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Effects of G-CSF on telomere lengths in PBMCs from human immunodeficiency virus-infected patients: results from a randomized, placebo-controlled trial.

Abstract：

:Telomeres are unique terminal chromosomal structures, the length of which has been shown to decrease with cell division in vitro and with increased age in vivo for human somatic cells. In human immunodeficiency virus (HIV)-1 infection, decrease of telomere length is primarily found in CD8+ T cells, and not in CD4+ T cells. In this double-blind placebo-controlled study, we investigated the effect of granulocyte colony stimulating factor (G-CSF) treatment combined with highly active antiretroviral therapy (HAART) on mean telomere length in peripheral blood mononuclear cells (PBMC). The terminal restriction fragment (TRF) length showed no changes during G-CSF treatment although the number of lymphocytes increased significantly. The mean TRF length correlated positively (R = 0.552, P = 0.009) and negatively (R = -0.503, P = 0.02) to the proportion of CD4+ memory and naïve cells, respectively. Our data suggest that during G-CSF treatment lymphocytes are recruited by a combination of central and peripheral proliferation.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Aladdin H,Ullum H,Schjerling P,Skov Jensen M,Dam Nielsen S,Mathiesen L,Gerstoft J,Skinhøj P,Klarlund Pedersen B

doi

10.1046/j.1365-3083.2000.00771.x

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

212-6

issue

2

eissn

0300-9475

issn

1365-3083

pii

sji771

journal_volume

52

pub_type

临床试验,杂志文章,随机对照试验

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