Abstract:
PURPOSE OF REVIEW:This review examines neonatal bacterial skin infections with respect to host immunity, bacterial pathogens, patterns of infection, and new therapeutic approaches. RECENT FINDINGS:Advances have been made in our understanding of innate host defense and the emerging role of cutaneous antimicrobial peptides of the cathelicidin and defensin families. Toll-like receptors are being investigated with respect to their interactions with bacteria and other components of the innate immune defense, such as the antimicrobial peptides. The epidermal barrier remains an active area of research. Studies confirm that maintaining an intact epidermal barrier by minimizing exposure to soap and by not removing vernix caseosa are simple measures to improve skin barrier function. Active barrier-enhancing measures such as the application of topical emollients have shown mixed results in the prevention of nosocomial infection. A meta-analysis of studies performed in developed countries showed a trend of increasing risk for coagulase-negative staphylococcal infection. By contrast, a randomized controlled trial showed that infants treated with sunflower oil are less likely to experience nosocomial infections than are control infants. Infants with bacteremia and no known source of infection should be carefully examined because cutaneous abscesses have been shown to be an important nidus of infection. Methicillin-resistant Staphylococcus aureus is reaching epidemic proportions, making surface cultures an essential part of the evaluation of cutaneous bacterial infection. SUMMARY:New insights have been gained regarding the basic science of neonatal host defense and these advances may produce new ways of approaching the prevention and treatment of bacterial skin infections in the newborn period.
journal_name
Curr Opin Pediatrjournal_title
Current opinion in pediatricsauthors
Larson AA,Dinulos JGdoi
10.1097/01.mop.0000171321.68806.bdkeywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
481-5issue
4eissn
1040-8703issn
1531-698Xpii
00008480-200508000-00008journal_volume
17pub_type
杂志文章,评审abstract::This paper reviews recent studies of attention deficit-hyperactivity disorder, focusing on research with implications for adolescents. Only 10 of the 31 recent investigations discussed employed an exclusively adolescent sample, necessitating considerable extrapolation from studies of children or adults or mixed sample...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-199608000-00003
更新日期:1996-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To emphasize an exploration of mechanisms of kidney stone disease based on a molecular understanding of excess urinary excretions of calcium, oxalate, cystine, and uric acid. RECENT FINDINGS:Hypercalciuria is discussed relative to mutations in the renal chloride genes CLCN5 and CLCNKB, WNK kinases, A...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-200404000-00013
更新日期:2004-04-01 00:00:00
abstract::Dyslipidemia increases the risk of cardiovascular events among individuals with renal disease, and there is a growing body of evidence that it hastens the progression of renal disease itself. Children with nephrotic syndrome or renal transplants have easily recognized hyperlipidemia. Among those with chronic renal ins...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-200204000-00009
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abstract:PURPOSE OF REVIEW:The purpose of this study is to review advances in both the pathogenesis and clinical management of biliary atresia. RECENT FINDINGS:Immunologic studies have further characterized roles of helper T-cells, B-cells, and natural killer cells in the immune dysregulation following viral replication within...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0000000000000214
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Recognizing inflammatory bowel disease (IBD) is straightforward when alarm symptoms are present, such as bloody diarrhea and weight loss. When the presentation is subtle or atypical, physicians must determine which patients warrant evaluation for IBD. Appropriate use of noninvasive tests can help iden...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e32830d3aaf
更新日期:2008-10-01 00:00:00
abstract:PURPOSE OF REVIEW:According to recent Centers for Disease Control (CDC) data, the annual incidence of traumatic brain injury (TBI) in the United States is 1.6-3.2 million, of which the majority is classified as mild. Over half of these injuries occur in the pediatric population, and can often be attributed to a sports-...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e32835a1a44
更新日期:2012-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews three common abnormalities requiring surgical treatment in adults with congenital heart disease (CHD): Ebstein's anomaly, the failing Fontan, and pulmonary valve disease. RECENT FINDINGS:As of 2000, more adults than children are alive with CHD. Each year, more of these adults wit...
