Differences between the effects of noradrenaline and the beta-adrenoceptor agonist BRL 28410 in brown adipose tissue and hind limb of the anaesthetized rat.

abstract：:Ethanol (0.3 g/kg) was administered intravenously to adult, male rats at 3 h or at 1 and 3 h after gastric intubation of 7 mg/kg calcium carbimide (CC). For animals administered CC and two ethanol doses, blood ethanol concentration was similar for the two doses; however, blood acetaldehyde concentration was significan...

journal_title：Canadian journal of physiology and pharmacology

authors： Loomis CW,Brien JF

更新日期：1984-05-01 00:00:00

abstract：:As an activator of AMPK, the effect of AICAR on insulin signaling has not been investigated extensively. PI3K-Akt is a critical node involved in the insulin signaling pathway. We observed that concomitant with the activation of AMPK by AICAR, the protein level of PI3K p85α and the insulin-induced phosphorylation of Ak...

journal_title：Canadian journal of physiology and pharmacology

authors： Liu J,Ye C,Liu W,Zhao W,Zhang YJ,Zhang H,Ying H

更新日期：2016-02-01 00:00:00

abstract：:The objective of this study was to investigate under controlled conditions the effects of fentanyl on the rat locus coeruleus catechol oxidation current. Using differential normal pulse voltammetry combined with electrochemically treated carbon fiber electrodes to measure the catechol oxidation current, catecholamine ...

journal_title：Canadian journal of physiology and pharmacology

authors： Milne B,Quintin L,Gillon JY,Pujol JF

更新日期：1989-05-01 00:00:00

abstract：:Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2a subclass increased significantly when isolated P. senega saponins were used ...

journal_title：Canadian journal of physiology and pharmacology

authors： Katselis GS,Estrada A,Gorecki DK,Barl B

更新日期：2007-11-01 00:00:00

abstract：:Complexes of vanadyl(IV) with 4 monosaccharides and 5 disaccharides were tested in 2 osteoblast-like cell lines (MC3T3E1 and UMR106). Many complexes caused stimulation of UMR106 proliferation (120% basal) in the range of 2.5 to 25 micromol/L. In the nontransformed osteoblasts, some vanadyl-saccharide complexes stimula...

journal_title：Canadian journal of physiology and pharmacology

authors： Barrio DA,Cattáneo ER,Apezteguía MC,Etcheverry SB

更新日期：2006-07-01 00:00:00

abstract：:Cardiac injury and loss of cardiomyocytes is a causative as well as a resultant condition of cardiovascular disorders, which are the leading cause of death throughout the world. This loss of cardiomyocytes cannot be completely addressed through the currently available drugs being administered, which mainly function on...

journal_title：Canadian journal of physiology and pharmacology

authors： Padda J,Sequiera GL,Sareen N,Dhingra S

更新日期：2015-10-01 00:00:00

abstract：:The endothelin receptors in rabbit isolated rings of saphenous artery and saphenous vein have been characterized using endothelin-1, endothelin-2, endothelin-3, sarafotoxin S6c, and BQ123. Although artery rings were more sensitive than those from vein to the contractile action of phenylephrine, endothelin-1 was about ...

journal_title：Canadian journal of physiology and pharmacology

authors： Auguet M,Delaflotte S,Chabrier PE,Braquet P

更新日期：1993-10-01 00:00:00

abstract：:Our previous results showed that addition of agonists, such as vasopressin and angiotensin, added to incubation medium with freshly excised rat atria caused marked release of atrial natriuretic factor (ANF). This release was in the form of prohormone rather than active peptide. Since others had difficulty reproducing ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Milojevic S,Yip C,Veress AT

更新日期：1989-10-01 00:00:00

abstract：:The arterio--alveolar nitrogen difference (aADN2) has been associated in 27 normal adult subjects aged 20--60 years. As it may be assumed that venous and arterial PN2 are identical, we have used a sample of venous blood. There is a significant positive correlation between aADN2 and age. As the increase of aADN2 with a...

journal_title：Canadian journal of physiology and pharmacology

authors： Corbet AJ,Ross JA,Beaudry PH

更新日期：1975-02-01 00:00:00

abstract：:In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MT...

journal_title：Canadian journal of physiology and pharmacology

authors： Makary S,Abdo M,Fekry E

更新日期：2018-04-01 00:00:00

abstract：:In many species systemic toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is manifested by a generalized wasting syndrome accompanied by a variety of specific organ changes including atrophy of the thymus and spleen. TCDD toxicity in most tissues is thought to be mediated by the Ah receptor. Although the spleen ...

