Vascular receptors for angiotensin, vasopressin, and atrial natriuretic peptide in experimental hypertension.

abstract：:In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MT...

journal_title：Canadian journal of physiology and pharmacology

authors： Makary S,Abdo M,Fekry E

更新日期：2018-04-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions that are characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of NAFLD is rapidly increasing in proportion to the rising incidence of obesity and type 2 diabetes. Because NAFLD is a multifaceted di...

journal_title：Canadian journal of physiology and pharmacology

authors： Sid V,Siow YL,O K

更新日期：2017-10-01 00:00:00

abstract：:Metformin, the first medication that is often prescribed for the treatment of Type-2 Diabetes Mellitus (T2DM), was recently found to be neuroprotective. To study the mechanism underlying the neuroprotective effect of metformin, we pre-treated primary spinal cord neurons with 50 µM or 100 µM µM metformin for 2 hours pr...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang G,Chen S,Shao Z,Li Y,Wang W,Mao L,Li J,Mei X

更新日期：2020-11-17 00:00:00

abstract：:Mepivacaine is an aminoamide local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. This study investigated the arachidonic acid metabolic pathways involved in mepivacaine-induced contraction, and elucidated the associated cellular mechanism with a partic...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee HM,Ok SH,Sung HJ,Eun SY,Kim HJ,Lee SH,Kang S,Shin IW,Lee HK,Chung YK,Choi MJ,Bae SI,Sohn JT

更新日期：2013-04-01 00:00:00

abstract：:The role that thromboxane A2 plays in contractions induced by leukotriene D4 in guinea-pig isolated lung parenchyma was investigated under equilibrium conditions. Lung tissue generated thromboxane A2 and prostacyclin spontaneously as evidenced by the slow accumulation of their biologically inactive metabolites, thromb...

journal_title：Canadian journal of physiology and pharmacology

authors： Giembycz MA,Rodger IW

更新日期：1987-07-01 00:00:00

abstract：:To elucidate the involvement of the brain renin-angiotensin system and the brain atrial natriuretic polypeptide (ANP) system in the regulation of ANP secretion from the heart, the effects of intracerebroventricular administration of angiotensin II and ANP on the plasma ANP level were examined in conscious unrestrained...

journal_title：Canadian journal of physiology and pharmacology

authors： Itoh H,Nakao K,Yamada T,Morii N,Shiono S,Sugawara A,Saito Y,Mukoyama M,Arai H,Imura H

更新日期：1988-03-01 00:00:00

abstract：:Allicin, the active substance of garlic, exerts a broad spectrum of pharmacological activities and is considered to have potential therapeutic applications. The present study was designed to investigate the possible beneficial effects of allicin against oxidative stress, inflammation, and endothelial dysfunction in hy...

journal_title：Canadian journal of physiology and pharmacology

authors： El-Sheakh AR,Ghoneim HA,Suddek GM,Ammar ESM

更新日期：2016-02-01 00:00:00

abstract：:Recent studies demonstrate the critical role of the extracellular matrix in the organization of parenchymal cells in the heart. Thus, an understanding of the modes of regulation of matrix production by cardiac myofibroblasts is essential. Transforming growth factor beta (TGF-beta) signaling is transduced through the c...

journal_title：Canadian journal of physiology and pharmacology

authors： Cunnington RH,Nazari M,Dixon IM

更新日期：2009-10-01 00:00:00

abstract：:Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Annunzio V,Donato M,Buchholz B,Pérez V,Miksztowicz V,Berg G,Gelpi RJ

更新日期：2012-09-01 00:00:00

abstract：:The responses of the circular muscle of canine colon to stimulation of intrinsic nerves and to the probable mediators of these nerves were studied in vivo. In vivo studies were carried out using close intra-arterial injections and local field stimulation of proximal, mid-, and distal colon while recording circumferent...

journal_title：Canadian journal of physiology and pharmacology

authors： Gonda T,Daniel EE,Kostolanska F,Oki M,Fox JE

更新日期：1988-04-01 00:00:00

abstract：:The effects of two structurally similar pyrazine derivatives, tetramethylpyrazine (TMP) and tetraethylpyrazine (TEP) on the contractile responses of dog saphenous vein to KCl (via membrane depolarization), phenylephrine (PHE, alpha 1-adrenergic agonist), and B-HT 920 (alpha 2-adrenergic agonist) were investigated. The...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang ZL,Kwan CY,Ohta A,Chen MC

