirements for a continuous-time Markov chain analysis consisting of four directional states defined by the four quadrants of a Cartesian plane and state 0 in which the cells are stationary. T...

journal_title：Canadian journal of physiology and pharmacology

authors： Noble PB,Boyarsky A,Bentley KC

更新日期：1979-01-01 00:00:00