Biology of thrombopoietin.

abstract：:Autoimmune Lymphoproliferative Syndrome (ALPS) is a recently recognized disease in which a genetic defect in programmed cell death, or apoptosis, leads to breakdown of lymphocyte homeostasis and normal immunologic tolerance. Some authors have referred to ALPS as Canale-Smith syndrome or lymphoproliferative syndrome wi...

journal_title：Current opinion in pediatrics

authors： Jackson CE,Puck JM

更新日期：1999-12-01 00:00:00

abstract：:Two toddlers presented to their primary medical providers with anasarca and severe anemia. Laboratory evaluation revealed iron deficiency along with hypoproteinemia and hypoalbuminemia. Both children were diagnosed with iron deficiency anemia and were suspected to have an associated protein-losing enteropathy. A brief...

journal_title：Current opinion in pediatrics

authors： Salstrom JL,Kent M,Liang X,Wang M

更新日期：2012-02-01 00:00:00

abstract：:Dietary long-chain polyunsaturated fatty acids have demonstrable beneficial effects on early development. The effects on neural development are of particular interest. Human milk is the best and only time-proven source of fat and essential fatty acids in the infant diet. Technologic procedures based on chemical and ph...

journal_title：Current opinion in pediatrics

authors： Uauy R,Mena P

更新日期：1999-04-01 00:00:00

abstract：:Risk factors for infant development are considered in three areas: infant temperament, postpartum depression, and prenatal cocaine exposure. Investigations of all three areas indicate that contextual characteristics of infant development must be incorporated into models attempting to link early risk factors with later...

journal_title：Current opinion in pediatrics

authors： Zeanah CH,Scheeringa M,Boris N

更新日期：1994-08-01 00:00:00

abstract：:In the past year, significant progress has been achieved in the research on aquaporins (AQPs), a family of structurally related molecular water channels. Three novel AQPs were identified, giving a total of ten mammalian AQPs. An important step forward in identifying the aqueous pore in AQP molecules was the determinat...

journal_title：Current opinion in pediatrics

authors： Knoers NV,Deen PM

更新日期：1998-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to highlight some of the advances in the way we think about rhabdomyosarcoma (RMS). Recent outcome and biological analyses have shifted the risk stratification and treatment paradigms for pediatric RMS. RECENT FINDINGS:The presence or absence of the FOXO1 translocation i...

journal_title：Current opinion in pediatrics

authors： Hawkins DS,Gupta AA,Rudzinski ER

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Owing to its aggressive clinical course and associated immunologic abnormalities, pediatric inflammatory bowel disease (IBD) is increasingly managed with immunomodulators and biologic agents. Clinical experience with therapy targeted against tumor necrosis factor-alpha has raised important questions a...

journal_title：Current opinion in pediatrics

authors： Rosh JR

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:According to recent Centers for Disease Control (CDC) data, the annual incidence of traumatic brain injury (TBI) in the United States is 1.6-3.2 million, of which the majority is classified as mild. Over half of these injuries occur in the pediatric population, and can often be attributed to a sports-...

journal_title：Current opinion in pediatrics

authors： Choe MC,Babikian T,DiFiori J,Hovda DA,Giza CC

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Altered epigenetics is central to oncogenesis in many pediatric cancers. Aberrant epigenetic states are induced by mutations in histones or epigenetic regulatory genes, aberrant expression of genes regulating chromatin complexes, altered DNA methylation patterns, or dysregulated expression of noncodin...

journal_title：Current opinion in pediatrics

authors： Panditharatna E,Filbin MG

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Prenatal genetic screening and diagnostic testing can identify many disorders that will require specialized newborn care and follow-up. Pediatricians should be aware of recent advances in testing that may have implications for their patients and families. RECENT FINDINGS:Over the last half decade, th...

journal_title：Current opinion in pediatrics

authors： Cunniff C,Hudgins L

更新日期：2010-12-01 00:00:00

abstract：:In 1995, the incidence of childhood thyroid cancer in England and Wales was only 0.5 cases per million children per year. Papillary cancers in younger children were histologically distinct from tumors in older individuals. The incidence of thyroid cancer in the vicinity of Chernobyl increased by 62 times within 5 year...

journal_title：Current opinion in pediatrics

authors： Zimmerman D

更新日期：1997-08-01 00:00:00

abstract：:Injury is our children's greatest health problem, and pediatricians will frequently see finger and hand injuries in the office and emergency room. Many of these will be fingertip crush injuries, which are quite common in toddlers and are often undertreated. Pediatric finger and wrist fractures and sprains generally do...

journal_title：Current opinion in pediatrics

authors： Innis PC

更新日期：1995-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Diverse methodological approaches pose significant challenges to assess environmental exposure effects on child health outcomes. Although transdisciplinary research efforts offer unique opportunities for understanding the complex and multidimensional facets of lifespan health and disease trajectories,...

journal_title：Current opinion in pediatrics

authors： Blackwell CK,Wakschlag LS,Gershon RC,Cella D,with the ECHO PRO Core.