更新日期：1991-08-01 00:00:00

abstract：:The threshold for electrically induced ventricular fibrillation was determined in anesthetized open-chest dogs, before and after blockade of atrioventricular (A-V) conduction. Without exception, the threshold was significantly elevated after creation of the block. The precise mechanism of this effect is not known at t...

journal_title：Canadian journal of physiology and pharmacology

authors： Reynolds AK,Dresel PE

更新日期：1983-09-01 00:00:00

abstract：:The objective of this study was to explore the action of angiotensin II (AII) on cardiac contractility and cyclic AMP (cAMP) generation by forskolin and isoproterenol in the hypertrophic myocardium of the salt-sensitive Dahl rat. Inbred Dahl S and Dahl R rats that had been on a diet supplemented with 6% NaCl were stud...

journal_title：Canadian journal of physiology and pharmacology

authors： Sunga PS,Rabkin SW

更新日期：1994-06-01 00:00:00

abstract：:The systemic and inotropic properties of prostaglandin E1 (PGE1) were investigated in 20 unanesthetized dogs. Pairs of ultrasonic dimension gauges and a micromanometer were implanted in the subendocardium and the apex of the left ventricle (LV), respectively. Seven to ten days later, increasing doses of PGE1 were infu...

journal_title：Canadian journal of physiology and pharmacology

authors： Roux S,Latour JG,Théroux P,Clozel JP,Bourassa MG

更新日期：1984-12-01 00:00:00

abstract：:Single-electrode voltage-clamp experiments were made on CA1 neurons in the presence of tetrodotoxin and K channel blockers. Applications of halothane (1-3% v/v) for 3-10 min caused a similar marked and reversible depression of slow inward currents (probably Ca currents) evoked by depolarizing pulses from a holding pot...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Puil E

更新日期：1988-12-01 00:00:00

abstract：:Cerebrocrast is a novel lipophilic dihydropyridine derivative with potential neuroprotective and antidiabetic properties. We have analyzed its interaction with L-type (CaV1.2b) and T-type (CaV3.1) calcium channels using a whole-cell patch clamp in HEK 293 cells. Cerebrocrast inhibited current flux through both CaV1.2b...

journal_title：Canadian journal of physiology and pharmacology

authors： Drígelová M,Tarabová B,Duburs G,Lacinová L

更新日期：2009-11-01 00:00:00

abstract：:Perfusion of isolated rat hearts with Na-free medium resulted in an immediate increase in contractile force followed by a decline and complete loss of contractile force within 25 s. The recovery of the contractile force upon reperfusion was only partial if the duration of Na-free perfusions was 10 min or longer. Ca bi...

journal_title：Canadian journal of physiology and pharmacology

authors： Dhalla NS,Lee SL,Singal PK,Yates JC,Panagia V

更新日期：1980-12-01 00:00:00

abstract：:The kinetics of sodium gradient dependent phosphate uptake by the renal brush border membrane vesicles of the rat have ben studied under various conditions of temperature and pH. From 7 to 30 degrees C the Lineweaver-Burk plots are linear, and the apparent Km progressively increases from 54 to 91 microM. Above 30 degr...

journal_title：Canadian journal of physiology and pharmacology

authors： Brunette MG,Beliveau R,Chan M

更新日期：1984-02-01 00:00:00

abstract：:This report reviews the research and mentoring career of Richard B. Stein (1940-). In 1962, he completed a B.S. degree in physics at the Massachusetts Institute of Technology, USA, and thereafter an M.A. (1964), Ph.D. (1966), and postdoctoral training (1966-68) at the University of Oxford, UK. He subsequently assumed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuart DG

更新日期：2004-08-01 00:00:00

abstract：:Gripp-Heel is a homeopathic preparation frequently used in the treatment of respiratory viral infections such as various types of influenza and the common cold. The antiviral activity of Gripp-Heel was studied in vitro on human pathogenic enveloped and nonenveloped RNA and DNA viruses. Before the antiviral assays, in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Glatthaar-Saalmüller B

更新日期：2007-11-01 00:00:00

abstract：:Myometrial tissues from guinea pigs were quantitatively examined for gap junctions in electron micrographs. Small numbers of gap junctions were present between smooth muscle cells in myometria of pregnant guinea pigs at days 50 and 65 of gestation. The junctions increased in number and size at parturition on day 69 an...