journal_title:Current opinion in pediatrics
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更新日期:2009-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Allergic rhinitis, conjunctivitis, and asthma impact quality of life and cost billions of dollars in lost wages, productivity, and medical expenditures. Allergen immunotherapy is the only therapy that alters the allergen immune response, resulting in fewer symptoms upon natural exposure. This review s...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e3282495939
更新日期:2007-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Atypical skull shapes occur in as many as 20% of infants. The purpose of this review is to discuss the clinical approach to the evaluation of a child with an abnormal head shape. Readers will learn how to identify the head shapes caused by environmental deformation and craniosynostosis. We also review...
journal_title:Current opinion in pediatrics
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更新日期:2007-12-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review, recent advances in the epidemiology, genetics, clinical associations and management of idiopathic hypercalciuria will be discussed. RECENT FINDINGS:A significant genetic contribution exists in the pathophysiology of hypercalciuria. Although several candidate genes and genetic alterati...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e3283223db7
更新日期:2009-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to examine the prevalence of vitamin D deficiency in pediatric gastrointestinal disease, specifically celiac disease and inflammatory bowel disease (IBD); to discuss the role of vitamin D and its deficiency in gastrointestinal disease pathophysiology; and to present curre...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0000000000000451
更新日期:2017-02-01 00:00:00
abstract::Fetal cardiac intervention is in a rapid state of progress now. Attempts are being made to prevent fetal hydrops due to congenital heart defects, to recruit hypoplastic ventricles, to create a two-ventricle circulation after birth, and to remodel the fetal pulmonary vascular bed whose outlet is obstructed. Open heart ...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/01.mop.0000141918.70698.3a
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Hypertension is an independent risk factor for progression of chronic kidney disease (CKD) in children. Children with early CKD develop hypertension secondary to renal disease. This review aims to highlight recent advances that help us better understand the current role of hypertension in progression ...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0000000000000595
更新日期:2018-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Nearing the end of the first decade of this new century, the challenges and changes in the field of outpatient pediatric cardiology continue to accelerate. RECENT FINDINGS:To help the general pediatrician and family practice physician become aware of several new care guidelines and practice trends as...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e32832ff3ec
更新日期:2009-10-01 00:00:00
abstract:PURPOSE OF REVIEW:We provide an overview of the past year's literature on congenital heart surgery. RECENT FINDINGS:This review focuses on selected disease entities, operative techniques, perioperative management strategies, and quality of care. SUMMARY:Congenital heart surgery is an evolving field. ...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/01.mop.0000172814.33896.ac
更新日期:2005-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Increasing numbers of children are now traveling to high-altitude destinations, and pediatricians often see these children prior to and immediately following their travels. Thus, pediatricians have the opportunity to provide guidance for the prevention of altitude illness and must treat high-altitude ...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0000000000000519
更新日期:2017-08-01 00:00:00
abstract:PURPOSE OF REVIEW:We present data from recently conducted research regarding the diagnosis of blunt cervical spine injury (CSI) in children. RECENT FINDINGS:Research in the prehospital setting to evaluate the need for cervical spine immobilization in children, regardless of clinical findings or mechanism of injury, su...
journal_title:Current opinion in pediatrics
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doi:10.1097/MOP.0b013e3283527035
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews recent developments in the assessment of changes in structure and function in the fetal heart with the focus on congenital heart disease malformations. RECENT FINDINGS:Use of the combination of the cardiovascular profile score, the biophysical profile score and additional physiol...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e3282efd2a2
更新日期:2007-10-01 00:00:00
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journal_title:Current opinion in pediatrics
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-200012000-00003
更新日期:2000-12-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/00008480-199602000-00015
更新日期:1996-02-01 00:00:00
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journal_title:Current opinion in pediatrics
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journal_title:Current opinion in pediatrics
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更新日期:2016-10-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:2014-02-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/01.mop.0000133632.33920.dd
更新日期:2004-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The prevalence of pediatric atopic dermatitis (AD) has increased throughout the world, now ranging from 10 to 20% in developed countries. Pediatric patients with AD make up a substantial proportion of patients seen by general pediatricians, allergists, dermatologists, and other specialists. As such, t...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:1994-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will examine the current evidence regarding pediatric blunt abdominal trauma and the physical exam findings, laboratory values, and radiographic imaging associated with the diagnosis of intra-abdominal injuries (IAI), as well as review the current literature on pediatric hollow viscus inju...
journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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journal_title:Current opinion in pediatrics
pub_type: 杂志文章,评审
doi:10.1097/MOP.0b013e3282f370c0
更新日期:2008-02-01 00:00:00