Ions, water, and energy in brain cells: a synopsis of interrelations.

abstract：:Negative chronotropic effects of beta-adrenoceptor (betaAR) antagonists on right atria from reserpine-treated rats and mice were determined as a test of their inverse agonist activities. BetaAR antagonist ICI-118,551 and nonselective betaAR antagonists alprenolol, propranolol, and timolol produced negative chronotropi...

journal_title：Canadian journal of physiology and pharmacology

authors： Varma DR

更新日期：1999-12-01 00:00:00

abstract：:The inhibition of hepatic microsomal aryl hydrocarbon hydroxylase (AHH) activity by SKF 525-A in vitro was studied in hepatic microsomes from rats of varying age, sex hormone status, and drug treatment. The concentration of SKF 525-A required to produce a 50% inhibition of AHH activity, the IC50, was determined for th...

journal_title：Canadian journal of physiology and pharmacology

authors： Gontovnick LS,Bellward GD

更新日期：1982-08-01 00:00:00

abstract：:Pathogenic mechanisms for essential hypertension are unclear despite striking efforts from numerous research teams over several decades. Increased production of reactive oxygen species (ROS) has been associated with the development of hypertension and the role of ROS in hypertension has been well documented in recent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang T,Wu L

更新日期：2006-12-01 00:00:00

abstract：:The effects of fast neutrons (10-100 Gy) on chromatin extracted from normal (liver of Wistar rats) and tumor (Walker carcinosarcoma maintained on Wistar rats) tissues were compared. The spectroscopic assays used were (i) chromatin intrinsic fluorescence, (ii) time-resolved fluorescence of chromatin - proflavine comple...

journal_title：Canadian journal of physiology and pharmacology

authors： Radu L,Constantinescu B,Gazdaru D

更新日期：2002-07-01 00:00:00

abstract：:The hypothesis was examined that phenoxybenzamine enhances both the overflow of noradrenaline and the mechanical response in guinea pig vas deferens by blockade of presynaptic inhibitory receptors located on adrenergic nerve terminals which serve a negative-feedback function. Preparations were stimulated with a consta...

journal_title：Canadian journal of physiology and pharmacology

authors： Kalsner S

更新日期：1979-07-01 00:00:00

abstract：:Thermal resistance as determined by survival time was examined in different age groups of spontaneously hypertensive (SHR) rats during terminal heating. A comparison with age or weight matched controls indicated that the thermal resistance of SHR animals was markedly inferior to that of normotensive animals as evidenc...

journal_title：Canadian journal of physiology and pharmacology

authors： Wright G,Iams S,Knecht E

更新日期：1977-10-01 00:00:00

abstract：:We investigated whether cell-to-cell coupling between myometrial cells of parturient rats is influenced by intracellular adenosine 3',5'-cyclic monophosphate (cAMP) concentration. To evaluate the coupling, we measured input resistance (Ro) and injected Lucifer Yellow (LY) using microelectrode techniques. The intercell...

journal_title：Canadian journal of physiology and pharmacology

authors： Sakai N,Blennerhassett MG,Garfield RE

更新日期：1992-03-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, is an effective antioxidant and possesses neuroprotective effects. Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis and synaptic plasticity. In this study, we aimed to assess the pr...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding ML,Ma H,Man YG,Lv HY

更新日期：2017-12-01 00:00:00

abstract：:The placental transfer of indomethacin was studied in the rabbit at 30 days of gestation and in the sheep between 120 and 135 days of gestation. Plasma concentrations of indomethacin reached a maximum of 13.7 +/- 1.6 and 10.9 +/- 1.5 microgram/mL in the doe and fetuses, respectively, at 1 h following a maternal subcut...

journal_title：Canadian journal of physiology and pharmacology

authors： Harris WH,Van Petten GR

更新日期：1981-04-01 00:00:00

abstract：:Redistribution of blood flow away from resting skeletal muscles does not occur during anemic hypoxia even when whole body oxygen uptake is not maintained. In the present study, the effects of sympathetic nerve stimulation on both skeletal muscle and hindlimb blood flow were studied prior to and during anemia in anesth...

journal_title：Canadian journal of physiology and pharmacology

authors： Kubes P,Chapler CK,Cain SM

更新日期：1988-02-01 00:00:00

abstract：:Experiments in right atria isolated from adult male rats were designed to determine which of the alpha 1-adrenergic receptor (alpha 1-AR) subtypes are involved in the positive chronotropic effect of phenylephrine, an alpha 1-AR agonist. Chloroethylclonidine (CEC), an irreversible alpha 1b-, alpha 1c-, and alpha 1d-AR ...

