Neural network control of simple limb movements.

abstract：:Histamine and specific H1- and H2-receptor agonists and antagonists in conjunction with phentolamine and (or) reserpine pretreatment were used to characterize histamine receptor(s) in the seminal vesicle of rat and guinea pig. Stimulation of H1 receptors produced a contraction whereas that of H2 receptors inhibited th...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIntosh CM,Vohra MM

更新日期：1981-08-01 00:00:00

abstract：:This paper provides a brief overview of the adaptive control of prehension. Several primary issues for research in the field are considered. One pertains to the stages of prehensile activity, with particular concern for the kinematic control of precontact phases, and the coordination of load and grip forces following ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lederman SJ

更新日期：1994-05-01 00:00:00

abstract：:The world-wide increase in cancer incidence imposes a corresponding significant increase in the use of chemotherapeutic agents. Nephrotoxicity is a side effect frequently encountered with cyclophosphamide (CP), which is also well-known to cause acute and chronic lung toxicities. The current study focuses on the evalua...

journal_title：Canadian journal of physiology and pharmacology

authors： Said E,Elkashef WF,Abdelaziz RR

更新日期：2016-04-01 00:00:00

abstract：:The exchange of Na+ and K+ in rat red cells at 40% hematocrit incubated in a physiological salt solution containing 1 MM ouabain was monitored with ion-specific glass electrodes. Because this system measures a change in the activity of an ion as a logarithmic function of its preexisting level, delta[K+]o is more accur...

journal_title：Canadian journal of physiology and pharmacology

authors： Friedman SM,Nakashima M,McIndoe

更新日期：1977-12-01 00:00:00

abstract：:The inotropic response induced by beta-adrenergic and H1 histaminergic receptor stimulation was characterized in guinea pig left atria by obtaining dose-response relationships for isoproterenol and histamine under various experimental conditions. Conditions (hypothermia, high frequencies of stimulation, and large extr...

journal_title：Canadian journal of physiology and pharmacology

authors： Tenner TE Jr,McNeill JH

更新日期：1978-12-01 00:00:00

abstract：:Heme plays a critical role in blood pressure regulation because it is required by a number of enzymes that synthesize vascular modulators, including nitric oxide (NO), carbon monoxide (CO), guanosine 3',5'-cyclic monophosphate (cGMP), endothelium-derived hyperpolarizing factor (EDHF), and prostacyclin. The goal of thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Soong J,Adams MA,Nakatsu K

更新日期：2008-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most life-threatening cancers. The present study was designed to chronologically analyze the HCC chemically induced by diethylnitrosamine (DEN) in male Wistar rats during a 27-week period. DEN was given to rats in drinking water (100 mg/L) to induce HCC. In the present stud...

journal_title：Canadian journal of physiology and pharmacology

authors： Fathy AH,Bashandy MA,Bashandy SAE,Mansour AM,Elsadek B

更新日期：2017-12-01 00:00:00

abstract：:The effects of clofibrate administration (200 mg/kg, po) on somatic growth, plasma levels of lipids, tryptophan, growth hormone (GH), and prolactin (PRL), as well as on brain concentrations of tryptophan and 5-hydroxytryptamine (5-HT) were studied in prepubertal male rats. The drug did not significantly alter ponderal...

journal_title：Canadian journal of physiology and pharmacology

authors： Tache Y,Letarte J,Collu R

更新日期：1978-04-01 00:00:00

abstract：:MicroRNA-146a (miR-146a) is reportedly implicated in the pathogenesis of ischemia-reperfusion (I/R) injury; however, its role in cerebral I/R injury is unclear and requires further investigation. In this study, cerebral I/R injury was established in mice via middle cerebral artery occlusion, and the expression of miR-...

journal_title：Canadian journal of physiology and pharmacology

authors： Chu B,Zhou Y,Zhai H,Li L,Sun L,Li Y

更新日期：2018-06-01 00:00:00

abstract：:This study aimed to investigate the anti-depressant effect of hesperidin (Hsp) in streptozotocin (STZ)-induced diabetic rats. Additionally, the effect of Hsp on hyperglycaemia, oxidative stress, inflammation, brain-derived neurotrophic factor (BDNF), and brain monoamines in diabetic rats was also assessed. The Wistar ...

journal_title：Canadian journal of physiology and pharmacology

authors： El-Marasy SA,Abdallah HM,El-Shenawy SM,El-Khatib AS,El-Shabrawy OA,Kenawy SA

