Tetrodotoxin-resistant relaxation to transmural nerve stimulation in canine saphenous veins: a possible neural origin.

abstract：:The effects of estrogen and progesterone domination, achieved by administering estrogen (E) and estrogen plus progesterone (E + P), on rat uterine reactivity to Ca2+ and to Ca2+ channel ligands (antagonist and activator) were compared. The inhibitory activities of nifedipine, diltiazem, and D 600 against K+ depolariza...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruzycky AL,Crankshaw DJ,Triggle DJ

更新日期：1987-10-01 00:00:00

abstract：:The structure of the artery wall is exquisitely sensitive to the hemodynamic forces imposed on it by blood pressure and blood flow. This sensitivity regulates growth and remodeling of arteries during development, and it regulates long-term adaptive restructuring of mature vessels. Since many vascular pathologies invol...

journal_title：Canadian journal of physiology and pharmacology

authors： Langille BL

更新日期：1996-07-01 00:00:00

abstract：:Ah receptor in hepatic cytosols from adult cynomolgus monkeys (Macaca fasicularis) was identified and quantitated by its binding of the highly toxic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the carcinogens 3-methylcholanthrene, benzo[a]pyrene, and dibenz[a,h]anthracene. The concentration of Ah receptor ...

journal_title：Canadian journal of physiology and pharmacology

authors： Okey AB,Vella LM,Iverson F

更新日期：1984-10-01 00:00:00

abstract：:Diabetic patients have a higher incidence of cardiac arrhythmias, including ventricular fibrillation and sudden death, and show important alterations in the electrocardiogram, most of these related to the repolarization. In myocytes isolated from diabetic hearts, the transient outward K+ current (Ito) is the repolariz...

journal_title：Canadian journal of physiology and pharmacology

authors： Gallego M,Alday A,Urrutia J,Casis O

更新日期：2009-02-01 00:00:00

abstract：:The purpose of this study was to determine the interaction of three factors that modify twitch contraction amplitude in the rat gastrocnemius muscle in situ: posttetanic potentiation, fatigue, and caffeine. Posttetanic (200 Hz for 1 s) twitch responses were observed before and after 15 Hz stimulation for 6 min (group ...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIntosh BR,Gardiner PF

更新日期：1987-02-01 00:00:00

abstract：:The development of cardiac hypertrophy was examined in rats given ethanol in a nutritionally adequate, liquid diet mixture, by intubation, in severely intoxicating doses at 8-h intervals for up to 96 h, alone or in combination with prazosin. Other groups of rats received isocalorically paired quantities of maltose-dex...

journal_title：Canadian journal of physiology and pharmacology

authors： Adams MA,Hirst M

更新日期：1989-03-01 00:00:00

abstract：:The effects of lithium chloride on ornithine decarboxylase (ODC) activity were compared in the adrenal and kidney of control (saline treated) and prolactin-treated rats. ODC activity was decreased in kidney of both groups of animals, the magnitude of the effect of lithium in the hormone-treated group varying with the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Strümpfer A,Hsiao J,Peng T,Richards J

更新日期：1992-09-01 00:00:00

abstract：:Angiotensin exerts numerous contractile and secretory effects by activating specific receptors. Recent pharmacological findings obtained with this peptide in various laboratories are analyzed, using the order of potency of agonists and the affinity of competitive antagonists as criteria for the classification of recep...

journal_title：Canadian journal of physiology and pharmacology

authors： Regoli D

更新日期：1979-02-01 00:00:00

abstract：:Energy balance studies suggest that the overall efficiency of energy utilization does not increase during pregnancy in rodents, other than as a consequence of "hyperphagia". Diet-induced thermogenesis is not stimulated in response to the increased energy intake of the pregnant animal, the extra intake being retained a...

journal_title：Canadian journal of physiology and pharmacology

authors： Trayhurn P

更新日期：1989-04-01 00:00:00

abstract：:Doxepin binds to intact astrocytes in primary cultures. The binding is competitively displaceable by excess cold doxepin and it is pronounced (Bmax = 27 nmol/mg protein) but the affinity is rather low (KD = 30 microM). The binding is inhibited by other antidepressants (amitriptyline, desipramine, tranylcypromine, ipri...

