Peptidergic inputs to sympathetic preganglionic neurons.

abstract：:Xerostomia is a self-conscious symptom. High-mobility group box 1 (HMGB1) promotes pro-inflammatory effects in many diseases. This study aimed to clarify the role of HMGB1 in Sjögren syndrome (SS)-triggered xerostomia. Nonobese diabetic (NOD)/Ltj mice were used to establish an SS-triggered xerostomia model. The result...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang D,Zhou M,Wang Y,Sun S

更新日期：2020-06-01 00:00:00

abstract：:Our objective was to investigate the effects of chronic excess iodine intake on thyroid functions and thyroid oxidative stress state in hypothyroid rats. Sixty rats were divided into euthyroid and hypothyroid (thiocyanate-induced) groups with or without administration of excess iodine (3000 or 6000 μg/L) for 8 weeks. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussein Ael-A,Abbas AM,El Wakil GA,Elsamanoudy AZ,El Aziz AA

更新日期：2012-05-01 00:00:00

abstract：:Space travelers experience anorexia and body weight loss in a microgravity environment, and microgravity-like situations cause changes in hypothalamic activity. Hypothalamic melanocortins play a critical role in the regulation of metabolism. Therefore, we hypothesized that microgravity affects metabolism through alter...

journal_title：Canadian journal of physiology and pharmacology

authors： Lew PS,Wong D,Yamaguchi T,Leckstrom A,Schwartz J,Dodd JG,Mizuno TM

更新日期：2009-10-01 00:00:00

abstract：:The effect of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on blood volume was studied in unanesthetized splenectomized and nonsplenectomized dogs. A significant increase in total blood volume essentially accounted for by a marked plasma volume expansion was found in both groups after 6-OHDA treatment (50 mg...

journal_title：Canadian journal of physiology and pharmacology

authors： Porlier GA,Nadeau RA,de Champlain J

更新日期：1977-06-01 00:00:00

abstract：:Aside from its established immunologic and hematologic functions, the spleen also plays an important role in cardiovascular regulation. This occurs through changes in intrasplenic microvascular tone, as well as through splenic neurohormonal modulation of the renal and mesenteric vascular beds. Splenic regulation of bl...

journal_title：Canadian journal of physiology and pharmacology

authors： Hamza SM,Kaufman S

更新日期：2009-01-01 00:00:00

abstract：:Diabetic patients have a higher incidence of cardiac arrhythmias, including ventricular fibrillation and sudden death, and show important alterations in the electrocardiogram, most of these related to the repolarization. In myocytes isolated from diabetic hearts, the transient outward K+ current (Ito) is the repolariz...

journal_title：Canadian journal of physiology and pharmacology

authors： Gallego M,Alday A,Urrutia J,Casis O

更新日期：2009-02-01 00:00:00

abstract：:Over the past few years, a number of cases of tendon injuries associated with statin therapy have been reported. In this study, we assessed whether statins can affect the extracellular matrix (ECM) of the deep digital flexor tendon (DDFT) and patellar tendon (PT). Wistar rats were assigned to groups treated with atorv...

journal_title：Canadian journal of physiology and pharmacology

authors： Oliveira LP,Vieira CP,Marques PP,Pimentel ER

更新日期：2017-04-01 00:00:00

abstract：:It has been proposed that the adult castrated male rat may be used as a model of human postmenopausal osteoporosis. If such a model is valid then the total body calcium of castrated rats should progressively decrease compared with normal rats. To search for this age-related difference, it will be necessary to use a me...

journal_title：Canadian journal of physiology and pharmacology

authors： Beachey DJ,Wickham M,Webber CE

更新日期：1985-10-01 00:00:00

abstract：:Premature weaning of rats to high carbohydrate diets causes a variety of short- and long-term changes in lipid metabolism, but the mechanisms involved are unclear. It is likely that interaction of diet with certain emerging hormonal control patterns during weaning might condition metabolic control and (or) subsequent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Angel JF,Back DW

更新日期：1985-05-01 00:00:00

abstract：:Alterations in electrical conductivity between smooth muscle cells (SMCs) can alter the spread and effectiveness of electromechanical SMC contraction. We attempted to determine whether alterations in pressure-dependent constriction (PDC) occurring in relation to stroke development within the middle cerebral arteries (...

