Current challenges in the diagnosis and management of fever.

abstract：PURPOSE OF REVIEW:To illustrate potential risks and benefits of disease screening for newborns using the example of Duchenne muscular dystrophy. RECENT FINDINGS:There is a wide range in the reported positive predictive value for screening male newborns for Duchenne muscular dystrophy by the creatine kinase level on dr...

journal_title：Current opinion in pediatrics

authors： Kemper AR,Wake MA

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to provide updates on the evolution of conceptual definitions as they relate to quality in healthcare, existing measurement platforms for performance benchmarking in pediatric surgery, and available tools for quality improvement that are relevant to care of the pediatric sur...

journal_title：Current opinion in pediatrics

authors： Cameron DB,Rangel SJ

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The small bowel has been a technically difficult area to examine. Indirect modalities such as barium follow-through have the disadvantage of attendant radiation exposure. Capsule endoscopy, a novel wireless method of investigation of the small bowel, has acquired an important role in both adult and pa...

journal_title：Current opinion in pediatrics

authors： Sidhu R,McAlindon ME,Sanders DS,Thomson M

更新日期：2007-10-01 00:00:00

abstract：:Major advances in the genetic understanding of the limb-girdle (LGMD) and congenital (CMD) muscular dystrophies have led to a new, genetically based classification of these disorders. The definition of the complex of dystrophin-associated proteins on a biochemical and subsequently genetic level has greatly accelerated...

journal_title：Current opinion in pediatrics

authors： Bönnemann CG,McNally EM,Kunkel LM

更新日期：1996-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Owing to its aggressive clinical course and associated immunologic abnormalities, pediatric inflammatory bowel disease (IBD) is increasingly managed with immunomodulators and biologic agents. Clinical experience with therapy targeted against tumor necrosis factor-alpha has raised important questions a...

journal_title：Current opinion in pediatrics

authors： Rosh JR

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This update explores the current management options for adolescent obesity with a specific focus on bariatric surgery. RECENT FINDINGS:Research has highlighted the serious health complications associated with adolescent obesity and thus emphasized the need for effective interventions. With the increa...

journal_title：Current opinion in pediatrics

authors： McGinty S,Richmond TK,Desai NK

更新日期：2015-08-01 00:00:00

abstract：:Aim of this review is to present the latest advances in the identification of the genetic determinants of intellectual deficiency. Mental retardation (MR) is often associated with other neurologic symptoms, metabolic disorders, or malformation syndromes. The purpose of the review is to subdivide the large field of MR ...

journal_title：Current opinion in pediatrics

authors： Chiurazzi P,Oostra BA

更新日期：2000-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The current review addresses the importance of the prospective cohort design in large, unselected populations starting early in life for understanding the origins of childhood health disorders. RECENT FINDINGS:Cohort studies originating in healthy populations have contributed to great advances in hea...

journal_title：Current opinion in pediatrics

authors： Paneth N,Monk C

更新日期：2018-04-01 00:00:00

abstract：:Gastrointestinal issues are a major chronic problem in 80 to 90% of children with cerebral palsy and in children with neurodevelopmental disabilities who are at special risk of developing malnutrition because of uncoordinated swallowing, gastroesophageal reflux, and constipation. In addition to poor linear growth, the...

journal_title：Current opinion in pediatrics

authors： Chong SK

更新日期：2001-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The interstitial lung diseases are a heterogeneous group of rare disorders of largely unknown etiology. The occurrence of familial cases of pediatric interstitial lung diseases with the onset of symptoms developing early in infancy has suggested a genetic basis for some forms of interstitial lung dise...

journal_title：Current opinion in pediatrics

authors： Nogee LM

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Major advances in our understanding of the genetic basis of neuroblastoma, and the role somatic alterations play in driving tumor growth, have led to improvements in risk-stratified therapy and have provided the rationale for targeted therapies. In this review, we highlight current risk-based treatmen...

journal_title：Current opinion in pediatrics

authors： Bagatell R,Cohn SL

更新日期：2016-02-01 00:00:00

abstract：:Tarsal coalition is a common abnormality of the hindfoot skeleton that only rarely leads to symptoms. These symptoms occur most commonly in adolescence but rarely can be found also in adults. Although most coalitions are congenital, as the consequence of autosomal dominant inheritance, coalitions also can be acquired ...

journal_title：Current opinion in pediatrics

authors： Bohne WH

更新日期：2001-02-01 00:00:00

abstract：:Slipped capital femoral epiphysis remains a diagnostic problem despite numerous papers written on the subject. The most important factor in the diagnosis of slipped capital femoral epiphysis is suspicion by the practitioner. The history, physical examination, and radiographic imaging are important in the confirmation ...

journal_title：Current opinion in pediatrics

authors： Reynolds RA

更新日期：1999-02-01 00:00:00

abstract：:Complete deficiency of one of the early components (C1, C4, or C2) of the classical pathway of the complement cascade is one of the strongest genetic risk factors for systemic lupus erythematosus that has been recognized. The lupus that occurs in complement-deficient individuals typically presents in early childhood. ...

journal_title：Current opinion in pediatrics

authors： Sullivan KE

更新日期：1998-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In fiscally challenging times, scientists must seek creative strategies and leverage existing resources to advance research. RECENT FINDINGS:This review describes programmes supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to promote resear...

