Endurance exercise in a rat model of metabolic syndrome.

abstract：:Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2a subclass increased significantly when isolated P. senega saponins were used ...

journal_title：Canadian journal of physiology and pharmacology

authors： Katselis GS,Estrada A,Gorecki DK,Barl B

更新日期：2007-11-01 00:00:00

abstract：:Mechanisms leading to ifosfamide (IF)-induced renal damage have not been fully elucidated. Recent work suggests that localized renal tubular metabolism of IF and the production of the nephrotoxic chloroacetaldehyde may lead to nephrotoxicity. Presently no pharmacological method to reduce IF nephrotoxicity has been ide...

journal_title：Canadian journal of physiology and pharmacology

authors： Aleksa K,Halachmi N,Ito S,Koren G

更新日期：2005-06-01 00:00:00

abstract：:Previous studies have demonstrated that abdominal irradiation alters intestinal uptake of nutrients. The purpose of this study was to determine the effect of an orally administered synthetic prostaglandin E2, enprostil, given on three occasions shortly prior to a single exposure to 600 cGy external abdominal irradiati...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson AB,Keelan M,Clandinin MT,Tavernini M,Lam T,Walker K,Cheeseman CI

更新日期：1989-10-01 00:00:00

abstract：:Agelasimine A and agelasimine B, two novel compounds related to adenine, have been isolated from the orange sponge, Agelas mauritiana, and have been tested for a variety of biological activities. Both compounds inhibited proliferation of cultured L1210 leukemia cells at nanomolar concentrations with accumulation in th...

journal_title：Canadian journal of physiology and pharmacology

authors： Fathi-Afshar R,Allen TM,Krueger CA,Cook DA,Clanachan AS,Vriend R,Baer HP,Cass CE

更新日期：1989-04-01 00:00:00

abstract：:It has been proposed that medullary washout secondary to increased blood flow will limit maximal urine osmolality and reabsorption of salt and water from the inner medullary collecting duct. We have tested this prediction. The function of the inner medullary collecting duct was examined by microcatheterization. Acetyl...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA,Sonnenberg H

更新日期：1987-12-01 00:00:00

abstract：:Physical activity and training have some potential as tools for examining immune responses to inflammation and trauma. Contributors to the present symposium review various aspects of the inflammatory process, including issues of lymphocyte recirculation and endotoxemia. They examine also the extent and nature of the i...

journal_title：Canadian journal of physiology and pharmacology

authors： Shephard RJ,Shek PN

更新日期：1998-05-01 00:00:00

abstract：:Physical activity promotes metabolic adaptations that improve body functionality and contribute to the prevention of some diseases. With respect to energy and fat balance, physical activity facilitates the equilibrium between energy intake and expenditure as well as between fat intake and fat oxidation. When combined ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tremblay A,Therrien F

更新日期：2006-02-01 00:00:00

abstract：:There is general agreement about potentiation in dose-response studies, characterized by a left shift of the dose-response curve of A by a fixed dose of B when B is causing no effect by itself (simple situation). When B causes an effect similar to A (complex situation) by binding to different molecular sites, we propo...

journal_title：Canadian journal of physiology and pharmacology

authors： Pöch G,Reiffenstein RJ,Köck P,Pancheva SN

更新日期：1995-11-01 00:00:00

abstract：:The effects of a number of peptides which are found in the gastrointestinal tract have been ascertained on the direct current recorded dorsal and ventral root responses of the isolated hemisected toad spinal cord. Motilin, substance P, bombesin, neurotensin, and thyrotropin releasing hormone had potent depolarizing ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Phillis JW,Kirkpatrick JR

更新日期：1979-08-01 00:00:00

abstract：:The effects of neomycin sulfate were examined upon the discharge activity and electrical membrane properties of an isolated invertebrate sensory neuron, the crayfish stretch receptor neuron. Neomycin depressed cell discharge activity in a concentration-dependent manner over the concentration range of 0.01-1.0 mM. Sign...

journal_title：Canadian journal of physiology and pharmacology

authors： Nation PN,Roth SH

更新日期：1988-01-01 00:00:00

abstract：:Rats fed a polychlorinated biphenyl (PCB) mixture in a high- or low-iodine diet (HID or LID respectively) for 15 days had thyroid enlargement, low serum thyroxine (T4), and high serum thyrotropin concentrations. Although binding of thyroid hormones to serum proteins was reduced in PCB-fed animals, the free T4 index (r...

