Synthetic nitrovasodilators are effective, in vitro, in relaxing penile tissue from impotent men: the findings and their implications.

abstract：:The numbers and sizes of nerve fibres to the dorsal neck muscles, splenius, complexus and biventer cervicis have been examined in the cat. The total number of fibres is unusually high as is the content of sensory fibres (estimated as the loss of fibres after ganglionectomy). The fibre spectra of these sensory nerves h...

journal_title：Canadian journal of physiology and pharmacology

authors： Richmond FJ,Anstee GC,Sherwin EA,Abrahams VC

更新日期：1976-06-01 00:00:00

abstract：:The sodium-hydrogen exchanger (NHE) helps the cell to recover from intracellular acidosis. In this study, we have investigated the effect of HOE 642 (a specific NHE1 blocker) on papillary muscles from rats and guinea pigs during transient acidosis and PKC activation by recording developed force (DF), action potential ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sundset R,Bertelsen G,Ytrehus K

更新日期：2003-10-01 00:00:00

abstract：:Our objective was to determine the effects of a clenbuterol (CB) treatment orally administered (2 mg per kg) to rats submitted to 14 days of hindlimb unloading (HU). The morphological and the contractile properties as well as the myosin heavy chain isoforms contained in each fiber type were determined in whole soleus ...

journal_title：Canadian journal of physiology and pharmacology

authors： Picquet F,De-Doncker L,Falempin M

更新日期：2004-05-01 00:00:00

abstract：:Input to the nucleus medianus of the preoptic region has been suggested to be involved in both the drinking and pressor responses elicited by the central administration of angiotensin II. Evidence in support of this suggestion has been gained principally from electrical lesion experiments. This lesion procedure does n...

journal_title：Canadian journal of physiology and pharmacology

authors： Jones DL

更新日期：1988-08-01 00:00:00

abstract：:The experiment examined biological responses produced by combined sequential exposure to low-level tritium contamination, followed by challenging irradiation with fast neutrons. Modifications of endogenous antioxidant potential of different organs in rats were discussed in relation to tissue radiosensitivity. Rats pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Petcu I,Moisol N,Savu D,Constantinescu B

更新日期：2002-07-01 00:00:00

abstract：:It has been proposed that medullary washout secondary to increased blood flow will limit maximal urine osmolality and reabsorption of salt and water from the inner medullary collecting duct. We have tested this prediction. The function of the inner medullary collecting duct was examined by microcatheterization. Acetyl...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA,Sonnenberg H

更新日期：1987-12-01 00:00:00

abstract：:Infusion of glucose alone or glucose with insulin in cats subjected to acute myocardial ischemia did not alter the hemodynamic response of the cats to coronary artery ligation. Furthermore, determination of myocardial creatine phosphokinase (CPK) (ATP:creatine N-phosphotransferase, EC 2.7.3.2) activities failed to rev...

journal_title：Canadian journal of physiology and pharmacology

authors： Spath JA,Ogletree ML,Lefer AM

更新日期：1976-08-01 00:00:00

abstract：:A new antagonist of the vasoconstrictor eicosanoids, L-640,035, was studied in a standardized model of myocardial ischemia (MI) in anesthetized cats. This eicosanoid antagonist was not found to exert any overt hemodynamic action in cats subjected to a sham myocardial ischemia protocol. However, the antagonist markedly...

journal_title：Canadian journal of physiology and pharmacology

authors： Lefer AM,Burke SE,Lepran I

更新日期：1984-12-01 00:00:00

abstract：:The aim of this study was to explore the possibility of identifying clusters of children's games based on estimated energy expenditures and (or) intensity when performed in a guided active play format. The study also investigated whether the identified active play game clusters were repeatable when the games were perf...

journal_title：Canadian journal of physiology and pharmacology

authors： Belcastro AN,Morrison KS,Hicks E,Matta H

更新日期：2012-09-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of pomegranate (Punica granatum) juice (PGJ) on oxidative damages in liver tissue and erythrocytes of rats intoxicated by sodium fluoride (NaF). Rats were randomly divided into two groups: group I received standard diet and group II received orally ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouasla A,Bouasla I,Boumendjel A,Abdennour C,El Feki A,Messarah M

更新日期：2016-07-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs), including endothelin receptor A (ETA) and B (ETB), may form dimers or higher-order oligomers that profoundly influence signaling. Here we examined a PDZ finger motif within the C-terminus of ETA and its role in heterodimerization with ETB, and in homodimerization with itself, when ...