journal_title：Canadian journal of physiology and pharmacology

authors： Hertz L,Richardson JS,Mukerji S

更新日期：1980-12-01 00:00:00

abstract：:The influences of hypertension and hypothyroidism on diabetic cardiomyopathy are not clear. We studied this problem further by characterizing the effects of chronic triiodothyronine (T3) treatment on cardiac performance of diabetic renovascular hypertensive (RVH) rats. Hypertension was effected by clipping the left re...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodgers RL,Davidoff AJ,Mariani MJ

更新日期：1991-03-01 00:00:00

abstract：:The role of nitric oxide (NO) on the vasorelaxant effect of atrial natriuretic peptide (ANP) on the basal tone of rabbit aortic rings conditioned to angiotensin II (Ang II) was studied. ANP aortic relaxation and nitrite release were measured in the presence and absence of endothelium and a NO-synthase inhibitor. Ang I...

journal_title：Canadian journal of physiology and pharmacology

authors： Romano L,Coviello A,Jerez S,Peral de Bruno M

更新日期：2002-10-01 00:00:00

abstract：:To investigate the capacity of efferent sympathetic neurons to modulate the failing heart, stellate ganglion stimulation was performed in dogs with biventricular heart failure induced by rapid ventricular pacing (240 beats/min) for 4-6 weeks. Less noradrenaline was released from cardiac myoneural junctions into corona...

journal_title：Canadian journal of physiology and pharmacology

authors： Cardinal R,Nadeau R,Laurent C,Boudreau G,Armour JA

更新日期：1996-09-01 00:00:00

abstract：:Hydroxytyrosol (HT), a phenolic compound in olive oil, exerts an anti-inflammatory effect in cardiovascular diseases. Recent studies found that autophagy was a therapeutic target of diseases. However, the effect of HT on autophagy in vascular adventitial fibroblasts (VAFs) remains unknown. Thus, in this study, we aime...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang W,Jing T,Yang X,He Y,Wang B,Xiao Y,Shang C,Zhang J,Lin R

更新日期：2018-01-01 00:00:00

abstract：:The alcohol oxidase membrane technique is available for measurement of ethanol in commercial fluids. In this paper we examined its usefulness for cat and human blood in comparison with gas-liquid chromatography (GLC). The membrane method proved to be simple, reproducible, accurate, and inexpensive. Analysis took 1-2 m...

journal_title：Canadian journal of physiology and pharmacology

authors： Greenway CV,Pushka K,Sitar DS,Rogers LK

更新日期：1988-04-01 00:00:00

abstract：:The role of iron-loaded transferrin in xanthine-xanthine oxidase (X-XO) induced cardiac injury in isolated perfused rat hearts was examined. X (2 mM) - XO (10 U/L) perfusion resulted in contractile failure, a rise in resting tension, an increase in lipid peroxidation, and myocardial cell damage. The addition of transf...

journal_title：Canadian journal of physiology and pharmacology

authors： Tiede R,Sareen S,Singal PK

更新日期：1990-04-01 00:00:00

abstract：:Using radioligand binding techniques, the effect of reserpine pretreatment on ventricular adrenergic receptors from guinea pig was studied. [3H]Prazosin and [3H]dihydroalprenolol were used to label alpha 1- and beta-adrenergic receptors, respectively. Administration of 2.5 mg/kg reserpine for 2 days caused a significa...

journal_title：Canadian journal of physiology and pharmacology

authors： Latifpour J,McNeill JH

更新日期：1984-01-01 00:00:00

abstract：:To evaluate the clinical efficacy of azithromycin, cefaclor, and amoxicillin in treatment of pediatric tonsillitis, a total of 256 children with Group A β-hemolytic streptococcus (GAS) tonsillitis were randomly divided into 3 groups. Only patients assessed with streptococcus-positive tonsillitis, considered to be comp...

journal_title：Canadian journal of physiology and pharmacology

authors： Li P,Jiang G,Shen X

更新日期：2019-10-01 00:00:00

abstract：:The postprandial release of immunoreactive insulin, glucagon, gastrin, somatostatin, pancreatic polypeptide (PP), and gastric inhibitory polypeptide (GIP) was studied in parallel with the absorption of sugars and amino acids in conscious pigs. Six pigs fitted with permanent catheters in the portal vein and arterial bl...

journal_title：Canadian journal of physiology and pharmacology

authors： Rérat A,Chayvialle JA,Kandé J,Vaissade P,Vaugelade P,Bourrier T

更新日期：1985-12-01 00:00:00

abstract：:In cultures of rat granulosa cells, luteinizing hormone-releasing hormone (LHRH) increases 32P incorporation into both phosphatidylinositol (PI) and phosphatidic acid (PA). After 20 min, the level of radioactivity was three- to four-fold (p less than 0.01) above control in the PI and PA fractions, respectively. The st...

