Influence of exogenous fatty acids and ketone bodies on rates of lipolysis in isolated ventricular myocytes from normal and diabetic rats.

abstract：:In the wake of demographic change in Western countries, atrial fibrillation has reached an epidemiological scale, yet current strategies for drug treatment of the arrhythmia lack sufficient efficacy and safety. In search of novel medications, atrial-selective drugs that specifically target atrial over other cardiac fu...

journal_title：Canadian journal of physiology and pharmacology

authors： Ravens U

更新日期：2017-11-01 00:00:00

abstract：:Spironolactone at 10 mg per kilogram per day was given to control and 'one-kidney-one-clip' hypertensive dogs for 6--7 weeks. Compared with untreated animals the treated animals had a lower arterial water content, a higher arterial, myocardial, and skeletal muscle sodium content, and variable changes in tissue potassi...

journal_title：Canadian journal of physiology and pharmacology

authors： Constantopoulos G,Gutkowska J,Genest J

更新日期：1979-06-01 00:00:00

abstract：:Previous studies have shown that when atrial natriuretic peptide (ANF) is given to anaesthetized dogs with hypovolemic acute pancreatitis, it will produce a diuresis and natriuresis but will not elevate the glomerular filtration rate (GFR). When the same dose of peptide is given to dogs equally hypovolemic (hemorrhage...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M,Cernacek P

更新日期：1990-06-01 00:00:00

abstract：:Although mitochondrial transcription factor A (TFAM) is a protective component of mitochondrial DNA and a regulator of calcium and reactive oxygen species (ROS) production, the mechanism remains unclear. In heart failure, TFAM is significantly decreased and cardiomyocyte instability ensues. TFAM inhibits nuclear facto...

journal_title：Canadian journal of physiology and pharmacology

authors： Kunkel GH,Chaturvedi P,Thelian N,Nair R,Tyagi SC

更新日期：2018-02-01 00:00:00

abstract：:Physical activity promotes metabolic adaptations that improve body functionality and contribute to the prevention of some diseases. With respect to energy and fat balance, physical activity facilitates the equilibrium between energy intake and expenditure as well as between fat intake and fat oxidation. When combined ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tremblay A,Therrien F

更新日期：2006-02-01 00:00:00

abstract：:Chrysin (CH) is a natural flavonoid with pharmacological influences. The purpose of the current study was the assessment of possible protective effects of CH against oxidative damage in the serum, liver, brain, and pancreas of streptozotocin (STZ)- induced diabetic rats. In the present study, the rats were divided int...

journal_title：Canadian journal of physiology and pharmacology

authors： Samarghandian S,Azimi-Nezhad M,Samini F,Farkhondeh T

更新日期：2016-04-01 00:00:00

abstract：:The purpose of the present work was to study the rate of basal luteinizing hormone (LH) glycosylation, discriminating the co-translational (proximal) and the post-translational (distal) glycosylation. The experiments were performed to determine the temporal relationship between the biosynthesis of the peptide chains (...

journal_title：Canadian journal of physiology and pharmacology

authors： Pérez GT,Apfelbaum ME

更新日期：1997-07-01 00:00:00

abstract：:Microwaves may exert adverse biological effects on the cardiovascular system at the integrated system and cellular levels. However, the mechanism underlying such effects remains poorly understood. Here, we report a previously uncharacterized mechanism through which microwaves damage myocardial cells. Rats were treated...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhu W,Cui Y,Feng X,Li Y,Zhang W,Xu J,Wang H,Lv S

更新日期：2016-08-01 00:00:00

abstract：:Diabetes increases the risk and severity of cognitive impairment, especially after ischemic stroke. It is also known that the activation of the endothelin (ET) system is associated with cognitive impairment and microglia around the periinfarct area produce ET-1. However, little is known about the effect of ET-1 on mic...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdul Y,Jamil S,He L,Li W,Ergul A

更新日期：2020-09-01 00:00:00

abstract：:The effect of various doses of i.p. injection of the adenosine receptor agonist (R)-phenylisopropyladenosine (R-PIA), ranging from nanomolar to micromolar concentrations, on plasma levels of free fatty acids, glucose, insulin, glucagon, ACTH, and corticosterone was examined in 200-g male rats. At the lowest dose of R-...

