Effect of 6-hydroxydopamine on brain and blood catecholamine, ammonia, and amino acid metabolism in rats subjected to high pressure oxygen induced convulsions.

abstract：:The antioxidant glutathione-S-transferase (GST) is a crucial determinant of the development of ischaemic-reperfusion (I/R) injury, and plays a pivotal role in the regulation of the mitogen activated protein kinase (MAPK) pathways involved in stress response and apoptosis. The aim of this study was to investigate wheth...

journal_title：Canadian journal of physiology and pharmacology

authors： Balatonyi B,Gasz B,Kovács V,Lantos J,Jancsó G,Marczin N,Rőth E

更新日期：2013-08-01 00:00:00

abstract：:Beneficial effects of an antioxidant (N-acetyl-L-cysteine, NAC) and an angiotensin I-converting enzyme (ACE) inhibitor (ramipril) were assessed in a rat model of insulin resistance induced by 10% glucose feeding for 20 weeks. Treatments with NAC (2 g/kg per day) and ramipril (1 mg/kg per day) were initiated at 16 week...

journal_title：Canadian journal of physiology and pharmacology

authors： El Midaoui A,Ismael MA,Lu H,Fantus IG,de Champlain J,Couture R

更新日期：2008-11-01 00:00:00

abstract：:Ovalbumin (OA) and the calcium ionophore A23187 induced a dose-dependent contraction of guinea pig tracheal strips. The OA-induced contraction (of sensitized trachea) consisted of an initial peak concentration, maximal between 5 and 10 min, followed by a very gradual decline from the peak. On the other hand, A23187 in...

journal_title：Canadian journal of physiology and pharmacology

authors： Burka JF,Paterson NA

更新日期：1981-10-01 00:00:00

abstract：:An investigation was made of the radiosensitivity of the toxic and immunological properties of Androctonus australis hector venom. This venom was irradiated with two doses of gamma rays (1 and 2 kGy) from a 60Co source. The results showed that venom toxicity was abolished for the two radiation doses (1 and 2 kGy) with...

journal_title：Canadian journal of physiology and pharmacology

authors： Abib L,Laraba-Djebari F

更新日期：2003-12-01 00:00:00

abstract：:It has been proposed that the adult castrated male rat may be used as a model of human postmenopausal osteoporosis. If such a model is valid then the total body calcium of castrated rats should progressively decrease compared with normal rats. To search for this age-related difference, it will be necessary to use a me...

journal_title：Canadian journal of physiology and pharmacology

authors： Beachey DJ,Wickham M,Webber CE

更新日期：1985-10-01 00:00:00

abstract：:We investigated the influence of four different culture media: 20% fetal bovine serum (FBS), 5% FBS, 5% FBS supplemented with 10 mg x L(-1) linoleic acid (18:2(n-6)) or alpha-linolenic acid (18:3(n-3)) on alpha-linolenic acid apical uptake in clone TC7 of human intestinal Caco-2 cell line. Neither cellular viability n...

journal_title：Canadian journal of physiology and pharmacology

authors： Tranchant T,Besson P,Hoinard C,Pinault M,Alessandri JM,Delarue J,Couet C,Goré J

更新日期：1998-06-01 00:00:00

abstract：:Puerarin (Pur), an isoflavonoid extracted from the dried roots of Pueraria lobata, has been reported to be useful in the treatment of various diseases. This study was designed to evaluate the anti-apoptotic and anti-inflammatory activities of Pur against 3-nitropropionic acid (3-NP) induced neurotoxicity. For 5 consec...

journal_title：Canadian journal of physiology and pharmacology

authors： Mahdy HM,Mohamed MR,Emam MA,Karim AM,Abdel-Naim AB,Khalifa AE

更新日期：2014-03-01 00:00:00

abstract：:We hypothesized that the respiratory baroreflex in conscious rats is either more transient, or has a higher pressure threshold than in other species. To characterize the effect of arterial pressure changes on respiration in conscious rats, ventilation (V) was measured by the plethysmographic technique during injection...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker JK,Jennings DB

更新日期：1998-07-01 00:00:00

abstract：:Using the glycogen depletion technique, we have examined utilization of specific fibre types during prolonged submaximal exercise to investigate the recruitment pattern employed by the central nervous system to sustain force generation in the face of a progressive glycogen depletion. Six male subjects (Vo2 max, 52.8 +...

journal_title：Canadian journal of physiology and pharmacology

authors： Green HJ,Smith D,Murphy P,Fraser I

更新日期：1990-10-01 00:00:00

abstract：:Single-channel recordings from central neurons of the helix snail, Cepaea nemoralis, revealed two types of channels that could be activated by stretch (i.e., by the membrane deformation produced when suction is applied to the patch pipette). One, a K+ channel (58 pS in physiological solution), was evident in excised a...

