[Radiosensitizing effect of conjugated linoleic acid on tumor cells MCF-7 and MDA-MB-231].

abstract：:Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Daim MM,Taha R,Ghazy EW,El-Sayed YS

更新日期：2016-01-01 00:00:00

abstract：:Physical activity and training have some potential as tools for examining immune responses to inflammation and trauma. Contributors to the present symposium review various aspects of the inflammatory process, including issues of lymphocyte recirculation and endotoxemia. They examine also the extent and nature of the i...

journal_title：Canadian journal of physiology and pharmacology

authors： Shephard RJ,Shek PN

更新日期：1998-05-01 00:00:00

abstract：:Electrical stimulation of the diencephalon and rostral mesencephalon produced a biphasic pressor response consisting of an initial sharp rise followed by a more prolonged elevation in blood pressure. Active sites from which comparable responses could be evoked were found in the ventral medial and lateral hypothalamus,...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier P

更新日期：1981-05-01 00:00:00

abstract：:Chronic caval dogs with ascites were identified as being natriuretic "responders" or "nonresponders" (delta UNaV less than 20 microequiv./min) following an infusion of atrial natriuretic peptide (ANP) (100 ng.kg-1.min-1). To learn more about the factors modulating tubular resistance to ANP, we attempted to convert res...

journal_title：Canadian journal of physiology and pharmacology

authors： Legault L,Cernacek P,Levy M

更新日期：1992-06-01 00:00:00

abstract：:Lingonberry grown in northern Manitoba, Canada, contains exceptionally high levels of anthocyanins and other polyphenols. Previous studies from our lab have shown that lingonberry anthocyanins can protect H9c2 cells from ischemia-reperfusion injury and anthocyanin-rich diets have been shown to be associated with decre...

journal_title：Canadian journal of physiology and pharmacology

authors： Isaak CK,Petkau JC,Blewett H,O K,Siow YL

更新日期：2017-08-01 00:00:00

abstract：:It is possible to embed the control and computation of a simple single-joint movement at different speeds by a small non-linear network of neuron-like elements. The network "learns" by appropriate adjustment of the strengths of interconnection, or synaptic weights, between the neuron-like elements. The learning of a f...

journal_title：Canadian journal of physiology and pharmacology

authors： Kwan HC,Yeap TH,Jiang BC,Borrett D

更新日期：1990-01-01 00:00:00

abstract：:For 10 days, dogs were fed a normal salt diet containing 70 mequiv. Na+/day (NSD) followed by a high salt diet containing 170 mequiv. Na+/day (HSD) or 240 mequiv. Na+/day (VHSD), or the order was reversed. K+ in these diets was fixed at 40 mequiv./day. The different diets did not influence the basal level of serum cat...

journal_title：Canadian journal of physiology and pharmacology

authors： Carrière S,Cardinal J,Le Grimellec C

更新日期：1980-09-01 00:00:00

abstract：:Local microinjections of harmaline evoked sustained rhythmic activity in the inferior olive of decerebrate cats. Harmaline appears to exert its action within restricted areas of the inferior olivary complex: the caudal halves of the dorsal and medial accessory nuclei. Since the highly synchronized activity generated b...

journal_title：Canadian journal of physiology and pharmacology

authors： De Montigny C,Lamarre Y

更新日期：1975-10-01 00:00:00

abstract：:Chronic potassium deficiency in one-kidney one-clip hypertensive dogs significantly reduces blood pressure and plasma potassium, with a simultaneous increase in plasma renin activity. Tissue potassium concentration was decreased and tissue sodium concentration was increased in striated muscle and adrenal glands, which...

journal_title：Canadian journal of physiology and pharmacology

authors： Garcia R,Constantopoulos G,Gutkowska J,Genest J

更新日期：1983-12-01 00:00:00

abstract：:Tolerance to ethanol was induced in male Sprague-Dawley rats (225-250 g) by chronic feeding with a liquid diet containing 6.5% ethanol (v/v). Control rats were pair-fed with a liquid diet in which the ethanol was replaced by an equicaloric concentration of sucrose. Immediately following sacrifice of the animals the ne...

journal_title：Canadian journal of physiology and pharmacology

authors： Gianoulakis C,Chan JS,Kalant H,Chrétien M

更新日期：1983-09-01 00:00:00

abstract：:Excitation-contraction coupling in crab muscle fibers was studied in voltage-clamp conditions. Extracellular calcium is essential for the mechanical activity. Two calcium influxes induced by membrane depolarization contribute to tension development: one is the inward calcium current responsible for the phasic tension,...

