Preimplantation genetic diagnosis.

Abstract:

:Preimplantation genetic diagnosis now represents an alternative reproductive option for parents at high risk of having offspring affected with certain genetic diseases. Progress in the past year has included increasing reliability in embryo sexing by both polymerase chain reaction and fluorescent in situ hybridization techniques; delivery of babies free of specific diseases such as cystic fibrosis, Lesch-Nyhan syndrome, and Tay-Sachs disease; and successful development of molecular techniques for detecting common diseases such as fragile-X syndrome. In addition, sperm separation in combination with preimplantation genetic diagnosis appears to be an exciting advance in yielding more in vitro fertilization female embryos for transfer and subsequent pregnancy in families at risk for X-linked diseases. Accumulated world experience can now be reviewed to provide couples considering preimplantation genetic diagnosis with observed pregnancy rates and accuracy of diagnosis.

journal_name

Curr Opin Pediatr

authors

Black SH

doi

10.1097/00008480-199412000-00018

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

712-6

issue

6

eissn

1040-8703

issn

1531-698X

journal_volume

6

pub_type

杂志文章,评审
  • Complement disorders and hemolytic uremic syndrome.

    abstract:PURPOSE OF REVIEW:Complement mediated hemolytic uremic syndrome (aHUS) accounts for a significant proportion of non-shiga toxin HUS. The purpose of this review is to outline the pathophysiology, clinical features and therapeutic options for aHUS. RECENT FINDINGS:In the last decade, strides have been made in identifyin...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32835df48a

    authors: Joseph C,Gattineni J

    更新日期:2013-04-01 00:00:00

  • Sport-related concussion in the young athlete.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to present an overview of sport-related concussion in the young athlete and review recent publications of clinical and scientific importance. RECENT FINDINGS:Recent findings show that young athletes are more susceptible to concussions than older athletes and more likely ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000236385.26284.ec

    authors: Buzzini SR,Guskiewicz KM

    更新日期:2006-08-01 00:00:00

  • Requirements for long-chain polyunsaturated fatty acids in the preterm infant.

    abstract::Dietary long-chain polyunsaturated fatty acids have demonstrable beneficial effects on early development. The effects on neural development are of particular interest. Human milk is the best and only time-proven source of fat and essential fatty acids in the infant diet. Technologic procedures based on chemical and ph...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199904000-00003

    authors: Uauy R,Mena P

    更新日期:1999-04-01 00:00:00

  • Genetics of pediatric interstitial lung disease.

    abstract:PURPOSE OF REVIEW:The interstitial lung diseases are a heterogeneous group of rare disorders of largely unknown etiology. The occurrence of familial cases of pediatric interstitial lung diseases with the onset of symptoms developing early in infancy has suggested a genetic basis for some forms of interstitial lung dise...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000193310.22462.1f

    authors: Nogee LM

    更新日期:2006-06-01 00:00:00

  • Recent advances regarding attention deficit-hyperactivity disorder in adolescence.

    abstract::This paper reviews recent studies of attention deficit-hyperactivity disorder, focusing on research with implications for adolescents. Only 10 of the 31 recent investigations discussed employed an exclusively adolescent sample, necessitating considerable extrapolation from studies of children or adults or mixed sample...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199608000-00003

    authors: Phillips S,Soffer SL

    更新日期:1996-08-01 00:00:00

  • Rash diagnostics: an update on the diagnosis of allergic rashes.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize recent research regarding the diagnosis of allergic rashes and to suggest future directions for the promotion of accurate diagnosis and endotype specification. RECENT FINDINGS:Multiple cohort studies demonstrate that with appropriate clinical evaluation, dru...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000489

    authors: Happel CS

    更新日期:2017-06-01 00:00:00

  • Mosquito repellents and superwarfarin rodenticides--are they really toxic in children?

    abstract:PURPOSE OF REVIEW:In many United States households, there are many substances used to control the exposure of our children to mosquitoes, mice and rats. This review provides information on common mosquito repellents and rodenticides used in households and discusses their toxicity, in order to help pediatricians better ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000193273.54742.6f

    authors: Kendrick DB

    更新日期:2006-04-01 00:00:00

  • Family member presence in the pediatric emergency department.

    abstract::Traditionally, family members were excluded from viewing invasive procedures and cardiopulmonary resuscitation in the pediatric emergency department. The concept of family-centered care in the emergency department has now become more widespread. Consequently, family member presence during routine invasive procedures s...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200306000-00012

    authors: Eppich WJ,Arnold LD

    更新日期:2003-06-01 00:00:00

  • Novel initiatives of the National Institutes of Health to support congenital heart disease research.

