Beneficial effects of kinin B1 receptor antagonism on plasma fatty acid alterations and obesity in Zucker diabetic fatty rats.

abstract：:Recent evidence suggests that some Ca2+ channels are regulated by a tyrosine kinase pathway. The possibility that Ca2+ entry is regulated by tyrosine kinase was investigated in canine vascular muscles. Functional studies were carried out in the dog mesenteric arteries and saphenous veins. Nicardipine-insensitive refil...

journal_title：Canadian journal of physiology and pharmacology

authors： Low AM

更新日期：1996-03-01 00:00:00

abstract：:Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2a subclass increased significantly when isolated P. senega saponins were used ...

journal_title：Canadian journal of physiology and pharmacology

authors： Katselis GS,Estrada A,Gorecki DK,Barl B

更新日期：2007-11-01 00:00:00

abstract：:We describe postsynaptic Ca2+ signals that subserve induction of two forms of neuronal plasticity, long-term potentiation (LTP) and long-term depression (LTD), in rat hippocampal neurons. The common induction protocol for LTP, a 1-s, 50-Hz tetanus, generates Ca2+ increases of about 50-Hz in dendritic spines of CA1 neu...

journal_title：Canadian journal of physiology and pharmacology

authors： Connor JA,Petrozzino J,Pozzo-Miller LD,Otani S

更新日期：1999-09-01 00:00:00

abstract：:Both the kidney and colon secrete bicarbonate and transport water and electrolytes. The respective contributions of these two organs to acid-base and electrolyte balance in normal man has thus been studied in eight healthy male volunteers who underwent simultaneous renal clearance studies, and colonic perfusion with a...

journal_title：Canadian journal of physiology and pharmacology

authors： Crepeau R,Romeder JM,Devroede G,Plante GE

更新日期：1977-02-01 00:00:00

abstract：:While conducting studies on the prevention of mortality from acute iron intoxication in rats, diazepam, given to prevent animal suffering, was observed to be associated with reduced mortality in a limited number of animals. The objective was to assess whether diazepam reduces mortality following acute iron intoxicatio...

journal_title：Canadian journal of physiology and pharmacology

authors： Fassos FF,Berkovitch M,Daneman N,Koren L,Cameron R,Klein J,Falcitelli C,St Louis P,Daneman R,Koren G

更新日期：1998-09-01 00:00:00

abstract：:Isolated rabbit hearts undergo ventricular depolarization when exposed to 0.5 mM K--Krebs during 30 to 45 min. A ventricular tachyarrhythmia develops when these hearts are allowed to repolarize in 1.5 mM K--Krebs. Ventricular fibrillation usually follows. These arrhythmias do not cease spontaneously. Initially, perfus...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruiz-Ceretti E,Ponce-Zumino A,Blaney R,Chartier D

更新日期：1982-12-01 00:00:00

abstract：:The effects of estrogen and progesterone domination, achieved by administering estrogen (E) and estrogen plus progesterone (E + P), on rat uterine reactivity to Ca2+ and to Ca2+ channel ligands (antagonist and activator) were compared. The inhibitory activities of nifedipine, diltiazem, and D 600 against K+ depolariza...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruzycky AL,Crankshaw DJ,Triggle DJ

更新日期：1987-10-01 00:00:00

abstract：:The present research was to assess the relationship between ABCB1 (G2677T/A, C3435T) polymorphisms and lipid homeostasis as well as risk of liver injury induced by atorvastatin in in-patients from China. The lipid levels (total cholesterol, high-density lipoprotein, triglycerides) as well as metabolic enzymes of hepar...

journal_title：Canadian journal of physiology and pharmacology

authors： Qu KK,Zhang CN,Dong LX,Wang SS,Zhang ZD,Zhang L

更新日期：2020-01-01 00:00:00

abstract：:The mammalian daily (circadian) clock is located in the suprachiasmatic nuclei of the hypothalamus. Clock function can be detected by the measurement of the circadian change in spontaneous firing rate of suprachiasmatic nuclei cells in a brain slice preparation in vitro. We investigated the effects of neuropeptide Y o...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrington ME,Schak KM

更新日期：2000-02-01 00:00:00

abstract：:To determine if increased endometrial vascular permeability (a response which precedes decidualization) could be obtained in temporally nonsensitized uteri by treatments designed to increase endometrial adenosine 3':5'-cyclic monophosphate (cAMP) concentrations, cholera toxin (an activator of adenylate cyclase) was in...