更新日期：2014-11-01 00:00:00

abstract：:The effect of isoproterenol on mean right and left atrial pressures (RAP, LAP) and dimensions (RAD, LAD), and plasma immunoreactive atrial natriuretic factor (IR-ANF) was investigated in anesthetized rabbits. Infusion of isoproterenol (10 micrograms.kg-1.min-1 for 10 min) significantly increased plasma IR-ANF and hear...

journal_title：Canadian journal of physiology and pharmacology

authors： King KA,Wong A,Ledsome JR

更新日期：1991-04-01 00:00:00

abstract：:Using labelled microspheres, the effect of norepinephrine (NE) infusions (15 microgram and 30 microgram/min) on coronary blood flow and its intramyocardial distribution during ischemia was studied. The results reported here show that in the ischemic myocardium, the ratio of endocardial to epicardial flow was 0.67. Thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Dumont L,Lelorier J

更新日期：1977-08-01 00:00:00

abstract：:Dual agonism of glucagon and glucagon-like peptide-1 (GLP-1) receptors reduce body weight without inducing hyperglycemia in rodents. However, the effect of a co-agonist on insulin sensitivity and lipid metabolism has not been thoroughly assessed. Diet-induced obese (DIO) mice received 0.5 mg·kg(-1) of co-agonist or 2....

journal_title：Canadian journal of physiology and pharmacology

authors： Patel V,Joharapurkar A,Dhanesha N,Kshirsagar S,Patel K,Bahekar R,Shah G,Jain M

更新日期：2013-12-01 00:00:00

abstract：:The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normo...

journal_title：Canadian journal of physiology and pharmacology

authors： Salahuddin M,Jalalpure SS,Gadge NB

更新日期：2010-02-01 00:00:00

abstract：:Changes in force and stiffness during contractions of mouse extensor digitorum longus and soleus muscles were measured over a range of extracellular pH from 6.4 to 7.4. Muscle stiffness was measured using small amplitude (less than 0.1% of muscle length), high frequency (1.5 kHz) oscillations in length. Twitch force w...

journal_title：Canadian journal of physiology and pharmacology

authors： Renaud JM,Stein RB,Gordon T

更新日期：1987-08-01 00:00:00

abstract：:Tea is perceived as more relaxing than coffee, even though both contain caffeine. L-theanine in tea may account for the difference. Consumed together, caffeine and theanine exert similar cognitive effects to that of caffeine alone, but exert opposite effects on arousal, in that caffeine accentuates and theanine mitiga...

journal_title：Canadian journal of physiology and pharmacology

authors： Giles GE,Mahoney CR,Brunyé TT,Taylor HA,Kanarek RB

更新日期：2017-01-01 00:00:00

abstract：:The effects of L-641,953 (R-8-fluoro-dibenzo[b, f]thiepin-3-carboxylic acid-5-oxide) have been studied on pulmonary and other smooth muscle preparations in vitro and in vivo. When studied in vitro on guinea-pig tracheal chains, L-641,933 produced significant shifts in the dose-response curves to the prostaglandin endo...

journal_title：Canadian journal of physiology and pharmacology

authors： Hall RA,Rokach JR,Bélanger P,Bianchi L,Ethier D,Ford-Hutchinson AW,Girard Y,Hamel P,Hamel R,Lord A

更新日期：1987-04-01 00:00:00

abstract：:The neural connections from the medial prefrontal cortex to the ventral pallidum were investigated in urethane-anesthetized rats. Extracellular recordings were made from 124 spontaneously firing neurons in the ventral pallidum while the medial prefrontal cortex was electrically stimulated. The most frequent response t...

journal_title：Canadian journal of physiology and pharmacology

authors： Delgado-Martínez AD,Vives F

更新日期：1993-05-01 00:00:00

abstract：:Allicin, the active substance of garlic, exerts a broad spectrum of pharmacological activities and is considered to have potential therapeutic applications. The present study was designed to investigate the possible beneficial effects of allicin against oxidative stress, inflammation, and endothelial dysfunction in hy...

journal_title：Canadian journal of physiology and pharmacology

authors： El-Sheakh AR,Ghoneim HA,Suddek GM,Ammar ESM

更新日期：2016-02-01 00:00:00

abstract：:This review presents, from the author's viewpoint, avenues of histamine research likely to produce new information. One potentially useful approach may be to attempt to relate histamine's function to its occurrence in different body tissues such as the pituitary and hypothalamus, the gastrointestinal mucosa, and the b...

journal_title：Canadian journal of physiology and pharmacology

authors： Code CF

更新日期：1985-06-01 00:00:00

abstract：:Apoptotic pathways in breast cancer cells are frequently altered, reducing the efficiency of radiotherapy. Conjugated linoleic acid (CLA), known to trigger apoptosis, was tested as radiosensitizer in breast cancer cells MCF-7 and MDA-MB-231. The CLA-mix, made up of the isomers CLA-9cis 11trans and CLA-10trans 12cis, w...