更新日期：2018-04-01 00:00:00

abstract：PURPOSE OF REVIEW:A brief delay in clamping the umbilical cord after birth offers health benefits to the newborn, with no adverse effects to the mother or her infant. Yet, in most obstetric practice, the cord is clamped soon after birth. A summary of the current evidence on delayed cord clamping and some reasons for th...

journal_title：Current opinion in pediatrics

authors： Raju TN

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Enteroviruses cause a wide variety of diseases with neurologic, respiratory, skin, and gastrointestinal findings. The purpose of this review is to clarify changes in the classification of enteroviruses, provide information about recent disease outbreaks, and to summarize progress toward the treatment ...

journal_title：Current opinion in pediatrics

authors： Lugo D,Krogstad P

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the significance of studies published over the previous year regarding the pathogenesis and treatment of atopic dermatitis, including prevention, skin care, environmental modifications, nutrition, education, and anti-inflammatory medications. RECENT FINDINGS:Recent evidence shows that 42.5...

journal_title：Current opinion in pediatrics

authors： Anderson PC,Dinulos JG

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The current review will focus on the current knowledge of the contribution of both germline and somatic mutations to the development and management of cancer in pediatric patients. RECENT FINDINGS:It has long been thought that genetic mutations in both germline and somatic cells can contribute to the...

journal_title：Current opinion in pediatrics

authors： Dean SJ,Farmer M

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this Position Statement is to emphasize the importance of an affirmative approach to the health care of transgender individuals, as well as to improve the understanding of the rights of transgender youth. RECENT FINDINGS:Transgender youth have optimal outcomes when affirmed in their ge...

journal_title：Current opinion in pediatrics

authors： Lopez X,Marinkovic M,Eimicke T,Rosenthal SM,Olshan JS,Pediatric Endocrine Society Transgender Health Special Interest Group.

更新日期：2017-08-01 00:00:00

abstract：:Treatment of patients with anorexia nervosa is a topic that continues to spark debate. Two particular areas of controversy include the role of exercise and the use of selective serotonergic reuptake inhibitors (SSRI). Few randomized controlled trials have addressed these two issues. The psychological impact of exercis...

journal_title：Current opinion in pediatrics

authors： Rosenblum J,Forman SF

更新日期：2003-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Gynecomastia is a common finding in adolescent men. The primary care provider should feel equipped to thoroughly evaluate this condition and to differentiate physiologic from pathologic breast enlargement. The present review focuses on the epidemiology, pathogenesis, evaluation, and treatment of gynec...

journal_title：Current opinion in pediatrics

authors： Nordt CA,DiVasta AD

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to describe current concepts on inflammation, immunity and insulin resistance. Metabolic and immune systems are closely involved in inflammation and significantly contribute to the pathology seen in the pediatric intensive care unit. The ability of insulin to decrease hep...

journal_title：Current opinion in pediatrics

authors： Dhar A,Castillo L

更新日期：2011-06-01 00:00:00

abstract：:The insulin-like growht factors (IGFs) are potent mitogenic agents that have been recognized for three decades. Recently, however, the complex milieu in which they operate has begun to be unraveled. Endocrine and autocrine patterns of IGF secretion have been identified and specific receptors that bind IGFs and mediate...

journal_title：Current opinion in pediatrics

authors： Cohen P,Rosenfeld RG

更新日期：1994-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Concern regarding appendicitis is a common reason for presentation to the paediatric emergency department. We review recent progress in the use of biomarkers, imaging and clinical scoring systems in improving diagnostic accuracy in suspected appendicitis in children. RECENT FINDINGS:Use of ultrasound...

journal_title：Current opinion in pediatrics

authors： Lawton B,Goldstein H,Davis T,Tagg A

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines neonatal bacterial skin infections with respect to host immunity, bacterial pathogens, patterns of infection, and new therapeutic approaches. RECENT FINDINGS:Advances have been made in our understanding of innate host defense and the emerging role of cutaneous antimicrobial pepti...

journal_title：Current opinion in pediatrics

authors： Larson AA,Dinulos JG

更新日期：2005-08-01 00:00:00

abstract：:Complete deficiency of one of the early components (C1, C4, or C2) of the classical pathway of the complement cascade is one of the strongest genetic risk factors for systemic lupus erythematosus that has been recognized. The lupus that occurs in complement-deficient individuals typically presents in early childhood. ...

journal_title：Current opinion in pediatrics

authors： Sullivan KE

更新日期：1998-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Sepsis is the leading cause of pediatric death worldwide. In the United States alone, there are 72 000 children hospitalized for sepsis annually with a reported mortality rate of 25% and an economic cost estimated to be $4.8 billion. However, it is only recently that the definition and management of p...

journal_title：Current opinion in pediatrics

authors： Mathias B,Mira JC,Larson SD

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The study provides an overview of recent studies on behavioral interventions for children and adolescents with autism spectrum disorder (ASD). RECENT FINDINGS:Recent reviews of the effectiveness of early intensive behavioral intervention (EIBI) conclude that EIBI can improve language and cognitive sk...

journal_title：Current opinion in pediatrics

authors： Dawson G,Burner K

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in medical care, preterm birth and its associated racial/ethnic disparities remain major public health issues. Environmental exposures may contribute to racial disparities in preterm birth. RECENT FINDINGS:Recent work in Iran demonstrated lead levels less than 10 μg/dl to be associat...

journal_title：Current opinion in pediatrics

authors： Burris HH,Collins JW Jr,Wright RO

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Simulation has been widely adopted as a training and assessment tool in medical education. Conventional teaching methods may be inadequate to properly train healthcare providers for rare but potentially lethal events in pediatrics such as trauma and respiratory arrest. Recent studies suggest pediatric...

journal_title：Current opinion in pediatrics

authors： Weinberg ER,Auerbach MA,Shah NB

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Screening, brief intervention and referral to treatment (SBIRT) offers a practical, integrated model for addressing substance use in primary care settings. This review provides an update of the research on SBIRT for adolescents in primary care, examines current dissemination challenges and suggests fu...

journal_title：Current opinion in pediatrics

authors： DʼSouza-Li L,Harris SK

更新日期：2016-08-01 00:00:00