journal_title：Canadian journal of physiology and pharmacology

authors： Johnston ME,Kennedy TG

更新日期：1985-09-01 00:00:00

abstract：:Biochemical studies using highly condensed Xenopus sperm chromatin and protein extracts prepared from multiple systems have lead to the identification of conserved proteins involved in chromosome decondensation. However, mutations to these proteins are unavailable as the systems used are not amenable to genetic studie...

journal_title：Canadian journal of physiology and pharmacology

authors： Harkness TA

更新日期：2006-03-01 00:00:00

abstract：:Theanine and caffeine, 2 naturally occurring components in tea, have repeatedly been shown to deliver unique cognitive benefits when consumed in combination. In this study, we assessed the beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral damage in rats. Theanine and ca...

journal_title：Canadian journal of physiology and pharmacology

authors： Sun L,Tian X,Gou L,Ling X,Wang L,Feng Y,Yin X,Liu Y

更新日期：2013-07-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and CNTF analogs were reported to have hepatoprotective effect and ameliorate hepatic steatosis in db/db or high-fat-diet-fed mice. Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate h...

journal_title：Canadian journal of physiology and pharmacology

authors： Cui MX,Jiang JF,Min GN,Han W,Wu YJ

更新日期：2017-05-01 00:00:00

abstract：:Malnutrition and inflammation are associated with end-stage renal disease (ESRD). Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) powerfully predict death from cardiovascular disease. The aim of our study was to establish an association between markers of inflammation and parameters of malnutrition in p...

journal_title：Canadian journal of physiology and pharmacology

authors： Perunicic-Pekovic G,Pljesa S,Rasic-Milutinovic Z,Stankovic S,Ilic M,Maletic R

更新日期：2008-04-01 00:00:00

abstract：:A method for the determination of the specific activity of plasma glycerol is described. Anionic contaminants are first removed from deproteinzed plasma by anionic exchange resins (treated plasma). Glycerol in treated plasma is then quantitatively converted to glycerol-3-phosphate (G3P), which is isolated by column ch...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier C,Layberry R

更新日期：1982-06-01 00:00:00

abstract：:The twitch-potentiating effects of opioids in the frog's skeletal muscle which are naloxone resistant and nonstereospecific were further studied. The rapid kinetics of the onset and of the offset (following washout) of the opioid effect indicates that the site for this action is the surface membrane of the muscle fibr...

journal_title：Canadian journal of physiology and pharmacology

authors： Shetty SS,Frank GB

更新日期：1986-07-01 00:00:00

abstract：:Epinephrine caused hyperglycemia in part by increasing gluconeogenesis. However, the mechanism of its gluconeogenic effects has not been studied in ruminants. This study was undertaken to examine the effect of epinephrine on the net hepatic uptake of selected glucose precursors in sheep. The major abdominal blood vess...

journal_title：Canadian journal of physiology and pharmacology

authors： Brockman RP

更新日期：1991-04-01 00:00:00

abstract：:We have previously demonstrated a 40% increase in myocardial blood flow (MBF) during hypercapnia but no significant decrease of MBF during hypocapnia. The present study was undertaken to evaluate if epinephrine infusion, which increases both myocardial oxygen consumption (MVo2) and myocardial performance, might influe...

journal_title：Canadian journal of physiology and pharmacology

authors： Wexels JC,Myhre ES,Mjøs OD

更新日期：1986-01-01 00:00:00

abstract：:A single-dose administration of 6-hydroxydopamine (50 mg/kg body weight, sc) to infant rats resulted in an enlargement, higher fresh weight, markedly elevated lipid content, and higher total protein content of their interscapular and cervical brown adipose tissue. The protein kinase (EC 2.7.1.37) activation ratio in t...

journal_title：Canadian journal of physiology and pharmacology

authors： Skala JP,Hahn P

更新日期：1977-04-01 00:00:00

abstract：:The cannabinoid system has been suspected to play a role in the mechanisms of action of dipyrone and paracetamol. Our purpose was to measure the local endocannabinoid and N-acylethanolamide levels in the brain and spinal cord of rats following dipyrone and paracetamol administration. Nociception was assessed 1, 5, and...

journal_title：Canadian journal of physiology and pharmacology

authors： Topuz RD,Gunduz O,Karadag CH,Dokmeci D,Ulugol A

更新日期：2019-11-01 00:00:00

abstract：:The systemic and inotropic properties of prostaglandin E1 (PGE1) were investigated in 20 unanesthetized dogs. Pairs of ultrasonic dimension gauges and a micromanometer were implanted in the subendocardium and the apex of the left ventricle (LV), respectively. Seven to ten days later, increasing doses of PGE1 were infu...

