Insulin resistance of glucose response produced by hepatic denervations.

abstract：:This report reviews the research and mentoring career of Richard B. Stein (1940-). In 1962, he completed a B.S. degree in physics at the Massachusetts Institute of Technology, USA, and thereafter an M.A. (1964), Ph.D. (1966), and postdoctoral training (1966-68) at the University of Oxford, UK. He subsequently assumed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuart DG

更新日期：2004-08-01 00:00:00

abstract：:Existing literature provides an equivocal picture of the behavior of mitochondrial synthesis during the time course of cardiac hypertrophy. Therefore, we examined the effect of cardiac hypertrophy on mitochondrial cytochrome c oxidase (CYTOX) activity, the content of CYTOX subunit VIc mRNA, and the expression of molec...

journal_title：Canadian journal of physiology and pharmacology

authors： Nishio ML,Ornatsky OI,Craig EE,Hood DA

更新日期：1995-05-01 00:00:00

abstract：:The release of endothelium-derived relaxing factor (EDRF), prostacyclin (PGI2), and endothelin-1 (ET-1) was measured from endothelial cells (EC) cultured from either bovine vena cava (BVCEC) or bovine aorta (BAEC). EDRF release was determined by using the superfusion bioassay technique, whereas ET-1 and PGI2 were meas...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Orleans-Juste P,Mitchell JA,Wood EG,Hecker M,Vane JR

更新日期：1992-05-01 00:00:00

abstract：:Intra- and extra-cellular concentrations of calcium were measured in hippocampal neurons of areas CA1 and CA3 during 8 min ischaemia and short-term (up to 60 min) recovery. During an ischaemic insult, [Ca2+]i increased progressively and [Ca2+]e decreased. There were large interneuronal differences, although, in genera...

journal_title：Canadian journal of physiology and pharmacology

authors： Erecińska M,Silver IA

更新日期：1992-01-01 00:00:00

abstract：:In the rat, prolonged enteral or parenteral alimentation with a high-carbohydrate diet results in hyperinsulinemia, which is substantially greater with the parenteral route. Supplementing the parenteral infusate with porcine gastric inhibitory polypeptide (GIP) to approximate plasma immunoreactive GIP levels achieved ...

journal_title：Canadian journal of physiology and pharmacology

authors： Baer AR,Dupré J

更新日期：1989-09-01 00:00:00

abstract：:The rat atrium contains a potent natriuretic factor which appears to inhibit the sodium reabsorption in the collecting tubules of the kidneys. We examined the effects of the injection of partially purified atrial natriuretic factor (ANF) and synthetic ANF (8-33) into rats with simultaneous infusions of dextrose or apr...

journal_title：Canadian journal of physiology and pharmacology

authors： Thibault G,Garcia R,Cantin M,Genest J

更新日期：1984-06-01 00:00:00

abstract：:The physiological action of alpha bungarotoxin in the central nervous system of the horseshoe crab Limulus polyphemus was investigated. Two types of effects were produced by the toxin. The predominant effect was an inhibition of spontaneous activity. However, in some instances alpha bungarotoxin caused a stimulation o...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomas W,Townsel JG

更新日期：1981-02-01 00:00:00

abstract：:In assessing the role that atrial natriuretic peptide (ANP) might have in the homeostasis of fluid volume and blood pressure, it is important to define the physiological and pathophysiological conditions that determine its release into the circulation. There is substantial evidence that ANP is released through atrial ...

journal_title：Canadian journal of physiology and pharmacology

authors： Rankin AJ

更新日期：1987-08-01 00:00:00

abstract：:Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2a subclass increased significantly when isolated P. senega saponins were used ...

journal_title：Canadian journal of physiology and pharmacology

authors： Katselis GS,Estrada A,Gorecki DK,Barl B

更新日期：2007-11-01 00:00:00

abstract：:Dissociated neuronal cultures have become a popular tool to address a number of questions in neurobiology. These culture systems may provide useful paradigms to approach problems related to in vivo neurotoxicity of xenobiotics. The clinical spectra of vinca neurotoxicity and alcohol teratogenesis is reviewed, and some...

