Cutaneous bacterial infections in the newborn.

Abstract:

PURPOSE OF REVIEW:This review examines neonatal bacterial skin infections with respect to host immunity, bacterial pathogens, patterns of infection, and new therapeutic approaches. RECENT FINDINGS:Advances have been made in our understanding of innate host defense and the emerging role of cutaneous antimicrobial peptides of the cathelicidin and defensin families. Toll-like receptors are being investigated with respect to their interactions with bacteria and other components of the innate immune defense, such as the antimicrobial peptides. The epidermal barrier remains an active area of research. Studies confirm that maintaining an intact epidermal barrier by minimizing exposure to soap and by not removing vernix caseosa are simple measures to improve skin barrier function. Active barrier-enhancing measures such as the application of topical emollients have shown mixed results in the prevention of nosocomial infection. A meta-analysis of studies performed in developed countries showed a trend of increasing risk for coagulase-negative staphylococcal infection. By contrast, a randomized controlled trial showed that infants treated with sunflower oil are less likely to experience nosocomial infections than are control infants. Infants with bacteremia and no known source of infection should be carefully examined because cutaneous abscesses have been shown to be an important nidus of infection. Methicillin-resistant Staphylococcus aureus is reaching epidemic proportions, making surface cultures an essential part of the evaluation of cutaneous bacterial infection. SUMMARY:New insights have been gained regarding the basic science of neonatal host defense and these advances may produce new ways of approaching the prevention and treatment of bacterial skin infections in the newborn period.

journal_name

Curr Opin Pediatr

authors

Larson AA,Dinulos JG

doi

10.1097/01.mop.0000171321.68806.bd

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

481-5

issue

4

eissn

1040-8703

issn

1531-698X

pii

00008480-200508000-00008

journal_volume

17

pub_type

杂志文章,评审
  • Recent advances regarding attention deficit-hyperactivity disorder in adolescence.

    abstract::This paper reviews recent studies of attention deficit-hyperactivity disorder, focusing on research with implications for adolescents. Only 10 of the 31 recent investigations discussed employed an exclusively adolescent sample, necessitating considerable extrapolation from studies of children or adults or mixed sample...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199608000-00003

    authors: Phillips S,Soffer SL

    更新日期:1996-08-01 00:00:00

  • The molecular basis of kidney stones.

    abstract:PURPOSE OF REVIEW:To emphasize an exploration of mechanisms of kidney stone disease based on a molecular understanding of excess urinary excretions of calcium, oxalate, cystine, and uric acid. RECENT FINDINGS:Hypercalciuria is discussed relative to mutations in the renal chloride genes CLCN5 and CLCNKB, WNK kinases, A...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200404000-00013

    authors: Langman CB

    更新日期:2004-04-01 00:00:00

  • Dyslipidemia in pediatric renal disease: epidemiology, pathophysiology, and management.

    abstract::Dyslipidemia increases the risk of cardiovascular events among individuals with renal disease, and there is a growing body of evidence that it hastens the progression of renal disease itself. Children with nephrotic syndrome or renal transplants have easily recognized hyperlipidemia. Among those with chronic renal ins...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200204000-00009

    authors: Saland JM,Ginsberg H,Fisher EA

    更新日期:2002-04-01 00:00:00

  • Recent advances in the pathogenesis and management of biliary atresia.

    abstract:PURPOSE OF REVIEW:The purpose of this study is to review advances in both the pathogenesis and clinical management of biliary atresia. RECENT FINDINGS:Immunologic studies have further characterized roles of helper T-cells, B-cells, and natural killer cells in the immune dysregulation following viral replication within...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000214

    authors: Zagory JA,Nguyen MV,Wang KS

    更新日期:2015-06-01 00:00:00

  • Laboratory evaluation of inflammatory bowel disease.

