Antagonism of biogenic amine-induced depression of cerebral cortical neurones by Na+, K+-ATPase in inhibitors.

abstract：:Acetylcholine (ACh)-mediated vagal transmission as well as nonneuronal ACh release are considered cardioprotective in pathological situations with increased sympathetic drive such as ischemia-reperfusion and cardiac remodeling. ACh action is terminated by hydrolysis by the cholinesterases (ChEs), acetylcholinesterase,...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilianova Z,Ciznarova N,Szmicsekova K,Slobodova L,Hrabovska A

更新日期：2020-07-01 00:00:00

abstract：:To investigate the capacity of efferent sympathetic neurons to modulate the failing heart, stellate ganglion stimulation was performed in dogs with biventricular heart failure induced by rapid ventricular pacing (240 beats/min) for 4-6 weeks. Less noradrenaline was released from cardiac myoneural junctions into corona...

journal_title：Canadian journal of physiology and pharmacology

authors： Cardinal R,Nadeau R,Laurent C,Boudreau G,Armour JA

更新日期：1996-09-01 00:00:00

abstract：:Depletion of divalent cations before fractionation of the longitudinal muscle of the guinea pig ileum yielded a sarcolemma-enriched microsomal fraction free of mitochondria. A major portion of the ATPase activity in the presence of Mg, Na, and K was due to stimulation by Na alone. A further small stimulation by K was ...

journal_title：Canadian journal of physiology and pharmacology

authors： James MR,Roufogalis BD

更新日期：1977-10-01 00:00:00

abstract：:Agelasimine A and agelasimine B, two novel compounds related to adenine, have been isolated from the orange sponge, Agelas mauritiana, and have been tested for a variety of biological activities. Both compounds inhibited proliferation of cultured L1210 leukemia cells at nanomolar concentrations with accumulation in th...

journal_title：Canadian journal of physiology and pharmacology

authors： Fathi-Afshar R,Allen TM,Krueger CA,Cook DA,Clanachan AS,Vriend R,Baer HP,Cass CE

更新日期：1989-04-01 00:00:00

abstract：:The effect of one bout of acute exercise on impaired glucose metabolism was studied in obese (480 +/- 20 g), untrained rats, at rest (n = 10) and after 60 min of swimming (n = 5). Using the euglycemic, hyperinsulinemic (10 mU.kg-1 x min-1) clamp, glucose clearance rate increased from 7.6 +/- 0.9 at rest to 9.7 +/- 0.5...

journal_title：Canadian journal of physiology and pharmacology

authors： Burstein R,Zissholtz A,Zick-Bachar Y,Epstein Y,Shapiro Y,Karnieli E

更新日期：1992-11-01 00:00:00

abstract：:Our objective was to investigate the effects of chronic excess iodine intake on thyroid functions and thyroid oxidative stress state in hypothyroid rats. Sixty rats were divided into euthyroid and hypothyroid (thiocyanate-induced) groups with or without administration of excess iodine (3000 or 6000 μg/L) for 8 weeks. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussein Ael-A,Abbas AM,El Wakil GA,Elsamanoudy AZ,El Aziz AA

更新日期：2012-05-01 00:00:00

abstract：:Despite major advances in conventional medical therapy, patients with heart failure continue to experience significant morbidity and mortality. Endothelin-1 (ET-1) is a potent vasocontrictor and mitogenic peptide that is activated in heart failure. There is increasing experimental and clinical evidence in support of a...

journal_title：Canadian journal of physiology and pharmacology

authors： Moe GW,Rouleau JL,Nguyen QT,Cernacek P,Stewart DJ

更新日期：2003-06-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00

abstract：:Type 1 diabetes mellitus reduces lipoprotein lipase (LPL) activity in the heart. The diabetic phenotype of decreased LPL activity in freshly isolated cardiomyocytes persisted after overnight culture (16 h). Total cellular LPL activity was 311+/-56 nmol oleate released x h(-1) x mg(-1) cell protein in diabetic cultured...

journal_title：Canadian journal of physiology and pharmacology

authors： Ewart HS,Carroll R,Severson DL

更新日期：1999-08-01 00:00:00

abstract：:Using radioligand binding techniques, the effect of reserpine pretreatment on ventricular adrenergic receptors from guinea pig was studied. [3H]Prazosin and [3H]dihydroalprenolol were used to label alpha 1- and beta-adrenergic receptors, respectively. Administration of 2.5 mg/kg reserpine for 2 days caused a significa...

