Pharmacogenetics and development: are infants and children at increased risk for adverse outcomes?

abstract：PURPOSE OF REVIEW:This article evaluates the field of radiogenomics within recent developments in genomics and radiation biology. RECENT FINDINGS:Many pediatric cancer survivors have undergone treatment with radiation, putting them at risk for long-term side-effects associated with this therapy, especially cardiac dis...

journal_title：Current opinion in pediatrics

authors： Roberson JD 2nd,Burnett OL 3rd,Robin N

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The management of displaced medial humeral epicondyle fractures in children remains controversial. The indications for surgery, the ideal surgical strategy and the implications of a painful nonunion remain unclear. RECENT FINDINGS:This article describes the state of the evidence and the art in the ma...

journal_title：Current opinion in pediatrics

authors： Firth AM,Marson BA,Hunter JB

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients seen at pediatric rheumatology are at increased risk of immediate and long-term consequences from sun exposure. The objective of this review is to build awareness of the need of sun protection in pediatric rheumatology patients. RECENT FINDINGS:Sun exposure can lead to disease exacerbations ...

journal_title：Current opinion in pediatrics

authors： Dayrit-Castro C,Tantuco K,Lara-Corrales I

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Considerable attention has recently been focused on the pathogenesis, diagnosis and treatment of osteogenesis imperfecta. Two new genes have been defined in patients with recessive severe or lethal osteogenesis imperfecta types. Diagnostic concerns involve testing procedures, either skin biopsies or D...

journal_title：Current opinion in pediatrics

authors： Shapiro JR,Sponsellor PD

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Over 80% of children diagnosed with cancer are now cured. The burgeoning population of survivors of childhood cancer experiences high rates of morbidity and mortality due to 'late-effects' of treatment. These can be defined as any consequence of treatment that persists beyond or develops after the com...

journal_title：Current opinion in pediatrics

authors： Song A,Fish JD

更新日期：2018-12-01 00:00:00

abstract：:A 10-month-old infant with multiple infantile hepatic hemangiomas and developmental delay is reported. He was found to be profoundly hypothyroid. Evaluation and management issues are discussed. This case emphasizes the importance of screening for hypothyroidism in patients with hemangiomas and the potential therapeuti...

journal_title：Current opinion in pediatrics

authors： Cho YH,Taplin C,Mansour A,Howman-Giles R,Hardwick R,Lord D,Howard NJ

更新日期：2008-04-01 00:00:00

abstract：:Until recently, tetanus was estimated to be killing well over half a million children each year in the developing world, most commonly through neonatal tetanus, the incidence of which was around six per 1000 live births. Neonatal tetanus most commonly occurs through cord contamination of the umbilical stump. Vaccinati...

journal_title：Current opinion in pediatrics

authors： Thayaparan B,Nicoll A

更新日期：1998-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recommended work-up in a child who presents with elevated blood pressure as well as innovative evaluation techniques under development. RECENT FINDINGS:'The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents' contains several ...

journal_title：Current opinion in pediatrics

authors： Nguyen M,Mitsnefes M

更新日期：2007-04-01 00:00:00

abstract：:Medical informatics is both a science, which seeks to understand the information requirements of medical practice, research, and education, and an engineering discipline, which applies new technologies to help manage the explosion of data and new knowledge that confront contemporary physicians. Computerization of the ...

journal_title：Current opinion in pediatrics

authors： Shiffman RN

更新日期：1994-10-01 00:00:00

abstract：:Guidelines are an increasingly prominent part of the practice of pediatrics. Aiming from studies of variability in care, they are widely used as a mechanism to assess and improve quality. Rigorous methods of guideline development differentiate current guidelines from past consensus efforts. The American Academy of Ped...

journal_title：Current opinion in pediatrics

authors： Homer CJ,Grossman RG,Rodman J

更新日期：1996-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in medical care, preterm birth and its associated racial/ethnic disparities remain major public health issues. Environmental exposures may contribute to racial disparities in preterm birth. RECENT FINDINGS:Recent work in Iran demonstrated lead levels less than 10 μg/dl to be associat...

journal_title：Current opinion in pediatrics

authors： Burris HH,Collins JW Jr,Wright RO

更新日期：2011-04-01 00:00:00

abstract：:Fetal cardiac intervention is in a rapid state of progress now. Attempts are being made to prevent fetal hydrops due to congenital heart defects, to recruit hypoplastic ventricles, to create a two-ventricle circulation after birth, and to remodel the fetal pulmonary vascular bed whose outlet is obstructed. Open heart ...

journal_title：Current opinion in pediatrics

authors： Huhta J,Quintero RA,Suh E,Bader R

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide clinicians with an updated overview of key considerations related to the clinical assessment and management of attention-deficit/hyperactivity disorder (ADHD) in adolescents. RECENT FINDINGS:The American Psychiatric Association's recently revised Diagnostic and Statistical Manual of Mental...

journal_title：Current opinion in pediatrics

authors： Obioha O,Adesman A

更新日期：2014-02-01 00:00:00

abstract：:The biology of human breast milk, and the policy of encouraging breastfeeding, continue to be the object of much scientific inquiry. The past year has seen several advances in these fields of nutrition, and this article reviews some of the most interesting and pertinent studies. Four general themes have been apparent ...

journal_title：Current opinion in pediatrics

authors： Kelleher DK,Duggan C

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To familiarize primary care pediatricians with basic detection and treatment strategies of lower extremity stress fractures, while highlighting new research related to improving diagnosis and management approaches for pediatric and adolescent athletes. RECENT FINDINGS:Young age appears to be a risk f...

