Motor and sensory fibres of neck muscle nerves in the cat.

abstract：:Induced ketosis may acutely prolong hypoxic tolerance by altering glucose and (or) beta-hydroxybutyrate extraction by the brain. Anesthetized dogs were ventilated and instrumental for arterial and cerebral venous blood sampling, taken during baseline, infusion, test, and recovery periods. Each dog received one of four...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang AS,D'Alecy LG

更新日期：1993-07-01 00:00:00

abstract：:The physiological action of alpha bungarotoxin in the central nervous system of the horseshoe crab Limulus polyphemus was investigated. Two types of effects were produced by the toxin. The predominant effect was an inhibition of spontaneous activity. However, in some instances alpha bungarotoxin caused a stimulation o...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomas W,Townsel JG

更新日期：1981-02-01 00:00:00

abstract：:The isometric contractile properties of frog (Rana pipiens) and toad (Bufo bufo) sartorii have been studied over the temperature range from 0 to 20 degrees C. The isometric twitch tension was found to vary considerably between these two species and between muscles in the same species. Between 0 and 4 degrees C there w...

journal_title：Canadian journal of physiology and pharmacology

authors： Bressler BH

更新日期：1981-06-01 00:00:00

abstract：:Opioid and N-methyl-d-aspartate (NMDA) receptors mediate different effects of fluoxetine. We investigated whether opioid and NMDA receptors are involved in the protective effect of fluoxetine against the behavioral despair induced by acute physical stress in male mice. We used the forced swimming test (FST), tail susp...

journal_title：Canadian journal of physiology and pharmacology

authors： Haj-Mirzaian A,Kordjazy N,Ostadhadi S,Amiri S,Haj-Mirzaian A,Dehpour A

更新日期：2016-06-01 00:00:00

abstract：:Guanine nucleotide binding proteins (G proteins) are largely grouped into three classes: heterotrimeric G proteins, ras-like or small molecular weight GTP binding proteins, and others like Gh. In the heart G proteins transduce signals from a variety of membrane receptors to generate diverse effects on contractility, h...

journal_title：Canadian journal of physiology and pharmacology

authors： Zolk O,Kouchi I,Schnabel P,Böhm M

更新日期：2000-03-01 00:00:00

abstract：:Hedysarum polybotrys polysaccharide (HPS) is the principal active fraction responsible for the antidiabetic properties of this species. The aim of this study was to determine the antidiabetic properties of 4 purified fractions of different molecular weight range HPSs (HPS1, HPS2, HPS3, HPS4). HPS3 was selected for exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Hu F,Li X,Zhao L,Feng S,Wang C

更新日期：2010-01-01 00:00:00

abstract：:The combined and separate effects of exercise training and bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight postmenopausal women were randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength training (3 d/week) and r...

journal_title：Canadian journal of physiology and pharmacology

authors： Chilibeck PD,Davison KS,Whiting SJ,Suzuki Y,Janzen CL,Peloso P

更新日期：2002-10-01 00:00:00

abstract：:Insulin sensitivity and resistance were examined in vivo in uremic rats by using tracer methods which permit the assessment of "non-steady-state" glucose kinetics. By relating the changes in the rates of glucose output by the liver (Ra), uptake by tissues (Rd), and metabolic clearance (MCR) to immunoreactive glucagon ...

journal_title：Canadian journal of physiology and pharmacology

authors： Perez G,Carteni G,Ungaro B,Saccà L

更新日期：1980-03-01 00:00:00

abstract：:Endothelin 1 (ET-1) is a potent vasoconstrictor implicated in the control of blood pressure and renal function. Its effects can be modulated by nitric oxide (NO), which inhibits ET-1 production and action. Recently, we reported that ET-1 production can also be modulated by angiotensin II (AngII) in vivo. To investigat...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Amours M,Lebel M,Grose JH,Larivière R

更新日期：1999-01-01 00:00:00

abstract：:There is general agreement about potentiation in dose-response studies, characterized by a left shift of the dose-response curve of A by a fixed dose of B when B is causing no effect by itself (simple situation). When B causes an effect similar to A (complex situation) by binding to different molecular sites, we propo...

journal_title：Canadian journal of physiology and pharmacology

authors： Pöch G,Reiffenstein RJ,Köck P,Pancheva SN

更新日期：1995-11-01 00:00:00

abstract：:In a porcine coronary artery helical strip preparation, the tyrosine kinase inhibitors genistein and tyrphostin (AG82) attenuated the contractile actions of angiotensin II, arginine vasopressin, epidermal growth factor--urogastrone, noradrenaline, and prostaglandin F2 alpha, under conditions where contractions due to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Laniyonu AA,Saifeddine M,Yang SG,Hollenberg MD