    abstract:PURPOSE OF REVIEW:In fiscally challenging times, scientists must seek creative strategies and leverage existing resources to advance research. RECENT FINDINGS:This review describes programmes supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to promote resear...

    journal_title:Current opinion in pediatrics

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/MOP.0b013e328364b8a7

    authors: Burns KM,Pearson GD,Kaltman JR

    更新日期:2013-10-01 00:00:00

  • ALARA: is there a cause for alarm? Reducing radiation risks from computed tomography scanning in children.

    abstract:PURPOSE OF REVIEW:Radiation exposure from computed tomography is associated with a small but significant increase in risk for fatal cancer over a child's lifetime. This review aims to heighten awareness and spearhead efforts to reduce unnecessary computed tomography scans in children. RECENT FINDINGS:The use of pediat...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3282ffafd2

    authors: Shah NB,Platt SL

    更新日期:2008-06-01 00:00:00

  • Rotavirus vaccines: an update.

    abstract:PURPOSE OF REVIEW:Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and has a major global impact on childhood morbidity and mortality. Vaccination is the only control measure likely to have a significant impact on the incidence of severe dehydrating rotavir...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000147907.30720.04

    authors: Dennehy PH

    更新日期:2005-02-01 00:00:00

  • Cutaneous bacterial infections in the newborn.

    abstract:PURPOSE OF REVIEW:This review examines neonatal bacterial skin infections with respect to host immunity, bacterial pathogens, patterns of infection, and new therapeutic approaches. RECENT FINDINGS:Advances have been made in our understanding of innate host defense and the emerging role of cutaneous antimicrobial pepti...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000171321.68806.bd

    authors: Larson AA,Dinulos JG

    更新日期:2005-08-01 00:00:00

  • Atopic dermatitis update.

    abstract:PURPOSE OF REVIEW:Atopic dermatitis, one of the most common chronic illnesses of childhood, is encountered routinely by all providers of health care to children. RECENT FINDINGS:In recent years there has been a dramatic rise in the prevalence of atopic dermatitis and therefore a rapid increase in the number of studies...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000133632.33920.dd

    authors: Sturgill S,Bernard LA

    更新日期:2004-08-01 00:00:00

  • Diagnostic testing for SARS-CoV-2/COVID19.

    abstract:PURPOSE OF REVIEW:SARS-CoV-2 is the novel human coronavirus responsible for the COVID19 pandemic. Accurate detection of infection with SARS-CoV-2 is an essential component of efforts to treat individual patients and to contain spread of the virus in the community. The purpose of this review is to describe current diagn...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000972

    authors: Spearman P

    更新日期:2021-02-01 00:00:00

  • Capsule endoscopy in the evaluation of gastrointestinal disease.

    abstract:PURPOSE OF REVIEW:The small bowel has been a technically difficult area to examine. Indirect modalities such as barium follow-through have the disadvantage of attendant radiation exposure. Capsule endoscopy, a novel wireless method of investigation of the small bowel, has acquired an important role in both adult and pa...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3282e2aaf8

    authors: Sidhu R,McAlindon ME,Sanders DS,Thomson M

    更新日期:2007-10-01 00:00:00

  • New advances in fertility preservation for pediatric cancer patients.

    abstract:PURPOSE OF REVIEW:The number of pediatric cancer survivors is growing rapidly as treatments become more effective. However, many current regimens cause gonadotoxicity and permanent infertility, significantly impacting quality of life. The purpose of this review is to update pediatric oncologists on risk factors for can...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3283420fb6

    authors: Ginsberg JP

    更新日期:2011-02-01 00:00:00

  • An update on lasers in children.

    abstract:PURPOSE OF REVIEW:A variety of new indications for laser treatment have been raised in the dermatology field recently. They offer significant opportunities to manage a large spectrum of conditions in the pediatric population. Therefore, it is necessary to know the current trends and limitations of their use for the tre...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32832e084f

    authors: Cordisco MR

    更新日期:2009-08-01 00:00:00

  • Vitamin D in pediatric gastrointestinal disease.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to examine the prevalence of vitamin D deficiency in pediatric gastrointestinal disease, specifically celiac disease and inflammatory bowel disease (IBD); to discuss the role of vitamin D and its deficiency in gastrointestinal disease pathophysiology; and to present curre...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000451

    authors: Ahlawat R,Weinstein T,Pettei MJ

    更新日期:2017-02-01 00:00:00

  • The airway microbiome in cystic fibrosis and implications for treatment.

    abstract:PURPOSE OF REVIEW:Lung disease in cystic fibrosis (CF) results from chronic airway infection and inflammation leading to progressive bronchiectasis and respiratory failure. Bacterial pathogens, including Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia, are known contributors. Recent studies usin...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32834604f2

    authors: Zemanick ET,Sagel SD,Harris JK

    更新日期:2011-06-01 00:00:00

  • Pharmacogenetics and development: are infants and children at increased risk for adverse outcomes?

