Transient outward potassium channel regulation in healthy and diabetic hearts.

abstract：:The purpose of the present investigation was to determine the nature of the functional interaction of muscarinic agonists with cAMP-generating and cAMP-independent agonists in left atria. Negative inotropic responses of rabbit isolated left atrial strips to the muscarinic agonist carbachol were measured in the absence...

journal_title：Canadian journal of physiology and pharmacology

authors： MacLeod KM

更新日期：1986-05-01 00:00:00

abstract：:Previous work suggested that sulfhydryl groups and disulfide bridges have important functions in opioid binding to the delta opioid receptor. The question regarding which cysteines are essential for ligand binding was approached by replacement of cysteine residues in the cloned delta opioid receptor using site-directe...

journal_title：Canadian journal of physiology and pharmacology

authors： Ehrlich GK,Andria ML,Zheng X,Kieffer B,Gioannini TL,Hiller JM,Rosenkranz JE,Veksler BM,Zukin RS,Simon EJ

更新日期：1998-03-01 00:00:00

abstract：:The synthesis, receptor binding, and agonist activity of a series of truncated atrial natriuretic analogs (ANF) are described. These analogs incorporate two portions of the native 28 amino peptide, the eight amino acids C-terminal to Cys7, and two amino acids from the C-terminus (phenylalanine and arginine), into disu...

journal_title：Canadian journal of physiology and pharmacology

authors： Holleman WH,Budzik GP,Devine EM,Pollock DM,Opgenorth TJ,Thomas AM,von Geldern TW,Rockway TW

更新日期：1991-10-01 00:00:00

abstract：:The effect of high potassium depolarization on the release of exogenously supplied [3H]glutamate and endogenous glutamate from tissue slices of the cestode Hymenolepis diminuta was examined. Increasing concentrations of potassium stimulated the release of radiolabel from tissues preloaded with [3H]glutamate. This rele...

journal_title：Canadian journal of physiology and pharmacology

authors： Webb RA

更新日期：1988-07-01 00:00:00

abstract：:Gripp-Heel is a homeopathic preparation frequently used in the treatment of respiratory viral infections such as various types of influenza and the common cold. The antiviral activity of Gripp-Heel was studied in vitro on human pathogenic enveloped and nonenveloped RNA and DNA viruses. Before the antiviral assays, in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Glatthaar-Saalmüller B

更新日期：2007-11-01 00:00:00

abstract：:Perfusion of isolated rat hearts with Na-free medium resulted in an immediate increase in contractile force followed by a decline and complete loss of contractile force within 25 s. The recovery of the contractile force upon reperfusion was only partial if the duration of Na-free perfusions was 10 min or longer. Ca bi...

journal_title：Canadian journal of physiology and pharmacology

authors： Dhalla NS,Lee SL,Singal PK,Yates JC,Panagia V

更新日期：1980-12-01 00:00:00

abstract：:Prolongation of bradykinin half-life following kininase inhibition has been proposed as the reason for the potentiation of kinin effects. We have reassessed this assumption by using three different isolated smooth muscle preparations and simultaneously studying the inhibition of kininase activity and the potentiation ...

journal_title：Canadian journal of physiology and pharmacology

authors： Schaffel R,Rodrigues MS,Assreuy J

更新日期：1991-07-01 00:00:00

abstract：:Increased expression of DNA methyltransferase-1 (DNMT1) associates with the progression of many human diseases. Because DNMT1 induces cell proliferation, drugs that inhibit DNMT1 have been used to treat proliferative diseases. Because these drugs are nonspecific inhibitors of DNMT1, subsidiary events or the compensato...

journal_title：Canadian journal of physiology and pharmacology

authors： Boosani CS,Gunasekar P,Block M,Jiang W,Zhang Z,Radwan MM,Agrawal DK

更新日期：2018-10-01 00:00:00

abstract：:In sepsis, systemic inflammatory response syndrome (SIRS), and multiorgan dysfunction syndrome (MODS), a severe prognostically relevant cardiac autonomic dysfunction exists, as manifested by a strong attenuation of sympathetically and vagally mediated heart rate variability (HRV). The mechanisms underlying this attenu...

journal_title：Canadian journal of physiology and pharmacology

authors： Werdan K,Schmidt H,Ebelt H,Zorn-Pauly K,Koidl B,Hoke RS,Heinroth K,Müller-Werdan U

