Endothelin A and B receptor antagonist bosentan reduces postischemic myocardial injury in the rat: critical timing of administration.

abstract：:The influences of hypertension and hypothyroidism on diabetic cardiomyopathy are not clear. We studied this problem further by characterizing the effects of chronic triiodothyronine (T3) treatment on cardiac performance of diabetic renovascular hypertensive (RVH) rats. Hypertension was effected by clipping the left re...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodgers RL,Davidoff AJ,Mariani MJ

更新日期：1991-03-01 00:00:00

abstract：:The effect of a novel antianginal agent, molsidomine (N-ethoxycarbonyl-3-morpholinosydnonimine) (SIN-10) and its metabolites, 3-morpholinosydnonimine (SIN-1) and N-nitroso-N-morpholinoaminoacetonitrile (SIN-1A) on isolated dog blood vessels were investigated. SIN-1 and SIN-1A elicited a concentration-dependent relaxat...

journal_title：Canadian journal of physiology and pharmacology

authors： Muramatsu I,Fujii K,Sakakibara Y,Fujiwara M

更新日期：1983-09-01 00:00:00

abstract：:The importance of the sympathetic innervation in the regulation of 5'-deiodinase activity in the interscapular brown adipose tissue (BAT) of the Djungarian hamster was studied. Interscapular BAT of Djungarian hamsters was either unilaterally or bilaterally denervated, and thereafter the animals were maintained at ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Meywirth A,Redlin U,Steinlechner S,Heldmaier G,Reiter RJ

更新日期：1991-12-01 00:00:00

abstract：:In the literature there appears to be variability in reported levels of certain hormones during haemorrhage, specifically adrenocorticotrophic hormone (ACTH) and β-endorphin. It is possible that this variability may be due to the choice of anaesthetic. Therefore, the effect of 3 common research-only anaesthetic agents...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruane-O'Hora T,Hall WJ,Markos F

更新日期：2011-07-01 00:00:00

abstract：:Spironolactone at 10 mg per kilogram per day was given to control and 'one-kidney-one-clip' hypertensive dogs for 6--7 weeks. Compared with untreated animals the treated animals had a lower arterial water content, a higher arterial, myocardial, and skeletal muscle sodium content, and variable changes in tissue potassi...

journal_title：Canadian journal of physiology and pharmacology

authors： Constantopoulos G,Gutkowska J,Genest J

更新日期：1979-06-01 00:00:00

abstract：:This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the norepinephrine, epinephrine, mRNA, and protein levels of tyrosine hy...

journal_title：Canadian journal of physiology and pharmacology

authors： Stefanovic B,Spasojevic N,Jovanovic P,Dronjak S

更新日期：2019-07-01 00:00:00

abstract：:The mesangial cell is a contractile secreting cell found in a key position in the renal glomerulus. Several kidney and systemic diseases are associated with dysfunctions of the mesangial cells. We compared the effect of bradykinin (BK; B2 agonist) and des-Arg9-bradykinin (DBK; B1 agonist) on intracellular calcium mobi...

journal_title：Canadian journal of physiology and pharmacology

authors： Girolami JP,Ouardani M,Bascands JL,Pécher C,Bompart G,Leung-Tack J

更新日期：1995-07-01 00:00:00

abstract：:Negative chronotropic effects of beta-adrenoceptor (betaAR) antagonists on right atria from reserpine-treated rats and mice were determined as a test of their inverse agonist activities. BetaAR antagonist ICI-118,551 and nonselective betaAR antagonists alprenolol, propranolol, and timolol produced negative chronotropi...

journal_title：Canadian journal of physiology and pharmacology

authors： Varma DR

更新日期：1999-12-01 00:00:00

abstract：:The vasoconstrictors norepinephrine (NE) and angiotensin II (AII) mediate increases in oxygen uptake (VO2) by the constant flow perfused rat hind limb that are inhibited by quinidine-like membrane-stabilizing effects (involving the interruption of action potential) of (+/-)-propranolol with little effect on vasoconstr...

journal_title：Canadian journal of physiology and pharmacology

authors： Tong AC,Rattigan S,Clark MG

更新日期：1998-02-01 00:00:00

abstract：:The effects of clofibrate administration (200 mg/kg, po) on somatic growth, plasma levels of lipids, tryptophan, growth hormone (GH), and prolactin (PRL), as well as on brain concentrations of tryptophan and 5-hydroxytryptamine (5-HT) were studied in prepubertal male rats. The drug did not significantly alter ponderal...