journal_title：Canadian journal of physiology and pharmacology

authors： Bastomsky CH

更新日期：1977-04-01 00:00:00

abstract：:Ethanol was administered to rats by oral intubation 3 h after intraperitoneal administration of calcium carbimide. Increased blood acetaldehyde concentration and the presence of acetaldehyde in brain were found for the calcium carbimide--ethanol interaction. There was no detectable brain acetaldehyde for ethanol admin...

journal_title：Canadian journal of physiology and pharmacology

authors： Hoover DJ,Brien JF

更新日期：1981-01-01 00:00:00

abstract：:Guanine nucleotide binding proteins (G proteins) are largely grouped into three classes: heterotrimeric G proteins, ras-like or small molecular weight GTP binding proteins, and others like Gh. In the heart G proteins transduce signals from a variety of membrane receptors to generate diverse effects on contractility, h...

journal_title：Canadian journal of physiology and pharmacology

authors： Zolk O,Kouchi I,Schnabel P,Böhm M

更新日期：2000-03-01 00:00:00

abstract：:In vivo fatty acid synthesis and the pathways of glycerol-3-phosphate (G3P) production were investigated in brown adipose tissue (BAT) from rats fed a cafeteria diet for 3 weeks. In spite of BAT activation, the diet promoted an increase in the carcass fatty acid content. Plasma insulin levels were markedly increased i...

journal_title：Canadian journal of physiology and pharmacology

authors： Chaves VE,Frasson D,Martins-Santos ME,Navegantes LC,Galban VD,Garófalo MA,Kettelhut IC,Migliorini RH

更新日期：2008-07-01 00:00:00

abstract：:This study was designed to investigate whether and how triiodothyronine (T3) affects renal function in an experimental model of chronic kidney disease. Twenty-four female rats were divided into the following groups: sham-operated control group (n = 8), 5/6 nephrectomized group (Nx, n = 8), and 5/6 nephrectomized group...

journal_title：Canadian journal of physiology and pharmacology

authors： El Agaty SM

更新日期：2018-06-01 00:00:00

abstract：:Glucagon causes marked elevations of glomerular filtration rate (GFR) in dogs when administered intravenously (i.v.) in small doses. The associated natriuresis is thought to be entirely due to increments in the filtered sodium load. In this study, renal denervation, thyroparathyroidectomy, and blockade of cholinergic,...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1975-02-01 00:00:00

abstract：:The aim of the present study was to characterize the effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the endocrine pancreas in anesthetized dogs. PACAP(1-27) and a PACAP receptor (PAC(1)) blocker, PACAP(6-27), were locally administered to the pancreas. PACAP(1-27) (0.005-5 microg) increased ba...

journal_title：Canadian journal of physiology and pharmacology

authors： Yamaguchi N,Minassian TR,Yamaguchi S

更新日期：2003-07-01 00:00:00

abstract：:The effects of barbiturates on human platelet function are not fully understood. Since we have already revealed the effects and mechanisms of thiopental, thiamylal, and pentobarbital in platelets, the present study attempted to elucidate (i) the effects of other barbiturates on human platelet aggregation, (ii) the und...

journal_title：Canadian journal of physiology and pharmacology

authors： Sato M,Hirakata H,Ikeda M,Fukuda K

更新日期：2003-08-01 00:00:00

abstract：:Several studies suggest that heat stress affects placental functions including uteroplacental circulation, subsequently leading to pregnancy failure and birth weight reduction. To clarify the involvement of endothelin and placental prostaglandin (PG) systems in the uteroplacental circulation during heat stress, we exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Nakamura H,Matsuzaki I,Hatta K,Ogino K

更新日期：2004-04-01 00:00:00

abstract：:Sensorimotor mechanisms were studied on the basis of kinematic and electromyographic data as well as the static torque developed by the muscles as a function of joint angle. The latter relationship is known as the torque/angle characteristic. Fast single-joint movement may result from a shift in this characteristic an...