journal_title：Canadian journal of physiology and pharmacology

authors： Bédard E,Morris CE

更新日期：1992-02-01 00:00:00

abstract：:In rats anesthetized with alpha-chloralose, doses of 0.1, 0.5, and 1 g/kg of ethanol produced an upward shift of baroreflex curves constructed by plotting the heart rate response against mean arterial pressure following evoked rises in mean arterial pressures by phenylephrine or angiotensin II. Whereas the upward shif...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Rahman AR,Russ R,Strickland JA,Wooles WR

更新日期：1987-05-01 00:00:00

abstract：:Barbital-sedated, warm-acclimated (WA) or cold-acclimated (CA) rats were infused intravenously with noradrenaline (NA) at doses that elicited graded calorigenic responses. Blood flow (Q) to the various bodies of brown adipose tissue (BAT), the major sites of the NA-induced calorigenesis, was measured with labeled micr...

journal_title：Canadian journal of physiology and pharmacology

authors： Foster DO,Depocas F,Frydman ML

更新日期：1980-08-01 00:00:00

abstract：:The major functional alpha1-adrenoceptor in the rat aorta is of the alpha1Dsubtype and that in the caudal artery is of the alpha1A subtype. In the present study, the participation of protein kinase C (PKC) and Rho kinase (RhoK) in contractile responses to stimulation of the alpha1-adrenoceptors in these two arteries w...

journal_title：Canadian journal of physiology and pharmacology

authors： Mueed I,Bains P,Zhang L,Macleod KM

更新日期：2004-10-01 00:00:00

abstract：:There are conflicting reports concerning the existence of severe hypermethioninemia in rats made diabetic with the pancreotoxin, streptozotocin. To determine whether this discrepancy is due to experimental differences in the severity of diabetes or the diet fed to the animals, streptozotocin-diabetic and control rats ...

journal_title：Canadian journal of physiology and pharmacology

authors： Dyer JR,Greenwood CE,McBurney MI

更新日期：1988-02-01 00:00:00

abstract：:Phosphofructokinase activity was measured in the sciatic nerve of streptozotocin-induced diabetic and nondiabetic rats. Average steady-state phosphofructokinase activity was obtained from three consecutive segments of the mid-femoral region in the left sciatic nerve in both diabetic (4 and 24 weeks) and nondiabetic, a...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilgour RD,Gardiner K,Gardiner PF

更新日期：1990-10-01 00:00:00

abstract：:Pioglitazone (Pio) and swimming exercise (SE) are insulin sensitisers. This investigation was suggested because of the significant side effects associated with Pio treatment in metabolic syndrome (MetS). This study was, therefore, designed to investigate the preventive role of Pio treatment and SE in terms of efficien...

journal_title：Canadian journal of physiology and pharmacology

authors： Sakr HF,Al-Hashem FH,El-Naby WM,Alkhateeb MA,Zaki MS,Refaey HM,Morsy MD

更新日期：2014-02-01 00:00:00

abstract：:To investigate the capacity of efferent sympathetic neurons to modulate the failing heart, stellate ganglion stimulation was performed in dogs with biventricular heart failure induced by rapid ventricular pacing (240 beats/min) for 4-6 weeks. Less noradrenaline was released from cardiac myoneural junctions into corona...

journal_title：Canadian journal of physiology and pharmacology

authors： Cardinal R,Nadeau R,Laurent C,Boudreau G,Armour JA

更新日期：1996-09-01 00:00:00

abstract：:The combined effect of a beta 2-antagonist and an alpha 2-agonist on the release of adrenal catecholamines was studied in the anaesthetized and vagotomized dog. The electrical stimulation of the splanchnic nerve (5-V pulses of 2 ms duration for 3 min at a frequency of 3 Hz) produced a significant rise in adrenal catec...

journal_title：Canadian journal of physiology and pharmacology

authors： Foucart S,de Champlain J,Nadeau R

更新日期：1988-10-01 00:00:00

abstract：:Rapamycin, a new antifungal antibiotic, was found to inhibit the immune response in rats. It totally prevented the development of two experimental immunopathies (experimental allergic encephalomyelitis (EAE) and adjuvant arthritis (AA)) and the formation of humoral (IgE-like) antibody. It was about half as potent as c...

journal_title：Canadian journal of physiology and pharmacology

authors： Martel RR,Klicius J,Galet S

更新日期：1977-02-01 00:00:00

abstract：:Inactivation of endothelin B receptors (ETB), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration of endothelin-1 (ET-1), suggesting ETB plays an important role in clearance of this peptide. However, the cellular site of ETB-mediated clearance has not yet be...

journal_title：Canadian journal of physiology and pharmacology

authors： Kelland NF,Kuc RE,McLean DL,Azfer A,Bagnall AJ,Gray GA,Gulliver-Sloan FH,Maguire JJ,Davenport AP,Kotelevtsev YV,Webb DJ