journal_title：Canadian journal of physiology and pharmacology

authors： Minegishi T,Leung PC

更新日期：1985-04-01 00:00:00

abstract：:The aim of this study was to investigate the effects of melatonin on rat gastric fundus smooth muscle. Melatonin (10(-4) to 10(-3) M) had no effect on the basal tone of gastric smooth muscle. After precontraction with carbachol (10(-6) M) or serotonin (10(-7) M), melatonin caused a concentration dependent inhibitory a...

journal_title：Canadian journal of physiology and pharmacology

authors： Storr M,Schusdziarra V,Allescher HD

更新日期：2000-10-01 00:00:00

abstract：:H2S is an important gasotransmitter with a vasorelaxant property. The modulation of endogenous H2S generation from different tissues and the functional consequence of this modulation are not clear. In the present study, the production of H2S from vascular tissues as well as the liver and ileum of rats was measured. Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhao W,Ndisang JF,Wang R

更新日期：2003-09-01 00:00:00

abstract：:Vascular smooth muscle tone is regulated primarily by the sarcoplasmic free Ca2+ concentration, which determines the level of myosin phosphorylation. Stimulation of the muscle results in an increase in free [Ca2+], whereupon Ca2+ binds to calmodulin, inducing a conformational change enabling calmodulin to interact wit...

journal_title：Canadian journal of physiology and pharmacology

authors： Walsh MP

更新日期：1994-08-01 00:00:00

abstract：:This study investigated the effects of prolonged exercise on muscle sarcoplasmic reticulum (SR) Ca2+ cycling properties and the metabolic responses with and without a session of exercise designed to reduce muscle glycogen reserves while on a normal carbohydrate (CHO) diet. Eight untrained males (VO(2peak) = 3.81 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Duhamel TA,Green HJ,Perco JG,Ouyang J

更新日期：2005-07-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of pomegranate (Punica granatum) juice (PGJ) on oxidative damages in liver tissue and erythrocytes of rats intoxicated by sodium fluoride (NaF). Rats were randomly divided into two groups: group I received standard diet and group II received orally ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouasla A,Bouasla I,Boumendjel A,Abdennour C,El Feki A,Messarah M

更新日期：2016-07-01 00:00:00

abstract：:Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach d...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Salama RB,Coceani F,Olley PM

更新日期：1984-04-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs), including endothelin receptor A (ETA) and B (ETB), may form dimers or higher-order oligomers that profoundly influence signaling. Here we examined a PDZ finger motif within the C-terminus of ETA and its role in heterodimerization with ETB, and in homodimerization with itself, when ...

journal_title：Canadian journal of physiology and pharmacology

authors： Evans NJ,Walker JW

更新日期：2008-08-01 00:00:00

abstract：:We used thermoluminescence, electron spin resonance, and viscosimetric measurements to establish whether or not a spice had been irradiated. Thermoluminescence, using the 1788 EN official protocol with an alternative method for the extraction of mineral impurities, led to proof of irradiation or proof of no treatment....

journal_title：Canadian journal of physiology and pharmacology

authors： Chabane S,Pouliquen-Sonaglia I,Raffi J

更新日期：2001-02-01 00:00:00

abstract：:The response pattern of the isolated longitudinal muscle of the rabbit ileum to adenosine-5'-alpha, beta-methylenediphosphonate (APCP) was found to differ from that caused by adenosine or ATP in that the rapid initial phase of relaxation is absent and that at doses above 10 muM a secondary increase of contractile acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Frew R,McKenzie SG,Bär HP,Hutchison KJ

更新日期：1976-08-01 00:00:00

abstract：:The effect of one bout of acute exercise on impaired glucose metabolism was studied in obese (480 +/- 20 g), untrained rats, at rest (n = 10) and after 60 min of swimming (n = 5). Using the euglycemic, hyperinsulinemic (10 mU.kg-1 x min-1) clamp, glucose clearance rate increased from 7.6 +/- 0.9 at rest to 9.7 +/- 0.5...

journal_title：Canadian journal of physiology and pharmacology

authors： Burstein R,Zissholtz A,Zick-Bachar Y,Epstein Y,Shapiro Y,Karnieli E

更新日期：1992-11-01 00:00:00