    abstract:PURPOSE OF REVIEW:Recognizing inflammatory bowel disease (IBD) is straightforward when alarm symptoms are present, such as bloody diarrhea and weight loss. When the presentation is subtle or atypical, physicians must determine which patients warrant evaluation for IBD. Appropriate use of noninvasive tests can help iden...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32830d3aaf

    authors: Wong A,Bass D

    更新日期:2008-10-01 00:00:00

  • A pediatric perspective on concussion pathophysiology.

    abstract:PURPOSE OF REVIEW:According to recent Centers for Disease Control (CDC) data, the annual incidence of traumatic brain injury (TBI) in the United States is 1.6-3.2 million, of which the majority is classified as mild. Over half of these injuries occur in the pediatric population, and can often be attributed to a sports-...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32835a1a44

    authors: Choe MC,Babikian T,DiFiori J,Hovda DA,Giza CC

    更新日期:2012-12-01 00:00:00

  • Surgical advances in the treatment of adults with congenital heart disease.

    abstract:PURPOSE OF REVIEW:This article reviews three common abnormalities requiring surgical treatment in adults with congenital heart disease (CHD): Ebstein's anomaly, the failing Fontan, and pulmonary valve disease. RECENT FINDINGS:As of 2000, more adults than children are alive with CHD. Each year, more of these adults wit...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章

    doi:10.1097/MOP.0b013e3283303fa7

    authors: Dearani JA,Mavroudis C,Quintessenza J,Deal BJ,Backer CL,Fitzgerald P,Connolly HM,Jacobs JP

    更新日期:2009-10-01 00:00:00

  • New developments in allergen immunotherapy.

    abstract:PURPOSE OF REVIEW:Allergic rhinitis, conjunctivitis, and asthma impact quality of life and cost billions of dollars in lost wages, productivity, and medical expenditures. Allergen immunotherapy is the only therapy that alters the allergen immune response, resulting in fewer symptoms upon natural exposure. This review s...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000267

    authors: Vadlamudi A,Shaker M

    更新日期:2015-10-01 00:00:00

  • Genodermatoses with malignant potential.

    abstract:PURPOSE OF REVIEW:The delineation of syndromes carrying a predisposition to malignancy has led to great insights into the molecular biology of malignancy. Many such syndromes have cutaneous findings which can precede the development of neoplasia. Early recognition of the cutaneous stigmata of the genodermatoses with ma...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3282495939

    authors: Holman JD,Dyer JA

    更新日期:2007-08-01 00:00:00

  • Evaluation of the infant with an abnormal skull shape.

    abstract:PURPOSE OF REVIEW:Atypical skull shapes occur in as many as 20% of infants. The purpose of this review is to discuss the clinical approach to the evaluation of a child with an abnormal head shape. Readers will learn how to identify the head shapes caused by environmental deformation and craniosynostosis. We also review...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3282f1581a

    authors: Cunningham ML,Heike CL

    更新日期:2007-12-01 00:00:00

  • Diagnosis and management of hypercalciuria in children.

    abstract:PURPOSE OF REVIEW:In this review, recent advances in the epidemiology, genetics, clinical associations and management of idiopathic hypercalciuria will be discussed. RECENT FINDINGS:A significant genetic contribution exists in the pathophysiology of hypercalciuria. Although several candidate genes and genetic alterati...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3283223db7

    authors: Srivastava T,Schwaderer A

    更新日期:2009-04-01 00:00:00

  • Vitamin D in pediatric gastrointestinal disease.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to examine the prevalence of vitamin D deficiency in pediatric gastrointestinal disease, specifically celiac disease and inflammatory bowel disease (IBD); to discuss the role of vitamin D and its deficiency in gastrointestinal disease pathophysiology; and to present curre...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000451

    authors: Ahlawat R,Weinstein T,Pettei MJ

    更新日期:2017-02-01 00:00:00

  • Advances in fetal cardiac intervention.

