Uptake of organic anions by hepatocyte monolayers: codiffusion versus facilitated dissociation.

abstract：:The aim of the present investigation was to elucidate the pharmacological mechanism by which U44069, a stable PGH2 analogue, contracts the rat aorta. The results obtained demonstrate that while the contractile effect of potassium chloride is obliterated by removal of extracellular calcium, a substantial proportion of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Heaslip RJ,Rahwan RG

更新日期：1982-05-01 00:00:00

abstract：:Several studies suggest that heat stress affects placental functions including uteroplacental circulation, subsequently leading to pregnancy failure and birth weight reduction. To clarify the involvement of endothelin and placental prostaglandin (PG) systems in the uteroplacental circulation during heat stress, we exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Nakamura H,Matsuzaki I,Hatta K,Ogino K

更新日期：2004-04-01 00:00:00

abstract：:Our studies are guided by the novel hypothesis that protein tyrosine phosphorylation is an important mechanism for regulating contraction of smooth muscle. Several lines of evidence are reviewed which suggest that enhanced tyrosine phosphorylation participates in mechanisms that regulate cytosolic Ca2+ and Ca2+ sensit...

journal_title：Canadian journal of physiology and pharmacology

authors： Di Salvo J,Pfitzer G,Semenchuk LA

更新日期：1994-11-01 00:00:00

abstract：:The metabolic and body weight changes in two non-pregnant beef cows were studied during prolonged exposure to warm (20 +/- 3 degrees C, relative humidity 50-70%) and cold (-10 +/- 2 or -25 +/- 4 degrees C) temperatures. Other factors including daily food intake were held constant throughout each 8-week exposure. Durin...

journal_title：Canadian journal of physiology and pharmacology

authors： Young BA

更新日期：1975-10-01 00:00:00

abstract：:Selected topics on the roles of sarcoplasmic reticulum (SR) in the control of vascular smooth muscle (VSM) tone are briefly reviewed with particular reference to the regulation of cytosolic concentration of free calcium ions, [Ca2+]i. Although morphological evidence and subcellular membrane studies indicate a relative...

journal_title：Canadian journal of physiology and pharmacology

authors： Daniel EE,van Breemen C,Schilling WP,Kwan CY

更新日期：1995-05-01 00:00:00

abstract：:The purpose of this study was to characterize the biological activity of the synthetic rat growth hormone releasing factor analogue rGRF(1-29)NH2 and to compare its action on growth hormone (GH) release to that of authentic rGRF(1-43)OH. We first compared the concentration-response characteristics of the two peptides ...

journal_title：Canadian journal of physiology and pharmacology

authors： Kraicer J,French MB,Lussier BT,Moor BC,Brazlan P

更新日期：1991-02-01 00:00:00

abstract：:Premature weaning of rats to high carbohydrate diets causes a variety of short- and long-term changes in lipid metabolism, but the mechanisms involved are unclear. It is likely that interaction of diet with certain emerging hormonal control patterns during weaning might condition metabolic control and (or) subsequent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Angel JF,Back DW

更新日期：1985-05-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a key pathogenic factor in sepsis, and its recognition by toll-like receptor 4 (TLR4) can activate two district signaling pathways, leading to activation of transcription factors including NF-κB and interferon regulatory factor 3 (IRF3). Chloroquine (CQ) has been shown to affect LPS-TLR4 co...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding C,Li F,Long Y,Zheng J

更新日期：2017-05-01 00:00:00

abstract：:A hydroperoxide compound structurally related to acetylsalicylic acid, 3-hydroperoxy-3-methylphthalide, inhibits both the first and second phases of adenosine diphosphate induced, biphasic, human platelet aggregation. This occurs over the same concentration range (0.05-0.5 mM) that acetylsalicylic acid inhibits second...

journal_title：Canadian journal of physiology and pharmacology

authors： Killackey JJ,Killackey BA,Cerskus I,Philp RB

更新日期：1984-03-01 00:00:00

abstract：:Aortas were removed from six mature lambs and four sheep and pressure fixed at 100 and 120 mmHg pressure (1 mmHg = 133.322 Pa), respectively, in 10% buffered formalin. The numbers of elastin layers were counted from cross sections at different distances down the aorta, from the distal arch to the iliac bifurcation, an...

journal_title：Canadian journal of physiology and pharmacology

authors： van Baardwijk C,Roach MR

更新日期：1983-02-01 00:00:00

abstract：:The effects of leukotrienes (LTs) have been widely studied in the isolated perfused mammalian heart; however, little is known about the effect or metabolism of LTs in the isolated bullfrog heart. Isolated perfused bullfrog hearts were administered randomized doses of LTC4, LTD4, or LTE4. The cardiac parameters of hear...