journal_title：Canadian journal of physiology and pharmacology

authors： Roberts EA,Vella LM,Golas CL,Dafoe LA,Okey AB

更新日期：1989-06-01 00:00:00

abstract：:The major hallmark of rotator cuff tendinopathies (RCT) is the disorganization of tendon extracellular matrix (ECM) which is due to decrease in the collagen I-to-collagen III ratio. In addition, the pathology of tendon matrisome remains asymptomatic and hypoxia has been identified to be the priming signal to initiate ...

journal_title：Canadian journal of physiology and pharmacology

authors： Thankam FG,Agrawal DK

更新日期：2020-08-15 00:00:00

abstract：:The activation of mast cells (MC) due to immunological stimulation causes an immediate and dramatic inflammatory response. We review current evidence indicating that the membrane permeabilities for calcium, chloride, sodium, and potassium have a significant role in the activation of these cells, and in some cases, spe...

journal_title：Canadian journal of physiology and pharmacology

authors： Janiszewski J,Huizinga JD,Blennerhassett MG

更新日期：1992-01-01 00:00:00

abstract：:The systemic and inotropic properties of prostaglandin E1 (PGE1) were investigated in 20 unanesthetized dogs. Pairs of ultrasonic dimension gauges and a micromanometer were implanted in the subendocardium and the apex of the left ventricle (LV), respectively. Seven to ten days later, increasing doses of PGE1 were infu...

journal_title：Canadian journal of physiology and pharmacology

authors： Roux S,Latour JG,Théroux P,Clozel JP,Bourassa MG

更新日期：1984-12-01 00:00:00

abstract：:In the wake of demographic change in Western countries, atrial fibrillation has reached an epidemiological scale, yet current strategies for drug treatment of the arrhythmia lack sufficient efficacy and safety. In search of novel medications, atrial-selective drugs that specifically target atrial over other cardiac fu...

journal_title：Canadian journal of physiology and pharmacology

authors： Ravens U

更新日期：2017-11-01 00:00:00

abstract：:The reported efficiencies of drug encapsulation into liposomes range from less than 0.1% to more than 10% per micromole phospholipid, depending on the nature of the drug and of the liposome employed. We have sought to investigate some of the factors which control the efficiency of drug encapsulation. We have found tha...

journal_title：Canadian journal of physiology and pharmacology

authors： Stamp D,Juliano RL

更新日期：1979-05-01 00:00:00

abstract：:We investigated the role of receptor tyrosine kinases in Ang II-stimulated generation of reactive oxygen species (ROS) and assessed whether MAP kinase signaling by Ang II is mediated via redox-sensitive pathways. Production of ROS and activation of NADPH oxidase were determined by DCFDA (dichlorodihydrofluorescein dia...

journal_title：Canadian journal of physiology and pharmacology

authors： Touyz RM,Cruzado M,Tabet F,Yao G,Salomon S,Schiffrin EL

更新日期：2003-02-01 00:00:00

abstract：:Over the last 2 decades, mi(cro)RNAs have emerged as one of the key regulators of metabolic homeostasis. Most of the studies have highlighted that, in the cytoplasm, miRNAs directly bind to the 3'-UTR (untranslated region) of a mRNA. Conventional RNA-induced silencing complex (RISC) formation results in the post-trans...

journal_title：Canadian journal of physiology and pharmacology

authors： Baradan R,Hollander JM,Das S

更新日期：2017-10-01 00:00:00

abstract：:The first steps of leucine utilization are reversible deamination to α-ketoisocaproic acid (α-KIC) and irreversible oxidation. Recently, the regulatory role of leucine deamination over oxidation was underlined in rodents. Our aim was to measure leucine deamination and reamination in the whole body, in respect to previ...

journal_title：Canadian journal of physiology and pharmacology

authors： Garibotto G,Verzola D,Vettore M,Tessari P

更新日期：2018-04-01 00:00:00

abstract：:Acetylcholine (ACh)-mediated vagal transmission as well as nonneuronal ACh release are considered cardioprotective in pathological situations with increased sympathetic drive such as ischemia-reperfusion and cardiac remodeling. ACh action is terminated by hydrolysis by the cholinesterases (ChEs), acetylcholinesterase,...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilianova Z,Ciznarova N,Szmicsekova K,Slobodova L,Hrabovska A