journal_title：Canadian journal of physiology and pharmacology

authors： Smeda JS,King SR

更新日期：1998-02-01 00:00:00

abstract：:This study was designed to determine if tonic beta-adrenergic control of plasma renin activity (PRA) during dietary sodium restriction is due to stimulation of renal beta-adrenoceptors, extrarenal beta-adrenoceptors, or both. Experiments were performed in six conscious resting uninephrectomized dogs with chronically i...

journal_title：Canadian journal of physiology and pharmacology

authors： Blair ML,Gengo FM

更新日期：1995-08-01 00:00:00

abstract：:The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 or calcitriol), is known to inhibit the proliferation and invasiveness of many types of cancer cells, including breast, colon, pancreatic, prostate, and liver cancer cells. These findings support the use of 1α,25(OH)2D3 for the treatment of these t...

journal_title：Canadian journal of physiology and pharmacology

authors： Matsumoto Y,Kittaka A,Chen TC

更新日期：2015-05-01 00:00:00

abstract：:Altered sympathetic nervous activity has been linked to the development and persistence of obesity, partly relating to overfeeding. Binding of the selective, positron-emitting phosphodiesterase-4 (PDE4) inhibitor (R)-[11C]rolipram provides a direct index of the cAMP-hydrolyzing enzyme PDE4. This study examines progres...

journal_title：Canadian journal of physiology and pharmacology

authors： Greene M,Thackeray JT,Kenk M,Thorn SL,Bevilacqua L,Harper ME,Beanlands RS,Dasilva JN

更新日期：2009-03-01 00:00:00

abstract：:Strips of rabbit thoracic aorta precontracted with phenylephrine relaxed when exposed to selected synthetic peptides derived from the cell attachment domain of fibronectin. The relaxations elicited by both acetylcholine and the hexapeptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) were dependent on the presence of an intact en...

journal_title：Canadian journal of physiology and pharmacology

authors： Laplante C,St-Pierre S,Beaulieu AD,Marceau F

更新日期：1988-06-01 00:00:00

abstract：:Double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of K+, Na+, and Cl- (aKi, aNai, aCli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex. In sympathetic neurones, carbachol and gamma-aminobutyric acid (GABA) p...

journal_title：Canadian journal of physiology and pharmacology

authors： Grafe P,Ballanyi K

更新日期：1987-05-01 00:00:00

abstract：:Hormonal replacement therapy (HRT) has failed to provide a cardioprotective action in postmenopausal women, and thus alternative pharmacological approaches are required. The present study examined the therapeutic potential of the partial estrogen receptor agonist tamoxifen and the angiotensin II type-1 receptor antago...

journal_title：Canadian journal of physiology and pharmacology

authors： Pham-Dang ML,Clement R,Mercier I,Calderone A

更新日期：2003-09-01 00:00:00

abstract：:The adenylate cyclase activity induced by norepinephrine (10(-8)-10(-9) M) was studied in hypothalamic particulate fractions from female rats. The effect of estradiol on this activity was studied in rats that were ovariectomized in diestrus 1, injected with estradiol benzoate (50 micrograms/kg body weight), and killed...

journal_title：Canadian journal of physiology and pharmacology

authors： Zubin P,Defagot C

更新日期：1994-11-01 00:00:00

abstract：:The aim of this study was to determine if there was a synergistic or additive effect of a thiazolidinedione derivative (rosiglitazone (ROS)) and a vanadium compound (bis(ethylmaltolato)oxovanadium(IV) (BEOV)) on plasma glucose and insulin levels following chronic oral administration to Zucker diabetic fatty (ZDF) rats...

journal_title：Canadian journal of physiology and pharmacology

authors： Yuen VG,Bhanot S,Battell ML,Orvig C,McNeill JH

更新日期：2003-11-01 00:00:00

abstract：:The influence of a program of high intensity training and of a combined program of high intensity training and prolonged submaximal training on adaptations to the vastus lateralis muscle was investigated in two groups of elite athletes. The high intensity training (H) consisted of ice hockey practices and games over a...

journal_title：Canadian journal of physiology and pharmacology

authors： Daub WD,Green HJ,Houston ME,Thomson JA,Fraser IG,Ranney DA

更新日期：1982-05-01 00:00:00

abstract：:The present research was to assess the relationship between ABCB1 (G2677T/A, C3435T) polymorphisms and lipid homeostasis as well as risk of liver injury induced by atorvastatin in in-patients from China. The lipid levels (total cholesterol, high-density lipoprotein, triglycerides) as well as metabolic enzymes of hepar...