journal_title：Canadian journal of physiology and pharmacology

authors： Tache Y,Letarte J,Collu R

更新日期：1978-04-01 00:00:00

abstract：:Between 1 and 7 days of life, the newborn rabbit heart shifts from predominantly using carbohydrates to predominantly using fatty acids as an energy substrate. We therefore used isolated working hearts from 1- or 7-day-old rabbits to determine the effects of fatty acids on myocardial glucose use and the ability of hea...

journal_title：Canadian journal of physiology and pharmacology

authors： Lopaschuk GD,Spafford MA

更新日期：1992-10-01 00:00:00

abstract：:Previous studies have demonstrated that abdominal irradiation alters intestinal uptake of nutrients. The purpose of this study was to determine the effect of an orally administered synthetic prostaglandin E2, enprostil, given on three occasions shortly prior to a single exposure to 600 cGy external abdominal irradiati...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson AB,Keelan M,Clandinin MT,Tavernini M,Lam T,Walker K,Cheeseman CI

更新日期：1989-10-01 00:00:00

abstract：:The endothelin receptors in rabbit isolated rings of saphenous artery and saphenous vein have been characterized using endothelin-1, endothelin-2, endothelin-3, sarafotoxin S6c, and BQ123. Although artery rings were more sensitive than those from vein to the contractile action of phenylephrine, endothelin-1 was about ...

journal_title：Canadian journal of physiology and pharmacology

authors： Auguet M,Delaflotte S,Chabrier PE,Braquet P

更新日期：1993-10-01 00:00:00

abstract：:The isometric potentiation associated with myosin phosphorylation is force dependent. The purpose of this study was to assess the influence of a pre-existing period of isometric force on the concentric force potentiation displayed by mouse muscles with and without the ability to phosphorylate myosin. We tested isometr...

journal_title：Canadian journal of physiology and pharmacology

authors： Gittings W,Aggarwal H,Stull JT,Vandenboom R

更新日期：2015-01-01 00:00:00

abstract：:We have measured the responses to endurance exercise training on body composition and glucose regulation, as well as cardiovascular and liver structure and function in rats fed a high carbohydrate and high fat (HCHF) diet as a model of human metabolic syndrome. Male Wistar rats (9-10 weeks old) were randomly allocated...

journal_title：Canadian journal of physiology and pharmacology

authors： Cameron I,Alam MA,Wang J,Brown L

更新日期：2012-11-01 00:00:00

abstract：:We have recently shown that vasoactive peptides such as angiotensin II (Ang II) and endothelin-1 (ET-1) increased the expression of G(i) proteins and proliferation of A10 vascular smooth muscle cells (VSMC) through MAP kinase / PI3 kinase pathways. The present study was undertaken to examine the implication of growth ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gomez Sandoval YH,Lévesque LO,Anand-Srivastava MB

更新日期：2009-12-01 00:00:00

abstract：:In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MT...

journal_title：Canadian journal of physiology and pharmacology

authors： Makary S,Abdo M,Fekry E

更新日期：2018-04-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and CNTF analogs were reported to have hepatoprotective effect and ameliorate hepatic steatosis in db/db or high-fat-diet-fed mice. Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate h...

journal_title：Canadian journal of physiology and pharmacology

authors： Cui MX,Jiang JF,Min GN,Han W,Wu YJ

更新日期：2017-05-01 00:00:00

abstract：:Sequestration of nitric oxide (NO) by subcellular fractions isolated from bovine pulmonary arterial medial layer (BPA) and rabbit platelets (RP) was studied utilizing a novel chemiluminescence--headspace gas technique. Sequestration in all fractions was similarly rapid (5 min) and remained constant for at least 30 min...

journal_title：Canadian journal of physiology and pharmacology

authors： Liu Z,Nakatsu K,Brien JF,Beaton ED,Marks GS,Maurice DH

更新日期：1993-12-01 00:00:00

abstract：:Sulforaphane, a natural isothiocyanate, demonstrates cardioprotection associated with its capacity to stimulate endogenous antioxidants and to inhibit inflammation. The aim of this study was to investigate whether sulforaphane is capable of attenuating oxidative stress and inflammatory responses through the TLR4/MyD88...