journal_title：Canadian journal of physiology and pharmacology

authors： Evans NJ,Walker JW

更新日期：2008-08-01 00:00:00

abstract：:The objective of this study was to investigate under controlled conditions the effects of fentanyl on the rat locus coeruleus catechol oxidation current. Using differential normal pulse voltammetry combined with electrochemically treated carbon fiber electrodes to measure the catechol oxidation current, catecholamine ...

journal_title：Canadian journal of physiology and pharmacology

authors： Milne B,Quintin L,Gillon JY,Pujol JF

更新日期：1989-05-01 00:00:00

abstract：:We examined whether there was a threshold for change in fetal arterial PO2 to elicit alterations in plasma adrenocorticotropic hormone, arginine vasopressin, or cortisol, or to affect the incidence of fetal breathing movements or eye movements and we determined whether such a threshold changed with gestational age. Fe...

journal_title：Canadian journal of physiology and pharmacology

authors： Akagi K,Challis JR

更新日期：1990-05-01 00:00:00

abstract：:When carbon tetrachloride (CCl4) was administered to rats, a localized region of hepatic edema could be detected within 1 h by in vivo proton magnetic resonance imaging. However, if rats were pretreated with gadolinium chloride (GdCl3), an inhibitor of Kupffer cell function, the CCl4-induced edema was greatly decrease...

journal_title：Canadian journal of physiology and pharmacology

authors： Towner RA,Reinke LA,Janzen EG,Yamashiro S

更新日期：1994-05-01 00:00:00

abstract：:It has been reported that the intraportal infusion of glutamine in Munich-Wistar rats will cause depression of renal perfusion and the urinary excretion of salt and water. We have attempted to reproduce these findings in anaesthetized dogs. L-Glutamine was infused at doses between 120 and 150 mumol/min into the portal...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1992-10-01 00:00:00

abstract：:Visual acuity was measured behaviorally in various groups of cats by using a two-choice discrimination procedure. Cats in group 1 were rendered strabismic soon after birth by sectioning the tendon of the lateral rectus muscle (unilateral esotropia); at adulthood, their visual acuity (VA) was evaluated, after which the...

journal_title：Canadian journal of physiology and pharmacology

authors： Ptito M,Bouchard P,Lepore F,Quessy S,Di Stefano M,Guillemot JP

更新日期：1995-09-01 00:00:00

abstract：:Phosphofructokinase activity was measured in the sciatic nerve of streptozotocin-induced diabetic and nondiabetic rats. Average steady-state phosphofructokinase activity was obtained from three consecutive segments of the mid-femoral region in the left sciatic nerve in both diabetic (4 and 24 weeks) and nondiabetic, a...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilgour RD,Gardiner K,Gardiner PF

更新日期：1990-10-01 00:00:00

abstract：:The level of circulating triacylglycerols is determined by the balance between their delivery into the plasma and their removal from it. Plasma triacylglycerols are derived either from dietary fat as chylomicrons or from endogenous hepatic synthesis as very low density lipoproteins. Their removal occurs through the ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Herzberg GR

更新日期：1991-11-01 00:00:00

abstract：:The cannabinoid system has been suspected to play a role in the mechanisms of action of dipyrone and paracetamol. Our purpose was to measure the local endocannabinoid and N-acylethanolamide levels in the brain and spinal cord of rats following dipyrone and paracetamol administration. Nociception was assessed 1, 5, and...

journal_title：Canadian journal of physiology and pharmacology

authors： Topuz RD,Gunduz O,Karadag CH,Dokmeci D,Ulugol A

更新日期：2019-11-01 00:00:00

abstract：:Heme plays a critical role in blood pressure regulation because it is required by a number of enzymes that synthesize vascular modulators, including nitric oxide (NO), carbon monoxide (CO), guanosine 3',5'-cyclic monophosphate (cGMP), endothelium-derived hyperpolarizing factor (EDHF), and prostacyclin. The goal of thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Soong J,Adams MA,Nakatsu K

更新日期：2008-09-01 00:00:00

abstract：:Alterations in electrical conductivity between smooth muscle cells (SMCs) can alter the spread and effectiveness of electromechanical SMC contraction. We attempted to determine whether alterations in pressure-dependent constriction (PDC) occurring in relation to stroke development within the middle cerebral arteries (...

