Abstract:
:The exchange of Na+ and K+ in rat red cells at 40% hematocrit incubated in a physiological salt solution containing 1 MM ouabain was monitored with ion-specific glass electrodes. Because this system measures a change in the activity of an ion as a logarithmic function of its preexisting level, delta[K+]o is more accurately measured than delta[Na+]o; within this limitation, the downhill ion movements were close to 1:1 over the temperature span from 37 to 3 degrees C. These transmembrane movements are reasonably well expressed in terms of first-order kinetics and an Arrhenius plot constructed for K+ as the accurate indicator of the exchange yields an activation energy of 12 kcal/mol. A well-defined reversal of the usual direct relation of temperature to exchange rate was observed between 6 and 3 degrees C. The net ion movements were distinctly faster at low temperature in cells from rats with spontaneous hypertension (SHR-Okamoto) than in cells from matched controls (Woodlyn and WKY).
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Friedman SM,Nakashima M,McIndoedoi
10.1139/y77-175subject
Has Abstractpub_date
1977-12-01 00:00:00pages
1302-10issue
6eissn
0008-4212issn
1205-7541journal_volume
55pub_type
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journal_title:Canadian journal of physiology and pharmacology
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