journal_title：Canadian journal of physiology and pharmacology

authors： Roux S,Latour JG,Théroux P,Clozel JP,Bourassa MG

更新日期：1984-12-01 00:00:00

abstract：:Previous studies have demonstrated that abdominal irradiation alters intestinal uptake of nutrients. The purpose of this study was to determine the effect of an orally administered synthetic prostaglandin E2, enprostil, given on three occasions shortly prior to a single exposure to 600 cGy external abdominal irradiati...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson AB,Keelan M,Clandinin MT,Tavernini M,Lam T,Walker K,Cheeseman CI

更新日期：1989-10-01 00:00:00

abstract：:Geniposide (GP) is one of main compounds in Gardenia jasminoides Ellis, with both medicinal and nutritional value. This study was designed to determine, for the first time, how GP from G. jasminoides protects against acute alcohol-induced liver injury, and the underlying mechanisms. Mice were orally administered alcoh...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang J,Zhang Y,Liu R,Li X,Cui Y,Qu L

更新日期：2015-04-01 00:00:00

abstract：:Transmural nerve stimulation following sympathetic (guanethidine 10(-4) mol/L, phenoxybenzamine 2 X 10(-5) mol/L, propanolol 2 X 10(-6) mol/L) and muscarinic blockade (atropine 5 X 10(-5) mol/L) produces a relaxatory response in canine saphenous veins contracted with prostaglandin F2 alpha. This relaxatory response wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Senaratne MP,Kappagoda T

更新日期：1986-10-01 00:00:00

abstract：:The effect of high potassium depolarization on the release of exogenously supplied [3H]glutamate and endogenous glutamate from tissue slices of the cestode Hymenolepis diminuta was examined. Increasing concentrations of potassium stimulated the release of radiolabel from tissues preloaded with [3H]glutamate. This rele...

journal_title：Canadian journal of physiology and pharmacology

authors： Webb RA

更新日期：1988-07-01 00:00:00

abstract：:The role of sympathetic innervation in the regulation of hindlimb skeletal muscle blood flow (QL) and metabolism was studied prior to and during acute anemia in anesthetized, paralyzed, and ventilated dogs (n = 8). Neural activity in the sciatic nerve was reversibly cold blocked for a 15-min period at control hematocr...

journal_title：Canadian journal of physiology and pharmacology

authors： Kubes P,Cain SM,Chapler CK

更新日期：1988-09-01 00:00:00

abstract：:This year, 2011, the Department of Pharmacology at the University of Alberta celebrated its 50th anniversary. This timeframe covers nearly the entire history of Cys-loop pentameric ligand-gated ion channel (pLGIC) research. In this review we consider how major technological advancements affected our current understand...

journal_title：Canadian journal of physiology and pharmacology

authors： Kozuska JL,Paulsen IM

更新日期：2012-06-01 00:00:00

abstract：:17 beta-Hydroxy-11 beta(4-dimethylaminophenyl)-17 alpha-(1-propynyl)estra-4, 9-dien-3-one (RU486) inhibited the in vitro development of different stages of mouse preimplantation embryos under study. Two-celled embryos, morulae, and early blastocysts were obtained from B6D2F1 mice. The embryos were grown in Ham F-10 nu...

journal_title：Canadian journal of physiology and pharmacology

authors： Juneja SC,Dodson MG

更新日期：1990-11-01 00:00:00

abstract：:The Na+/H+ exchanger isoform 1 is an integral membrane protein that regulates intracellular pH. It extrudes 1 intracellular H+ in exchange for 1 extracellular Na+. It has 2 large domains, an N-terminal membrane domain of 12 transmembrane segments and an intracellular C-terminal regulatory domain. We characterized the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding J,Ng RW,Fliegel L

更新日期：2007-03-01 00:00:00

abstract：:The pulmonary vascular resistance in a peripheral portion of the pulmonary vascular bed can be determined with a catheter wedged in a peripheral branch of the pulmonary artery, from the pressure increase induced by infusion of mixed venous blood at known flow rates. The volume of the wedged vascular bed can be estimat...

journal_title：Canadian journal of physiology and pharmacology

authors： Chabot F,Saunier C,Schrijen F

更新日期：1997-01-01 00:00:00