Arterial remodeling: relation to hemodynamics.

abstract：:Nonsteroidal anti-inflammatory drugs are widely used for the treatment of osteoarthritis and rheumatoid arthritis, but their ability to cause gastrointestinal bleeding is a significant limitation to this use. A better understanding of the pathogenesis of gastric and intestinal injury induced by these agents will permi...

journal_title：Canadian journal of physiology and pharmacology

authors： Wallace JL

更新日期：1994-12-01 00:00:00

abstract：:The activity of the lipolytic system of the obese hyperglycemic mouse was assessed after treatment with physiological doses of thyroxin (T4). The treatment significantly increased fatty acid mobilization in response to adrenaline over the levels observed in the control mice under all conditions studied. The activities...

journal_title：Canadian journal of physiology and pharmacology

authors： Bégin-Heick N,Heick HM

更新日期：1977-12-01 00:00:00

abstract：:The effects of 5-hydroxytryptamine (5-HT) on spinal motoneurons were examined in pentobarbital-anaesthetized cats and in nonanaesthetized decerebrate cats by intracellular recording and extracellular iontophoresis of 5-HT. 5-HT first induced a depolarization and then a long-lasting hyperpolarization (up to 60 min) wit...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang L

更新日期：1991-02-01 00:00:00

abstract：:To assess development changes in kinetic properties of the cardiac sodium current, whole-cell voltage-clamp experiments were conducted using 3-, 10-, and 17-day-old embryonic chick ventricular heart cells. Experimental data were quantified according to the Hodgkin-Huxley model. While the Na current density, as examine...

journal_title：Canadian journal of physiology and pharmacology

authors： Sada H,Ban T,Fujita T,Ebina Y,Sperelakis N

更新日期：1995-10-01 00:00:00

abstract：:The combined effect of a beta 2-antagonist and an alpha 2-agonist on the release of adrenal catecholamines was studied in the anaesthetized and vagotomized dog. The electrical stimulation of the splanchnic nerve (5-V pulses of 2 ms duration for 3 min at a frequency of 3 Hz) produced a significant rise in adrenal catec...

journal_title：Canadian journal of physiology and pharmacology

authors： Foucart S,de Champlain J,Nadeau R

更新日期：1988-10-01 00:00:00

abstract：:In the present study we characterized the receptor(s) that mediates non-adrenergic non-cholinergic (NANC) contractions of isolated guinea pig cervical trachea, using CP-99,994, a selective neurokinin (NK1) receptor antagonist, and SR-48,968, a selective neurokinin (NK2) receptor antagonist. The activity of these two a...

journal_title：Canadian journal of physiology and pharmacology

authors： Charette L,Foulon D,Rodger IW,Jones TR

更新日期：1994-02-01 00:00:00

abstract：:Ten minutes after KCl-depolarization of rat myometrial strips, at which time the muscles were in a state of sustained contracture, tissue levels of adenosine 3',5'-cyclic monophosphate (cyclic AMP) were increased by approximately 40% over relaxed controls, and levels of guanosine 3',5'-cyclic monophosphate (cyclic GMP...

journal_title：Canadian journal of physiology and pharmacology

authors： Diamond J,Holmes TG

更新日期：1975-12-01 00:00:00

abstract：:Our previous studies have suggested that GATA-4 increases the differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) into cardiac phenotypes. This study further investigated whether GATA-4 enhances MSC-mediated cardioprotection following hypoxia. MSCs were harvested from rat bone marrow and transduced wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Li HX,Zhou YF,Zhao X,Jiang B,Yang XJ

更新日期：2014-08-01 00:00:00

abstract：:Selected topics on the roles of sarcoplasmic reticulum (SR) in the control of vascular smooth muscle (VSM) tone are briefly reviewed with particular reference to the regulation of cytosolic concentration of free calcium ions, [Ca2+]i. Although morphological evidence and subcellular membrane studies indicate a relative...

journal_title：Canadian journal of physiology and pharmacology

authors： Daniel EE,van Breemen C,Schilling WP,Kwan CY

更新日期：1995-05-01 00:00:00

abstract：:Systolic blood pressure was measured weekly in conscious and in anesthetized female Sprague-Dawley (SD) and Wistar-Furth (W/Fu) rats following adrenal enucleation, unilateral nephrectomy, and the imposition of a high salt intake. SD rats quickly developed adrenal-regeneration hypertension (ARH) which progressed rapidl...

journal_title：Canadian journal of physiology and pharmacology

authors： Hall CE,Nasseth D

更新日期：1978-12-01 00:00:00

abstract：:Angiotensin exerts numerous contractile and secretory effects by activating specific receptors. Recent pharmacological findings obtained with this peptide in various laboratories are analyzed, using the order of potency of agonists and the affinity of competitive antagonists as criteria for the classification of recep...