journal_title：Current opinion in pediatrics

authors： Heyworth BE,Green DW

更新日期：2008-02-01 00:00:00

abstract：:Dietary long-chain polyunsaturated fatty acids have demonstrable beneficial effects on early development. The effects on neural development are of particular interest. Human milk is the best and only time-proven source of fat and essential fatty acids in the infant diet. Technologic procedures based on chemical and ph...

journal_title：Current opinion in pediatrics

authors： Uauy R,Mena P

更新日期：1999-04-01 00:00:00

abstract：:Prevention of injuries to child passengers is a significant public health priority, as motor vehicle-related injuries remain a leading cause of death for children. Improvements in child restraint use have contributed to significant declines in child occupant mortality rates over the past 20 years. However, although ov...

journal_title：Current opinion in pediatrics

authors： Durbin DR

更新日期：1999-12-01 00:00:00

abstract：:Recent neonatal intensive care outcome studies are asking more focused research questions and incorporating, at least implicitly, pathogenetic models. A few have grappled with the complex issues of health-related quality of life and functional outcomes and the many factors that affect these outcomes. The need to evalu...

journal_title：Current opinion in pediatrics

authors： Allen MC

更新日期：2000-04-01 00:00:00

abstract：PURPOSE OF REVIEW:We review recommendations from recent publications on the management of fever with antipyretics, the classification and diagnosis of fevers of unknown origin (FUO), and the evaluation of fever in infants under 90 days of age. RECENT FINDINGS:Anxiety about fever persists in the population, while the t...

journal_title：Current opinion in pediatrics

authors： Sherman JM,Sood SK

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To emphasize an exploration of mechanisms of kidney stone disease based on a molecular understanding of excess urinary excretions of calcium, oxalate, cystine, and uric acid. RECENT FINDINGS:Hypercalciuria is discussed relative to mutations in the renal chloride genes CLCN5 and CLCNKB, WNK kinases, A...

journal_title：Current opinion in pediatrics

authors： Langman CB

更新日期：2004-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The clinical importance of overgrowth syndromes in the pediatric patient population has been increasingly recognized during the past decade, but clinical overlap among overgrowth syndromes often makes diagnostic categorization difficult. Advances in the molecular delineation of overgrowth syndromes in...

journal_title：Current opinion in pediatrics

authors： Cytrynbaum CS,Smith AC,Rubin T,Weksberg R

更新日期：2005-12-01 00:00:00

abstract：:Lemierre's disease, also known as 'postanginal sepsis', 'necrobacillosis', or 'internal jugular vein thrombosis', is a rare but serious emerging infection. Although Lemierre's disease remains rare, the number of reported cases has risen in recent years as more judicious antimicrobial prescribing practices for viral up...

journal_title：Current opinion in pediatrics

authors： Sharma D,Rouphael N

更新日期：2009-06-01 00:00:00

abstract：:Over the past several years, many new strategies have evolved for improving the care of patients with acute lung injury and respiratory failure. Although many of these new modalities remain unproven, some show much promise for decreasing the morbidity and mortality seen in critically ill patients who need assisted ven...

journal_title：Current opinion in pediatrics

authors： Donnelly KM,Bogue CW

更新日期：1998-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Concern regarding appendicitis is a common reason for presentation to the paediatric emergency department. We review recent progress in the use of biomarkers, imaging and clinical scoring systems in improving diagnostic accuracy in suspected appendicitis in children. RECENT FINDINGS:Use of ultrasound...

journal_title：Current opinion in pediatrics

authors： Lawton B,Goldstein H,Davis T,Tagg A

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:We present data from recently conducted research regarding the diagnosis of blunt cervical spine injury (CSI) in children. RECENT FINDINGS:Research in the prehospital setting to evaluate the need for cervical spine immobilization in children, regardless of clinical findings or mechanism of injury, su...

journal_title：Current opinion in pediatrics

authors： Tilt L,Babineau J,Fenster D,Ahmad F,Roskind CG

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Adolescents, in particular those that are most disenfranchised, are increasingly at risk of acquiring HIV and, when acquiring HIV, have worse outcomes than adults. This article reviews the recent approaches to combination prevention aiming to optimize the HIV prevention and HIV treatment continua. RE...

journal_title：Current opinion in pediatrics

authors： Rotheram-Borus MJ,Davis E,Rezai R

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the importance of appropriate developmental surveillance in early childhood, what is known about its effectiveness in current pediatric practice, and ways in which its delivery can be improved to optimize child outcomes. RECENT FINDINGS:Many infants and young children with develo...

journal_title：Current opinion in pediatrics

authors： King TM,Glascoe FP

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The mid-gestation fetus is capable of regenerative healing with wound healing indistinguishable from surrounding skin. This review aims to evaluate the current knowledge of how the mid-gestation fetus heals without scar and the implications of these findings in efforts to recapitulate the fetal regene...

journal_title：Current opinion in pediatrics

authors： Leung A,Crombleholme TM,Keswani SG

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The term 'dual diagnosis' most commonly refers to the combination of severe mental illness and substance-use disorder (SUD). It is estimated that 7-10 million people in the USA alone have at a minimum one psychiatric disorder in addition to a SUD. As many of the psychiatric illnesses implicated have t...

journal_title：Current opinion in pediatrics

authors： Santucci K

更新日期：2012-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonaccidental trauma and neglect continue to be major problems for children, families, and the providers who care for them. Whereas prevention is the key to ending child abuse and neglect, diagnosis and treatment continue to be the mainstays of practice. This article will briefly review the epidemiolo...

journal_title：Current opinion in pediatrics

authors： Tenney-Soeiro R,Wilson C

更新日期：2004-04-01 00:00:00