Renal extraction of glutamine from plasma and whole blood: studies in dogs and rats.

abstract：:Previous studies have demonstrated that abdominal irradiation alters intestinal uptake of nutrients. The purpose of this study was to determine the effect of an orally administered synthetic prostaglandin E2, enprostil, given on three occasions shortly prior to a single exposure to 600 cGy external abdominal irradiati...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson AB,Keelan M,Clandinin MT,Tavernini M,Lam T,Walker K,Cheeseman CI

更新日期：1989-10-01 00:00:00

abstract：:Neuronal factors co-released with neurotransmitters may play an important role in synapse development and function. Calcitonin gene related peptide (CGRP) and adenosine 5'-triphosphate (ATP), two principal neuromodulators present in the motor nerve terminals, were studied for their roles and mechanisms during early de...

journal_title：Canadian journal of physiology and pharmacology

authors： Lu B,Fu WM

更新日期：1995-07-01 00:00:00

abstract：:This study was designed to investigate whether and how triiodothyronine (T3) affects renal function in an experimental model of chronic kidney disease. Twenty-four female rats were divided into the following groups: sham-operated control group (n = 8), 5/6 nephrectomized group (Nx, n = 8), and 5/6 nephrectomized group...

journal_title：Canadian journal of physiology and pharmacology

authors： El Agaty SM

更新日期：2018-06-01 00:00:00

abstract：:A major limitation of the use of organic nitrates in cardiovascular medicine is the development of tolerance, which has been attributed, in part, to a decrease in their metabolic activation in the vascular smooth muscle cell. Recently, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) was shown to potentiate vascu...

journal_title：Canadian journal of physiology and pharmacology

authors： O'Reilly DA,McLaughlin BE,Marks GS,Brien JF,Nakatsu K

更新日期：2001-01-01 00:00:00

abstract：:In recent experiments in conscious lambs, we showed that in addition to its well-known natriuretic and diuretic effects, i.v. injection of 2 mg/kg of furosemide resulted in a sustained increase in heart rate and an age-dependent increase in plasma renin activity. To determine whether these responses were dose dependen...

journal_title：Canadian journal of physiology and pharmacology

authors： Patel A,Smith FG

更新日期：1997-09-01 00:00:00

abstract：:In previous studies we have been able to demonstrate tighter metabolic control of muscle metabolism during prolonged steady-state exercise 5 to 6 days after the initiation of training and well before changes in oxidative potential. To examine whether the metabolic adaptations are manifested during the non-steady-state...

journal_title：Canadian journal of physiology and pharmacology

authors： Green HJ,Cadefau J,Cussó R,Ball-Burnett M,Jamieson G

更新日期：1995-04-01 00:00:00

abstract：:The postprandial release of immunoreactive insulin, glucagon, gastrin, somatostatin, pancreatic polypeptide (PP), and gastric inhibitory polypeptide (GIP) was studied in parallel with the absorption of sugars and amino acids in conscious pigs. Six pigs fitted with permanent catheters in the portal vein and arterial bl...

journal_title：Canadian journal of physiology and pharmacology

authors： Rérat A,Chayvialle JA,Kandé J,Vaissade P,Vaugelade P,Bourrier T

更新日期：1985-12-01 00:00:00

abstract：:Idiopathic pulmonary arterial hypertension (IPAH) is a rare and devastating condition. There is no known cure for IPAH, and current treatment options are not always effective. Autologous myeloid angiogenic cells (MACs) have been explored as a novel therapy for IPAH, but preliminary data from clinical trials show limit...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang Q,Zucco L,Toshner M,Morrell NW,Granton J,Stewart DJ,Kutryk MJB

更新日期：2019-04-01 00:00:00

abstract：:In cats under pentobarbital anaesthesia, intramotoneuronal administrations of 4-aminopyridine significantly prolong the falling phase of the antidromic action potential but have much less effect on the orthodromic action potential. 4-aminopyridine probably blocks the fast K channels involved in the repolarization of t...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang L,Krnjević K

更新日期：1986-11-01 00:00:00

abstract：:This study aimed to investigate the antiulcer and antioxidant activities of myrtle berry seed aqueous extract (MBSAE) in a peptic ulcer model induced by ethanol in male Wistar rats. MBSAE is rich in total polyphenols, total flavonoids, and unsaturated fatty acids, particularly linoleic (18:2) and oleic (18:1) acids. M...