journal_title：Canadian journal of physiology and pharmacology

authors： Regoli D

更新日期：1979-02-01 00:00:00

abstract：:The electrophysiologist's view of brain astrocytes has changed markedly in recent years. In the past astrocytes were viewed as passive, K+ selective cells, but it is now evident that they are capable of expressing voltage- and ligand-activated channels previously thought to be restricted to neurons. The functional imp...

journal_title：Canadian journal of physiology and pharmacology

authors： Sontheimer H

更新日期：1992-01-01 00:00:00

abstract：:Early studies indicated that the baCl2-induced contractions in the guinea pig ileum longitudinal muscle strip (GPI-LMS) were, in part, neuronal in origin. However, recent studies have suggested that BaCl2-induced contractions were produced by an action directly on the smooth muscle membrane. The purpose of this study ...

journal_title：Canadian journal of physiology and pharmacology

authors： Clement JG

更新日期：1981-06-01 00:00:00

abstract：:The hypotensive effect of clonidine in anaesthetised (pentobarbitone) cat has been analysed with the help of pharmacological tools. Application of clonidine (0.1%) to the exposed ventral surface of medulla oblongata produced hypotension (28.6%) and bradycardia (18%). Similar application of glycine (5%) and GABA (10%) ...

journal_title：Canadian journal of physiology and pharmacology

authors： Srimal RC,Gulati K,Dhawan BN

更新日期：1977-10-01 00:00:00

abstract：:In hypertension, the relationship between atrial natriuretic peptide (ANP) and vasopressin (AVP) is not yet clear, although their renal actions are effectively autoregulation. To examine the possible interaction further, the responses to ANP infusion (75 ng x min (-1), i.v.) have been investigated in both hypertensive...

journal_title：Canadian journal of physiology and pharmacology

authors： Abu-Amarah I,Balment RJ

更新日期：1999-02-01 00:00:00

abstract：:The administration of small doses of somatostatin (SRIF) (0.01 and 0.1 microgram) into the neostriatal complex of unrestrained, freely moving rats induced general behavioral excitation associated with a variety of stereotyped movements, tremors, and a reduction of rapid eye movements (REM) and deep slow wave sleep (SW...

journal_title：Canadian journal of physiology and pharmacology

authors： Rezek M,Havlicek V,Leybin L,Pinsky C,Kroeger EA,Hughes KR,Friesen H

更新日期：1977-04-01 00:00:00

abstract：:We have studied during 30 days the effect of a low dose of NG-nitro-L-arginine methyl ester (1 mg.kg-1.day-1 in drinking water) in the presence of D- or L-arginine (1 mg.kg-1.day-1 in drinking water) in comparison with D- or L-arginine alone on blood pressure and renal function in conscious uninephrectomized female sp...

journal_title：Canadian journal of physiology and pharmacology

authors： Reverte M,Flores O,Gallego B,Lestón A,López-Novoa JM

更新日期：1998-01-01 00:00:00

abstract：:We investigated the effects of 4% fructose plus moderately high salt (MHS) (4% NaCl) treatment on tissue aldehyde conjugates, platelet cytosolic free calcium ([Ca2+]i), renal morphology, and systolic blood pressure (SBP) in Wistar-Kyoto rats, and whether these effects were reversible (R) after withdrawal of treatment....

journal_title：Canadian journal of physiology and pharmacology

authors： Vasdev S,Gill V,Parai S,Gadag V

更新日期：2007-03-01 00:00:00

abstract：:The contractile recoverability of isolated portal veins made hypodynamic by removal of glucose from the perfusion medium by diverse exogenous substrates was studied. It was found that glucose, mannose, pyruvate, lactate, acetate, and butyrate readily restored contraction. The effects of anoxia and metabolic inhibitors...

journal_title：Canadian journal of physiology and pharmacology

authors： Cremer-Lacuara MG,Lacuara JL,Fiol de Cuneo M,Ruiz RD

更新日期：1980-06-01 00:00:00

abstract：:In the present study we have compared the effect of intravenous infusion of a calcium channel blocker, nifedipine (1.0 micrograms.kg-1.min-1 for 20 min), with that of isoproterenol (0.1 micrograms.kg-1.min-1 for 20 min) on the hemodynamic parameters and the vascular response of different locations and tissue layers of...

