Extracellular K+, pH, and volume changes in spinal cord of adult rats and during postnatal development.

abstract：:Resting membrane potentials and membrane conductances of chick skeletal muscle in culture were determined from the 3rd to the 10th day after plating. The effect of tetraethylammonium (TEA) and of replacement of potassium with caesium on these parameters was investigated. Resting membrane potential (Em) rises during my...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson CM,Dryden WF

更新日期：1980-06-01 00:00:00

abstract：:Geniposide (GP) is one of main compounds in Gardenia jasminoides Ellis, with both medicinal and nutritional value. This study was designed to determine, for the first time, how GP from G. jasminoides protects against acute alcohol-induced liver injury, and the underlying mechanisms. Mice were orally administered alcoh...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang J,Zhang Y,Liu R,Li X,Cui Y,Qu L

更新日期：2015-04-01 00:00:00

abstract：:High buffer cardioplegia may provide protection against ischemic damage by reducing the extent of intracellular acidosis. Secondary cardioplegia may improve postischemic recovery by restoration of high energy phosphates, ionic gradients, and intracellular pH. To test these hypotheses, pig hearts were arrested with hig...

journal_title：Canadian journal of physiology and pharmacology

authors： Tian GH,Mainwood GW,Biro GP,Smith KE,Butler KW,Lawrence D,Deslauriers R

更新日期：1991-11-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a key pathogenic factor in sepsis, and its recognition by toll-like receptor 4 (TLR4) can activate two district signaling pathways, leading to activation of transcription factors including NF-κB and interferon regulatory factor 3 (IRF3). Chloroquine (CQ) has been shown to affect LPS-TLR4 co...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding C,Li F,Long Y,Zheng J

更新日期：2017-05-01 00:00:00

abstract：:Tachykinin receptors in guinea-pig airways were examined using radioligand binding techniques in lung homogenates, and using isolated bronchial segments. Binding of the NK1 selective radioligand 125I-labelled Bolton-Hunter [Sar9,Met(O2)11]substance P ([125I]BHSarSP) was saturable and of high affinity (KD, 0.26 nM). Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Burcher E,Zeng XP,Strigas J,Geraghty DP,Lavielle S

更新日期：1995-07-01 00:00:00

abstract：:Visual acuity was measured behaviorally in various groups of cats by using a two-choice discrimination procedure. Cats in group 1 were rendered strabismic soon after birth by sectioning the tendon of the lateral rectus muscle (unilateral esotropia); at adulthood, their visual acuity (VA) was evaluated, after which the...

journal_title：Canadian journal of physiology and pharmacology

authors： Ptito M,Bouchard P,Lepore F,Quessy S,Di Stefano M,Guillemot JP

更新日期：1995-09-01 00:00:00

abstract：:The response pattern of the isolated longitudinal muscle of the rabbit ileum to adenosine-5'-alpha, beta-methylenediphosphonate (APCP) was found to differ from that caused by adenosine or ATP in that the rapid initial phase of relaxation is absent and that at doses above 10 muM a secondary increase of contractile acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Frew R,McKenzie SG,Bär HP,Hutchison KJ

更新日期：1976-08-01 00:00:00

abstract：:Previous work suggested that sulfhydryl groups and disulfide bridges have important functions in opioid binding to the delta opioid receptor. The question regarding which cysteines are essential for ligand binding was approached by replacement of cysteine residues in the cloned delta opioid receptor using site-directe...

journal_title：Canadian journal of physiology and pharmacology

authors： Ehrlich GK,Andria ML,Zheng X,Kieffer B,Gioannini TL,Hiller JM,Rosenkranz JE,Veksler BM,Zukin RS,Simon EJ

更新日期：1998-03-01 00:00:00

abstract：:The neural connections from the medial prefrontal cortex to the ventral pallidum were investigated in urethane-anesthetized rats. Extracellular recordings were made from 124 spontaneously firing neurons in the ventral pallidum while the medial prefrontal cortex was electrically stimulated. The most frequent response t...

journal_title：Canadian journal of physiology and pharmacology

authors： Delgado-Martínez AD,Vives F

更新日期：1993-05-01 00:00:00

abstract：:This year, 2011, the Department of Pharmacology at the University of Alberta celebrated its 50th anniversary. This timeframe covers nearly the entire history of Cys-loop pentameric ligand-gated ion channel (pLGIC) research. In this review we consider how major technological advancements affected our current understand...