journal_title：Canadian journal of physiology and pharmacology

authors： Qu KK,Zhang CN,Dong LX,Wang SS,Zhang ZD,Zhang L

更新日期：2020-01-01 00:00:00

abstract：:The intraperitoneal administration of insulin has been recommended because it was found to effectively control the plasma glucose level. Several authors have suggested that intraperitoneal insulin administration may be more "physiological" and therefore preferable because the insulin is absorbed into the portal venous...

journal_title：Canadian journal of physiology and pharmacology

authors： Zingg W,Rappaport AM,Leibel BS

更新日期：1986-03-01 00:00:00

abstract：:Lesion to the posterior parietal cortex in monkeys and humans produces spatial deficits in movement and perception. In recording experiments from area 7a, a cortical subdivision in the posterior parietal cortex in monkeys, we have found neurons whose responses are a function of both the retinal location of visual stim...

journal_title：Canadian journal of physiology and pharmacology

authors： Andersen RA,Zipser D

更新日期：1988-04-01 00:00:00

abstract：:The reported efficiencies of drug encapsulation into liposomes range from less than 0.1% to more than 10% per micromole phospholipid, depending on the nature of the drug and of the liposome employed. We have sought to investigate some of the factors which control the efficiency of drug encapsulation. We have found tha...

journal_title：Canadian journal of physiology and pharmacology

authors： Stamp D,Juliano RL

更新日期：1979-05-01 00:00:00

abstract：:Changes in dietary omega-6/3 polyunsaturated fatty acids (PUFA) ratios affect anti- and proinflammatory equilibrium. As reperfused myocardial infarction (MI) is an inflammatory pathology that alters the cell integrity of the myocardium but also of other tissues, such as the hippocampus and amygdala, attenuation of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Rondeau I,Picard S,Bah TM,Roy L,Godbout R,Rousseau G

更新日期：2011-03-01 00:00:00

abstract：:We recently reported that the two-chain form of human high molecular weight kininogen (HKa) inhibits angiogenesis by inducing endothelial cell apoptosis (Zhang et al. 2000). This property appears to be primarily conferred by HKa domain 5 (HKa D5). In this manuscript, we further characterize the activity of these polyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang JC,Qi X,Juarez J,Plunkett M,Donaté F,Sakthivel R,Mazar AP,McCrae KR

更新日期：2002-02-01 00:00:00

abstract：:Hydroxytyrosol (HT), a phenolic compound in olive oil, exerts an anti-inflammatory effect in cardiovascular diseases. Recent studies found that autophagy was a therapeutic target of diseases. However, the effect of HT on autophagy in vascular adventitial fibroblasts (VAFs) remains unknown. Thus, in this study, we aime...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang W,Jing T,Yang X,He Y,Wang B,Xiao Y,Shang C,Zhang J,Lin R

更新日期：2018-01-01 00:00:00

abstract：:Torbafylline, a novel xanthine derivative, was given to rats by gavage (2 x 25 mg.kg-1.day-1, morning and evening) to study its effect upon fast muscles (tibialis anterior and extensor digitorum longus) made ischemic by unilateral ligation of the common iliac artery and subjected to two types of activity imposed by ch...

journal_title：Canadian journal of physiology and pharmacology

authors： Hudlicka O,Egginton S,Brown MD,Okyayuz-Baklouti I

更新日期：1994-07-01 00:00:00

abstract：:The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle. Ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Stammers AN,Susser SE,Hamm NC,Hlynsky MW,Kimber DE,Kehler DS,Duhamel TA

更新日期：2015-10-01 00:00:00

abstract：:The present paper reviews current knowledge of the development and plasticity of the inhibitory gamma-aminobutyric acid (GABA) containing circuitry of the cerebral neocortex, in particular, the rat somatosensory barrel field cortex. Recent studies reveal a delayed and protracted maturation of the inhibitory compared w...

journal_title：Canadian journal of physiology and pharmacology

authors： Micheva KD,Beaulieu C

更新日期：1997-05-01 00:00:00

abstract：:The beneficial hypolipidemic and antioxidant influences of the dietary spice compounds curcumin and capsaicin were evaluated. Curcumin, capsaicin, or their combination were included in the diet of high-(30%)-fat-fed rats for 8 weeks. Dietary high-fat-induced hypertriglyceridemia was countered by dietary curcumin, caps...

journal_title：Canadian journal of physiology and pharmacology

authors： Manjunatha H,Srinivasan K

更新日期：2007-06-01 00:00:00