journal_title：Current opinion in pediatrics

authors： Burns KM,Pearson GD,Kaltman JR

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent progress in our understanding of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders. RECENT FINDINGS:A number of Mendelian disorders of immune dysregulation and autoimmunity have been noted to result from defects in T regulatory cell,...

journal_title：Current opinion in pediatrics

authors： Verbsky JW,Chatila TA

更新日期：2013-12-01 00:00:00

abstract：:Superior mesenteric artery (SMA) syndrome describes vascular compression of the third portion of the duodenum and presents with nausea, postprandial vomiting, and epigastric abdominal pain. The syndrome is rare and may be missed if appropriate radiologic studies are not performed or the clinical presentation is atypic...

journal_title：Current opinion in pediatrics

authors： Kurbegov A,Grabb B,Bealer J

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight recent advances in management of peanut allergy. RECENT FINDINGS:Peanut allergy presents during early childhood. The prevalence of peanut allergy in children in developed countries appears to be increasing. Several factors, such as peanut-specific or environmental, are hypothesized as co...

journal_title：Current opinion in pediatrics

authors： Pansare M,Kamat D

更新日期：2010-10-01 00:00:00

abstract：:Atopic dermatitis is the most common chronic skin disease of young children and is frequently associated with asthma and allergies. Th2-type cytokine secreting T cells expressing the cutaneous lymphocyte-associated antigen play a central role in the induction of local IgE responses and recruitment of eosinophils in th...

journal_title：Current opinion in pediatrics

authors： Boguniewicz M

更新日期：1997-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoid osteoma is a benign painful bone tumor usually found in the lower extremities of children and young adults. It has been traditionally treated by surgical excision. Despite the small size of the lesion, the operative procedure for its removal can be extensive, but still sometimes remains incomp...

journal_title：Current opinion in pediatrics

authors： Ghanem I

更新日期：2006-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Altered epigenetics is central to oncogenesis in many pediatric cancers. Aberrant epigenetic states are induced by mutations in histones or epigenetic regulatory genes, aberrant expression of genes regulating chromatin complexes, altered DNA methylation patterns, or dysregulated expression of noncodin...

journal_title：Current opinion in pediatrics

authors： Panditharatna E,Filbin MG

更新日期：2020-02-01 00:00:00

abstract：:The biology of human breast milk, and the policy of encouraging breastfeeding, continue to be the object of much scientific inquiry. The past year has seen several advances in these fields of nutrition, and this article reviews some of the most interesting and pertinent studies. Four general themes have been apparent ...

journal_title：Current opinion in pediatrics

authors： Kelleher DK,Duggan C

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The International Liaison Committee on Resuscitation (ILCOR) recommends initiating neonatal resuscitation with concentrations of oxygen between 21 and 100%. This wide range of oxygen concentrations recommended for resuscitation highlights the lack of evidence supporting either 21 or 100% O2. The purpo...

journal_title：Current opinion in pediatrics

authors： Ten VS,Matsiukevich D

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Epidermolysis bullosa is a hereditary skin disorder characterized by skin fragility. However, the disease can manifest in many different organ systems, therefore children born with epidermolysis bullosa may have life long, complex medical needs. In this review, we will use a system-based approach to h...

journal_title：Current opinion in pediatrics

authors： Cohn HI,Teng JM

更新日期：2016-08-01 00:00:00

abstract：:Miniaturization of echocardiographic transducers, improved crystal technology, and enhanced digital processing of ultrasound signals have resulted in newer, more sophisticated equipment and imaging techniques. These technologic advances include transesophageal echocardiography, stress echocardiography (both pharmacolo...

journal_title：Current opinion in pediatrics

authors： Marx GR

更新日期：1995-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The mid-gestation fetus is capable of regenerative healing with wound healing indistinguishable from surrounding skin. This review aims to evaluate the current knowledge of how the mid-gestation fetus heals without scar and the implications of these findings in efforts to recapitulate the fetal regene...

journal_title：Current opinion in pediatrics

authors： Leung A,Crombleholme TM,Keswani SG

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The current review describes recent advances and unique challenges in precision medicine for pediatric cancers and highlights clinical trials assessing the clinical impact of targeted therapy matched to molecular alterations identified by tumor profiling. RECENT FINDINGS:Multiple prospective clinical...

journal_title：Current opinion in pediatrics

authors： Forrest SJ,Geoerger B,Janeway KA

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews recent developments in the assessment of changes in structure and function in the fetal heart with the focus on congenital heart disease malformations. RECENT FINDINGS:Use of the combination of the cardiovascular profile score, the biophysical profile score and additional physiol...

journal_title：Current opinion in pediatrics

authors： Acharya G,Archer N,Huhta JC

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We provide an overview of the past year's literature on congenital heart surgery. RECENT FINDINGS:This review focuses on selected disease entities, operative techniques, perioperative management strategies, and quality of care. SUMMARY:Congenital heart surgery is an evolving field. ...

journal_title：Current opinion in pediatrics

authors： Welke KF,Komanapalli C,Shen I,Ungerleider RM

更新日期：2005-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This article evaluates the field of radiogenomics within recent developments in genomics and radiation biology. RECENT FINDINGS:Many pediatric cancer survivors have undergone treatment with radiation, putting them at risk for long-term side-effects associated with this therapy, especially cardiac dis...

journal_title：Current opinion in pediatrics

authors： Roberson JD 2nd,Burnett OL 3rd,Robin N

更新日期：2016-12-01 00:00:00