更新日期：2010-06-01 00:00:00

abstract：:The effects of hydralazine (Hyd) on vascular smooth muscle contractile response to alpha-receptor stimulation by exogeneous and endogenous noradrenaline (NA) in the absence and presence of Mg2+ (1.2 mM) were examined using a proximal segment of rabbit's ear artery. Intraluminal perfusion with Hyd (2 x 10(-4) M) in nor...

journal_title：Canadian journal of physiology and pharmacology

authors： Krishnamurty VS

更新日期：1981-11-01 00:00:00

abstract：:Several studies suggest that heat stress affects placental functions including uteroplacental circulation, subsequently leading to pregnancy failure and birth weight reduction. To clarify the involvement of endothelin and placental prostaglandin (PG) systems in the uteroplacental circulation during heat stress, we exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Nakamura H,Matsuzaki I,Hatta K,Ogino K

更新日期：2004-04-01 00:00:00

abstract：:It is possible to embed the control and computation of a simple single-joint movement at different speeds by a small non-linear network of neuron-like elements. The network "learns" by appropriate adjustment of the strengths of interconnection, or synaptic weights, between the neuron-like elements. The learning of a f...

journal_title：Canadian journal of physiology and pharmacology

authors： Kwan HC,Yeap TH,Jiang BC,Borrett D

更新日期：1990-01-01 00:00:00

abstract：:The guanylin family of peptides has 3 subclasses of peptides containing either 3 intramolecular disulfide bonds found in bacterial heat-stable enterotoxins (ST), or 2 disulfides observed in guanylin and uroguanylin, or a single disulfide exemplified by lymphoguanylin. These peptides bind to and activate cell-surface r...

journal_title：Canadian journal of physiology and pharmacology

authors： Fonteles MC,do Nascimento NR

更新日期：2011-08-01 00:00:00

abstract：:The effect of one bout of acute exercise on impaired glucose metabolism was studied in obese (480 +/- 20 g), untrained rats, at rest (n = 10) and after 60 min of swimming (n = 5). Using the euglycemic, hyperinsulinemic (10 mU.kg-1 x min-1) clamp, glucose clearance rate increased from 7.6 +/- 0.9 at rest to 9.7 +/- 0.5...

journal_title：Canadian journal of physiology and pharmacology

authors： Burstein R,Zissholtz A,Zick-Bachar Y,Epstein Y,Shapiro Y,Karnieli E

更新日期：1992-11-01 00:00:00

abstract：:The heat production (HP), heart rate (HR), respiration rate, rumen motility, and body temperature responses to 2.5-h adrenaline (A) and noradrenaline (NA) intrajugular infusions at 0.00, 0.15, 0.30, 0.60, and 0.90 micrograms.kg-1.min-1 were studied in 10 shorn wethers which had been chronically (3-8 weeks) exposed to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Graham AD,Christopherson RJ

更新日期：1981-09-01 00:00:00

abstract：:The effect of hepoxilin A, a newly isolated hydroxyepoxide metabolite of arachidonic acid, on calcium transport across the visceral yolk sac membrane of the guinea pig was investigated in vitro in Ussing chambers. While 1-14C-labelled hepoxilin A itself was not transported across the membrane, it increased the rate of...

journal_title：Canadian journal of physiology and pharmacology

authors： Derewlany LO,Pace-Asciak CR,Radde IC

更新日期：1984-12-01 00:00:00

abstract：:Recent lines of evidence suggest that the beneficial effects of olive oil are not only related to its high content of oleic acid, but also to the antioxidant potential of its polyphenols. The aim of this work was determine the effects of olive oil and its components, oleic acid and the polyphenol dihydroxyphenylethano...

journal_title：Canadian journal of physiology and pharmacology

authors： Faine LA,Rodrigues HG,Galhardi CM,Ebaid GM,Diniz YS,Padovani CR,Novelli EL

更新日期：2006-02-01 00:00:00

abstract：:To evaluate the clinical efficacy of azithromycin, cefaclor, and amoxicillin in treatment of pediatric tonsillitis, a total of 256 children with Group A β-hemolytic streptococcus (GAS) tonsillitis were randomly divided into 3 groups. Only patients assessed with streptococcus-positive tonsillitis, considered to be comp...

journal_title：Canadian journal of physiology and pharmacology

authors： Li P,Jiang G,Shen X

更新日期：2019-10-01 00:00:00

abstract：:To develop a mathematical model of the distribution and metabolism of rat corticotropin-releasing factor (rCRF), the time course of 125I-labelled rCRF in plasma was measured in male Sprague-Dawley rats (i) following a rapid injection of 24 ng rCRF/100 g body weight (BW), or (ii) following a rapid injection of 424 ng r...

journal_title：Canadian journal of physiology and pharmacology

authors： Candas B,Lalonde J,Normand M

更新日期：1986-06-01 00:00:00