journal_title：Canadian journal of physiology and pharmacology

authors： Williamson AP,Seifen E,Lindemann JP,Kennedy RH

更新日期：1994-12-01 00:00:00

abstract：:Phosphocreatine (PCr) and intracellular pH changes were monitored by 31P-NMR spectroscopy in isolated, arterially perfused cat biceps and soleus muscles, while the pH of the CO2-bicarbonate buffered perfusate was decreased from 7.1-7.4 to 6.4-6.7 by increasing the CO2 in the equilibrating gas from 5 to up to 70%. In b...

journal_title：Canadian journal of physiology and pharmacology

authors： Meyer RA,Adams GR,Fisher MJ,Dillon PF,Krisanda JM,Brown TR,Kushmerick MJ

更新日期：1991-02-01 00:00:00

abstract：:The role of iron-loaded transferrin in xanthine-xanthine oxidase (X-XO) induced cardiac injury in isolated perfused rat hearts was examined. X (2 mM) - XO (10 U/L) perfusion resulted in contractile failure, a rise in resting tension, an increase in lipid peroxidation, and myocardial cell damage. The addition of transf...

journal_title：Canadian journal of physiology and pharmacology

authors： Tiede R,Sareen S,Singal PK

更新日期：1990-04-01 00:00:00

abstract：:The role that thromboxane A2 plays in contractions induced by leukotriene D4 in guinea-pig isolated lung parenchyma was investigated under equilibrium conditions. Lung tissue generated thromboxane A2 and prostacyclin spontaneously as evidenced by the slow accumulation of their biologically inactive metabolites, thromb...

journal_title：Canadian journal of physiology and pharmacology

authors： Giembycz MA,Rodger IW

更新日期：1987-07-01 00:00:00

abstract：:Lumbar spine and mid-radius bone mineral density was measured repeatedly in 48 postmenopausal women who completed 7 years of taking either a 500 mg x day(-1) calcium supplement (n = 22) or calcium supplementation with hormone replacement therapy. The hormone replacement was either a low dose (n = 15) or a moderate dos...

journal_title：Canadian journal of physiology and pharmacology

authors： Blake JM,Ryan ED,Beaumont LF,Webber CE

更新日期：1999-07-01 00:00:00

abstract：:Male spontaneously hypertensive stroke-prone (SHRsp) rats were fed 4% NaCl diets containing either 0.75% (normal) K or 2.11% (high) K, starting at 6 weeks of age. After 8 months on these diets, 40 out of 58 SHRsp rats on the 0.75% K diet had died (69% mortality) versus 2 dead out of 95 on the 2.11% K diet (2% mortalit...

journal_title：Canadian journal of physiology and pharmacology

authors： Tobian L

更新日期：1986-06-01 00:00:00

abstract：:In the literature there appears to be variability in reported levels of certain hormones during haemorrhage, specifically adrenocorticotrophic hormone (ACTH) and β-endorphin. It is possible that this variability may be due to the choice of anaesthetic. Therefore, the effect of 3 common research-only anaesthetic agents...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruane-O'Hora T,Hall WJ,Markos F

更新日期：2011-07-01 00:00:00

abstract：:Single-electrode voltage-clamp experiments were made on CA1 neurons in the presence of tetrodotoxin and K channel blockers. Applications of halothane (1-3% v/v) for 3-10 min caused a similar marked and reversible depression of slow inward currents (probably Ca currents) evoked by depolarizing pulses from a holding pot...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Puil E

更新日期：1988-12-01 00:00:00

abstract：:Inactivation of endothelin B receptors (ETB), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration of endothelin-1 (ET-1), suggesting ETB plays an important role in clearance of this peptide. However, the cellular site of ETB-mediated clearance has not yet be...

journal_title：Canadian journal of physiology and pharmacology

authors： Kelland NF,Kuc RE,McLean DL,Azfer A,Bagnall AJ,Gray GA,Gulliver-Sloan FH,Maguire JJ,Davenport AP,Kotelevtsev YV,Webb DJ

更新日期：2010-06-01 00:00:00

abstract：:Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against high mobility group box 1 (HMGB1)-mediated septi...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee W,Yoon EK,Kim KM,Park DH,Bae JS

