Mechanisms of TFAM-mediated cardiomyocyte protection.

abstract：:Slow alpha2-globulin (salpha2G), a high molecular weight glycoprotein, appears as a component of rat serum in a wide variety of both physiologic and pathologic conditions, including pregnancy; it is also present in the neonate. In the present study, the protein was detectable in serum after 6 to 10 days, and was prese...

journal_title：Canadian journal of physiology and pharmacology

authors： Kirkcaldy M,Beaton GH

更新日期：1977-06-01 00:00:00

abstract：:Resveratrol, a polyphenol compound with anti-inflammatory properties, has been previously evaluated for its beneficial effects in several ulcerative colitis models. However, the current study elucidates the effect of resveratrol on adhesion molecules, as well as its antioxidant efficacy in a trinitrobenzene sulfonic a...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdallah DM,Ismael NR

更新日期：2011-11-01 00:00:00

abstract：:The validity of a Hodgkin-Huxley type voltage-dependent inactivation of slow inward Ca current (Isi) was tested in frog heart using a computer simulation. The time course of Isi was calculated during the development of a frog atrial action potential (AP). With a time constant of inactivation (tauf) of 55 ms at a membr...

journal_title：Canadian journal of physiology and pharmacology

authors： Fischmeister R,Horackova M

更新日期：1982-09-01 00:00:00

abstract：:D-Serine, a recently identified gliotransmitter, serves as an endogenous coagonist binding to the glycine site of N-methyl-D-aspartate (NMDA) receptors. However, it is not clear whether this native ligand is able to bind to and modulate alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptors. In the pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Gong XQ,Zabek RL,Bai D

更新日期：2007-05-01 00:00:00

abstract：:Hedysarum polybotrys polysaccharide (HPS) is the principal active fraction responsible for the antidiabetic properties of this species. The aim of this study was to determine the antidiabetic properties of 4 purified fractions of different molecular weight range HPSs (HPS1, HPS2, HPS3, HPS4). HPS3 was selected for exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Hu F,Li X,Zhao L,Feng S,Wang C

更新日期：2010-01-01 00:00:00

abstract：:The most important reason for the non-approval and withdrawal of drugs by the Food and Drug Administration is hepatotoxicity. Therefore, this study was undertaken to evaluate the protective effects of hesperidin against cyclophosphamide (CYP)-induced hepatotoxicity in Wistar rats. The rats received a single intraperit...

journal_title：Canadian journal of physiology and pharmacology

authors： Mahmoud AM

更新日期：2014-09-01 00:00:00

abstract：:The expression of tissue factor (TF) in tumors reportedly exacerbates the aggressiveness of several types of cancers. The shedding of TF-containing membrane particles is believed to influence the ability of tumors to expand and metastasize, and these microparticles may also be harmful in the onset of disseminated intr...

journal_title：Canadian journal of physiology and pharmacology

authors： Brousseau C,Morissette G,Fortin JP,Marceau F,Petitclerc E

更新日期：2009-09-01 00:00:00

abstract：:Ah receptor in hepatic cytosols from adult cynomolgus monkeys (Macaca fasicularis) was identified and quantitated by its binding of the highly toxic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the carcinogens 3-methylcholanthrene, benzo[a]pyrene, and dibenz[a,h]anthracene. The concentration of Ah receptor ...

journal_title：Canadian journal of physiology and pharmacology

authors： Okey AB,Vella LM,Iverson F

更新日期：1984-10-01 00:00:00

abstract：:The effect of a novel antianginal agent, molsidomine (N-ethoxycarbonyl-3-morpholinosydnonimine) (SIN-10) and its metabolites, 3-morpholinosydnonimine (SIN-1) and N-nitroso-N-morpholinoaminoacetonitrile (SIN-1A) on isolated dog blood vessels were investigated. SIN-1 and SIN-1A elicited a concentration-dependent relaxat...

journal_title：Canadian journal of physiology and pharmacology

authors： Muramatsu I,Fujii K,Sakakibara Y,Fujiwara M

更新日期：1983-09-01 00:00:00

abstract：:Lingonberry grown in northern Manitoba, Canada, contains exceptionally high levels of anthocyanins and other polyphenols. Previous studies from our lab have shown that lingonberry anthocyanins can protect H9c2 cells from ischemia-reperfusion injury and anthocyanin-rich diets have been shown to be associated with decre...