journal_title：Canadian journal of physiology and pharmacology

authors： Jabri MA,Rtibi K,Tounsi H,Hosni K,Marzouki L,Sakly M,Sebai H

更新日期：2017-05-01 00:00:00

abstract：:To evaluate the clinical efficacy of azithromycin, cefaclor, and amoxicillin in treatment of pediatric tonsillitis, a total of 256 children with Group A β-hemolytic streptococcus (GAS) tonsillitis were randomly divided into 3 groups. Only patients assessed with streptococcus-positive tonsillitis, considered to be comp...

journal_title：Canadian journal of physiology and pharmacology

authors： Li P,Jiang G,Shen X

更新日期：2019-10-01 00:00:00

abstract：:Diabetes with vascular complication needs strict interventions to retard possible serious complications. This research estimated the possible interaction of rosiglitazone (RGN) with losartan (Los) in diabetic rats. Male Sprague-Dawley rats were randomly divided into nondiabetic rats, diabetic rats, and diabetic rats t...

journal_title：Canadian journal of physiology and pharmacology

authors： Ateyya H,Nader MA,El-Sherbeeny NA

更新日期：2018-03-01 00:00:00

abstract：:We studied the in vitro effect of corticosterone on insulin binding, uptake of 2-deoxy-D-glucose, glycolysis, and glycogenesis in the soleus and extensor digitorum longus (EDL) of Swiss-Webster mice. In each experiment, one muscle (soleus/EDL) was incubated with corticosterone (0.1, 1, 50, and 100 micrograms/mL) and t...

journal_title：Canadian journal of physiology and pharmacology

authors： Tan MH,Bonen A

更新日期：1985-09-01 00:00:00

abstract：:A knowledge of the mechanical properties of valve tissue is a necessary prerequisite for a better understanding of valvular behavior and design of prosthetic heart valves. Elastic response of chordae tendineae under strain rates of 0.05 cm min(-1)(6.25% min(-1)) to 12.7 cm min(-1)(1600% min(-1)) were obtained by the a...

journal_title：Canadian journal of physiology and pharmacology

authors： Lim KO,Boughner DR

更新日期：1975-06-01 00:00:00

abstract：:Kinins are the endogenous ligands of the constitutive B2 receptor (B2R) and the inducible B1 receptor (B1R). Whereas B2R prevents insulin resistance, B1R is involved in insulin resistance and metabolic syndrome. However, the contribution of B1R in type 2 diabetes associated with obesity remains uncertain. The aim of t...

journal_title：Canadian journal of physiology and pharmacology

authors： Talbot S,Dias JP,El Midaoui A,Couture R

更新日期：2016-07-01 00:00:00

abstract：:The LA/N-corpulent (LA/N-cp) rat is a normotensive strain derived from Koltesky's original mutant strain of the spontaneously hypertensive rat (SHR). When homozygous for the cp gene (cp/cp), the rats are hyperphagous, hyperlipidemic, hyperinsulinemic, and obese. The rats have been shown, by scanning electron microscop...

journal_title：Canadian journal of physiology and pharmacology

authors： Russell JC,Amy RM

更新日期：1986-10-01 00:00:00

abstract：:Space travelers experience anorexia and body weight loss in a microgravity environment, and microgravity-like situations cause changes in hypothalamic activity. Hypothalamic melanocortins play a critical role in the regulation of metabolism. Therefore, we hypothesized that microgravity affects metabolism through alter...

journal_title：Canadian journal of physiology and pharmacology

authors： Lew PS,Wong D,Yamaguchi T,Leckstrom A,Schwartz J,Dodd JG,Mizuno TM

更新日期：2009-10-01 00:00:00

abstract：:Single-channel recordings from central neurons of the helix snail, Cepaea nemoralis, revealed two types of channels that could be activated by stretch (i.e., by the membrane deformation produced when suction is applied to the patch pipette). One, a K+ channel (58 pS in physiological solution), was evident in excised a...

journal_title：Canadian journal of physiology and pharmacology

authors： Bédard E,Morris CE

更新日期：1992-02-01 00:00:00

abstract：:There is now evidence for the involvement of four beta-adrenoceptor populations in the regulation of cardiac function by catecholamines. Beta1- and beta2-adrenoceptor stimulation classically produces an increase in contractility. A fourth beta-adrenoceptor, as yet uncloned and designated provisionally as a beta4-adren...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier C,Leblais V,Moniotte S,Langin D,Balligand JL

更新日期：2000-09-01 00:00:00

abstract：:The role of sodium and calcium on strophanthidin inotropy was studied in canine cardiac Purkinje fibers perfused in vitro under conditions that vary cellular sodium and calcium. With high concentrations of strophanthidin (greater than or equal to 10(-7) M), force increases more in the presence of low [Ca]0 or high [Na...