更新日期：2015-08-01 00:00:00

abstract：:The combined effect of a beta 2-antagonist and an alpha 2-agonist on the release of adrenal catecholamines was studied in the anaesthetized and vagotomized dog. The electrical stimulation of the splanchnic nerve (5-V pulses of 2 ms duration for 3 min at a frequency of 3 Hz) produced a significant rise in adrenal catec...

journal_title：Canadian journal of physiology and pharmacology

authors： Foucart S,de Champlain J,Nadeau R

更新日期：1988-10-01 00:00:00

abstract：:The most important reason for the non-approval and withdrawal of drugs by the Food and Drug Administration is hepatotoxicity. Therefore, this study was undertaken to evaluate the protective effects of hesperidin against cyclophosphamide (CYP)-induced hepatotoxicity in Wistar rats. The rats received a single intraperit...

journal_title：Canadian journal of physiology and pharmacology

authors： Mahmoud AM

更新日期：2014-09-01 00:00:00

abstract：:It is commonly thought that central nervous system depressant drugs exert their actions through enhancement of gamma-aminobutyrate (GABA)-mediated mechanisms. Recently, the cellular electrophysiological evidence from this laboratory and others suggests that both sedative hypnotics and general anaesthetics inhibit cent...

journal_title：Canadian journal of physiology and pharmacology

authors： Carlen PL,Gurevich N,Davies MF,Blaxter TJ,O'Beirne M

更新日期：1985-07-01 00:00:00

abstract：:The purpose of this study was to examine the effects of norepinephrine infusion alone and during alkalosis on oxygen uptake in the dog gastrocnemius-plantaris muscle group under conditions of constant muscle blood flow. The animals were not cold acclimatized. Blood flow was pump controlled, alkalosis was produced by h...

journal_title：Canadian journal of physiology and pharmacology

authors： Chapler CK,Stainsby WN,Gladden LB

更新日期：1980-01-01 00:00:00

abstract：:The antioxidant glutathione-S-transferase (GST) is a crucial determinant of the development of ischaemic-reperfusion (I/R) injury, and plays a pivotal role in the regulation of the mitogen activated protein kinase (MAPK) pathways involved in stress response and apoptosis. The aim of this study was to investigate wheth...

journal_title：Canadian journal of physiology and pharmacology

authors： Balatonyi B,Gasz B,Kovács V,Lantos J,Jancsó G,Marczin N,Rőth E

更新日期：2013-08-01 00:00:00

abstract：:In 2-kidney, 1-clip hypertensive rats, the time course of changes in blood pressure (BP), heart rate, activity of the sympathetic nervous system and the renin-angiotensin system, plasma and blood volumes, left ventricular (LV) and right ventricular (RV) weight, and LV dimensions were evaluated during treatment with hy...

journal_title：Canadian journal of physiology and pharmacology

authors： Tsoporis J,Leenen FH

更新日期：1986-12-01 00:00:00

abstract：:Transmural nerve stimulation following sympathetic (guanethidine 10(-4) mol/L, phenoxybenzamine 2 X 10(-5) mol/L, propanolol 2 X 10(-6) mol/L) and muscarinic blockade (atropine 5 X 10(-5) mol/L) produces a relaxatory response in canine saphenous veins contracted with prostaglandin F2 alpha. This relaxatory response wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Senaratne MP,Kappagoda T

更新日期：1986-10-01 00:00:00

abstract：:The pHi regulation from intracellular acidosis in the central nervous system appears to be mediated by mechanisms driven by the large inwardly directed Na+ gradient. The involvement of these mechanisms in pHi regulation of neurones and glial cells has been investigated in the leech central nervous system using ion-sel...

journal_title：Canadian journal of physiology and pharmacology

authors： Schlue WR,Dörner R

更新日期：1992-01-01 00:00:00

abstract：:Cardiac adenosine receptors are coupled to adenylate cyclase inhibition. In the guinea pig heart, the relative agonist potencies observed for adenylate cyclase inhibition were R-N6-phenylisopropyladenosine (R-PIA) = N6-cyclohexyladenosine greater than 5'-N-ethylcarboxamidoadenosine much greater than S-PIA. In both atr...

journal_title：Canadian journal of physiology and pharmacology

authors： Leung E,Woodcock EA

更新日期：1986-12-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00