journal_title：Canadian journal of physiology and pharmacology

authors： Drouin G,Douillette A,Lacasse P,Paquette B

更新日期：2004-02-01 00:00:00

abstract：:The present study was designed to evaluate the role of endothelial NO in the hemodynamics and vascular changes that occur in heart failure following myocardial infarction in rats. Left ventricular systolic pressure (LVSP), mean blood pressure (MBP), aortic morphology (media thickness) and reactivity were evaluated in ...

journal_title：Canadian journal of physiology and pharmacology

authors： da Cunha V,Stefanon I,Mill JG

更新日期：2004-06-01 00:00:00

abstract：:The goal of the present study was to investigate the formation of portacaval shunts in a new experimental model of chronic portal hypertension, portal vein stenosis in the cat. The procedure gradually occluded the portal vein by use of an Ameroid constrictor around the portal vein. After 4 weeks, the portal vein was c...

journal_title：Canadian journal of physiology and pharmacology

authors： Inglés AC,Légaré DJ,Lautt WW

更新日期：1993-09-01 00:00:00

abstract：:The utilization of triacylglycerol in slow oxidative, fast oxidative-glycolytic, and fast glycolytic skeletal muscle fiber types was examined in rats subjected to a prolonged exhaustive swim. Significant reductions of intramuscular triacylglycerol occurred following 2 h and 40 min of swimming in all muscles containing...

journal_title：Canadian journal of physiology and pharmacology

authors： Spriet LL,Peters SJ,Heigenhauser GJ,Jones NL

更新日期：1985-06-01 00:00:00

abstract：:The numbers and sizes of nerve fibres to the dorsal neck muscles, splenius, complexus and biventer cervicis have been examined in the cat. The total number of fibres is unusually high as is the content of sensory fibres (estimated as the loss of fibres after ganglionectomy). The fibre spectra of these sensory nerves h...

journal_title：Canadian journal of physiology and pharmacology

authors： Richmond FJ,Anstee GC,Sherwin EA,Abrahams VC

更新日期：1976-06-01 00:00:00

abstract：:This review updates our current knowledge on the regulation of Na+/H+ exchanger, Na+,K+,Cl- cotransporter, Na+,Pi cotransporter, and Na+,K+ pump in isolated epithelial cells from mammalian kidney by protein kinase C (PKC). In cells derived from different tubule segments, an activator of PKC, 4beta-phorbol 12-myristate...

journal_title：Canadian journal of physiology and pharmacology

authors： Gagnon F,Hamet P,Orlov SN

更新日期：1999-05-01 00:00:00

abstract：:Cerebrocrast is a novel lipophilic dihydropyridine derivative with potential neuroprotective and antidiabetic properties. We have analyzed its interaction with L-type (CaV1.2b) and T-type (CaV3.1) calcium channels using a whole-cell patch clamp in HEK 293 cells. Cerebrocrast inhibited current flux through both CaV1.2b...

journal_title：Canadian journal of physiology and pharmacology

authors： Drígelová M,Tarabová B,Duburs G,Lacinová L

更新日期：2009-11-01 00:00:00

abstract：:To elucidate the involvement of the brain renin-angiotensin system and the brain atrial natriuretic polypeptide (ANP) system in the regulation of ANP secretion from the heart, the effects of intracerebroventricular administration of angiotensin II and ANP on the plasma ANP level were examined in conscious unrestrained...

journal_title：Canadian journal of physiology and pharmacology

authors： Itoh H,Nakao K,Yamada T,Morii N,Shiono S,Sugawara A,Saito Y,Mukoyama M,Arai H,Imura H

更新日期：1988-03-01 00:00:00

abstract：:The intraperitoneal administration of insulin has been recommended because it was found to effectively control the plasma glucose level. Several authors have suggested that intraperitoneal insulin administration may be more "physiological" and therefore preferable because the insulin is absorbed into the portal venous...

journal_title：Canadian journal of physiology and pharmacology

authors： Zingg W,Rappaport AM,Leibel BS

更新日期：1986-03-01 00:00:00

abstract：:The alcohol oxidase membrane technique is available for measurement of ethanol in commercial fluids. In this paper we examined its usefulness for cat and human blood in comparison with gas-liquid chromatography (GLC). The membrane method proved to be simple, reproducible, accurate, and inexpensive. Analysis took 1-2 m...

journal_title：Canadian journal of physiology and pharmacology

authors： Greenway CV,Pushka K,Sitar DS,Rogers LK

更新日期：1988-04-01 00:00:00