journal_title：Canadian journal of physiology and pharmacology

authors： Prokopiw I,Dinda PK,Beck IT

更新日期：1990-12-01 00:00:00

abstract：:We investigated potential sex differences in bone resorption and the conservation of whole body bone mass in 24-week-old Sprague-Dawley rats maintained on a 1.0% calcium diet and then fed diets containing 0.02, 0.5, 1.0, or 1.75% calcium for 31 days. Lowering dietary calcium from 1.00% to 0.02% doubled whole skeleton ...

journal_title：Canadian journal of physiology and pharmacology

authors： Geng W,Wright GL

更新日期：2001-05-01 00:00:00

abstract：:The long noncoding RNA (lncRNA) GAS5 has been found to act as a decoy for the glucocorticoid receptor (GR), thus implicating GAS5 as a potential regulator of glucocorticoid sensitivity and resistance. Airway smooth muscle (ASM) cells and airway epithelial cells (AEC) play an important role in the pathogenesis and pers...

journal_title：Canadian journal of physiology and pharmacology

authors： Keenan CR,Schuliga MJ,Stewart AG

更新日期：2015-03-01 00:00:00

abstract：:Steady state glucose kinetics were measured in 19 premature and 16 full-term piglets. Bodyweight, plasma glucose concentration, total body glucose turnover rate, and glucose pool size were not significantly different between the two groups. This suggests that the premature piglet is capable of maintaining glucose home...

journal_title：Canadian journal of physiology and pharmacology

authors： Flecknell PA,Wootton R,John M,Royston JP

更新日期：1981-10-01 00:00:00

abstract：:Anti-mitogenic agents currently used to prevent restenosis in drug-eluting stents delay re-endothelialization. Delayed re-endothelialization is now considered as the main cause of late stent thrombosis with drug-eluting stents, which emphasizes the need for new treatments. We have shown that systemic insulin treatment...

journal_title：Canadian journal of physiology and pharmacology

authors： Chiang S,Breen DM,Guo J,Mori Y,Giacca A

更新日期：2013-12-01 00:00:00

abstract：:Effect of Ni2+ on Zn2+-induced potentiation of twitch tension was studied electrophysiologically in the toe muscle fibers of Rana catesbeiana. The major findings of this investigation are as follows. When 2 mM Ni2+ was applied to fibers in a normal Ringer's solution containing 50 microM Zn2+ (Zn2+ solution), the Zn2+-...

journal_title：Canadian journal of physiology and pharmacology

authors： Oba T,Hotta K

更新日期：1986-05-01 00:00:00

abstract：:The hemodynamic effects of the combination of clonidine and propranolol were studied in conscious rats with portal hypertension owing to secondary biliary cirrhosis. Pressure and blood flow measurements (radioactive microsphere method) were performed in three groups of eight rats before and after drug administration. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Roulot D,Gaudin C,Braillon A,Sekiyama T,Bacq Y,Lebrec D

更新日期：1989-10-01 00:00:00

abstract：:In addition to cytostatic treatment and surgery, the most common cancer treatment is gamma radiation. Despite sophisticated radiological techniques however, in addition to irradiation of the tumor, irradiation of the surrounding healthy tissue also takes place, which results in various side-effects, depending on the a...

journal_title：Canadian journal of physiology and pharmacology

authors： Slezak J,Kura B,Ravingerová T,Tribulova N,Okruhlicova L,Barancik M

更新日期：2015-09-01 00:00:00

abstract：:Aside from its established immunologic and hematologic functions, the spleen also plays an important role in cardiovascular regulation. This occurs through changes in intrasplenic microvascular tone, as well as through splenic neurohormonal modulation of the renal and mesenteric vascular beds. Splenic regulation of bl...

journal_title：Canadian journal of physiology and pharmacology

authors： Hamza SM,Kaufman S

更新日期：2009-01-01 00:00:00

abstract：:Activators of the slow delayed rectifier K⁺ current (IKs) have been suggested as promising tools for suppressing ventricular arrhythmias due to prolongation of repolarization. Recently, L-364,373 (R-L3) was nominated to activate IKs in myocytes from several species; however, in some studies, it failed to activate IKs....

journal_title：Canadian journal of physiology and pharmacology

authors： Corici C,Kohajda Z,Kristóf A,Horváth A,Virág L,Szél T,Nagy N,Szakonyi Z,Fülöp F,Muntean DM,Varró A,Jost N

更新日期：2013-08-01 00:00:00

abstract：:The effects of localized distension of the pulmonary vein - left atrial junctions on plasma arginine vasopressin (AVP) have been examined in chloralose anaesthetized dogs. Pulmonary vein distension caused an increase in heart rate and a decrease in plasma AVP concentration. Cooling the vagosympathetic nerves to 10 deg...

journal_title：Canadian journal of physiology and pharmacology

authors： Wilson N,Ledsome JR

更新日期：1983-08-01 00:00:00