journal_title：Canadian journal of physiology and pharmacology

authors： Latifpour J,McNeill JH

更新日期：1984-01-01 00:00:00

abstract：:The effects of fatigue on the membrane conductance of frog sartorius muscle at the resting potential and during an action potential were studied. When muscles were exposed to an extracellular pH of 8.0 the membrane conductance at the resting potential increased during fatigue by about 20% and returned to prefatigue le...

journal_title：Canadian journal of physiology and pharmacology

authors： Renaud JM,Mainwood GW

更新日期：1985-11-01 00:00:00

abstract：:Gripp-Heel is a homeopathic preparation frequently used in the treatment of respiratory viral infections such as various types of influenza and the common cold. The antiviral activity of Gripp-Heel was studied in vitro on human pathogenic enveloped and nonenveloped RNA and DNA viruses. Before the antiviral assays, in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Glatthaar-Saalmüller B

更新日期：2007-11-01 00:00:00

abstract：:Hereditary muscular hypertrophy is a character that has been selected in several animal species for industrial meat production. The selection of this character in cattle produces animals of exceptional commercial value but ones with a lower aerobic capacity than that of conventional cattle. The purpose of this work wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Amory H,McEntee K,Linden AS,Desmecht DJ,Beduin JM,D'Orio V,Lekeux PM

更新日期：1993-12-01 00:00:00

abstract：:The role of nitric oxide (NO) on the vasorelaxant effect of atrial natriuretic peptide (ANP) on the basal tone of rabbit aortic rings conditioned to angiotensin II (Ang II) was studied. ANP aortic relaxation and nitrite release were measured in the presence and absence of endothelium and a NO-synthase inhibitor. Ang I...

journal_title：Canadian journal of physiology and pharmacology

authors： Romano L,Coviello A,Jerez S,Peral de Bruno M

更新日期：2002-10-01 00:00:00

abstract：:The change in plasma and blood cell pools of L-glutamine during a single pass through the kidney was studied in dogs and rats. It was shown that the glutamine content of blood cells does not change following one passage through the renal vascular bed in normal or acidotic dogs. Furthermore, an infusion of L-glutamine ...

journal_title：Canadian journal of physiology and pharmacology

authors： Vinay P,Khoury N,Soowamber M,Gougoux A

更新日期：1985-07-01 00:00:00

abstract：:The effects of barbiturates on human platelet function are not fully understood. Since we have already revealed the effects and mechanisms of thiopental, thiamylal, and pentobarbital in platelets, the present study attempted to elucidate (i) the effects of other barbiturates on human platelet aggregation, (ii) the und...

journal_title：Canadian journal of physiology and pharmacology

authors： Sato M,Hirakata H,Ikeda M,Fukuda K

更新日期：2003-08-01 00:00:00

abstract：:This study evaluated the in vitro expression of bone-related proteins by osteoblasts in the presence of different concentrations of human recombinant bone morphogenetic protein-2 (rhBMP-2). Immortalized human fetal osteoblastic cell line 1.19 (hFOB) were exposed to different concentrations of rhBMP-2 (10, 50, or 100 n...

journal_title：Canadian journal of physiology and pharmacology

authors： de Oliveira EM,Martinez EF,Bossonaro JP,Ribeiro RC,de Araújo VC,Napimoga MH

更新日期：2013-11-01 00:00:00

abstract：:Effects of 6-hydroxydopamine (6-OHDA) on rat brain and blood adrenaline (A), noradrenaline (NA), ammonia (NH3), gamma-aminobutyric acid (GABA), and amino acid metabolism prior to and after high pressure oxygen (OHP) induced convulsions have been studied. 6-OHDA reduces GABA and glutamate (Glu) rior to OHP exposure in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Singh AK,Banister EW

更新日期：1978-04-01 00:00:00

abstract：:The connections of area postrema include a set of nuclei with a common topographical location immediately deep to the ependyma or pia mater. These nuclei are all within two principal synapses of the area postrema and can be reached by more than one route from it. There is direct evidence that, like the area postrema, ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lawes IN

更新日期：1990-02-01 00:00:00

abstract：:The effects of hydralazine (Hyd) on vascular smooth muscle contractile response to alpha-receptor stimulation by exogeneous and endogenous noradrenaline (NA) in the absence and presence of Mg2+ (1.2 mM) were examined using a proximal segment of rabbit's ear artery. Intraluminal perfusion with Hyd (2 x 10(-4) M) in nor...

journal_title：Canadian journal of physiology and pharmacology

authors： Krishnamurty VS

更新日期：1981-11-01 00:00:00

abstract：:Lingonberry grown in northern Manitoba, Canada, contains exceptionally high levels of anthocyanins and other polyphenols. Previous studies from our lab have shown that lingonberry anthocyanins can protect H9c2 cells from ischemia-reperfusion injury and anthocyanin-rich diets have been shown to be associated with decre...