journal_title：Canadian journal of physiology and pharmacology

authors： Mounier Y,Goblet C

更新日期：1987-04-01 00:00:00

abstract：:Hepatotoxicity and nephrotoxicity are important drawbacks of cisplatin. The objective of this study is to evaluate the ability of ambroxol in 2 different doses (35 and 70 mg/kg, i.p.) to protect liver and kidney from damage induced by a single dose of cisplatin (10 mg/kg, i.p.) in comparison with N-acetylcysteine (250...

journal_title：Canadian journal of physiology and pharmacology

authors： Bishr A,Sallam N,Nour El-Din M,Awad AS,Kenawy SA

更新日期：2019-01-01 00:00:00

abstract：:A study of the relationship between the mechanical response of human iliac arteries subjected to sinusoidally varying dynamic pressures superimposed on a static pressure of 100 mm Hg (1mm Hg = 133 N/m2) and the development of arterial dilatation, with particular reference to poststenotic dilatation has been conducted....

journal_title：Canadian journal of physiology and pharmacology

authors： Vito R,Tso WK,Schwartz CJ

更新日期：1975-12-01 00:00:00

abstract：:We studied the effect of lowering the extracellular potassium concentration ([K+]o) on the electrophysiological actions of disopyramide phosphate, a new antiarrhythmic drug. At low [K+]o, therapeutic concentrations of disopyramide phosphate caused significantly less depression of action potential amplitude and maximum...

journal_title：Canadian journal of physiology and pharmacology

authors： Kus T,Sasyniuk BI

更新日期：1978-02-01 00:00:00

abstract：:The purpose of this study was to determine the interaction of three factors that modify twitch contraction amplitude in the rat gastrocnemius muscle in situ: posttetanic potentiation, fatigue, and caffeine. Posttetanic (200 Hz for 1 s) twitch responses were observed before and after 15 Hz stimulation for 6 min (group ...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIntosh BR,Gardiner PF

更新日期：1987-02-01 00:00:00

abstract：:Glycine has been used to reduce oxidative stress and proinflammatory mediators in some metabolic disorders; however, its effect on the vasculature has been poorly studied. The aim of this work was to explore the effect of glycine on endothelial dysfunction in aged rats. Aortic rings with intact or denuded endothelium ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gómez-Zamudio JH,García-Macedo R,Lázaro-Suárez M,Ibarra-Barajas M,Kumate J,Cruz M

更新日期：2015-06-01 00:00:00

abstract：:The effects of haloperidol, an antipsychotic butyrophenone, on excitability and action potential production in frog's sartorius muscle fibers were studied. This drug produced a local-anestheticlike effect which developed slowly over 1 to 5 h with lower concentrations (2.7 to 5.3 X 10(-6 M) but was completely reversed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Durham HD,Frank GB,Marwaha J

更新日期：1977-06-01 00:00:00

abstract：:The objective of the present study was to assess the cardioprotective effect of dual NEP-ACE inhibition in relation to endogenous cardiac bradykinin (BK), its active metabolite des-Arg9-BK, endogenous brain natriuretic peptides (BNP), and cGMP. Rats were treated with the dual metallopeptidase inhibitor, omapatrilat, o...

journal_title：Canadian journal of physiology and pharmacology

authors： Dumoulin MJ,Adam A,Burnett J,Heublein D,Yamaguchi N,Lamontagne D

更新日期：2005-02-01 00:00:00

abstract：:Intra- and extra-cellular concentrations of calcium were measured in hippocampal neurons of areas CA1 and CA3 during 8 min ischaemia and short-term (up to 60 min) recovery. During an ischaemic insult, [Ca2+]i increased progressively and [Ca2+]e decreased. There were large interneuronal differences, although, in genera...

journal_title：Canadian journal of physiology and pharmacology

authors： Erecińska M,Silver IA

更新日期：1992-01-01 00:00:00

abstract：:There is increasing evidence for a beneficial effect of ginseng on cardiac pathology. Here, we determined whether North American ginseng can modulate the deleterious effects of the β-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. Isoproterenol was administ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tang X,Gan XT,Rajapurohitam V,Huang CX,Xue J,Lui EM,Karmazyn M

更新日期：2016-12-01 00:00:00

abstract：:Cyclophosphamide (CP) is an antineoplastic drug that induces kidney damage via producing oxidative stress. Carvacrol (CAR) has antioxidative effect and we postulated that it can be protective against CP-induced nephrotoxicity. Six groups (n = 7) of rats (control, 100 mg/kg CP, CP+5 mg/kg CAR, CP+10 mg/kg CAR, 5 mg/kg ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gunes S,Ayhanci A,Sahinturk V,Altay DU,Uyar R