journal_title：Canadian journal of physiology and pharmacology

authors： Levin MF,Lamarre Y,Feldman AG

更新日期：1995-02-01 00:00:00

abstract：:The novel biological effect of statins in alleviating myocardium fibrosis following infarction has been increasingly recognized, yet the underlying mechanisms are not fully understood. The purpose of this study was to characterize the effect of simvastatin on myocardial fibrosis and collagen I deposition in the non-in...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang J,Xu Y,Pan L,Chen T,Chen Z,Zhao R

更新日期：2010-11-01 00:00:00

abstract：:Cytosolic Ca(2+) is a versatile secondary messenger that regulates a wide range of cellular activities. In the past decade, evidence has accumulated that free Ca(2+) within the nucleus also plays an important messenger function. Here we review the mechanisms and effects of Ca(2+) signals within the nucleus. In particu...

journal_title：Canadian journal of physiology and pharmacology

authors： Gomes DA,Leite MF,Bennett AM,Nathanson MH

更新日期：2006-03-01 00:00:00

abstract：:Electrophysiological studies were performed on in vitro slice preparations of sympathetic ganglia excised from peripherally perfused, brain-dead human donors. The intracellular recordings in 16 neurons showed resting potentials and input resistances mostly in the ranges reported for sympathetic neurons in other mammal...

journal_title：Canadian journal of physiology and pharmacology

authors： Puil E,el-Beheiry H,Spigelman I

更新日期：1988-06-01 00:00:00

abstract：:The effect of sex hormones on vascular reactivity is considered one of the underlying factors contributing to gender differences in cardiovascular functions and diseases. Experiments were designed to investigate the role of androgens in salt-induced hypertension by assessing the relaxation response of isolated aortic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Oloyo AK,Sofola OA,Anigbogu CN

更新日期：2011-04-01 00:00:00

abstract：:A brief summary is given of some of the key points of the individual contributions at this International Brain Research Organization satellite meeting, presenting up-to-date, expert knowledge of energy metabolism, ionic turnover, and cell swelling at the cellular level of the mammalian central nervous system. On the b...

journal_title：Canadian journal of physiology and pharmacology

authors： Hertz L,Code WE,Sykova E

更新日期：1992-01-01 00:00:00

abstract：:Most cardiac diseases are associated with fibrosis. Calcineurin (CaN) is regulated by Ca(2+)/calmodulin (CaM). The CaN-NFAT (nuclear factor of activated T cell) pathway is involved in the process of cardiac diseases, such as cardiac hypertrophy, but its effect on myocardial fibrosis remains unclear. The present study ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chen QQ,Zhang W,Chen XF,Bao YJ,Wang J,Zhu WZ

更新日期：2012-12-01 00:00:00

abstract：:Electrical stimulation of the diencephalon and rostral mesencephalon produced a biphasic pressor response consisting of an initial sharp rise followed by a more prolonged elevation in blood pressure. Active sites from which comparable responses could be evoked were found in the ventral medial and lateral hypothalamus,...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier P

更新日期：1981-05-01 00:00:00

abstract：:An acidic proteinase was purified from human kidney cortex. The enzyme showed a molecular mass of 31 kDa by SDS-PAGE, 36 kDa by gel filtration, and isoelectric points of 5.2 and 6.1. The optimum pH for hydrolysis of bovine hemoglobin was about 3.5. Reverse-phase HPLC analysis of the incubation mixture of the enzyme wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Gomes RA,Juliano L,Chagas JR,Hial V

更新日期：1997-06-01 00:00:00

abstract：:Both physical activity and exposure to environmental stressors such as cold, heat, and high altitudes modify various components of immune function: T cell counts, natural killer (NK) cell counts, and cytolytic activity, cytokine secretion, lymphocyte proliferation and immunoglobulin levels. Light physical activity or ...

journal_title：Canadian journal of physiology and pharmacology

authors： Shephard RJ

更新日期：1998-05-01 00:00:00

abstract：:The electrophysiologist's view of brain astrocytes has changed markedly in recent years. In the past astrocytes were viewed as passive, K+ selective cells, but it is now evident that they are capable of expressing voltage- and ligand-activated channels previously thought to be restricted to neurons. The functional imp...

journal_title：Canadian journal of physiology and pharmacology

authors： Sontheimer H

更新日期：1992-01-01 00:00:00