Enteroviruses in the early 21st century: new manifestations and challenges.

Abstract:

PURPOSE OF REVIEW:Enteroviruses cause a wide variety of diseases with neurologic, respiratory, skin, and gastrointestinal findings. The purpose of this review is to clarify changes in the classification of enteroviruses, provide information about recent disease outbreaks, and to summarize progress toward the treatment and prevention of these infections. RECENT FINDINGS:Enteroviruses are now classified into four distinct species. New variants of coxsackievirus B1, enterovirus-A71, and enterovirus-D68 (EV-D68) have emerged as causes of recent outbreaks in the United States and other countries, including more severe disease manifestations than previously described. EV-D68 now commonly circulates in the United States, and has been linked to severe respiratory disease and associated with acute flaccid myelitis (AFM). Overcoming enormous political and logistical challenges, fewer than 100 cases of polio have been reported in 2015, and the initiation of 'endgame' strategies appears imminent. Unfortunately, treatment for enterovirus infections remains supportive, although the recently completed pleconaril trial in newborns suggests that antiviral therapy may reduce mortality in neonatal disease. SUMMARY:Clinicians should be aware of the respiratory and neurological manifestations associated with EV-D68 and the potential for severe disease seen with other recently described enterovirus variants. Healthcare professionals should recognize the utility of rapid diagnostic methods and progress toward prevention and treatment of enterovirus infections.

journal_name

Curr Opin Pediatr

authors

Lugo D,Krogstad P

doi

10.1097/MOP.0000000000000303

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

107-13

issue

1

eissn

1040-8703

issn

1531-698X

journal_volume

28

pub_type

杂志文章,评审
  • Management of anorexia nervosa with exercise and selective serotonergic reuptake inhibitors.

    abstract::Treatment of patients with anorexia nervosa is a topic that continues to spark debate. Two particular areas of controversy include the role of exercise and the use of selective serotonergic reuptake inhibitors (SSRI). Few randomized controlled trials have addressed these two issues. The psychological impact of exercis...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200306000-00022

    authors: Rosenblum J,Forman SF

    更新日期:2003-06-01 00:00:00

  • Case report: atypical Lemierre's disease secondary to Porphyromonas asaccharolytica.

    abstract::Lemierre's disease, also known as 'postanginal sepsis', 'necrobacillosis', or 'internal jugular vein thrombosis', is a rare but serious emerging infection. Although Lemierre's disease remains rare, the number of reported cases has risen in recent years as more judicious antimicrobial prescribing practices for viral up...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章

    doi:10.1097/MOP.0b013e3283294c5e

    authors: Sharma D,Rouphael N

    更新日期:2009-06-01 00:00:00

  • Extracorporeal membrane oxygenation in the pediatric population - who should go on, and who should not.

    abstract:PURPOSE OF REVIEW:The role of extracorporeal membrane oxygenation (ECMO), a method of providing cardiorespiratory support in instances of cardiac or respiratory failure, in neonates and children continues to expand and evolve. This review details the current landscape of ECMO as it applies to neonates and children. RE...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000904

    authors: Etchill EW,Dante SA,Garcia AV

    更新日期:2020-06-01 00:00:00

  • Developmental outcome of neonatal intensive care: what questions are we asking?

    abstract::Recent neonatal intensive care outcome studies are asking more focused research questions and incorporating, at least implicitly, pathogenetic models. A few have grappled with the complex issues of health-related quality of life and functional outcomes and the many factors that affect these outcomes. The need to evalu...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200004000-00005

    authors: Allen MC

    更新日期:2000-04-01 00:00:00

  • Folate protection from congenital heart defects linked with canonical Wnt signaling and epigenetics.

    abstract:PURPOSE OF REVIEW:Environmental factors, such as drugs, chemicals, or abnormal concentrations of natural metabolites, induce birth defects. Environmental effects on cardiogenesis have been little studied in contrast to neurogenesis. This review presents evidence on three environmental factors: alcohol, the drug lithium...

    journal_title:Current opinion in pediatrics

    pub_type: 社论,评审

    doi:10.1097/MOP.0b013e32833e2723

    authors: Linask KK,Huhta J

    更新日期:2010-10-01 00:00:00

  • Strength training and nutritional supplement use in adolescents.

    abstract::The "win at all costs" mentality is becoming increasingly common in youth sports, and young athletes are often looking for methods to improve sports performance and avoid injury. As organized sports participation continues to increase among American adolescents, questions related to sports medicine are more frequently...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199908000-00004

    authors: Metzl JD

    更新日期:1999-08-01 00:00:00

  • Gynecomastia in adolescents.

    abstract:PURPOSE OF REVIEW:Gynecomastia is a common finding in adolescent men. The primary care provider should feel equipped to thoroughly evaluate this condition and to differentiate physiologic from pathologic breast enlargement. The present review focuses on the epidemiology, pathogenesis, evaluation, and treatment of gynec...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e328306a07c

    authors: Nordt CA,DiVasta AD

    更新日期:2008-08-01 00:00:00

  • Surgical advances in the treatment of adults with congenital heart disease.