journal_title：Canadian journal of physiology and pharmacology

authors： Smeda JS,King SR

更新日期：1998-02-01 00:00:00

abstract：:The our objective was to investigate the adaptations induced by a low-protein, high-carbohydrate (LPHC) diet in growing rats, which by comparison with the rats fed a control (C) diet at displayed lower fasting glycemia and similar fasting insulinemia, despite impairment in insulin signaling in adipose tissues. In the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Pereira MP,Buzelle SL,Batistela E,Doneda DL,França SA,Santos MP,Andrade CM,Garófalo MA,Kettelhut Ido C,Navegantes LC,Chaves VE,Bertolini GL,Kawashita NH

更新日期：2014-06-01 00:00:00

abstract：:Lumbar spine and mid-radius bone mineral density was measured repeatedly in 48 postmenopausal women who completed 7 years of taking either a 500 mg x day(-1) calcium supplement (n = 22) or calcium supplementation with hormone replacement therapy. The hormone replacement was either a low dose (n = 15) or a moderate dos...

journal_title：Canadian journal of physiology and pharmacology

authors： Blake JM,Ryan ED,Beaumont LF,Webber CE

更新日期：1999-07-01 00:00:00

abstract：:This study has investigated the oral activity, following intragastric administration, of three potent and long-acting peptide-based bradykinin antagonists, HOE-140, B9430, and CP-0597, in the anesthetized rat, using bradykinin-induced hypotension. Two of the three bradykinin antagonists, B9430 and HOE-140, but not CP-...

journal_title：Canadian journal of physiology and pharmacology

authors： Whalley ET,Hanson WL,Stewart JM,Gera L

更新日期：1997-06-01 00:00:00

abstract：:It was recently shown that a peptide (hypertensive factor, HF) isolated from erythrocyte hemolysates from spontaneously hypertensive rats induced a prolonged elevation of blood pressure in normotensive rats. In addition, the peptide produced a marked stimulation of the in vitro uptake of lanthanum-resistant calcium by...

journal_title：Canadian journal of physiology and pharmacology

authors： Wright GL,Huang BS,Johnson PJ,McCumbee WD

更新日期：1988-10-01 00:00:00

abstract：:Childhood cancer survivors can develop significant cardiac dysfunction in adulthood as a consequence of their cancer treatment. Studies have linked heart failure during pregnancy to childhood doxorubicin (DOX) exposure. We hypothesized that DOX injection would reduce cardiac function peripartum and that DOX-treated da...

journal_title：Canadian journal of physiology and pharmacology

authors： Calvé A,Noiles W,Sebag IA,Chalifour LE

更新日期：2012-11-01 00:00:00

abstract：:The contribution of metabolic control to in vivo myocardial contractile function in response to beta 1-adrenergic stimulation was determined in the spontaneously diabetic BB Wor rat. The study involved a group of insulin-dependent BB Wor rats showing marked variations in metabolic control, assessed by the level of gly...

journal_title：Canadian journal of physiology and pharmacology

authors： Broderick TL,Kopp SJ,Daar JT,Romano FD,Paulson DJ

更新日期：1994-07-01 00:00:00

abstract：:Small, sinusoidal length changes were superimposed on isometric contractions of fast- and slow-twitch mouse muscles, which were stimulated maximally via their nerves. Stiffness increased with increasing frequency of sinusoidal stimulation, but the relative time course of force and stiffness changes during twitch, teta...

journal_title：Canadian journal of physiology and pharmacology

authors： Stein RB,Gordon T

更新日期：1986-09-01 00:00:00

abstract：:Connexin43 has been recognized as forming gap junctions in Leydig cells. However, previous work has shown that mouse Leydig cells lacking this connexin do not suffer any limitation of their ability to produce testosterone when stimulated with luteinizing hormone. The objective of this study was to identify additional ...

journal_title：Canadian journal of physiology and pharmacology

authors： Li D,Sekhon P,Barr KJ,Márquez-Rosado L,Lampe PD,Kidder GM

更新日期：2013-02-01 00:00:00

abstract：:Two natriuretic peptides, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), are found principally in the heart. In preliminary experiments with mouse kidney cells or slices, we found mouse BNP1-45 much more potent than ANP1-28 in causing elevations of cGMP (>50-fold). The guanylyl cyclase-A (GC-A)...

journal_title：Canadian journal of physiology and pharmacology

authors： Kishimoto I,Hamra FK,Garbers DL

更新日期：2001-08-01 00:00:00