journal_title：Canadian journal of physiology and pharmacology

authors： Kozuska JL,Paulsen IM

更新日期：2012-06-01 00:00:00

abstract：:Hepatotoxicity and nephrotoxicity are important drawbacks of cisplatin. The objective of this study is to evaluate the ability of ambroxol in 2 different doses (35 and 70 mg/kg, i.p.) to protect liver and kidney from damage induced by a single dose of cisplatin (10 mg/kg, i.p.) in comparison with N-acetylcysteine (250...

journal_title：Canadian journal of physiology and pharmacology

authors： Bishr A,Sallam N,Nour El-Din M,Awad AS,Kenawy SA

更新日期：2019-01-01 00:00:00

abstract：:Neuropeptide Y (NPY(1-36)), a sympathetic cotransmitter and neurohormone, has pleiotropic activities ranging from the control of obesity to anxiolysis and cardiovascular function. Its actions are mediated by multiple Gi/o-coupled receptors (Y1-Y5) and modulated by dipeptidyl peptidase IV (DPPIV/cd26), which inactivate...

journal_title：Canadian journal of physiology and pharmacology

authors： Zukowska Z,Pons J,Lee EW,Li L

更新日期：2003-02-01 00:00:00

abstract：:Both physical activity and exposure to environmental stressors such as cold, heat, and high altitudes modify various components of immune function: T cell counts, natural killer (NK) cell counts, and cytolytic activity, cytokine secretion, lymphocyte proliferation and immunoglobulin levels. Light physical activity or ...

journal_title：Canadian journal of physiology and pharmacology

authors： Shephard RJ

更新日期：1998-05-01 00:00:00

abstract：:This study examined whether the effects of FK506-binding protein dissociation from sarcoplasmic reticulum (SR) Ca(2+) release channels on excitation-contraction (EC) coupling changed when SR Ca(2+) reuptake and (or) the trans-sarcolemmal Ca(2+) extrusion were altered. The steady-state twitch Ca(2+) transient (CaT), ce...

journal_title：Canadian journal of physiology and pharmacology

authors： Yoshihara S,Satoh H,Saotome M,Katoh H,Terada H,Watanabe H,Hayashi H

更新日期：2005-04-01 00:00:00

abstract：:The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normo...

journal_title：Canadian journal of physiology and pharmacology

authors： Salahuddin M,Jalalpure SS,Gadge NB

更新日期：2010-02-01 00:00:00

abstract：:This study evaluated the in vitro expression of bone-related proteins by osteoblasts in the presence of different concentrations of human recombinant bone morphogenetic protein-2 (rhBMP-2). Immortalized human fetal osteoblastic cell line 1.19 (hFOB) were exposed to different concentrations of rhBMP-2 (10, 50, or 100 n...

journal_title：Canadian journal of physiology and pharmacology

authors： de Oliveira EM,Martinez EF,Bossonaro JP,Ribeiro RC,de Araújo VC,Napimoga MH

更新日期：2013-11-01 00:00:00

abstract：:The freezing point and the melting point of myoplasm were measured with two experimental models. In all samples, a supercooled stage was reached by lowering the temperature of the sample to approximately - 7 degrees C, and the freezing of the sample was mechanically induced. The freezing process was associated with a ...

journal_title：Canadian journal of physiology and pharmacology

authors： Caillé JP

更新日期：1983-10-01 00:00:00

abstract：:Selected topics on the roles of sarcoplasmic reticulum (SR) in the control of vascular smooth muscle (VSM) tone are briefly reviewed with particular reference to the regulation of cytosolic concentration of free calcium ions, [Ca2+]i. Although morphological evidence and subcellular membrane studies indicate a relative...

journal_title：Canadian journal of physiology and pharmacology

authors： Daniel EE,van Breemen C,Schilling WP,Kwan CY

更新日期：1995-05-01 00:00:00

abstract：:In cats under pentobarbital anaesthesia, intramotoneuronal administrations of 4-aminopyridine significantly prolong the falling phase of the antidromic action potential but have much less effect on the orthodromic action potential. 4-aminopyridine probably blocks the fast K channels involved in the repolarization of t...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang L,Krnjević K

更新日期：1986-11-01 00:00:00

abstract：:This study was designed to determine if tonic beta-adrenergic control of plasma renin activity (PRA) during dietary sodium restriction is due to stimulation of renal beta-adrenoceptors, extrarenal beta-adrenoceptors, or both. Experiments were performed in six conscious resting uninephrectomized dogs with chronically i...

journal_title：Canadian journal of physiology and pharmacology

authors： Blair ML,Gengo FM

更新日期：1995-08-01 00:00:00

abstract：:The major hallmark of rotator cuff tendinopathies (RCT) is the disorganization of tendon extracellular matrix (ECM) which is due to decrease in the collagen I-to-collagen III ratio. In addition, the pathology of tendon matrisome remains asymptomatic and hypoxia has been identified to be the priming signal to initiate ...