journal_title：Canadian journal of physiology and pharmacology

authors： Herman RP,Heller RS,Canavan CM,Herman CA

更新日期：1988-08-01 00:00:00

abstract：:Transactivation of epidermal growth factor receptor (EGFR) is a well-documented mechanism by which vasoactive peptides and H2O2 elicit their cellular responses. However, a role for the insulin-like growth factor type-1 receptor (IGF-1R) transactivation in mediating the effects of angiotensin II (Ang II) and H2O2 in va...

journal_title：Canadian journal of physiology and pharmacology

authors： Azar ZM,Mehdi MZ,Srivastava AK

更新日期：2007-01-01 00:00:00

abstract：:Since the discovery that apolipoprotein E, a cholesterol transport protein, is a major risk factor for Alzheimer's disease (AD) development, there has been a remarkable interest in understanding the many facets of the relationship between cholesterol and AD. Several lines of evidence have demonstrated the importance o...

journal_title：Canadian journal of physiology and pharmacology

authors： Posse de Chaves E

更新日期：2012-06-01 00:00:00

abstract：:This study examined whether the effects of FK506-binding protein dissociation from sarcoplasmic reticulum (SR) Ca(2+) release channels on excitation-contraction (EC) coupling changed when SR Ca(2+) reuptake and (or) the trans-sarcolemmal Ca(2+) extrusion were altered. The steady-state twitch Ca(2+) transient (CaT), ce...

journal_title：Canadian journal of physiology and pharmacology

authors： Yoshihara S,Satoh H,Saotome M,Katoh H,Terada H,Watanabe H,Hayashi H

更新日期：2005-04-01 00:00:00

abstract：:The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle. Ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Stammers AN,Susser SE,Hamm NC,Hlynsky MW,Kimber DE,Kehler DS,Duhamel TA

更新日期：2015-10-01 00:00:00

abstract：:Heme oxygenase (HO) has a central role in cellular antioxidant defences and vascular protection, and it may mediate pleiotropic actions of drugs used in cardiovascular therapy. We investigated whether long-term use of statins upregulates HO activity and increases carbon monoxide (CO) and bilirubin levels in vivo. Adul...

journal_title：Canadian journal of physiology and pharmacology

authors： Muchova L,Wong RJ,Hsu M,Morioka I,Vitek L,Zelenka J,Schröder H,Stevenson DK

更新日期：2007-08-01 00:00:00

abstract：:Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistance and metabolic disorders associated with cancer cachexia is not established. We investigated the MET effects, isolated or associated with INS, on INS resista...

journal_title：Canadian journal of physiology and pharmacology

authors： de Fatima Silva F,Ortiz-Silva M,Galia WBS,Cassolla P,da Silva FG,Graciano MFR,Carpinelli AR,de Souza HM

更新日期：2018-05-01 00:00:00

abstract：:Childhood cancer survivors can develop significant cardiac dysfunction in adulthood as a consequence of their cancer treatment. Studies have linked heart failure during pregnancy to childhood doxorubicin (DOX) exposure. We hypothesized that DOX injection would reduce cardiac function peripartum and that DOX-treated da...

journal_title：Canadian journal of physiology and pharmacology

authors： Calvé A,Noiles W,Sebag IA,Chalifour LE

更新日期：2012-11-01 00:00:00

abstract：:The endothelium, although only a single layer of cells lining the vascular and lymphatic systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 report by Robert Furchgott and John Zawadzki, there has been a phenomenal increase in our knowledge concerning the signalling molecules and path...

journal_title：Canadian journal of physiology and pharmacology

authors： Triggle CR,Samuel SM,Ravishankar S,Marei I,Arunachalam G,Ding H

更新日期：2012-06-01 00:00:00

abstract：:Calcineurin was isolated from bovine cerebrum extracts by sequential chromatography on Affi-Gel blue and calmodulin affinity columns. Calcineurin so isolated was approximately 90% pure and was composed of equimolar amounts of subunit A (Mr = 61 000-63 000) and subunit B (Mr = 15 000-17 000) when examined by sodium dod...

journal_title：Canadian journal of physiology and pharmacology

authors： Gupta RC,Khandelwal RL,Sulakhe PV

更新日期：1985-08-01 00:00:00

abstract：:Activators of the slow delayed rectifier K⁺ current (IKs) have been suggested as promising tools for suppressing ventricular arrhythmias due to prolongation of repolarization. Recently, L-364,373 (R-L3) was nominated to activate IKs in myocytes from several species; however, in some studies, it failed to activate IKs....