    abstract:PURPOSE OF REVIEW:This article reviews three common abnormalities requiring surgical treatment in adults with congenital heart disease (CHD): Ebstein's anomaly, the failing Fontan, and pulmonary valve disease. RECENT FINDINGS:As of 2000, more adults than children are alive with CHD. Each year, more of these adults wit...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章

    doi:10.1097/MOP.0b013e3283303fa7

    authors: Dearani JA,Mavroudis C,Quintessenza J,Deal BJ,Backer CL,Fitzgerald P,Connolly HM,Jacobs JP

    更新日期:2009-10-01 00:00:00

  • Bacterial meningitis in children.

    abstract::Bacterial meningitis is an important problem in childhood. Vaccines can prevent Haemophilus influenzae type b disease and are being developed for infections caused by meningococci and pneumococci. Lumbar puncture is an important part of the diagnostic workup although care is required with its use. Once meningitis is d...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199402000-00006

    authors: Booy R,Kroll S

    更新日期:1994-02-01 00:00:00

  • Lower extremity stress fractures in pediatric and adolescent athletes.

    abstract:PURPOSE OF REVIEW:To familiarize primary care pediatricians with basic detection and treatment strategies of lower extremity stress fractures, while highlighting new research related to improving diagnosis and management approaches for pediatric and adolescent athletes. RECENT FINDINGS:Young age appears to be a risk f...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3282f370c0

    authors: Heyworth BE,Green DW

    更新日期:2008-02-01 00:00:00

  • Strategies to improve antibiotic use in the neonatal ICU.

    abstract:PURPOSE OF REVIEW:Neonates are at a high risk of infection and may have nonspecific signs of sepsis. Accordingly, they are heavily exposed to antimicrobials. Neonates are also uniquely at risk of both short-term and long-term complications from antibiotic exposure. This review discusses advances in antibiotic stewardsh...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000716

    authors: Willis Z,de St Maurice A

    更新日期:2019-02-01 00:00:00

  • Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.

    abstract:PURPOSE OF REVIEW:To summarize recent progress in our understanding of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders. RECENT FINDINGS:A number of Mendelian disorders of immune dysregulation and autoimmunity have been noted to result from defects in T regulatory cell,...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000029

    authors: Verbsky JW,Chatila TA

    更新日期:2013-12-01 00:00:00

  • Common parenting misconceptions regarding infant care: setting the record straight for parents (and some pediatricians).

    abstract:PURPOSE OF REVIEW:First-time parents often turn to friends and family for advice regarding feeding, sleeping, bathing, diapering and toilet training, and childhood illnesses. Unfortunately, parents may at times be given incorrect and potentially dangerous advice as several widely embraced parenting practices are no lon...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000835

    authors: Kahan T,Adesman A

    更新日期:2019-12-01 00:00:00

  • Requirements for long-chain polyunsaturated fatty acids in the preterm infant.

    abstract::Dietary long-chain polyunsaturated fatty acids have demonstrable beneficial effects on early development. The effects on neural development are of particular interest. Human milk is the best and only time-proven source of fat and essential fatty acids in the infant diet. Technologic procedures based on chemical and ph...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199904000-00003

    authors: Uauy R,Mena P

    更新日期:1999-04-01 00:00:00

  • Current challenges in the diagnosis and management of fever.

    abstract:PURPOSE OF REVIEW:We review recommendations from recent publications on the management of fever with antipyretics, the classification and diagnosis of fevers of unknown origin (FUO), and the evaluation of fever in infants under 90 days of age. RECENT FINDINGS:Anxiety about fever persists in the population, while the t...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32835333e3

    authors: Sherman JM,Sood SK

    更新日期:2012-06-01 00:00:00

  • Pediatric mastocytosis.

    abstract:PURPOSE OF REVIEW:The current article highlights recent developments in the field of pediatric cutaneous mastocytosis. Mastocytosis is a spectrum of conditions that range from fleetingly benign to aggressively malignant. Through recognizing the natural progression of disease, the role of biomarkers and mutational analy...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000922

    authors: Hussain SH

    更新日期:2020-08-01 00:00:00

  • Vitamin D in pediatric gastrointestinal disease.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to examine the prevalence of vitamin D deficiency in pediatric gastrointestinal disease, specifically celiac disease and inflammatory bowel disease (IBD); to discuss the role of vitamin D and its deficiency in gastrointestinal disease pathophysiology; and to present curre...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000451

    authors: Ahlawat R,Weinstein T,Pettei MJ

    更新日期:2017-02-01 00:00:00

  • Dysfunctional voiding: update on evaluation and treatment.

    abstract:PURPOSE OF REVIEW:This review will be covering dysfunctional voiding, its diagnosis, and treatment options. This will focus primarily on dysfunctional voiding rather than all lower urinary tract dysfunction and we will focus on some of the newer findings and progress within this disease. RECENT FINDINGS:Dysfunctional ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章

    doi:10.1097/MOP.0000000000000980

    authors: Bauer A

    更新日期:2020-12-10 00:00:00

  • Advances in fetal cardiac intervention.

