Aquaporin molecular biology and clinical abnormalities of the water transport channels.

Abstract:

:In the past year, significant progress has been achieved in the research on aquaporins (AQPs), a family of structurally related molecular water channels. Three novel AQPs were identified, giving a total of ten mammalian AQPs. An important step forward in identifying the aqueous pore in AQP molecules was the determination of the three-dimensional structure of AQP1. The expression pattern of individual AQPs in different tissues was determined in more detail and AQP-knockout mice have been generated. The discovery of a severe urinary concentrating defect in AQP1-knockout mice was remarkable. Only AQP2, the vasopressin-sensitive water channel in the kidney, which is mutated in autosomal recessive and dominant cases of nephrogenic diabetes insipidus, has been shown to be involved in human disease. The finding of changed AQP2 expression in several acquired water balance disorders may pave the way toward developing treatments for these clinical problems.

journal_name

Curr Opin Pediatr

authors

Knoers NV,Deen PM

doi

10.1097/00008480-199808000-00018

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

428-34

issue

4

eissn

1040-8703

issn

1531-698X

journal_volume

10

pub_type

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