Abstract：
:Two species of macaques, including two Macaca fascicularis from the Philippines, two M. fascicularis from Mauritius, and one Macaca mulatta, were experimentally infected with blood stages of Plasmodium coatneyi and followed during their clinical, parasitological, biological, and immunological evolution. Plasma cytokine (TNF-alpha, IL-1beta, IL-6, IFN-gamma) production peaked for all monkeys 11 days after inoculation, concomitantly with peaks of parasitemia. Only the M. fascicularis from the Philippines survived the infection. The main features, which discriminated nonfatal from fatal cases, were the observation in M. fascicularis from the Philippines of a mean CD4+/CD8+ ratio below I and of their ability, as revealed by mitogenic stimulation of whole blood, to produce increasing amounts of IFN-gamma as infection evolved. The contribution of environmental and genetic factors, which may differentiate the three groups of monkeys and therefore explain fatal or nonfatal evolution of the infection among them, is discussed.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Migot-Nabias F,Ollomo B,Dubreuil G,Morelli A,Domarle O,Nabias R,Georges AJ,Millet Pdoi
10.1006/expr.1999.4342subject
Has Abstractpub_date
1999-01-01 00:00:00pages
30-9issue
1eissn
0014-4894issn
1090-2449pii
S0014-4894(99)94342-4journal_volume
91pub_type
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