journal_title：Canadian journal of physiology and pharmacology

authors： Isaak CK,Petkau JC,Blewett H,O K,Siow YL

更新日期：2017-08-01 00:00:00

abstract：:The adenylate cyclase activity induced by norepinephrine (10(-8)-10(-9) M) was studied in hypothalamic particulate fractions from female rats. The effect of estradiol on this activity was studied in rats that were ovariectomized in diestrus 1, injected with estradiol benzoate (50 micrograms/kg body weight), and killed...

journal_title：Canadian journal of physiology and pharmacology

authors： Zubin P,Defagot C

更新日期：1994-11-01 00:00:00

abstract：:Heparin was introduced into the stomach or duodenum of mice separately in doses of ca. 250 mg/kg. A slight anticoagulant effect in the systemic circulation was detected in whole blood clotting times and factor X inhibition. In contrast to most drugs, more heparin was absorbed from the stomach than from the intestine. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sue TK,Jaques LB,Yuen E

更新日期：1976-08-01 00:00:00

abstract：:The present experiments were designed to evaluate vascular reactivity to angiotensin II in rats with experimental cirrhosis of the liver (induced with CCl4 and phenobarbital) before ascites appearance. The systemic pressor response to angiotensin II in conscious animals and the contractile effect of angiotensin II in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Villamediana LM,García-Villalón AL,Caramelo C,López-Novoa JM

更新日期：1989-12-01 00:00:00

abstract：:The hypotensive effect of clonidine in anaesthetised (pentobarbitone) cat has been analysed with the help of pharmacological tools. Application of clonidine (0.1%) to the exposed ventral surface of medulla oblongata produced hypotension (28.6%) and bradycardia (18%). Similar application of glycine (5%) and GABA (10%) ...

journal_title：Canadian journal of physiology and pharmacology

authors： Srimal RC,Gulati K,Dhawan BN

更新日期：1977-10-01 00:00:00

abstract：:The effect of chlorpromazine on subcellular biosynthesis, hydrolysis, and transfer of lipids and liponucleotides participating in the biosynthesis of polyglycerophosphatides in guinea pig liver was studied. Chlorpromazine showed an apparent stimulation of accumulation of phosphatidic acid and CDP-diglycerides in micro...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuhne-Sekalec L,Chudzik J,Stanacev NZ

更新日期：1987-03-01 00:00:00

abstract：:Recent lines of evidence suggest that the beneficial effects of olive oil are not only related to its high content of oleic acid, but also to the antioxidant potential of its polyphenols. The aim of this work was determine the effects of olive oil and its components, oleic acid and the polyphenol dihydroxyphenylethano...

journal_title：Canadian journal of physiology and pharmacology

authors： Faine LA,Rodrigues HG,Galhardi CM,Ebaid GM,Diniz YS,Padovani CR,Novelli EL

更新日期：2006-02-01 00:00:00

abstract：:Angiotensin II (ANG II) causes a systemic pressor effect when injected into the cerebral ventricles. In the rat fourth ventricle, the effective doses for the ANG II pressor effect are over 100 times larger than in the systemic circulation. Considering the discrepancy of doses, the possibility that ANG II may reach the...

journal_title：Canadian journal of physiology and pharmacology

authors： Pesquero JB,Fior-Chadi DR,Yu YG,Merjan AJ,Lindsey CJ,Paiva AC

更新日期：2002-05-01 00:00:00

abstract：:For 10 days, dogs were fed a normal salt diet containing 70 mequiv. Na+/day (NSD) followed by a high salt diet containing 170 mequiv. Na+/day (HSD) or 240 mequiv. Na+/day (VHSD), or the order was reversed. K+ in these diets was fixed at 40 mequiv./day. The different diets did not influence the basal level of serum cat...

journal_title：Canadian journal of physiology and pharmacology

authors： Carrière S,Cardinal J,Le Grimellec C

更新日期：1980-09-01 00:00:00

abstract：:Increased expression of DNA methyltransferase-1 (DNMT1) associates with the progression of many human diseases. Because DNMT1 induces cell proliferation, drugs that inhibit DNMT1 have been used to treat proliferative diseases. Because these drugs are nonspecific inhibitors of DNMT1, subsidiary events or the compensato...

journal_title：Canadian journal of physiology and pharmacology

authors： Boosani CS,Gunasekar P,Block M,Jiang W,Zhang Z,Radwan MM,Agrawal DK

更新日期：2018-10-01 00:00:00