更新日期：2020-07-01 00:00:00

abstract：:The influence of variation in the extracellular concentrations of Na+, Mg2+, and Ca2+ in the depolarizing medium on isoproterenol-induced increases in cAMP levels and relaxation was studied in rat uterus. Isoproterenol (10(-8) M) failed to increase cAMP levels in the high-K+ medium containing no Na+. When 80 mM Na+ wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Meisheri KD,McNeill JH

更新日期：1979-10-01 00:00:00

abstract：:The pharmacological characteristics of postjunctional alpha-adrenoceptors in isolated canine internal carotid arteries were investigated by the use of selective agonists and antagonists for alpha 1- and alpha 2-adrenoceptors. Norepinephrine, phenylephrine, and xylazine caused concentration-dependent contractions in th...

journal_title：Canadian journal of physiology and pharmacology

authors： Kawai Y,Kobayashi S,Ohhashi T

更新日期：1988-05-01 00:00:00

abstract：:In vivo assessment of treatment efficacy on postinfarct left ventricular (LV) remodeling is crucial for experimental studies. We examined the technical feasibility of serial magnetic resonance imaging (MRI) for monitoring early postinfarct remodeling in rats. MRI studies were performed with a 7-Tesla unit, 1, 3, 8, 15...

journal_title：Canadian journal of physiology and pharmacology

authors： Prunier F,Marescaux L,Franconi F,Thia A,Legras P,Lejeune JJ,Furber A

更新日期：2005-12-01 00:00:00

abstract：:Glycine has been used to reduce oxidative stress and proinflammatory mediators in some metabolic disorders; however, its effect on the vasculature has been poorly studied. The aim of this work was to explore the effect of glycine on endothelial dysfunction in aged rats. Aortic rings with intact or denuded endothelium ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gómez-Zamudio JH,García-Macedo R,Lázaro-Suárez M,Ibarra-Barajas M,Kumate J,Cruz M

更新日期：2015-06-01 00:00:00

abstract：:This study was conducted to examine the protective role of crude polysaccharide from brown seaweed Sargassum polycystum against acetaminophen-induced abnormality in blood glucose, serum albumin/globulin ratio, and liver glycogen, lactate, and pyruvate. Liver and renal tissue histology was performed to confirm the effi...

journal_title：Canadian journal of physiology and pharmacology

authors： Raghavendran HR,Srinivasan P

更新日期：2008-10-01 00:00:00

abstract：:In cats anesthetized with pentobarbital, isoproterenol infused into a peripheral vein causes a reduction in hepatic blood volume measured by plethysmography. As this response is accompanied by increases in portal and hepatic lobar venous pressures, the decrease in hepatic volume cannot be a passive emptying secondary ...

journal_title：Canadian journal of physiology and pharmacology

authors： Seaman KL,Greenway CV

更新日期：1984-06-01 00:00:00

abstract：:The 3,5-pyrazolidinedione (3,5-P) drugs, phenylbutazone and sulfinpyrazone, have been reported to bind to receptors for the chemotactic peptide, f-Met-Leu-Phe, and to behave as functional antagonists of f-Met-Leu-Phe in human and rabbit neutrophils. To explore the structure-activity relationship of this family of drug...

journal_title：Canadian journal of physiology and pharmacology

authors： Levesque L,Gaudreault RC,Marceau F

更新日期：1991-03-01 00:00:00

abstract：:Curare action on nicotinic acetylcholine receptors has a number of facets, of which the best known is competitive antagonism. Here we describe the weak agonist action of 10(-5) M curare on the murine skeletal muscle cell line, G8. Although curare induces no depolarization in G8 cells, single-channel recordings reveal ...

journal_title：Canadian journal of physiology and pharmacology

authors： Morris CE,Montpetit MR,Sigurdson WJ,Iwasa K

更新日期：1989-02-01 00:00:00

abstract：:Our previous studies have suggested that GATA-4 increases the differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) into cardiac phenotypes. This study further investigated whether GATA-4 enhances MSC-mediated cardioprotection following hypoxia. MSCs were harvested from rat bone marrow and transduced wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Li HX,Zhou YF,Zhao X,Jiang B,Yang XJ

更新日期：2014-08-01 00:00:00

abstract：:The role of iron-loaded transferrin in xanthine-xanthine oxidase (X-XO) induced cardiac injury in isolated perfused rat hearts was examined. X (2 mM) - XO (10 U/L) perfusion resulted in contractile failure, a rise in resting tension, an increase in lipid peroxidation, and myocardial cell damage. The addition of transf...

journal_title：Canadian journal of physiology and pharmacology

authors： Tiede R,Sareen S,Singal PK

更新日期：1990-04-01 00:00:00