journal_title：Canadian journal of physiology and pharmacology

authors： Corici C,Kohajda Z,Kristóf A,Horváth A,Virág L,Szél T,Nagy N,Szakonyi Z,Fülöp F,Muntean DM,Varró A,Jost N

更新日期：2013-08-01 00:00:00

abstract：:The effects of neomycin sulfate were examined upon the discharge activity and electrical membrane properties of an isolated invertebrate sensory neuron, the crayfish stretch receptor neuron. Neomycin depressed cell discharge activity in a concentration-dependent manner over the concentration range of 0.01-1.0 mM. Sign...

journal_title：Canadian journal of physiology and pharmacology

authors： Nation PN,Roth SH

更新日期：1988-01-01 00:00:00

abstract：:An acidic proteinase was purified from human kidney cortex. The enzyme showed a molecular mass of 31 kDa by SDS-PAGE, 36 kDa by gel filtration, and isoelectric points of 5.2 and 6.1. The optimum pH for hydrolysis of bovine hemoglobin was about 3.5. Reverse-phase HPLC analysis of the incubation mixture of the enzyme wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Gomes RA,Juliano L,Chagas JR,Hial V

更新日期：1997-06-01 00:00:00

abstract：:Intra- and extra-cellular concentrations of calcium were measured in hippocampal neurons of areas CA1 and CA3 during 8 min ischaemia and short-term (up to 60 min) recovery. During an ischaemic insult, [Ca2+]i increased progressively and [Ca2+]e decreased. There were large interneuronal differences, although, in genera...

journal_title：Canadian journal of physiology and pharmacology

authors： Erecińska M,Silver IA

更新日期：1992-01-01 00:00:00

abstract：:This study investigated the glucose response to insulin infused after hepatic denervation. Hepatic denervations were performed on 13 anesthetized cats at different levels: (i) surgical hepatic anterior plexus denervation, (ii) chemical total hepatic denervation by painting phenol on the tissues around the portal vein,...

journal_title：Canadian journal of physiology and pharmacology

authors： Xie H,Tsybenko VA,Johnson MV,Lautt WW

更新日期：1993-02-01 00:00:00

abstract：:The effects of modulators of Ca-ATPase and alkaline phosphatase (AP) activity on placental calcium and phosphorus transfer were studied using the in situ perfused guinea pig placenta. The diuretics ethacrynic acid and furosemide had no significant effect on placental calcium and phosphorus transfer when injected into ...

journal_title：Canadian journal of physiology and pharmacology

authors： McKercher HG,Derewlany LO,Radde IC

更新日期：1983-11-01 00:00:00

abstract：:Opioid and N-methyl-d-aspartate (NMDA) receptors mediate different effects of fluoxetine. We investigated whether opioid and NMDA receptors are involved in the protective effect of fluoxetine against the behavioral despair induced by acute physical stress in male mice. We used the forced swimming test (FST), tail susp...

journal_title：Canadian journal of physiology and pharmacology

authors： Haj-Mirzaian A,Kordjazy N,Ostadhadi S,Amiri S,Haj-Mirzaian A,Dehpour A

更新日期：2016-06-01 00:00:00

abstract：:Obesity is associated with autonomic nervous system dysfunction. The aim of the study was to evaluate baroreflex sensitivity, an indicator of autonomic nervous function, in 20 obese children and adolescents in comparison with 20 age- and sex-matched nonobese subjects. All subjects were examined in the supine position ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lazarova Z,Tonhajzerova I,Trunkvalterova Z,Brozmanova A,Honzíková N,Javorka K,Baumert M,Javorka M

更新日期：2009-07-01 00:00:00

abstract：:Investigation of the relationship of diet to blood lipids and atherosclerosis has dominated the field of lipid nutritional biochemistry for the past 25 years. Although this subject has consumed considerable time, effort, and research funds, it has also proved beneficial to other areas of lipid biochemistry by attracti...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker BL

更新日期：1983-03-01 00:00:00

abstract：:In using pharmacologic stimuli, force-velocity (FV) curves are usually obtained by the method of quick release (QR) and redevelopment of shortening at peak tetanic tension; the advantage of the method being that the active state is at maximum. However, the QR may itself reduce the intensity of the active state and res...

journal_title：Canadian journal of physiology and pharmacology

authors： Stephens NL

更新日期：1985-01-01 00:00:00