更新日期：1994-09-01 00:00:00

abstract：:The objective of this study was to investigate under controlled conditions the effects of fentanyl on the rat locus coeruleus catechol oxidation current. Using differential normal pulse voltammetry combined with electrochemically treated carbon fiber electrodes to measure the catechol oxidation current, catecholamine ...

journal_title：Canadian journal of physiology and pharmacology

authors： Milne B,Quintin L,Gillon JY,Pujol JF

更新日期：1989-05-01 00:00:00

abstract：:We have investigated the influence of dopaminergic agents on the expression of brain-derived neurotrophic factor (BDNF) gene in relation with lipid levels in chronic mild stress (CMS). Mice subjected to CMS were treated with simvastatin (10 mg/kg, per os (orally)) along with bromocriptine (2 mg/kg, intraperitoneally (...

journal_title：Canadian journal of physiology and pharmacology

authors： Rana DG,Patel AK,Joshi CG,Jhala MK,Goyal RK

更新日期：2014-12-01 00:00:00

abstract：:Activity-related transient changes in extracellular K+ concentration ([K+]c), extracellular pH (pHc), and extracellular volume (EC volume) were studied by means of ion-selective microelectrodes in the adult rat spinal cord in vivo and in neonatal rat spinal cords isolated from pups 3-14 days of age. Repetitive electri...

journal_title：Canadian journal of physiology and pharmacology

authors： Syková E,Jendelová P,Svoboda J,Chvátal A

更新日期：1992-01-01 00:00:00

abstract：:Although dual endothelin receptor antagonists (ERAs) show great promise for treating various conditions, their propensity to induce liver injury limits their clinical usage. Inflammation and fibrosis are important processes in liver responses to injury and it has been suggested that they and dual ERA-induced liver inj...

journal_title：Canadian journal of physiology and pharmacology

authors： Ryanto GRT,Yorifuji K,Ikeda K,Emoto N

更新日期：2020-09-01 00:00:00

abstract：:An account is given of the current state of knowledge of the contributions of the cerebellum and the forelimb motor cortex (MC) to the neural control of walking movements in the cat. The main emphasis is on information obtained by recording from single MC and cerebellar neurones in chronically instrumented cats engage...

journal_title：Canadian journal of physiology and pharmacology

authors： Armstrong DM,Marple-Horvat DE

更新日期：1996-04-01 00:00:00

abstract：:The objective of the present study was to assess the cardioprotective effect of dual NEP-ACE inhibition in relation to endogenous cardiac bradykinin (BK), its active metabolite des-Arg9-BK, endogenous brain natriuretic peptides (BNP), and cGMP. Rats were treated with the dual metallopeptidase inhibitor, omapatrilat, o...

journal_title：Canadian journal of physiology and pharmacology

authors： Dumoulin MJ,Adam A,Burnett J,Heublein D,Yamaguchi N,Lamontagne D

更新日期：2005-02-01 00:00:00

abstract：:Despite the widespread use of furosemide in the treatment of various fluid and electrolyte disorders in the preterm and term human infant and child, the physiological effects of this potent diuretic agent on renal function and renin release during postnatal maturation are poorly understood. To test the hypothesis that...

journal_title：Canadian journal of physiology and pharmacology

authors： Smith FG,Abraham J

更新日期：1995-01-01 00:00:00

abstract：:The our objective was to investigate the adaptations induced by a low-protein, high-carbohydrate (LPHC) diet in growing rats, which by comparison with the rats fed a control (C) diet at displayed lower fasting glycemia and similar fasting insulinemia, despite impairment in insulin signaling in adipose tissues. In the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Pereira MP,Buzelle SL,Batistela E,Doneda DL,França SA,Santos MP,Andrade CM,Garófalo MA,Kettelhut Ido C,Navegantes LC,Chaves VE,Bertolini GL,Kawashita NH

更新日期：2014-06-01 00:00:00

abstract：:It is possible to embed the control and computation of a simple single-joint movement at different speeds by a small non-linear network of neuron-like elements. The network "learns" by appropriate adjustment of the strengths of interconnection, or synaptic weights, between the neuron-like elements. The learning of a f...

