Abstract：
:Pertussis toxin (PTX) is a heterohexameric protein, which is divided into subunits A and B. The A-subunit (protomer) possesses adenine diphosphate (ADP) ribosyltransferase activity, and the B-oligomer confers cell surface binding specificity on the toxin. By virtue of the ADP-ribosylation activity in the A-subunit, PTX has become a very useful pharmacological tool for the identification of inhibitory guanine nucleotide binding (Gi) proteins in the plasma membrane. However, the pharmacological properties of the PTX B-oligomer are largely unknown. In the course of identifying its binding site(s), PTX B-oligomer was recently found to elicit direct cellular responses in a variety of cell types. Several cell surface receptors with oligosaccharide side chains have been shown to be specifically bound by PTX B-oligomer. Moreover, occupation of these putative receptors by the B-oligomer alone can trigger phospholipase C and tyrosine kinase dependent signal transduction events. The impact of these B-oligomer-mediated rapid signaling responses on the subsequent ADP-ribosylation of Gi protein by the A-subunit remains to be determined. These recent findings caution investigators not to attribute inhibitory effects of PTX solely to ADP-ribosylation of Gi protein without first examining the cellular responses using PTX B-oligomer.
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Wong WS,Rosoff PMdoi
10.1139/cjpp-74-5-559subject
Has Abstractpub_date
1996-05-01 00:00:00pages
559-64issue
5eissn
0008-4212issn
1205-7541journal_volume
74pub_type
杂志文章abstract：:A survey of 'steady-state' serum levels of anticonvulsant drugs from 221 epileptic patients at a university hospital was conducted. Serum concentrations of phenobarbital, primidone, and diphenylhydantoin were determined by a gas chromatographic method. Sixty-five percent (130) of the patients receiving diphenylhydanto...
journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y76-119
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y92-120
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journal_title：Canadian journal of physiology and pharmacology
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y92-273
更新日期：1992-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/Y06-085
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y80-049
更新日期：1980-03-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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doi：10.1139/y92-025
更新日期：1992-02-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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doi：10.1139/y11-133
更新日期：2012-03-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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doi：10.1139/y94-115
更新日期：1994-07-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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doi：
更新日期：2000-08-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y86-019
更新日期：1986-02-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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doi：10.1139/y90-063
更新日期：1990-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1139/y09-127
更新日期：2010-04-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y89-195
更新日期：1989-10-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y02-019
更新日期：2002-03-01 00:00:00
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doi：10.1139/cjpp-77-1-75
更新日期：1999-01-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
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更新日期：1976-06-01 00:00:00
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更新日期：2003-04-01 00:00:00
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更新日期：1984-10-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y90-019
更新日期：1990-01-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/cjpp-76-4-407
更新日期：1998-04-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y84-047
更新日期：1984-03-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y76-087
更新日期：1976-08-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/y82-172
更新日期：1982-09-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
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journal_title：Canadian journal of physiology and pharmacology
pub_type： 杂志文章
doi：10.1139/cjpp-2018-0070
更新日期：2018-12-01 00:00:00
