Requirements for long-chain polyunsaturated fatty acids in the preterm infant.

abstract：PURPOSE OF REVIEW:To summarize recent progress in our understanding of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders. RECENT FINDINGS:A number of Mendelian disorders of immune dysregulation and autoimmunity have been noted to result from defects in T regulatory cell,...

journal_title：Current opinion in pediatrics

authors： Verbsky JW,Chatila TA

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Prenatal genetic screening and diagnostic testing can identify many disorders that will require specialized newborn care and follow-up. Pediatricians should be aware of recent advances in testing that may have implications for their patients and families. RECENT FINDINGS:Over the last half decade, th...

journal_title：Current opinion in pediatrics

authors： Cunniff C,Hudgins L

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The mid-gestation fetus is capable of regenerative healing with wound healing indistinguishable from surrounding skin. This review aims to evaluate the current knowledge of how the mid-gestation fetus heals without scar and the implications of these findings in efforts to recapitulate the fetal regene...

journal_title：Current opinion in pediatrics

authors： Leung A,Crombleholme TM,Keswani SG

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Lyme disease, caused by Borrelia burgdorferi, is the most common vector-borne illness in the United States. The pathogenesis, ecology, and epidemiology of Lyme disease have been well described, and antimicrobial treatment is very effective. There has been controversy about whether infection can persis...

journal_title：Current opinion in pediatrics

authors： Oliveira CR,Shapiro ED

更新日期：2015-02-01 00:00:00

abstract：:The biology of human breast milk, and the policy of encouraging breastfeeding, continue to be the object of much scientific inquiry. The past year has seen several advances in these fields of nutrition, and this article reviews some of the most interesting and pertinent studies. Four general themes have been apparent ...

journal_title：Current opinion in pediatrics

authors： Kelleher DK,Duggan C

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current evidence on the use of infection markers for diagnostic evaluation of sepsis in neonates. RECENT FINDINGS:Recent research in immunology has led to the discovery of cell surface antigens, chemokines, cytokines and acute phase proteins that can potentially be used to 'rule in' or ...

journal_title：Current opinion in pediatrics

authors： Ng PC,Lam HS

更新日期：2006-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite improvements in surgical techniques, valvular regurgitation results in major morbidity in children with heart disease. Functional anatomy, mechanisms of valve closure and adaptation to changing hemodynamic stress in normal mitral and tricuspid valves are complex and only partially understood. ...

journal_title：Current opinion in pediatrics

authors： Khoo NS,Smallhorn JF

更新日期：2011-10-01 00:00:00

abstract：:The atopic diseases of childhood consist of the triad of asthma, allergic rhinitis, and atopic dermatitis. All share a common pathogenesis, being mediated by IgE, and are frequently present together in the same individual and family. These disorders and their comorbidities comprise a large component of general pediatr...

journal_title：Current opinion in pediatrics

authors： Stone KD

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The diagnostic approach to children with possible appendicitis remains challenging. Although advances in imaging have improved diagnostic accuracy over clinical judgment alone, new management strategies continue to evolve. This review serves as an update on imaging, biomarkers, and management of appen...

journal_title：Current opinion in pediatrics

authors： Hennelly KE,Bachur R

更新日期：2011-06-01 00:00:00

abstract：:Food allergy or hypersensitivity is defined as an adverse reaction to food protein which is immune mediated. Without standard definitions and reliable tests for many forms of allergic disease of the bowel, studies are difficult to interpret. The proceedings of a recent workshop on the classification of adverse immunol...

journal_title：Current opinion in pediatrics

authors： Justinich CJ

更新日期：2000-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Radiation exposure from computed tomography is associated with a small but significant increase in risk for fatal cancer over a child's lifetime. This review aims to heighten awareness and spearhead efforts to reduce unnecessary computed tomography scans in children. RECENT FINDINGS:The use of pediat...

journal_title：Current opinion in pediatrics

authors： Shah NB,Platt SL

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:P450 oxidoreductase deficiency--a newly described form of congenital adrenal hyperplasia--typically presents a steroid profile suggesting combined deficiencies of steroid 21-hydroxylase and 17alpha-hydroxylase/17,20-lyase activities. These and other enzymes require electron donation from P450 oxidored...

journal_title：Current opinion in pediatrics

authors： Flück CE,Miller WL

更新日期：2006-08-01 00:00:00

abstract：:Necrotizing enterocolitis is an overwhelming gastrointestinal emergency that primarily afflicts premature infants born weighing less than 1500 g. Despite years of investigation, the etiology remains unclear, and accepted prevention and treatment strategies are lacking. Studies published over the last year have provide...

journal_title：Current opinion in pediatrics

authors： Caplan MS,Jilling T

更新日期：2001-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients seen at pediatric rheumatology are at increased risk of immediate and long-term consequences from sun exposure. The objective of this review is to build awareness of the need of sun protection in pediatric rheumatology patients. RECENT FINDINGS:Sun exposure can lead to disease exacerbations ...

journal_title：Current opinion in pediatrics

authors： Dayrit-Castro C,Tantuco K,Lara-Corrales I

更新日期：2019-08-01 00:00:00

abstract：:Pediatric cardiac intensive care has emerged as a distinct clinical entity to meet the unique needs of pediatric patients with congenital and acquired heart disease. This new subspecialty demands expertise and experience in the pediatric subspecialties of cardiology, intensive care, cardiac surgery, cardiac anesthesia...