journal_title：Canadian journal of physiology and pharmacology

authors： LeBlanc J,Soucy J

更新日期：1994-02-01 00:00:00

abstract：:Female rats subjected to 48 h of water deprivation drank more than similarly deprived males. There was no sexual difference in the dipsogenic responses to intracellular dehydration produced by intravenous hypertonic NaCl but females drank considerably more than males in response to the extracellular stimuli of hyperon...

journal_title：Canadian journal of physiology and pharmacology

authors： Kaufman S

更新日期：1980-10-01 00:00:00

abstract：:New methods for chronic instrumentation of the newborn piglet are described, which allow continuous monitoring of not only pressures in the pulmonary artery and aorta but also in the left and right atria, pulmonary vein, as well as main branch pulmonary artery flows. Changes in pulmonary vascular tone to short-acting ...

journal_title：Canadian journal of physiology and pharmacology

authors： Coe JY,Olley PM,Hamilton F,Vanhelder T,Coceani F

更新日期：1987-05-01 00:00:00

abstract：:Mechanisms leading to ifosfamide (IF)-induced renal damage have not been fully elucidated. Recent work suggests that localized renal tubular metabolism of IF and the production of the nephrotoxic chloroacetaldehyde may lead to nephrotoxicity. Presently no pharmacological method to reduce IF nephrotoxicity has been ide...

journal_title：Canadian journal of physiology and pharmacology

authors： Aleksa K,Halachmi N,Ito S,Koren G

更新日期：2005-06-01 00:00:00

abstract：:The Na+/H+ exchanger isoform 1 is an integral membrane protein that regulates intracellular pH. It extrudes 1 intracellular H+ in exchange for 1 extracellular Na+. It has 2 large domains, an N-terminal membrane domain of 12 transmembrane segments and an intracellular C-terminal regulatory domain. We characterized the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding J,Ng RW,Fliegel L

更新日期：2007-03-01 00:00:00

abstract：:Theanine and caffeine, 2 naturally occurring components in tea, have repeatedly been shown to deliver unique cognitive benefits when consumed in combination. In this study, we assessed the beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral damage in rats. Theanine and ca...

journal_title：Canadian journal of physiology and pharmacology

authors： Sun L,Tian X,Gou L,Ling X,Wang L,Feng Y,Yin X,Liu Y

更新日期：2013-07-01 00:00:00

abstract：:The most commonly observed effect of beta-blockade on cardiovascular function has been a reduction in heart rate both at rest and during exercise. The body attempts to compensate by increasing stroke volume and (or) increasing the extraction of O2 from the blood to maintain O2 delivery to the muscle. This paper examin...

journal_title：Canadian journal of physiology and pharmacology

authors： Hughson RL,Kowalchuk JM

更新日期：1991-02-01 00:00:00

abstract：:We recently reported that the two-chain form of human high molecular weight kininogen (HKa) inhibits angiogenesis by inducing endothelial cell apoptosis (Zhang et al. 2000). This property appears to be primarily conferred by HKa domain 5 (HKa D5). In this manuscript, we further characterize the activity of these polyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang JC,Qi X,Juarez J,Plunkett M,Donaté F,Sakthivel R,Mazar AP,McCrae KR

更新日期：2002-02-01 00:00:00

abstract：:Caffeine has been reported to have a positive and (or) a negative inotropic effect on cardiac muscle. In this study, the force-frequency and postrest characteristics of rat atrium were studied in the presence of caffeine (1.0-10 mM) to see if the interval between beats affected the response of cardiac muscle to caffei...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIntosh BR,Posner P,Lobo J,Harms R

更新日期：1992-02-01 00:00:00

abstract：:Selected parameters of cardiovascular function were evaluated in vitamin A-deficient rats at 70 days of age. Resting heart rate was increased by an average of 100 bpm (21.4+/-2.7%), whereas resting systolic blood pressure was normal in vitamin A-deficient animals. The maximal contractile force developed per milligram ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wright GL,Wang S,Fultz ME,Arif I,Matthews K,Chertow BS

更新日期：2002-01-01 00:00:00

abstract：:Long-lasting ischemia can result in cell loss; however, repeated episodes of brief ischemia increase the resistance of the heart against deleterious effects of subsequent prolonged ischemic insult and promote cell survival. Traditionally, it is believed that the supply of blood to the ischemic heart is associated with...