journal_title：Canadian journal of physiology and pharmacology

authors： Isaak CK,Petkau JC,Blewett H,O K,Siow YL

更新日期：2017-08-01 00:00:00

abstract：:The response pattern of the isolated longitudinal muscle of the rabbit ileum to adenosine-5'-alpha, beta-methylenediphosphonate (APCP) was found to differ from that caused by adenosine or ATP in that the rapid initial phase of relaxation is absent and that at doses above 10 muM a secondary increase of contractile acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Frew R,McKenzie SG,Bär HP,Hutchison KJ

更新日期：1976-08-01 00:00:00

abstract：:Transcranial magnetic stimulation over the motor cortex was used to construct a map of the effective sites on the scalp from which short-latency electromyogram responses could be evoked in muscles proximal to either an amputation stump (two subjects) or an ischemically anesthetized forearm (two subjects). At rest, the...

journal_title：Canadian journal of physiology and pharmacology

authors： Ridding MC,Rothwell JC

更新日期：1995-02-01 00:00:00

abstract：:The effects of neurokinins (NK) and related peptides on the secretion of 6-keto-prostaglandin F1 alpha, a stable metabolite of prostacyclin, were measured. These peptides enhanced three- to five-fold the basal secretion rate with the following rank order of potency (based on threshold concentrations for a significant ...

journal_title：Canadian journal of physiology and pharmacology

authors： Marceau F,Tremblay B,Couture R,Regoli D

更新日期：1989-02-01 00:00:00

abstract：:We investigated the role of receptor tyrosine kinases in Ang II-stimulated generation of reactive oxygen species (ROS) and assessed whether MAP kinase signaling by Ang II is mediated via redox-sensitive pathways. Production of ROS and activation of NADPH oxidase were determined by DCFDA (dichlorodihydrofluorescein dia...

journal_title：Canadian journal of physiology and pharmacology

authors： Touyz RM,Cruzado M,Tabet F,Yao G,Salomon S,Schiffrin EL

更新日期：2003-02-01 00:00:00

abstract：:Microiontophoretic applications of ibotenate, an amino acid analogue of glutamate, evoked biphasic responses from single dorsal horn interneurones of the cat spinal cord, i.e., an initial increase in the firing rate followed by a sustained depression of spontaneous firing. A reduced cell sensitivity to excitatory amin...

journal_title：Canadian journal of physiology and pharmacology

authors： MacDonald JF,Nistri A

更新日期：1977-08-01 00:00:00

abstract：:Diabetic patients have a higher incidence of cardiac arrhythmias, including ventricular fibrillation and sudden death, and show important alterations in the electrocardiogram, most of these related to the repolarization. In myocytes isolated from diabetic hearts, the transient outward K+ current (Ito) is the repolariz...

journal_title：Canadian journal of physiology and pharmacology

authors： Gallego M,Alday A,Urrutia J,Casis O

更新日期：2009-02-01 00:00:00

abstract：:Input to the nucleus medianus of the preoptic region has been suggested to be involved in both the drinking and pressor responses elicited by the central administration of angiotensin II. Evidence in support of this suggestion has been gained principally from electrical lesion experiments. This lesion procedure does n...

journal_title：Canadian journal of physiology and pharmacology

authors： Jones DL

更新日期：1988-08-01 00:00:00

abstract：:The role of leukotriene D4 (LTD4) as a mediator of immediate hypersensitivity reactions in the guinea-pig conjunctiva was examined using a potent, second-generation LTD4 receptor antagonist, MK-571 (also known as L-660,711). The microvascular permeability changes in the guinea-pig conjunctiva following challenge with ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chan CC,Dagenais F,Firby P,Foster A,Ford-Hutchinson AW

更新日期：1989-08-01 00:00:00

abstract：:Cumulative data suggest the significant role of the renin-angiotensin system in the development of the pathological consequences of diabetes mellitus (DM). Newly synthesized AT2 receptor agonists gained importance as a target for creating new antihypertensives. The aim of the present work was to study the effects of p...

journal_title：Canadian journal of physiology and pharmacology

authors： Pechlivanova D,Petrov K,Grozdanov P,Nenchovska Z,Tchekalarova J,Stoynev A

更新日期：2018-05-01 00:00:00

abstract：:The purpose of this study was to investigate the cardiac adrenergic neuronal changes induced by diabetes and hypertension by using an analogue of norepinephrine, meta-iodobenzylguanidine (MIBG), and to compare these changes with the contractile state of ventricular papillary muscle. The tissue concentration of norepin...