journal_title：Current opinion in pediatrics

authors： Chang AC

更新日期：2000-06-01 00:00:00

abstract：:Neurocutaneous syndromes are disorders with cutaneous and neurologic anomalies. Some of these disorders are hereditary. This review summarizes the advances in this field and the recent results obtained in clinical and scientific research on the following syndromes: neurofibromatosis type 1, tuberous sclerosis, Gorlin-...

journal_title：Current opinion in pediatrics

authors： Küster W,Happle R

更新日期：1993-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Abdominal wall defects comprising both gastroschisis and omphalocele remain a source of significant morbidity and mortality, despite the advances in neonatal and pediatric surgical care. Survival has improved over the past few decades, especially with parenteral nutrition and surgical repair. Yet, sti...

journal_title：Current opinion in pediatrics

authors： Islam S

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Environmental factors, such as drugs, chemicals, or abnormal concentrations of natural metabolites, induce birth defects. Environmental effects on cardiogenesis have been little studied in contrast to neurogenesis. This review presents evidence on three environmental factors: alcohol, the drug lithium...

journal_title：Current opinion in pediatrics

authors： Linask KK,Huhta J

更新日期：2010-10-01 00:00:00

abstract：:Preimplantation genetic diagnosis now represents an alternative reproductive option for parents at high risk of having offspring affected with certain genetic diseases. Progress in the past year has included increasing reliability in embryo sexing by both polymerase chain reaction and fluorescent in situ hybridization...

journal_title：Current opinion in pediatrics

authors： Black SH

更新日期：1994-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The term 'dual diagnosis' most commonly refers to the combination of severe mental illness and substance-use disorder (SUD). It is estimated that 7-10 million people in the USA alone have at a minimum one psychiatric disorder in addition to a SUD. As many of the psychiatric illnesses implicated have t...

journal_title：Current opinion in pediatrics

authors： Santucci K

更新日期：2012-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Juvenile myasthenia gravis is a relatively rare autoimmune neuromuscular disorder. The pathophysiology of juvenile myasthenia gravis is similar to that of adult myasthenia gravis, though there remain important differences regarding presentation and therapeutic options. We review the pathophysiology, c...

journal_title：Current opinion in pediatrics

authors： Liew WK,Kang PB

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:A second-generation 13-valent pneumococcal conjugate vaccine (PCV13) was licensed and recommended for universal immunization of children through age 5 years in 2010. Its introduction is intended to address the residual burden of pneumococcal diseases that persists a decade after the introduction of PC...

journal_title：Current opinion in pediatrics

authors： Grijalva CG,Pelton SI

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Neonatal erythroderma is a potentially life-threatening condition in neonates less than 1 month old. During the first month of life, erythroderma is generally a presentation of genodermatosis, primary immune deficiency, or, more exceptionally, severe psoriasis, metabolic disease or infection. Atopic e...

journal_title：Current opinion in pediatrics

authors： Fraitag S,Bodemer C

更新日期：2010-08-01 00:00:00

abstract：:The insulin-like growht factors (IGFs) are potent mitogenic agents that have been recognized for three decades. Recently, however, the complex milieu in which they operate has begun to be unraveled. Endocrine and autocrine patterns of IGF secretion have been identified and specific receptors that bind IGFs and mediate...

journal_title：Current opinion in pediatrics

authors： Cohen P,Rosenfeld RG

更新日期：1994-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In fiscally challenging times, scientists must seek creative strategies and leverage existing resources to advance research. RECENT FINDINGS:This review describes programmes supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to promote resear...

journal_title：Current opinion in pediatrics

authors： Burns KM,Pearson GD,Kaltman JR

更新日期：2013-10-01 00:00:00

abstract：:Malignant melanoma and mycosis fungoides (cutaneous T cell lymphoma) are rare malignancies in childhood. However, both are potentially fatal tumors that may be cured if detected early. The incidence of melanomas in adolescents has increased in the last 10 years. This makes it imperative that high-risk children be iden...

journal_title：Current opinion in pediatrics

authors： Hoang MT,Friedlander SF

更新日期：1999-10-01 00:00:00

abstract：:Major advances in the genetic understanding of the limb-girdle (LGMD) and congenital (CMD) muscular dystrophies have led to a new, genetically based classification of these disorders. The definition of the complex of dystrophin-associated proteins on a biochemical and subsequently genetic level has greatly accelerated...

journal_title：Current opinion in pediatrics

authors： Bönnemann CG,McNally EM,Kunkel LM

更新日期：1996-12-01 00:00:00

abstract：:Endocrine excesses or deficiencies frequently result in alterations of height as compared with age-matched children. Less clinically obvious are significant alterations in bone metabolism leading to osteoporosis, which can affect the child and may affect the patient as an adult. Slipped capital femoral epiphysis appea...

journal_title：Current opinion in pediatrics

authors： Mann DC

更新日期：1996-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to highlight the recent advances in epigenetic regulation and chromatin biology for a better understanding of gene regulation related to human disease. RECENT FINDINGS:Alterations to chromatin influence genomic function, including gene transcription. At its most simple l...

journal_title：Current opinion in pediatrics

authors： Iglesias-Platas I,Monk D

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in medical care, preterm birth and its associated racial/ethnic disparities remain major public health issues. Environmental exposures may contribute to racial disparities in preterm birth. RECENT FINDINGS:Recent work in Iran demonstrated lead levels less than 10 μg/dl to be associat...

journal_title：Current opinion in pediatrics

authors： Burris HH,Collins JW Jr,Wright RO

更新日期：2011-04-01 00:00:00