journal_title：Canadian journal of physiology and pharmacology

authors： Riopelle RJ,Dow KE,Eisenhauer E

更新日期：1984-08-01 00:00:00

abstract：:The influence of external potassium Ko and tetraethylammonium on the cellular K content of hypoxic myocardium was investigated. Perfused rabbit hearts were submitted to 60 min hypoxia in medium containing 5 mM K throughout or either low (1.5 mM) or high (10 mM) K during the last 20 min of hypoxia. Paced electrical act...

journal_title：Canadian journal of physiology and pharmacology

authors： Leblanc N,Ruiz-Ceretti E,Chartier D

更新日期：1987-05-01 00:00:00

abstract：:Rats were treated daily with atropine (2.5 mg/kg), imipramine (5 mg/kg), viloxazine (5 mg/kg), or saline for 14 days. Thirty-six hours following the final injection the rats were anaesthetized with urethane and the sensitivity of neurones in the somatosensory cortex to iontophoretically applied acetylcholine (ACh) was...

journal_title：Canadian journal of physiology and pharmacology

authors： Jones RS

更新日期：1980-05-01 00:00:00

abstract：:Inactivation of endothelin B receptors (ETB), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration of endothelin-1 (ET-1), suggesting ETB plays an important role in clearance of this peptide. However, the cellular site of ETB-mediated clearance has not yet be...

journal_title：Canadian journal of physiology and pharmacology

authors： Kelland NF,Kuc RE,McLean DL,Azfer A,Bagnall AJ,Gray GA,Gulliver-Sloan FH,Maguire JJ,Davenport AP,Kotelevtsev YV,Webb DJ

更新日期：2010-06-01 00:00:00

abstract：:Glucagon causes marked elevations of glomerular filtration rate (GFR) in dogs when administered intravenously (i.v.) in small doses. The associated natriuresis is thought to be entirely due to increments in the filtered sodium load. In this study, renal denervation, thyroparathyroidectomy, and blockade of cholinergic,...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1975-02-01 00:00:00

abstract：:To clarify the beneficial effects of cilnidipine, an L- and N-type calcium channel blocker, which were clinically observed against diastolic dysfunction in hypertrophied hearts of hypertensive patients, we investigated the effects of cilnidipine on cardiac remodeling and enhanced gene expression in stroke-prone, spont...

journal_title：Canadian journal of physiology and pharmacology

authors： Takemori K,Ishida H,Dote K,Yamamoto K,Ito H

更新日期：2005-08-01 00:00:00

abstract：:In the mesenteric circulation of the rat a myogenic autoregulatory system operates at 0.1-0.15 Hz. Negative admittance phase in the region above 0.2 Hz suggested operation of an arterial baroreflex. The present study was designed to test this interpretation and to identify the neurotransmitter involved. In rats anesth...

journal_title：Canadian journal of physiology and pharmacology

authors： Abu-Amarah I,Cupples WA

更新日期：2000-01-01 00:00:00

abstract：:The validity of a Hodgkin-Huxley type voltage-dependent inactivation of slow inward Ca current (Isi) was tested in frog heart using a computer simulation. The time course of Isi was calculated during the development of a frog atrial action potential (AP). With a time constant of inactivation (tauf) of 55 ms at a membr...

journal_title：Canadian journal of physiology and pharmacology

authors： Fischmeister R,Horackova M

更新日期：1982-09-01 00:00:00

abstract：:Ah receptor in hepatic cytosols from adult cynomolgus monkeys (Macaca fasicularis) was identified and quantitated by its binding of the highly toxic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the carcinogens 3-methylcholanthrene, benzo[a]pyrene, and dibenz[a,h]anthracene. The concentration of Ah receptor ...

journal_title：Canadian journal of physiology and pharmacology

authors： Okey AB,Vella LM,Iverson F

更新日期：1984-10-01 00:00:00

abstract：:Electrical stimulation of the diencephalon and rostral mesencephalon produced a biphasic pressor response consisting of an initial sharp rise followed by a more prolonged elevation in blood pressure. Active sites from which comparable responses could be evoked were found in the ventral medial and lateral hypothalamus,...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier P

更新日期：1981-05-01 00:00:00

abstract：:The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle. Ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Stammers AN,Susser SE,Hamm NC,Hlynsky MW,Kimber DE,Kehler DS,Duhamel TA