更新日期：2009-04-01 00:00:00

abstract：:Measurement of volume, pressure, and length were made on eight segments of human cerebral arteries perfused with chymotrypsin (CT) (EC 3.4.21.1) solution (pH = 7.8) for no more than 19 h, and on nine arterial segments perfused with combined enzyme (CT, trypsin (EC 3.4.21.4), elastase (EC 3.4.21.11)) solutions (pH = 7....

journal_title：Canadian journal of physiology and pharmacology

authors： Damude LC,Cope DA,Roach MR

更新日期：1977-04-01 00:00:00

abstract：:Animals treated with nitric oxide synthase (NOS) inhibitors exhibit marked hypersensitivity to the blood pressure lowering effects of exogenous nitric oxide (NO) donors. We used this model as a sensitive index to evaluate the relative importance of reduced biotransformation of glyceryl trinitrate (GTN) to NO in the de...

journal_title：Canadian journal of physiology and pharmacology

authors： Ratz JD,Adams MA,Bennett BM

更新日期：2002-11-01 00:00:00

abstract：:The effect of pinaverium was electrophysiologically characterized and compared with the established L-type calcium channel blockers diltiazem, D600, and nitrendipine on canine colonic circular smooth muscle. Effects were studied on the electrical activity of the smooth muscle cells, in particular the spontaneously occ...

journal_title：Canadian journal of physiology and pharmacology

authors： Malysz J,Farraway LA,Christen MO,Huizinga JD

更新日期：1997-08-01 00:00:00

abstract：:We tested the effects of inhibiting the carbonic anhydrase activity of rat soleus and extensor digitorum longus muscles on the isometric contractile properties and the resistance to fatigue. SOL and EDL muscles from female rats were incubated in vitro in the presence of methazolamide, a specific inhibitor of carbonic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Côté C,Tremblay D,Riverin H,Frémont P,Rogers PA

更新日期：1989-06-01 00:00:00

abstract：:Grains are global dietary staples that when consumed in whole grain form, offer considerable health benefits compared with milled grain foods, including reduced body weight gain and reduced cardiovascular and diabetes risks. Dietary patterns, functional foods, and other lifestyle factors play a fundamental role in the...

journal_title：Canadian journal of physiology and pharmacology

authors： Nelson K,Stojanovska L,Vasiljevic T,Mathai M

更新日期：2013-06-01 00:00:00

abstract：:Hormonal replacement therapy (HRT) has failed to provide a cardioprotective action in postmenopausal women, and thus alternative pharmacological approaches are required. The present study examined the therapeutic potential of the partial estrogen receptor agonist tamoxifen and the angiotensin II type-1 receptor antago...

journal_title：Canadian journal of physiology and pharmacology

authors： Pham-Dang ML,Clement R,Mercier I,Calderone A

更新日期：2003-09-01 00:00:00

abstract：:The novel biological effect of statins in alleviating myocardium fibrosis following infarction has been increasingly recognized, yet the underlying mechanisms are not fully understood. The purpose of this study was to characterize the effect of simvastatin on myocardial fibrosis and collagen I deposition in the non-in...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang J,Xu Y,Pan L,Chen T,Chen Z,Zhao R

更新日期：2010-11-01 00:00:00

abstract：:Activity-related transient changes in extracellular K+ concentration ([K+]c), extracellular pH (pHc), and extracellular volume (EC volume) were studied by means of ion-selective microelectrodes in the adult rat spinal cord in vivo and in neonatal rat spinal cords isolated from pups 3-14 days of age. Repetitive electri...

journal_title：Canadian journal of physiology and pharmacology

authors： Syková E,Jendelová P,Svoboda J,Chvátal A

更新日期：1992-01-01 00:00:00

abstract：:We have previously shown that A10 vascular smooth muscle cells (VSMC) exposed to angiotensin II (Ang II) exhibited overexpression of Giα proteins. In the present study, we examined the involvement of different signaling pathways in regulating Ang II induced enhanced expression of Giα proteins in VSMC by using pharmaco...

journal_title：Canadian journal of physiology and pharmacology

authors： Li Y,Anand-Srivastava MB

更新日期：2012-08-01 00:00:00

abstract：:Carbon monoxide (CO), a vasodilator, has been implicated as an activator of soluble guanylyl cyclase (sGC) to effect smooth muscle relaxation; however, this idea has not received universal support. The purpose of this study was to examine the effects of the sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussain AS,Marks GS,Brien JF,Nakatsu K

更新日期：1997-08-01 00:00:00

abstract：:In anaesthetized rabbits blood volume was altered by infusion and withdrawal of donor blood over the range of +60 to -40% of the blood volume. Right and left atrial pressures were measured and it was shown that sonomicrometry allowed adequate measurement of phasic changes in atrial dimensions. Plasma immunoreactive at...