journal_title：Canadian journal of physiology and pharmacology

authors： Garfield RE,Daniel EE,Dukes M,Fitzgerald JD

更新日期：1982-03-01 00:00:00

abstract：:Depletion of divalent cations before fractionation of the longitudinal muscle of the guinea pig ileum yielded a sarcolemma-enriched microsomal fraction free of mitochondria. A major portion of the ATPase activity in the presence of Mg, Na, and K was due to stimulation by Na alone. A further small stimulation by K was ...

journal_title：Canadian journal of physiology and pharmacology

authors： James MR,Roufogalis BD

更新日期：1977-10-01 00:00:00

abstract：:A single-dose administration of 6-hydroxydopamine (50 mg/kg body weight, sc) to infant rats resulted in an enlargement, higher fresh weight, markedly elevated lipid content, and higher total protein content of their interscapular and cervical brown adipose tissue. The protein kinase (EC 2.7.1.37) activation ratio in t...

journal_title：Canadian journal of physiology and pharmacology

authors： Skala JP,Hahn P

更新日期：1977-04-01 00:00:00

abstract：:The aim of this study was to elucidate the variables of gastroduodenal motility determining gastric emptying. For this purpose the effects of exogenous cholecystokinin, secretin, and gastric inhibitory polypeptide on motility and gastric emptying were studied during a meal. Motility was measured with extraluminal stra...

journal_title：Canadian journal of physiology and pharmacology

authors： Keinke O,Ehrlein HJ,Wulschke S

更新日期：1987-03-01 00:00:00

abstract：:We hypothesized that the respiratory baroreflex in conscious rats is either more transient, or has a higher pressure threshold than in other species. To characterize the effect of arterial pressure changes on respiration in conscious rats, ventilation (V) was measured by the plethysmographic technique during injection...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker JK,Jennings DB

更新日期：1998-07-01 00:00:00

abstract：:Kinins are the endogenous ligands of the constitutive B2 receptor (B2R) and the inducible B1 receptor (B1R). Whereas B2R prevents insulin resistance, B1R is involved in insulin resistance and metabolic syndrome. However, the contribution of B1R in type 2 diabetes associated with obesity remains uncertain. The aim of t...

journal_title：Canadian journal of physiology and pharmacology

authors： Talbot S,Dias JP,El Midaoui A,Couture R

更新日期：2016-07-01 00:00:00

abstract：:The level of circulating triacylglycerols is determined by the balance between their delivery into the plasma and their removal from it. Plasma triacylglycerols are derived either from dietary fat as chylomicrons or from endogenous hepatic synthesis as very low density lipoproteins. Their removal occurs through the ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Herzberg GR

更新日期：1991-11-01 00:00:00

abstract：:The purpose of this study was to characterize the biological activity of the synthetic rat growth hormone releasing factor analogue rGRF(1-29)NH2 and to compare its action on growth hormone (GH) release to that of authentic rGRF(1-43)OH. We first compared the concentration-response characteristics of the two peptides ...

journal_title：Canadian journal of physiology and pharmacology

authors： Kraicer J,French MB,Lussier BT,Moor BC,Brazlan P

更新日期：1991-02-01 00:00:00

abstract：:We investigated the influence of four different culture media: 20% fetal bovine serum (FBS), 5% FBS, 5% FBS supplemented with 10 mg x L(-1) linoleic acid (18:2(n-6)) or alpha-linolenic acid (18:3(n-3)) on alpha-linolenic acid apical uptake in clone TC7 of human intestinal Caco-2 cell line. Neither cellular viability n...

journal_title：Canadian journal of physiology and pharmacology

authors： Tranchant T,Besson P,Hoinard C,Pinault M,Alessandri JM,Delarue J,Couet C,Goré J

更新日期：1998-06-01 00:00:00

abstract：:In the rat, prolonged enteral or parenteral alimentation with a high-carbohydrate diet results in hyperinsulinemia, which is substantially greater with the parenteral route. Supplementing the parenteral infusate with porcine gastric inhibitory polypeptide (GIP) to approximate plasma immunoreactive GIP levels achieved ...

journal_title：Canadian journal of physiology and pharmacology

authors： Baer AR,Dupré J

更新日期：1989-09-01 00:00:00