    abstract::Over the past two decades, pharmacokinetic data have clearly demonstrated that development can markedly influence the absorption, distribution, excretion, and metabolism of xenobiotics. With respect to many of the processes that govern drug metabolism, the underlying pharmacogenetic determinants that may control eithe...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Kearns GL

    更新日期:1995-04-01 00:00:00

  • Herbal medicines for children: an illusion of safety?

    abstract::Herbal medicaments are in common use. In general, the judicious use of carefully selected and prepared herbal medications seems to cause few adverse effects and may be beneficial. However, toxic effects of these products have been reported with increasing frequency. Infants and children may be even more susceptible to...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200104000-00014

    authors: Tomassoni AJ,Simone K

    更新日期:2001-04-01 00:00:00

  • Role of hypertension in progression of chronic kidney disease in children.

    abstract:PURPOSE OF REVIEW:Hypertension is an independent risk factor for progression of chronic kidney disease (CKD) in children. Children with early CKD develop hypertension secondary to renal disease. This review aims to highlight recent advances that help us better understand the current role of hypertension in progression ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000595

    authors: Vidi SR

    更新日期:2018-04-01 00:00:00

  • Leukocyte function and nonmalignant leukocyte disorders.

    abstract::This review summarizes recent literature regarding the clinical and molecular features of nonmalignant leukocyte disorders in children. Leukocyte adhesion deficiency and chronic granulomatous disease, two inherited disorders of neutrophil function, continue to be the best-characterized disorders with respect to specif...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199302000-00013

    authors: Dinauer MC

    更新日期:1993-02-01 00:00:00

  • Behavioral interventions in children and adolescents with autism spectrum disorder: a review of recent findings.

    abstract:PURPOSE OF REVIEW:The study provides an overview of recent studies on behavioral interventions for children and adolescents with autism spectrum disorder (ASD). RECENT FINDINGS:Recent reviews of the effectiveness of early intensive behavioral intervention (EIBI) conclude that EIBI can improve language and cognitive sk...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32834cf082

    authors: Dawson G,Burner K

    更新日期:2011-12-01 00:00:00

  • Selective mutism.

    abstract:PURPOSE OF REVIEW:Selective mutism is a disorder in which an individual fails to speak in certain social situations though speaks normally in other settings. Most commonly, this disorder initially manifests when children fail to speak in school. Selective mutism results in significant social and academic impairment in ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000300

    authors: Hua A,Major N

    更新日期:2016-02-01 00:00:00

  • Promotion of physical activity in primary care for obesity treatment/prevention in children.

    abstract:PURPOSE OF REVIEW:Physical activity has been highlighted internationally as a beneficial intervention for weight control and the improvement of physical and mental health. This review highlights findings from recent literature to guide office-based promotion of physical activity for obesity treatment and prevention. R...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e328013c88c

    authors: Floriani V,Kennedy C

    更新日期:2007-02-01 00:00:00

  • Helping adolescents cope with stress during stressful times.

    abstract::Increasing levels of stress in the daily lives of adolescents is an important health concern. Adolescents experience a variety of stressful situations and use a wide range of coping strategies to help effectively manage stress. Recent research on adolescent coping with stressful situations is reviewed. Findings suppor...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200308000-00005

    authors: Bonica C,Daniel JH

    更新日期:2003-08-01 00:00:00

  • A paradigm shift in the treatment of extreme prematurity: the artificial placenta.

    abstract:PURPOSE OF REVIEW:Extremely low gestational age newborns (ELGANs), born at less than 28 weeks' estimated gestational age, suffer the greatest consequences of prematurity. There have been significant advances in their care over the last several decades, but the prospects for major advances within traditional treatment m...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000083

    authors: Davis RP,Bryner B,Mychaliska GB

    更新日期:2014-06-01 00:00:00

  • Treatment of acute diarrhea in children.

    abstract::In the past decade a number of studies have systematically addressed the questions that existed regarding optimal ways to rehydrate and then refeed infants and children with diarrhea. Two very thorough papers are the highlights of the past year's publications in the topic of acute gastroenteritis in children. One summ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199710000-00010

    authors: Lifschitz CH

    更新日期:1997-10-01 00:00:00

  • Environmental control in the prevention and treatment of pediatric allergic disease.

    abstract::Allergen avoidance should be considered as a first line of defense for all types of allergic disease. For some allergens, such as the common pollens, significant avoidance may be difficult or even impossible to accomplish without major alterations in lifestyle. For others, however, particularly the common indoor aller...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199312000-00009

    authors: Wood RA

    更新日期:1993-12-01 00:00:00