journal_title：Canadian journal of physiology and pharmacology

authors： Ledsome JR,King KA

更新日期：1991-10-01 00:00:00

abstract：:Our studies are guided by the novel hypothesis that protein tyrosine phosphorylation is an important mechanism for regulating contraction of smooth muscle. Several lines of evidence are reviewed which suggest that enhanced tyrosine phosphorylation participates in mechanisms that regulate cytosolic Ca2+ and Ca2+ sensit...

journal_title：Canadian journal of physiology and pharmacology

authors： Di Salvo J,Pfitzer G,Semenchuk LA

更新日期：1994-11-01 00:00:00

abstract：:Angiotensin II (ANG II) causes a systemic pressor effect when injected into the cerebral ventricles. In the rat fourth ventricle, the effective doses for the ANG II pressor effect are over 100 times larger than in the systemic circulation. Considering the discrepancy of doses, the possibility that ANG II may reach the...

journal_title：Canadian journal of physiology and pharmacology

authors： Pesquero JB,Fior-Chadi DR,Yu YG,Merjan AJ,Lindsey CJ,Paiva AC

更新日期：2002-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. In the clinic it is essential to limit the development of cognitive impairment after TBI. In this study, the effects of gallic acid (GA; 100 mg/kg, per oral, from 7 days before to 2 days after TBI induction) on neurologi...

journal_title：Canadian journal of physiology and pharmacology

authors： Sarkaki A,Farbood Y,Gharib-Naseri MK,Badavi M,Mansouri MT,Haghparast A,Mirshekar MA

更新日期：2015-08-01 00:00:00

abstract：:In the mesenteric circulation of the rat a myogenic autoregulatory system operates at 0.1-0.15 Hz. Negative admittance phase in the region above 0.2 Hz suggested operation of an arterial baroreflex. The present study was designed to test this interpretation and to identify the neurotransmitter involved. In rats anesth...

journal_title：Canadian journal of physiology and pharmacology

authors： Abu-Amarah I,Cupples WA

更新日期：2000-01-01 00:00:00

abstract：:H2S is an important gasotransmitter with a vasorelaxant property. The modulation of endogenous H2S generation from different tissues and the functional consequence of this modulation are not clear. In the present study, the production of H2S from vascular tissues as well as the liver and ileum of rats was measured. Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhao W,Ndisang JF,Wang R

更新日期：2003-09-01 00:00:00

abstract：:Norethandrolone (NE) and other androgenic steroids have been shown to be renotropic in various species and have also been reported to have salutary effects in patients with diminished renal function. Renal cortical slices prepared from rats pretreated with NE showed an increased capability to concentrate p-aminohippur...

journal_title：Canadian journal of physiology and pharmacology

authors： Watrous WM,Lacombe R,Brodeur J

更新日期：1975-10-01 00:00:00

abstract：:The effect of oleate (0.3 and 1.2 mM) and the combined effect of beta-hydroxybutyrate (4 and 8 mM) and acetoacetate (1 and 2 mM) on rates of lipolysis (glycerol output) was determined with calcium-tolerant myocytes isolated from the hearts of normal rats and hearts from acutely (2-3 days; 100 mg/kg streptozotocin) dia...

journal_title：Canadian journal of physiology and pharmacology

authors： Larsen TS,Severson DL

更新日期：1990-09-01 00:00:00

abstract：:Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach d...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Salama RB,Coceani F,Olley PM

更新日期：1984-04-01 00:00:00

abstract：:We investigated the influence of four different culture media: 20% fetal bovine serum (FBS), 5% FBS, 5% FBS supplemented with 10 mg x L(-1) linoleic acid (18:2(n-6)) or alpha-linolenic acid (18:3(n-3)) on alpha-linolenic acid apical uptake in clone TC7 of human intestinal Caco-2 cell line. Neither cellular viability n...

journal_title：Canadian journal of physiology and pharmacology

authors： Tranchant T,Besson P,Hoinard C,Pinault M,Alessandri JM,Delarue J,Couet C,Goré J

更新日期：1998-06-01 00:00:00

abstract：:The site of exercise-induced muscle fatigue is suggested to be the muscle membrane, which includes the sarcolemma and T-tubule membrane; the excitability of the membrane is dependent on the membrane potential. Significant potassium flux from the intracellular space of contracting muscle may decrease the membrane poten...

journal_title：Canadian journal of physiology and pharmacology

authors： Sjøgaard G

更新日期：1991-02-01 00:00:00