journal_title：Canadian journal of physiology and pharmacology

authors： Thankam FG,Agrawal DK

更新日期：2020-08-15 00:00:00

abstract：:Since human thermoregulation at rest is altered by cold exposure, it was hypothesized that physical training under cold conditions would alter thermoregulation. Three groups (n = 8) of male subjects (mean age 24.3 +/- 0.9 years) were evaluated: group T (interval training at 21 degrees C), group CT (interval training a...

journal_title：Canadian journal of physiology and pharmacology

authors： Launay JC,Besnard Y,Guinet A,Hanniquet AM,Bittel J,Savourey G

更新日期：2002-09-01 00:00:00

abstract：:Despite major advances in conventional medical therapy, patients with heart failure continue to experience significant morbidity and mortality. Endothelin-1 (ET-1) is a potent vasocontrictor and mitogenic peptide that is activated in heart failure. There is increasing experimental and clinical evidence in support of a...

journal_title：Canadian journal of physiology and pharmacology

authors： Moe GW,Rouleau JL,Nguyen QT,Cernacek P,Stewart DJ

更新日期：2003-06-01 00:00:00

abstract：:The aim of this study was to investigate the possible effects of captopril as a promoter in modulating the oxidant-antioxidant balance in rats with type 1 diabetes, and the influence of protein kinase C (PKC) pathways in the production of reactive oxygen species (ROS) induced by bradykinin in type 1 diabetic rats. Thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodrigues de Araujo G,Granato de Faria K,Lima WG,Pádua Bda C,Rossoni JV Jr,Souza AA,Chianca-Júnior D,Silva ME,Pedrosa ML,Chaves MM,Costa DC

更新日期：2011-12-01 00:00:00

abstract：:The force generated by tracheal spirals and lung parenchymal strips from normal and ovalbumin-sensitized guinea pigs was measured in vitro, after challenge with histamine, carbachol, leukotriene (LT) C4, LTD4, or a prostaglandin endoperoxide analog (U-44069). The responses and sensitivity of airway tissues to the abov...

journal_title：Canadian journal of physiology and pharmacology

authors： Saad MH,Burka JF

更新日期：1983-08-01 00:00:00

abstract：:Cardiac injury and loss of cardiomyocytes is a causative as well as a resultant condition of cardiovascular disorders, which are the leading cause of death throughout the world. This loss of cardiomyocytes cannot be completely addressed through the currently available drugs being administered, which mainly function on...

journal_title：Canadian journal of physiology and pharmacology

authors： Padda J,Sequiera GL,Sareen N,Dhingra S

更新日期：2015-10-01 00:00:00

abstract：:The effect of ionizing radiation on jejunal blood flow was investigated in rats receiving whole-body exposure to 10 Gy gamma-radiation. Irradiation resulted in increased myeloperoxidase activity, indicative of neutrophil infiltration, and prostaglandin E2 synthesis by 2 h post-irradiation, but had no effect on leukotr...

journal_title：Canadian journal of physiology and pharmacology

authors： MacNaughton WK,Prud'homme-Lalonde L

更新日期：1995-06-01 00:00:00

abstract：:Several lines of evidence suggest that the responsiveness of the airways is heterogeneous, although the magnitude of this heterogeneity has not been quantified. We have developed a videomicroscopic method that allows the measurements of the responsiveness of individual explanted airways to contractile agonists such as...

journal_title：Canadian journal of physiology and pharmacology

authors： Minshall E,Wang CG,Dandurand R,Eidelman D

更新日期：1997-07-01 00:00:00

abstract：:Administration of naloxone to morphine-dependent rats results in an elevation of tail skin temperature and a fall in core temperature. Previous studies have demonstrated a role of the adrenal gland in the thermal responses that accompany morphine withdrawal in the rat. In the present study, experiments were designed t...

journal_title：Canadian journal of physiology and pharmacology

authors： Katovich MJ,Pitman D,Schechtman O

更新日期：1992-08-01 00:00:00

abstract：:Since the discovery that apolipoprotein E, a cholesterol transport protein, is a major risk factor for Alzheimer's disease (AD) development, there has been a remarkable interest in understanding the many facets of the relationship between cholesterol and AD. Several lines of evidence have demonstrated the importance o...

journal_title：Canadian journal of physiology and pharmacology

authors： Posse de Chaves E

更新日期：2012-06-01 00:00:00