journal_title：Canadian journal of physiology and pharmacology

authors： Herman LM,Dai S,Hartman NG,McNeill JH

更新日期：1994-10-01 00:00:00

abstract：:In recent decades, the complexity of the endothelium and its major role in maintaining or altering blood vessel architecture are being revealed. In contrast, the vascular smooth muscle cell previously received the most attention. I suggest support of the hypothesis that the endothelium is the key to vascular disease. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Todd ME

更新日期：1992-04-01 00:00:00

abstract：:The mechanisms of the positive inotropic action of a new synthetic tetrahydroisoquinoline compound, SL-1, were investigated in isolated rat cardiac tissues and ventricular myocytes. SL-1 produced a rapidly developing, concentration-dependent positive inotropic response in both atrial and ventricular muscles and a nega...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang GJ,SU MJ,Lee PH,Lee SS,Liu KC

更新日期：1995-11-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease resulting in the formation of the atherosclerotic plaque. Plaque formation starts with the inflammation in fatty streaks and progresses through atheroma, atheromatous plaque, and fibroatheroma leading to development of stable plaque. Hypercholesterolemia, dyslipidemia,...

journal_title：Canadian journal of physiology and pharmacology

authors： Rai V,Agrawal DK

更新日期：2017-10-01 00:00:00

abstract：:17 beta-Hydroxy-11 beta(4-dimethylaminophenyl)-17 alpha-(1-propynyl)estra-4, 9-dien-3-one (RU486) inhibited the in vitro development of different stages of mouse preimplantation embryos under study. Two-celled embryos, morulae, and early blastocysts were obtained from B6D2F1 mice. The embryos were grown in Ham F-10 nu...

journal_title：Canadian journal of physiology and pharmacology

authors： Juneja SC,Dodson MG

更新日期：1990-11-01 00:00:00

abstract：:In mature (450-600 g) 21 degrees C-acclimated male rats, anaesthetized with urethane, blood flow (measured by the radioactive microsphere technique) to brown adipose tissue (BAT) was determined during the infusion of the beta-adrenoceptor agonist BRL 28410 or noradrenaline bitartrate at doses chosen to give similar in...

journal_title：Canadian journal of physiology and pharmacology

authors： Thurlby PL,Ellis RD

更新日期：1986-08-01 00:00:00

abstract：:The isometric contractile properties of frog (Rana pipiens) and toad (Bufo bufo) sartorii have been studied over the temperature range from 0 to 20 degrees C. The isometric twitch tension was found to vary considerably between these two species and between muscles in the same species. Between 0 and 4 degrees C there w...

journal_title：Canadian journal of physiology and pharmacology

authors： Bressler BH

更新日期：1981-06-01 00:00:00

abstract：:Diabetes with vascular complication needs strict interventions to retard possible serious complications. This research estimated the possible interaction of rosiglitazone (RGN) with losartan (Los) in diabetic rats. Male Sprague-Dawley rats were randomly divided into nondiabetic rats, diabetic rats, and diabetic rats t...

journal_title：Canadian journal of physiology and pharmacology

authors： Ateyya H,Nader MA,El-Sherbeeny NA

更新日期：2018-03-01 00:00:00

abstract：:In cats anesthetized with pentobarbital, isoproterenol infused into a peripheral vein causes a reduction in hepatic blood volume measured by plethysmography. As this response is accompanied by increases in portal and hepatic lobar venous pressures, the decrease in hepatic volume cannot be a passive emptying secondary ...

journal_title：Canadian journal of physiology and pharmacology

authors： Seaman KL,Greenway CV

更新日期：1984-06-01 00:00:00

abstract：:Experiments were carried out in pigs to investigate the relationship between concentration of intestinal calcium-binding protein (CaBP) and the presence of rickets. Pigs made rachitic by a diet deficient in calcium and in vitamin D had concentrations of intestinal CaBP no less than values obtained on control pigs. The...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrison JE,Hitchman AJ,Brown RG

更新日期：1975-02-01 00:00:00

abstract：:Tachykinin receptors in guinea-pig airways were examined using radioligand binding techniques in lung homogenates, and using isolated bronchial segments. Binding of the NK1 selective radioligand 125I-labelled Bolton-Hunter [Sar9,Met(O2)11]substance P ([125I]BHSarSP) was saturable and of high affinity (KD, 0.26 nM). Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Burcher E,Zeng XP,Strigas J,Geraghty DP,Lavielle S

更新日期：1995-07-01 00:00:00