Abstract:
PURPOSE OF REVIEW:Pulmonary vascular disease (PVD) complicates the course of many cardiovascular, pulmonary and other systemic diseases in children. The physiological sequelae (pulmonary hypertension and elevated pulmonary vascular resistance) can overwhelm the right ventricle and lead to circulatory collapse. Despite the common end-point, the preceding pathophysiology is complex and variable and requires a tailored approach to diagnosis and management. In this article, we will review the most recent evidence and explore an approach to current controversies in the diagnosis and management of common or challenging patient subgroups. RECENT FINDINGS:New methods of interpreting data derived from echocardiography and cardiac magnetic resonance imaging may assist in risk stratification and response to therapy. In specific patient subgroups, standard pharmacological therapies to reduce right ventricle afterload may be overutilized, ineffective and in some cases harmful. In the patient failing pharmacological therapy, new and novel techniques are being explored including temporary extracorporeal mechanical circulatory support, pumpless lung assist devices and novel surgical and catheterization procedures. SUMMARY:PVD is a diverse entity, and attention to the underlying pathophysiology is essential for appropriate management. Despite significant advances in our understanding, the majority of data comes from small uncontrolled studies and must be interpreted with caution.
journal_name
Curr Opin Pediatrjournal_title
Current opinion in pediatricsauthors
Brown G,Humpl Tdoi
10.1097/MOP.0000000000000626subject
Has Abstractpub_date
2018-06-01 00:00:00pages
326-331issue
3eissn
1040-8703issn
1531-698Xjournal_volume
30pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Slipped capital femoral epiphysis (SCFE) is the most common adolescent hip condition. Its importance lies in its high morbidity if not diagnosed and treated in its early stages, not only in childhood but also as a cause of osteoarthritis in adulthood. This article highlights key diagnostic tools and o...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e328320acea
更新日期:2009-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize recent research regarding the diagnosis of allergic rashes and to suggest future directions for the promotion of accurate diagnosis and endotype specification. RECENT FINDINGS:Multiple cohort studies demonstrate that with appropriate clinical evaluation, dru...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0000000000000489
更新日期:2017-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Tobacco use and secondhand tobacco smoke exposure of children are a significant problem faced by pediatricians. This article reviews the recommendations of the 2008 update of the guideline Treating Tobacco Use and Dependence and their application in the pediatric setting. RECENT FINDINGS:Every tobacc...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/mop.0b013e328317f1d2
更新日期:2008-12-01 00:00:00
abstract::Large and unusually large von Willebrand factor (vWf) multimers may be responsible for systemic platelet aggregation in thrombotic thrombocytopenic purpura (TTP). This possibility is supported by studies that show deficient vWf-cleaving metalloproteinase and increased platelet-vWf binding during TTP episodes. In acute...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-200002000-00005
更新日期:2000-02-01 00:00:00
abstract::Until recently, tetanus was estimated to be killing well over half a million children each year in the developing world, most commonly through neonatal tetanus, the incidence of which was around six per 1000 live births. Neonatal tetanus most commonly occurs through cord contamination of the umbilical stump. Vaccinati...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-199802000-00002
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abstract:PURPOSE OF REVIEW:Owing to its aggressive clinical course and associated immunologic abnormalities, pediatric inflammatory bowel disease (IBD) is increasingly managed with immunomodulators and biologic agents. Clinical experience with therapy targeted against tumor necrosis factor-alpha has raised important questions a...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e32832ff22c
更新日期:2009-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Patient education is an essential component of asthma management. The current paradigm of asthma education has moved away from the 'information-transfer' programmes that characterized earlier approaches and that were shown to be largely ineffective, to approaches that promote self-management education...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e32831551fa
更新日期:2008-12-01 00:00:00
abstract::Choledochal cysts are a relatively rare abnormality in the West but are more common in the East. The etiology of choledochal cysts remains unknown. Recently, the incidence in neonates and young infants has been increasing due to advances in diagnostic imaging, including antenatal diagnosis. Choledochal cysts can prese...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-199706000-00018
更新日期:1997-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This article evaluates the field of radiogenomics within recent developments in genomics and radiation biology. RECENT FINDINGS:Many pediatric cancer survivors have undergone treatment with radiation, putting them at risk for long-term side-effects associated with this therapy, especially cardiac dis...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e328334581f
更新日期:2010-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The prevalence of pediatric atopic dermatitis (AD) has increased throughout the world, now ranging from 10 to 20% in developed countries. Pediatric patients with AD make up a substantial proportion of patients seen by general pediatricians, allergists, dermatologists, and other specialists. As such, t...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e328318c529
更新日期:2008-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will outline the screening, diagnosis and management of cystic fibrosis related diabetes (CFRD). It will also discuss advances in the detection of early glucose abnormalities, their clinical significance and the emerging role for early insulin therapy. RECENT FINDINGS:Before the onset of ...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in infants and children. Early and appropriate recognition and treatment of hypoglycemia is vital to minimize neurocognitive impairment. RECENT FINDINGS:There are at least 11 known monogenic forms of hyperinsulinism and se...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0000000000000645
更新日期:2018-08-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-199510000-00015
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-200010000-00006
更新日期:2000-10-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-199908000-00004
更新日期:1999-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide a comprehensive review of complementary and alternative medicine (CAM) treatments for children and adolescents with attention deficit hyperactivity disorder (ADHD). RECENT FINDINGS:Many parents of children with ADHD are reluctant to pursue medication options and unable to access behavioral...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e32835a1a5f
更新日期:2012-12-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e32832ff38e
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journal_title:Current opinion in pediatrics
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journal_title:Current opinion in pediatrics
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journal_title:Current opinion in pediatrics
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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journal_title:Current opinion in pediatrics
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e3283504fbf
更新日期:2012-04-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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journal_title:Current opinion in pediatrics
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journal_title:Current opinion in pediatrics
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更新日期:2011-06-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
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journal_title:Current opinion in pediatrics
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更新日期:2021-02-01 00:00:00