Effects of acetylcholine, propranolol, and verapamil on sinus node refractoriness of the rabbit.

abstract：:The present study was undertaken to determine the beta-receptor subtype responsible for the enhanced anaphylactic histamine release from bovine leukocytes produced by isoprenaline. The selective beta 1 antagonist practolol competitively inhibited the enhancement of histamine release produced by isoprenaline. The selec...

journal_title：Canadian journal of physiology and pharmacology

authors： Perron R,Eyre P

更新日期：1982-07-01 00:00:00

abstract：:In anesthetized rats micropuncture and microcatheterization were used to collect tubular fluid from end proximal and distal tubules and from the outer medullary collecting duct. Urine was collected at the papilla tip. Samples were taken from the same sites before and after intravenous injection of atrial tissue extrac...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Cupples WA,de Bold AJ,Veress AT

更新日期：1982-09-01 00:00:00

abstract：:The enhancement of the response of an isolated strip of lactating mouse mammary gland to oxytocin, resulting from dilution of the Tyrode solution in which oxytocin is administered, is due to the effects of hypotonicity per se and not to changes in concentration of any of the ions in the bathing solution. Inhibition of...

journal_title：Canadian journal of physiology and pharmacology

authors： Ferrier BM

更新日期：1979-03-01 00:00:00

abstract：:The activation of mast cells (MC) due to immunological stimulation causes an immediate and dramatic inflammatory response. We review current evidence indicating that the membrane permeabilities for calcium, chloride, sodium, and potassium have a significant role in the activation of these cells, and in some cases, spe...

journal_title：Canadian journal of physiology and pharmacology

authors： Janiszewski J,Huizinga JD,Blennerhassett MG

更新日期：1992-01-01 00:00:00

abstract：:Liver blood flow and hepatic uptake of some indicator substances have been reported to fall with age in both rats and humans. We used an isolated liver system, which was perfused in one pass with hemoglobin free buffer, to investigate the effect of albumin concentration, buffer flow rate, and age upon hepatic clearanc...

journal_title：Canadian journal of physiology and pharmacology

authors： Montgomery PR,Sitar DS

更新日期：1988-05-01 00:00:00

abstract：:The combined and separate effects of exercise training and bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight postmenopausal women were randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength training (3 d/week) and r...

journal_title：Canadian journal of physiology and pharmacology

authors： Chilibeck PD,Davison KS,Whiting SJ,Suzuki Y,Janzen CL,Peloso P

更新日期：2002-10-01 00:00:00

abstract：:In older Aplysia, the central nervous system (CNS) (abdominal ganglion) exerts suppressive and facilitatory control over the peripheral nervous system (PNS) which initially mediates the gill withdrawal reflex and its subsequent habituation evoked by tactile stimulation of the siphon. In young animals, both the suppres...

journal_title：Canadian journal of physiology and pharmacology

authors： Lukowiak K

更新日期：1979-09-01 00:00:00

abstract：:The placental transfer of indomethacin was studied in the rabbit at 30 days of gestation and in the sheep between 120 and 135 days of gestation. Plasma concentrations of indomethacin reached a maximum of 13.7 +/- 1.6 and 10.9 +/- 1.5 microgram/mL in the doe and fetuses, respectively, at 1 h following a maternal subcut...

journal_title：Canadian journal of physiology and pharmacology

authors： Harris WH,Van Petten GR

更新日期：1981-04-01 00:00:00

abstract：:The change in plasma and blood cell pools of L-glutamine during a single pass through the kidney was studied in dogs and rats. It was shown that the glutamine content of blood cells does not change following one passage through the renal vascular bed in normal or acidotic dogs. Furthermore, an infusion of L-glutamine ...

journal_title：Canadian journal of physiology and pharmacology

authors： Vinay P,Khoury N,Soowamber M,Gougoux A

更新日期：1985-07-01 00:00:00

abstract：:Endothelin-1 has emerged as an important participant in the pathophysiology of a variety of cardiovascular diseases, where it may act on endocrine, paracrine and autocrine bases. Here we review its regulated biosynthesis, receptor-mediated signaling, and functional consequences in the heart, with particular emphasis o...

journal_title：Canadian journal of physiology and pharmacology

authors： Yang LL,Arab S,Liu P,Stewart DJ,Husain M

更新日期：2005-01-01 00:00:00

abstract：:Neuronal factors co-released with neurotransmitters may play an important role in synapse development and function. Calcitonin gene related peptide (CGRP) and adenosine 5'-triphosphate (ATP), two principal neuromodulators present in the motor nerve terminals, were studied for their roles and mechanisms during early de...

