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Antigenic phenotype of early intra-embryonic lymphoid progenitors in the chicken.

Abstract：

:The stem cells for the definitive haematopoiesis are derived from intra-embryonic sources originally described in an avian model and later also in mammals. However, the molecular make-up of the early embryonic haematopoietic progenitors is not yet clearly defined. We have recently characterized the phenotype of prethymic intra-embryonic progenitors capable of thymic colonization. Here we studied the ontogeny of cell-surface antigens HEMCAM, alpha2beta1 integrin, thrombomucin, chL12 and c-kit and their co-expression on prethymic T-cell progenitors. The early intra-embryonic expression of avian B-cell antigen chB6 was also demonstrated on cells derived from the intra-embryonic areas. We suggest that in the chicken, embryonic B-cell progenitors segregate earlier than T-cell progenitors in the differentiation of multipotent haematopoietic stem cells to committed progenitors.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Lampisuo M,Katevuo K,Lassila O

doi

10.1046/j.1365-3083.1998.00361.x

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

52-8

issue

1

eissn

0300-9475

issn

1365-3083

journal_volume

48

pub_type

杂志文章

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