Abstract：
:Childhood cancer survivors can develop significant cardiac dysfunction in adulthood as a consequence of their cancer treatment. Studies have linked heart failure during pregnancy to childhood doxorubicin (DOX) exposure. We hypothesized that DOX injection would reduce cardiac function peripartum and that DOX-treated dams would show greater cardiac remodeling postweaning. Weanling female Sprague-Dawley rats were injected with phospate-buffered saline, DOX (3 mg/kg), or DOX plus the cardioprotectant dexrazoxane (DEX; 60 mg/kg) and followed for 2 pregnancies. DOX and DOX:DEX dams were fertile, but had fewer pups and more pup losses. Echocardiography, 1-day postpartum after each pregnancy, revealed greater increases in cardiac mass and eccentric hypertrophy in DOX-treated dams and early dilation in DOX:DEX dams. The expression of calcium homeostasis proteins can change after DOX treatment and cardiac remodeling. SERCA2a expression did not change. Reductions in phospholamban and phospho-serine 16-specific phospholamban expression in DOX dams were not relieved by DEX coinjection. DOX binds and inactivates calsequestrin 2 expression so increased calsequestrin 2 expression in DOX:DEX-treated dams suggests some DEX compensation. The eccentric hypertrophy and dilation development, despite compensatory changes in proteins controlling calcium cycling, suggest DOX damage with repeat pregnancy that was not alleviated fully by DEX.
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Calvé A,Noiles W,Sebag IA,Chalifour LEdoi
10.1139/y2012-126subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1527-34issue
11eissn
0008-4212issn
1205-7541journal_volume
90pub_type
杂志文章abstract：:Anti-mitogenic agents currently used to prevent restenosis in drug-eluting stents delay re-endothelialization. Delayed re-endothelialization is now considered as the main cause of late stent thrombosis with drug-eluting stents, which emphasizes the need for new treatments. We have shown that systemic insulin treatment...
journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y75-153
更新日期：1975-12-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章,评审
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更新日期：1987-08-01 00:00:00
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更新日期：2003-02-01 00:00:00
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更新日期：1990-09-01 00:00:00
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更新日期：2004-07-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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更新日期：1991-10-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1139/y94-207
更新日期：1994-11-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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更新日期：1997-07-01 00:00:00
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更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-07-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2007-02-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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doi：
更新日期：1997-01-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y88-058
更新日期：1988-04-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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doi：
更新日期：1997-12-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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更新日期：1990-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-03-01 00:00:00
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更新日期：1981-03-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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更新日期：1984-10-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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更新日期：1995-07-01 00:00:00