journal_title：Canadian journal of physiology and pharmacology

authors： Bonetto JH,Fernandes RO,Seolin BG,Müller DD,Teixeira RB,Araujo AS,Vassallo D,Schenkel PC,Belló-Klein A

更新日期：2016-05-01 00:00:00

abstract：:Heme oxygenase (HO) has a central role in cellular antioxidant defences and vascular protection, and it may mediate pleiotropic actions of drugs used in cardiovascular therapy. We investigated whether long-term use of statins upregulates HO activity and increases carbon monoxide (CO) and bilirubin levels in vivo. Adul...

journal_title：Canadian journal of physiology and pharmacology

authors： Muchova L,Wong RJ,Hsu M,Morioka I,Vitek L,Zelenka J,Schröder H,Stevenson DK

更新日期：2007-08-01 00:00:00

abstract：:Female rats subjected to 48 h of water deprivation drank more than similarly deprived males. There was no sexual difference in the dipsogenic responses to intracellular dehydration produced by intravenous hypertonic NaCl but females drank considerably more than males in response to the extracellular stimuli of hyperon...

journal_title：Canadian journal of physiology and pharmacology

authors： Kaufman S

更新日期：1980-10-01 00:00:00

abstract：:We studied the role of enteric opioid neurons in the spontaneous motility of the longitudinal muscle in the isolated puppy ileum. Regular fluctuations in tone that rose above and returned to the basal level occurred at an interval of 4.7 +/- 0.3 min. Naloxone (10(-8) and 10(-7) M) reduced the spontaneous tonic contrac...

journal_title：Canadian journal of physiology and pharmacology

authors： Neya T,Mizutani M,Nakayama S

更新日期：1987-09-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs are widely used for the treatment of osteoarthritis and rheumatoid arthritis, but their ability to cause gastrointestinal bleeding is a significant limitation to this use. A better understanding of the pathogenesis of gastric and intestinal injury induced by these agents will permi...

journal_title：Canadian journal of physiology and pharmacology

authors： Wallace JL

更新日期：1994-12-01 00:00:00

abstract：:We present comparative experimental evidence for the induction of synaptic potentiation and depression in organotypic cultures of hippocampus and in visual cortex in vitro and in vivo. The effects of associative pairings on the efficacy of synaptic transmission are analyzed as a function of the temporal delay between ...

journal_title：Canadian journal of physiology and pharmacology

authors： Debanne D,Shulz DE,Frégnac Y

更新日期：1995-09-01 00:00:00

abstract：:Complexes of vanadyl(IV) with 4 monosaccharides and 5 disaccharides were tested in 2 osteoblast-like cell lines (MC3T3E1 and UMR106). Many complexes caused stimulation of UMR106 proliferation (120% basal) in the range of 2.5 to 25 micromol/L. In the nontransformed osteoblasts, some vanadyl-saccharide complexes stimula...

journal_title：Canadian journal of physiology and pharmacology

authors： Barrio DA,Cattáneo ER,Apezteguía MC,Etcheverry SB

更新日期：2006-07-01 00:00:00

abstract：:The effects of modulators of Ca-ATPase and alkaline phosphatase (AP) activity on placental calcium and phosphorus transfer were studied using the in situ perfused guinea pig placenta. The diuretics ethacrynic acid and furosemide had no significant effect on placental calcium and phosphorus transfer when injected into ...

journal_title：Canadian journal of physiology and pharmacology

authors： McKercher HG,Derewlany LO,Radde IC

更新日期：1983-11-01 00:00:00

abstract：:Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against high mobility group box 1 (HMGB1)-mediated septi...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee W,Yoon EK,Kim KM,Park DH,Bae JS

更新日期：2015-08-01 00:00:00

abstract：:Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2a subclass increased significantly when isolated P. senega saponins were used ...

journal_title：Canadian journal of physiology and pharmacology

authors： Katselis GS,Estrada A,Gorecki DK,Barl B

更新日期：2007-11-01 00:00:00

abstract：:In cats anesthetized with pentobarbital, isoproterenol infused into a peripheral vein causes a reduction in hepatic blood volume measured by plethysmography. As this response is accompanied by increases in portal and hepatic lobar venous pressures, the decrease in hepatic volume cannot be a passive emptying secondary ...

journal_title：Canadian journal of physiology and pharmacology

authors： Seaman KL,Greenway CV

更新日期：1984-06-01 00:00:00