journal_title：Canadian journal of physiology and pharmacology

authors： Li T,Bernabei R,Carbonin P,Vassalle M

更新日期：1986-11-01 00:00:00

abstract：:This study investigated the potential of shikonin as an anticancer agent against liver cancer and an in vitro human hepatoma cancer model system. The HepG2 cell line was the hepatoma cancer model in the present study. The inhibitory effect of shikonin on the growth of HepG2 cells was measured by MTT assay. To explore ...

journal_title：Canadian journal of physiology and pharmacology

authors： Yingkun N,Lvsong Z,Huimin Y

更新日期：2010-12-01 00:00:00

abstract：:The present paper reviews current knowledge of the development and plasticity of the inhibitory gamma-aminobutyric acid (GABA) containing circuitry of the cerebral neocortex, in particular, the rat somatosensory barrel field cortex. Recent studies reveal a delayed and protracted maturation of the inhibitory compared w...

journal_title：Canadian journal of physiology and pharmacology

authors： Micheva KD,Beaulieu C

更新日期：1997-05-01 00:00:00

abstract：:Thyrotoxicosis, a condition in which there is an excessive amount of circulating thyroid hormones, leads to reduced glycogen content in different tissues. In this study we analyzed the effects of aerobic swimming training on liver, heart, and skeletal muscle glycogen content in experimentally induced thyrotoxicosis. W...

journal_title：Canadian journal of physiology and pharmacology

authors： Ribeiro LF,Teixeira IP,Aparecido da Silva G,Dalia RA,Júnior MC,Bertolini NO,Rostom de Mello MA,Luciano E

更新日期：2012-05-01 00:00:00

abstract：:Acute administration of morphine sulfate at 20 mg/kg decreased mouse cerebellar adenosine 3',5'-cyclic phosphate (cAMP) levels while not affecting cAMP phosphodiesterase (EC 3.1.4.17). The cAMP levels and cAMP phosphodiesterase activies were not affected by chronic treatment. However, cAMP levels increased during abru...

journal_title：Canadian journal of physiology and pharmacology

authors： Charalampous KD,Askew WE

更新日期：1977-02-01 00:00:00

abstract：:Small, sinusoidal length changes were superimposed on isometric contractions of fast- and slow-twitch mouse muscles, which were stimulated maximally via their nerves. Stiffness increased with increasing frequency of sinusoidal stimulation, but the relative time course of force and stiffness changes during twitch, teta...

journal_title：Canadian journal of physiology and pharmacology

authors： Stein RB,Gordon T

更新日期：1986-09-01 00:00:00

abstract：:Diabetic patients have a higher incidence of cardiac arrhythmias, including ventricular fibrillation and sudden death, and show important alterations in the electrocardiogram, most of these related to the repolarization. In myocytes isolated from diabetic hearts, the transient outward K+ current (Ito) is the repolariz...

journal_title：Canadian journal of physiology and pharmacology

authors： Gallego M,Alday A,Urrutia J,Casis O

更新日期：2009-02-01 00:00:00

abstract：:In experiments on isolated guinea pig papillary muscles the effects of verapamil (5 mg/L) and caffeine (1 g/L) on the two-component contraction were investigated. The muscles were continuously superfused with normal Tyrode's solution containing 2 mg of noradrenaline/L at 20--22 degrees C. The first derivative of contr...

journal_title：Canadian journal of physiology and pharmacology

authors： Bogdanov KY,Zakharov SI,Rosenshtraukh LV

更新日期：1979-08-01 00:00:00

abstract：:Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Daim MM,Taha R,Ghazy EW,El-Sayed YS

更新日期：2016-01-01 00:00:00

abstract：:In Sprague-Dawley rats, we attempted to develop an experimental model to stimulate the cardiac sympathetic nerve. After transverse thoracotomy under anesthesia, a miniature, bipolar electrode was placed on the right ansa subclavia and it was stimulated electrically. The nerve stimulation at 2, 4, and 8.3 Hz (2 ms in d...

journal_title：Canadian journal of physiology and pharmacology

authors： Masuda Y,Matsuoka H

更新日期：1997-02-01 00:00:00

abstract：:Insulin sensitivity and resistance were examined in vivo in uremic rats by using tracer methods which permit the assessment of "non-steady-state" glucose kinetics. By relating the changes in the rates of glucose output by the liver (Ra), uptake by tissues (Rd), and metabolic clearance (MCR) to immunoreactive glucagon ...

journal_title：Canadian journal of physiology and pharmacology

authors： Perez G,Carteni G,Ungaro B,Saccà L

更新日期：1980-03-01 00:00:00