journal_title：Canadian journal of physiology and pharmacology

authors： Lu B,Fu WM

更新日期：1995-07-01 00:00:00

abstract：:The objective of this study was to explore the action of angiotensin II (AII) on cardiac contractility and cyclic AMP (cAMP) generation by forskolin and isoproterenol in the hypertrophic myocardium of the salt-sensitive Dahl rat. Inbred Dahl S and Dahl R rats that had been on a diet supplemented with 6% NaCl were stud...

journal_title：Canadian journal of physiology and pharmacology

authors： Sunga PS,Rabkin SW

更新日期：1994-06-01 00:00:00

abstract：:Female rats subjected to 48 h of water deprivation drank more than similarly deprived males. There was no sexual difference in the dipsogenic responses to intracellular dehydration produced by intravenous hypertonic NaCl but females drank considerably more than males in response to the extracellular stimuli of hyperon...

journal_title：Canadian journal of physiology and pharmacology

authors： Kaufman S

更新日期：1980-10-01 00:00:00

abstract：:Torbafylline, a novel xanthine derivative, was given to rats by gavage (2 x 25 mg.kg-1.day-1, morning and evening) to study its effect upon fast muscles (tibialis anterior and extensor digitorum longus) made ischemic by unilateral ligation of the common iliac artery and subjected to two types of activity imposed by ch...

journal_title：Canadian journal of physiology and pharmacology

authors： Hudlicka O,Egginton S,Brown MD,Okyayuz-Baklouti I

更新日期：1994-07-01 00:00:00

abstract：:Strips of rabbit thoracic aorta precontracted with phenylephrine relaxed when exposed to selected synthetic peptides derived from the cell attachment domain of fibronectin. The relaxations elicited by both acetylcholine and the hexapeptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) were dependent on the presence of an intact en...

journal_title：Canadian journal of physiology and pharmacology

authors： Laplante C,St-Pierre S,Beaulieu AD,Marceau F

更新日期：1988-06-01 00:00:00

abstract：:The role that thromboxane A2 plays in contractions induced by leukotriene D4 in guinea-pig isolated lung parenchyma was investigated under equilibrium conditions. Lung tissue generated thromboxane A2 and prostacyclin spontaneously as evidenced by the slow accumulation of their biologically inactive metabolites, thromb...

journal_title：Canadian journal of physiology and pharmacology

authors： Giembycz MA,Rodger IW

更新日期：1987-07-01 00:00:00

abstract：:It has been proposed that medullary washout secondary to increased blood flow will limit maximal urine osmolality and reabsorption of salt and water from the inner medullary collecting duct. We have tested this prediction. The function of the inner medullary collecting duct was examined by microcatheterization. Acetyl...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA,Sonnenberg H

更新日期：1987-12-01 00:00:00

abstract：:The development of cardiac hypertrophy was examined in rats given ethanol in a nutritionally adequate, liquid diet mixture, by intubation, in severely intoxicating doses at 8-h intervals for up to 96 h, alone or in combination with prazosin. Other groups of rats received isocalorically paired quantities of maltose-dex...

journal_title：Canadian journal of physiology and pharmacology

authors： Adams MA,Hirst M

更新日期：1989-03-01 00:00:00

abstract：:Ethanol (0.3 g/kg) was administered intravenously to adult, male rats at 3 h or at 1 and 3 h after gastric intubation of 7 mg/kg calcium carbimide (CC). For animals administered CC and two ethanol doses, blood ethanol concentration was similar for the two doses; however, blood acetaldehyde concentration was significan...

journal_title：Canadian journal of physiology and pharmacology

authors： Loomis CW,Brien JF

更新日期：1984-05-01 00:00:00

abstract：:The aim of the present investigation was to elucidate the pharmacological mechanism by which U44069, a stable PGH2 analogue, contracts the rat aorta. The results obtained demonstrate that while the contractile effect of potassium chloride is obliterated by removal of extracellular calcium, a substantial proportion of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Heaslip RJ,Rahwan RG

更新日期：1982-05-01 00:00:00

abstract：:A variety of porphyrinogenic xenobiotics cause mechanism-based inactivation of a number of rat hepatic cytochrome P450 isozymes. As a result, a mixture of four N-alkylprotoporphyin IX (N-alkylPP) regioisomers, with ferrochelatase-inhibitory properties, are formed. This study was designed to determine whether all four ...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamee JP,Kobus SM,Marks GS