journal_title：Canadian journal of physiology and pharmacology

authors： Kwan HC,Yeap TH,Jiang BC,Borrett D

更新日期：1990-01-01 00:00:00

abstract：:The effects of beta-adrenergic blocking agents, timolol and atenolol (1-1000 microM), were studied on rat heart sarcolemmal ATPase and Ca2+ binding activities. Timolol, unlike atenolol, increased both Ca2+-stimulated ATPase and ATP-dependent Ca2+ binding; the maximal effects were seen at 1 microM concentration of timo...

journal_title：Canadian journal of physiology and pharmacology

authors： Dzurba A,Ganguly PK,Beamish RE,Dhalla NS

更新日期：1983-03-01 00:00:00

abstract：:The influences of hypertension and hypothyroidism on diabetic cardiomyopathy are not clear. We studied this problem further by characterizing the effects of chronic triiodothyronine (T3) treatment on cardiac performance of diabetic renovascular hypertensive (RVH) rats. Hypertension was effected by clipping the left re...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodgers RL,Davidoff AJ,Mariani MJ

更新日期：1991-03-01 00:00:00

abstract：:The importance of the sympathetic innervation in the regulation of 5'-deiodinase activity in the interscapular brown adipose tissue (BAT) of the Djungarian hamster was studied. Interscapular BAT of Djungarian hamsters was either unilaterally or bilaterally denervated, and thereafter the animals were maintained at ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Meywirth A,Redlin U,Steinlechner S,Heldmaier G,Reiter RJ

更新日期：1991-12-01 00:00:00

abstract：:It has recently been demonstrated that the protein tyrosine phosphatase (PTP) PTP1B and the T-cell PTP (TC-PTP) target several substrates involved in immune cell signaling. Recent data have furthered the view of these 2 PTP members as key regulators of the immune response. This review will focus on the substrate speci...

journal_title：Canadian journal of physiology and pharmacology

authors： Simoncic PD,McGlade CJ,Tremblay ML

更新日期：2006-07-01 00:00:00

abstract：:The effect of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on blood volume was studied in unanesthetized splenectomized and nonsplenectomized dogs. A significant increase in total blood volume essentially accounted for by a marked plasma volume expansion was found in both groups after 6-OHDA treatment (50 mg...

journal_title：Canadian journal of physiology and pharmacology

authors： Porlier GA,Nadeau RA,de Champlain J

更新日期：1977-06-01 00:00:00

abstract：:The electrical activity of the duodenum and proximal jejunum was studied in conscious healthy dogs implanted with unipolar silver electrodes. A computerized method was used for the calculation of the mean frequency of the slow wave for each consecutive minute of the electromyographic signal. A "slow wave frequency com...

journal_title：Canadian journal of physiology and pharmacology

authors： Pousse A,Mendel C,Aprahamian M,Kachelhoffer J,Balboni G,Plas A

更新日期：1987-06-01 00:00:00

abstract：:Most physiological and pathophysiological responses to bradykinin are mediated by G-protein-coupled receptors designated B2 receptors. Discovery of antagonists for these receptors has brought about a revolution in research in the kinin field. The chemistry and development of antagonists for B2 kinin receptors are disc...

journal_title：Canadian journal of physiology and pharmacology

authors： Stewart JM

更新日期：1995-07-01 00:00:00

abstract：:The effect of isoproterenol on mean right and left atrial pressures (RAP, LAP) and dimensions (RAD, LAD), and plasma immunoreactive atrial natriuretic factor (IR-ANF) was investigated in anesthetized rabbits. Infusion of isoproterenol (10 micrograms.kg-1.min-1 for 10 min) significantly increased plasma IR-ANF and hear...

journal_title：Canadian journal of physiology and pharmacology

authors： King KA,Wong A,Ledsome JR

更新日期：1991-04-01 00:00:00

abstract：:In previous studies we have been able to demonstrate tighter metabolic control of muscle metabolism during prolonged steady-state exercise 5 to 6 days after the initiation of training and well before changes in oxidative potential. To examine whether the metabolic adaptations are manifested during the non-steady-state...

journal_title：Canadian journal of physiology and pharmacology

authors： Green HJ,Cadefau J,Cussó R,Ball-Burnett M,Jamieson G

更新日期：1995-04-01 00:00:00

abstract：:Changes in force and stiffness during contractions of mouse extensor digitorum longus and soleus muscles were measured over a range of extracellular pH from 6.4 to 7.4. Muscle stiffness was measured using small amplitude (less than 0.1% of muscle length), high frequency (1.5 kHz) oscillations in length. Twitch force w...

journal_title：Canadian journal of physiology and pharmacology

authors： Renaud JM,Stein RB,Gordon T

更新日期：1987-08-01 00:00:00