更新日期：2017-07-01 00:00:00

abstract：:The mechanisms responsible for microbially induced epithelial apoptosis and increased intestinal permeability remain unclear. This study assessed whether purified bacterial lipopolysaccharide (LPS) increases epithelial apoptosis and permeability and whether these changes are dependent on caspase-3 activation. In nontu...

journal_title：Canadian journal of physiology and pharmacology

authors： Chin AC,Flynn AN,Fedwick JP,Buret AG

更新日期：2006-10-01 00:00:00

abstract：:The present study was designed to investigate the effects of YC-1, a nitric oxide (NO)-independent soluble guanylate cyclase (sGC) activator, and DEA/NO, a NO donor, on smooth muscle responses in the preeclampsia model with suramin-treated rats and on the levels of cyclic guanosine monophosphate (cGMP) of thoracic aor...

journal_title：Canadian journal of physiology and pharmacology

authors： Turgut NH,Temiz TK,Turgut B,Karadas B,Parlak M,Bagcivan I

更新日期：2013-10-01 00:00:00

abstract：:Puerarin (Pur), an isoflavonoid extracted from the dried roots of Pueraria lobata, has been reported to be useful in the treatment of various diseases. This study was designed to evaluate the anti-apoptotic and anti-inflammatory activities of Pur against 3-nitropropionic acid (3-NP) induced neurotoxicity. For 5 consec...

journal_title：Canadian journal of physiology and pharmacology

authors： Mahdy HM,Mohamed MR,Emam MA,Karim AM,Abdel-Naim AB,Khalifa AE

更新日期：2014-03-01 00:00:00

abstract：:Garlic is a commonly used spice in folk medicine that can exert adverse health effects when given at a high dose. Grape seed and skin extract (GSSE) exhibits a variety of beneficial effects even at a high dose. In the present study we evaluated the toxicity of high-dose garlic treatment on liver and the protective eff...

journal_title：Canadian journal of physiology and pharmacology

authors： Hamlaoui-Gasmi S,Mokni M,Limam N,N'guessan P,Carrier A,Limam F,Amri M,Aouani E,Marzouki L

更新日期：2012-05-01 00:00:00

abstract：:We have previously shown that A10 vascular smooth muscle cells (VSMC) exposed to angiotensin II (Ang II) exhibited overexpression of Giα proteins. In the present study, we examined the involvement of different signaling pathways in regulating Ang II induced enhanced expression of Giα proteins in VSMC by using pharmaco...

journal_title：Canadian journal of physiology and pharmacology

authors： Li Y,Anand-Srivastava MB

更新日期：2012-08-01 00:00:00

abstract：:The binding of 125I-labelled human chorionic gonadotropin (HCG) was studied using thick slices (300 micron) of rabbit ovarian tissue. Binding was saturable, reversible, stereospecific, and of high affinity. The amount of binding was proportional to the number of slices used and could be destroyed by boiling. Ovarian s...

journal_title：Canadian journal of physiology and pharmacology

authors： YoungLai EV,Wilkinson M,Hibbert P,McMahon A,Jarrell JF

更新日期：1988-04-01 00:00:00

abstract：:A brief burst of electrical stimuli delivered to the vagus nerve during the cardiac cycle elicits a triphasic cardiac chronotropic response. The cardiac cycle length initially increases, then briefly decreases, and subsequently increases again. We studied the effects of a calcium channel blocking agent, verapamil, on ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wallick DW,Stuesse SL,Valencic F,Fratianne RB

更新日期：1986-07-01 00:00:00

abstract：:The structure of the artery wall is exquisitely sensitive to the hemodynamic forces imposed on it by blood pressure and blood flow. This sensitivity regulates growth and remodeling of arteries during development, and it regulates long-term adaptive restructuring of mature vessels. Since many vascular pathologies invol...

journal_title：Canadian journal of physiology and pharmacology

authors： Langille BL

更新日期：1996-07-01 00:00:00

abstract：:Histamine and specific H1- and H2-receptor agonists and antagonists in conjunction with phentolamine and (or) reserpine pretreatment were used to characterize histamine receptor(s) in the seminal vesicle of rat and guinea pig. Stimulation of H1 receptors produced a contraction whereas that of H2 receptors inhibited th...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIntosh CM,Vohra MM

更新日期：1981-08-01 00:00:00