更新日期：1996-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. In the clinic it is essential to limit the development of cognitive impairment after TBI. In this study, the effects of gallic acid (GA; 100 mg/kg, per oral, from 7 days before to 2 days after TBI induction) on neurologi...

journal_title：Canadian journal of physiology and pharmacology

authors： Sarkaki A,Farbood Y,Gharib-Naseri MK,Badavi M,Mansouri MT,Haghparast A,Mirshekar MA

更新日期：2015-08-01 00:00:00

abstract：:We have investigated the influence of dopaminergic agents on the expression of brain-derived neurotrophic factor (BDNF) gene in relation with lipid levels in chronic mild stress (CMS). Mice subjected to CMS were treated with simvastatin (10 mg/kg, per os (orally)) along with bromocriptine (2 mg/kg, intraperitoneally (...

journal_title：Canadian journal of physiology and pharmacology

authors： Rana DG,Patel AK,Joshi CG,Jhala MK,Goyal RK

更新日期：2014-12-01 00:00:00

abstract：:Taurine status and pregnancy outcome were assessed in rats fed low dietary taurine and varying doses of guanidinoethyl sulfonate (GES), a structural analogue of taurine. Female Sprague-Dawley rats (225-270 g) were mated overnight and assigned to one of four groups from day 0 to 20 of gestation. Taurine-deficient anima...

journal_title：Canadian journal of physiology and pharmacology

authors： Gottschall-Pass KT,Gorecki DK,Paterson PG

更新日期：1995-08-01 00:00:00

abstract：:Patients with Crohn's disease (CD) have higher risk for osteoporosis following decreased level of osteocalcin. We hypothesize that active inflammation following Mycobacterium avium subsp. paratuberculosis (MAP) infection results in elevation of undercarboxylated osteocalcin (ucOC) and downregulation of active osteocal...

journal_title：Canadian journal of physiology and pharmacology

authors： Naser A,Qasem A,Naser SA

更新日期：2018-07-01 00:00:00

abstract：:Exercise is a powerful therapy for preventing the onset of and slowing the progression of cardiovascular disease. Increased shear stress during exercise improves vascular homeostasis by both decreasing reactive oxygen species and increasing nitric oxide bioavailability in the endothelium. While these observations are ...

journal_title：Canadian journal of physiology and pharmacology

authors： Durand MJ,Gutterman DD

更新日期：2014-07-01 00:00:00

abstract：:The effects of oxytocin (OT) on holding current were studied in uterine smooth muscle cells freshly isolated from the longitudinal layer of 18-20 day pregnant rats, using the nystatin method of whole-cell voltage clamp. As we previously reported, the voltage-dependent Ca2+ current (L type) was partially inhibited by O...

journal_title：Canadian journal of physiology and pharmacology

authors： Shimamura K,Kusaka M,Sperelakis N

更新日期：1994-07-01 00:00:00

abstract：:The purpose of this article is to review the current state of knowledge of ethanol neurobehavioural teratogenesis and its postulated mechanisms. The review comprises an examination of ethanol teratogenesis in the human, including the fetal alcohol syndrome, and in experimental animals. Several current proposed mechani...

journal_title：Canadian journal of physiology and pharmacology

authors： Reynolds JD,Brien JF

更新日期：1995-09-01 00:00:00

abstract：:The inhibition of hepatic microsomal aryl hydrocarbon hydroxylase (AHH) activity by SKF 525-A in vitro was studied in hepatic microsomes from rats of varying age, sex hormone status, and drug treatment. The concentration of SKF 525-A required to produce a 50% inhibition of AHH activity, the IC50, was determined for th...

journal_title：Canadian journal of physiology and pharmacology

authors： Gontovnick LS,Bellward GD

更新日期：1982-08-01 00:00:00

abstract：:Recent studies demonstrate the critical role of the extracellular matrix in the organization of parenchymal cells in the heart. Thus, an understanding of the modes of regulation of matrix production by cardiac myofibroblasts is essential. Transforming growth factor beta (TGF-beta) signaling is transduced through the c...

journal_title：Canadian journal of physiology and pharmacology

authors： Cunnington RH,Nazari M,Dixon IM

更新日期：2009-10-01 00:00:00