更新日期：2015-10-01 00:00:00

abstract：:Beat-to-beat variability of cardiac action potential duration (short-term variability, SV) is a common feature of various cardiac preparations, including the human heart. Although it is believed to be one of the best arrhythmia predictors, the underlying mechanisms are not fully understood at present. The magnitude of...

journal_title：Canadian journal of physiology and pharmacology

authors： Nánási PP,Magyar J,Varró A,Ördög B

更新日期：2017-10-01 00:00:00

abstract：:Allicin, the active substance of garlic, exerts a broad spectrum of pharmacological activities and is considered to have potential therapeutic applications. The present study was designed to investigate the possible beneficial effects of allicin against oxidative stress, inflammation, and endothelial dysfunction in hy...

journal_title：Canadian journal of physiology and pharmacology

authors： El-Sheakh AR,Ghoneim HA,Suddek GM,Ammar ESM

更新日期：2016-02-01 00:00:00

abstract：:Changes in metabolic characteristics of the liver and jejunal epithelia as a result of feeding the beta-agonist albuterol to chickens for 3 and 6 weeks were studied. Feeding albuterol resulted in a change in weights of the liver and small intestines. Chickens fed albuterol for 6 weeks had greater levels of plasma none...

journal_title：Canadian journal of physiology and pharmacology

authors： Rompala RE,Darre MJ

更新日期：1989-05-01 00:00:00

abstract：:There are conflicting reports concerning the existence of severe hypermethioninemia in rats made diabetic with the pancreotoxin, streptozotocin. To determine whether this discrepancy is due to experimental differences in the severity of diabetes or the diet fed to the animals, streptozotocin-diabetic and control rats ...

journal_title：Canadian journal of physiology and pharmacology

authors： Dyer JR,Greenwood CE,McBurney MI

更新日期：1988-02-01 00:00:00

abstract：:Newborn hearts have restricted functional reserve and variable responsiveness to inotropes that could be partly due to differences in myocardial beta-adrenoceptors (beta-AR). To clarify this issue, this study documented ventricle-specific changes in myocardial beta-AR density and affinity during postnatal maturation. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wittnich C,Belanger MP,Bandali K

更新日期：2006-08-01 00:00:00

abstract：:The metabolic effect of intravenous infusion of ammonium chloride (60 mumol/(kg body weight.min] was compared in five sheep before and after adrenal denervation. Adrenal denervation completely abolished the hyperglycemic effect of ammonium chloride, diminished the rise of pyruvate and lactate concentration, and failed...

journal_title：Canadian journal of physiology and pharmacology

authors： Wiechetek M,Podgurniak P,Zabielski R,Podgurniak M

更新日期：1989-09-01 00:00:00

abstract：:The calyx-type synapse of the embryonic chick ciliary ganglion is reviewed as a model of transmitter release from a vertebrate presynaptic nerve terminal. This nerve terminal is extensive in area, enabling the penetration with microelectrodes and the application of patch-clamp techniques. In other respects the calyx s...

journal_title：Canadian journal of physiology and pharmacology

authors： Stanley EF

更新日期：1992-01-01 00:00:00

abstract：:Several laboratories have reported ligand binding studies using radioactive histamine H1 antagonists to label the H1 receptors in mammalian brain. We have extended these studies to a detailed examination of the binding of [3H]mepyramine to monkey brain and have shown that the distribution is similar to that in man, wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Bielkiewicz B,Cook DA

更新日期：1985-06-01 00:00:00

abstract：:The present research was to assess the relationship between ABCB1 (G2677T/A, C3435T) polymorphisms and lipid homeostasis as well as risk of liver injury induced by atorvastatin in in-patients from China. The lipid levels (total cholesterol, high-density lipoprotein, triglycerides) as well as metabolic enzymes of hepar...

journal_title：Canadian journal of physiology and pharmacology

authors： Qu KK,Zhang CN,Dong LX,Wang SS,Zhang ZD,Zhang L

更新日期：2020-01-01 00:00:00

abstract：:The effects of Bay K8644, a Ca2+ channel agonist, on the mechanical and electrical properties of frog skeletal muscle fibers were investigated. At relatively low concentrations, such as 10(-6) and 10(-5) M, Bay K8644 significantly potentiated the maximum amplitudes of twitch responses, and this effect was not reversed...

journal_title：Canadian journal of physiology and pharmacology

authors： Oz M,Frank GB

更新日期：1994-10-01 00:00:00