    abstract::Fetal cardiac intervention is in a rapid state of progress now. Attempts are being made to prevent fetal hydrops due to congenital heart defects, to recruit hypoplastic ventricles, to create a two-ventricle circulation after birth, and to remodel the fetal pulmonary vascular bed whose outlet is obstructed. Open heart ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000141918.70698.3a

    authors: Huhta J,Quintero RA,Suh E,Bader R

    更新日期:2004-10-01 00:00:00

  • Disorders of thyrotropin synthesis, secretion, and function.

    abstract::Advances related to thyrotropin during 1999 included better understanding of the genetic basis of pituitary development and genetic advances in identifying clinical entities and their mechanisms and enabling new therapies. Initial clinical use of recombinant thyrotropin in evaluation of thyroid cancer recurrence was d...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200008000-00017

    authors: Rose SR

    更新日期:2000-08-01 00:00:00

  • Contemporary approach to joint hypermobility and related disorders.

    abstract:PURPOSE OF REVIEW:Joint hypermobility is a common, although largely ignored physical sign. Joint hypermobility is often asymptomatic but may be a feature of an underlying genetic disorder with systemic manifestations. The present article presents a comprehensive approach to considering joint hypermobility and clinicall...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000541

    authors: Castori M,Hakim A

    更新日期:2017-12-01 00:00:00

  • Neonatal infections.

    abstract::Neonatal infections range from early-onset vertically acquired infections to nosocomial bacterial sepsis, and they account for significant morbidity and mortality globally. The recent emergence of perinatally acquired HIV-1 infection has also placed an enormous burden on existing meager health resources in developing ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199704000-00003

    authors: Bhutta ZA

    更新日期:1997-04-01 00:00:00

  • Air pollution and allergic diseases.

    abstract:PURPOSE OF REVIEW:Exposure to traffic-related air pollutants (TRAPs) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant because increasingly large segments of the population worldwide reside in zones that have high levels of TRAP, including children, as schools...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000286

    authors: Brandt EB,Myers JM,Ryan PH,Hershey GK

    更新日期:2015-12-01 00:00:00

  • Role of growth factors in lung repair and diseases.

    abstract::A number of growth factors have been identified that participate in lung growth and repair. The early stages of the repair cascade are important in preventing the later development of fibrosis. Both transforming growth factor-beta and basic fibroblast growth factor can have beneficial effects when given early in some ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199506000-00002

    authors: Perkett EA

    更新日期:1995-06-01 00:00:00

  • Beyond dystrophin: current progress in the muscular dystrophies.

    abstract::Major advances in the genetic understanding of the limb-girdle (LGMD) and congenital (CMD) muscular dystrophies have led to a new, genetically based classification of these disorders. The definition of the complex of dystrophin-associated proteins on a biochemical and subsequently genetic level has greatly accelerated...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Bönnemann CG,McNally EM,Kunkel LM

    更新日期:1996-12-01 00:00:00

  • The use of simulation for pediatric training and assessment.

    abstract:PURPOSE OF REVIEW:Simulation has been widely adopted as a training and assessment tool in medical education. Conventional teaching methods may be inadequate to properly train healthcare providers for rare but potentially lethal events in pediatrics such as trauma and respiratory arrest. Recent studies suggest pediatric...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32832b32dc

    authors: Weinberg ER,Auerbach MA,Shah NB

    更新日期:2009-06-01 00:00:00

  • Dyslipidemia in pediatric renal disease: epidemiology, pathophysiology, and management.

    abstract::Dyslipidemia increases the risk of cardiovascular events among individuals with renal disease, and there is a growing body of evidence that it hastens the progression of renal disease itself. Children with nephrotic syndrome or renal transplants have easily recognized hyperlipidemia. Among those with chronic renal ins...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200204000-00009

    authors: Saland JM,Ginsberg H,Fisher EA

    更新日期:2002-04-01 00:00:00

  • The developmental origins of adult disease.

    abstract:PURPOSE OF REVIEW:Intrauterine growth restriction (IUGR) is associated with an increased propensity to develop adult-onset disease and is described by the developmental origins of adult disease hypothesis. Sequelae of fetal growth restriction include metabolic disease as well as nonmetabolic disorders. Although it has ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/mop.0b013e328326773b

    authors: Joss-Moore LA,Lane RH

    更新日期:2009-04-01 00:00:00

  • Biology of thrombopoietin.

    abstract::Thrombopoietin is a hematopoietic growth factor that stimulates megakaryopoiesis. Recent results indicate that thrombopoietin has multilineage hematopoietic effects both in vitro and in vivo. Clinical studies of thrombopoietin have begun, and are reviewed. ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199802000-00012

    authors: Broudy VC,Kaushansky K

    更新日期:1998-02-01 00:00:00

  • Neurocutaneous disorders in children.

    abstract::Neurocutaneous syndromes are disorders with cutaneous and neurologic anomalies. Some of these disorders are hereditary. This review summarizes the advances in this field and the recent results obtained in clinical and scientific research on the following syndromes: neurofibromatosis type 1, tuberous sclerosis, Gorlin-...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199308000-00011

    authors: Küster W,Happle R

    更新日期:1993-08-01 00:00:00