journal_title：Canadian journal of physiology and pharmacology

authors： Adameova A,Hrdlicka J,Szobi A,Farkasova V,Kopaskova K,Murarikova M,Neckar J,Kolar F,Ravingerova T,Dhalla NS

更新日期：2017-10-01 00:00:00

abstract：:The present study was designed to examine the possible neuroprotective and antiepileptic effects of metformin (Metf) in a rat model of pentylenetetrazole (PTZ)-induced epilepsy and its possible underlying mechanisms. Forty male albino rats were assigned to 4 groups of equal size: (1) normal control (NC) group, (2) Met...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussein AM,Eldosoky M,El-Shafey M,El-Mesery M,Ali AN,Abbas KM,Abulseoud OA

更新日期：2019-01-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00

abstract：:The effects of forskolin, Ro 20-1724, rolipram, and 3-isobutyl-1-methylxanthine (IBMX) on morphine-evoked release of adenosine from dorsal spinal cord synaptosomes were evaluated to examine the potential involvement of cyclic AMP in this action of morphine. Ro 20-1724 (1-100 microM), rolipram (1-100 microM), and forsk...

journal_title：Canadian journal of physiology and pharmacology

authors： Nicholson D,White TD,Sawynok J

更新日期：1991-06-01 00:00:00

abstract：:The purpose of this study was to characterize the biological activity of the synthetic rat growth hormone releasing factor analogue rGRF(1-29)NH2 and to compare its action on growth hormone (GH) release to that of authentic rGRF(1-43)OH. We first compared the concentration-response characteristics of the two peptides ...

journal_title：Canadian journal of physiology and pharmacology

authors： Kraicer J,French MB,Lussier BT,Moor BC,Brazlan P

更新日期：1991-02-01 00:00:00

abstract：:alpha-Fluoromethylhistidine, a histidine decarboxylase inhibitor, induced a significant depletion in the hypothalamic, midbrain, and cortical brain histamine amounts in 12- and 3-month-old rats. In all three brain regions the most evident depletion occurred 2 h after treatment. In both groups of rats midbrain histamin...

journal_title：Canadian journal of physiology and pharmacology

authors： Mazurkiewicz-Kwilecki I,Nsonwah S

更新日期：1987-10-01 00:00:00

abstract：:Fetal and neonatal rats received daily subcutaneous injections of 10 microgram thyrotropin-releasing hormone (TRH) until 7 or 14 days postnatally. At 70 days the pups were challenged with 1 microgram TRH intravenously via an indwelling jugular cannula. Basal serum thyroxine, triiodothyronine, and thyroid-stimulating h...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker P,Dussault JH

更新日期：1979-01-01 00:00:00

abstract：:Measurement of volume, pressure, and length were made on eight segments of human cerebral arteries perfused with chymotrypsin (CT) (EC 3.4.21.1) solution (pH = 7.8) for no more than 19 h, and on nine arterial segments perfused with combined enzyme (CT, trypsin (EC 3.4.21.4), elastase (EC 3.4.21.11)) solutions (pH = 7....

journal_title：Canadian journal of physiology and pharmacology

authors： Damude LC,Cope DA,Roach MR

更新日期：1977-04-01 00:00:00

abstract：:A method for the determination of the specific activity of plasma glycerol is described. Anionic contaminants are first removed from deproteinzed plasma by anionic exchange resins (treated plasma). Glycerol in treated plasma is then quantitatively converted to glycerol-3-phosphate (G3P), which is isolated by column ch...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier C,Layberry R

更新日期：1982-06-01 00:00:00

abstract：:The aim of this study was to explore the possibility of identifying clusters of children's games based on estimated energy expenditures and (or) intensity when performed in a guided active play format. The study also investigated whether the identified active play game clusters were repeatable when the games were perf...

journal_title：Canadian journal of physiology and pharmacology

authors： Belcastro AN,Morrison KS,Hicks E,Matta H

更新日期：2012-09-01 00:00:00

abstract：:The vestibulo-ocular and vestibulo-collic reflexes are well-studied sensorimotor systems with dynamic properties that have been successfully modeled. Recently proposed matrix and tensorial models attempt to describe the spatial organization of these reflexes in three dimensions. Here we describe experiments that test ...

journal_title：Canadian journal of physiology and pharmacology

authors： Baker JF,Banovetz JM,Wickland CR

更新日期：1988-04-01 00:00:00