    abstract::Fetal cardiac intervention is in a rapid state of progress now. Attempts are being made to prevent fetal hydrops due to congenital heart defects, to recruit hypoplastic ventricles, to create a two-ventricle circulation after birth, and to remodel the fetal pulmonary vascular bed whose outlet is obstructed. Open heart ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000141918.70698.3a

    authors: Huhta J,Quintero RA,Suh E,Bader R

    更新日期:2004-10-01 00:00:00

  • Role of hypertension in progression of chronic kidney disease in children.

    abstract:PURPOSE OF REVIEW:Hypertension is an independent risk factor for progression of chronic kidney disease (CKD) in children. Children with early CKD develop hypertension secondary to renal disease. This review aims to highlight recent advances that help us better understand the current role of hypertension in progression ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000595

    authors: Vidi SR

    更新日期:2018-04-01 00:00:00

  • What's new in outpatient cardiology.

    abstract:PURPOSE OF REVIEW:Nearing the end of the first decade of this new century, the challenges and changes in the field of outpatient pediatric cardiology continue to accelerate. RECENT FINDINGS:To help the general pediatrician and family practice physician become aware of several new care guidelines and practice trends as...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e32832ff3ec

    authors: Lacina SJ

    更新日期:2009-10-01 00:00:00

  • Advances in congenital heart surgery.

    abstract:PURPOSE OF REVIEW:We provide an overview of the past year's literature on congenital heart surgery. RECENT FINDINGS:This review focuses on selected disease entities, operative techniques, perioperative management strategies, and quality of care. SUMMARY:Congenital heart surgery is an evolving field. ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000172814.33896.ac

    authors: Welke KF,Komanapalli C,Shen I,Ungerleider RM

    更新日期:2005-10-01 00:00:00

  • High-altitude illness in the pediatric population: a review of the literature on prevention and treatment.

    abstract:PURPOSE OF REVIEW:Increasing numbers of children are now traveling to high-altitude destinations, and pediatricians often see these children prior to and immediately following their travels. Thus, pediatricians have the opportunity to provide guidance for the prevention of altitude illness and must treat high-altitude ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000519

    authors: Garlick V,O'Connor A,Shubkin CD

    更新日期:2017-08-01 00:00:00

  • Blunt cervical spine injury in children.

    abstract:PURPOSE OF REVIEW:We present data from recently conducted research regarding the diagnosis of blunt cervical spine injury (CSI) in children. RECENT FINDINGS:Research in the prehospital setting to evaluate the need for cervical spine immobilization in children, regardless of clinical findings or mechanism of injury, su...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3283527035

    authors: Tilt L,Babineau J,Fenster D,Ahmad F,Roskind CG

    更新日期:2012-06-01 00:00:00

  • Functional assessment of the evolution of congenital heart disease in utero.

    abstract:PURPOSE OF REVIEW:This article reviews recent developments in the assessment of changes in structure and function in the fetal heart with the focus on congenital heart disease malformations. RECENT FINDINGS:Use of the combination of the cardiovascular profile score, the biophysical profile score and additional physiol...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3282efd2a2

    authors: Acharya G,Archer N,Huhta JC

    更新日期:2007-10-01 00:00:00

  • Case report: consumptive hypothyroidism consequent to multiple infantile hepatic haemangiomas.

    abstract::A 10-month-old infant with multiple infantile hepatic hemangiomas and developmental delay is reported. He was found to be profoundly hypothyroid. Evaluation and management issues are discussed. This case emphasizes the importance of screening for hypothyroidism in patients with hemangiomas and the potential therapeuti...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章

    doi:10.1097/MOP.0b013e3282f409c3

    authors: Cho YH,Taplin C,Mansour A,Howman-Giles R,Hardwick R,Lord D,Howard NJ

    更新日期:2008-04-01 00:00:00

  • Genetics of mental retardation.

    abstract::Aim of this review is to present the latest advances in the identification of the genetic determinants of intellectual deficiency. Mental retardation (MR) is often associated with other neurologic symptoms, metabolic disorders, or malformation syndromes. The purpose of the review is to subdivide the large field of MR ...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-200012000-00003

    authors: Chiurazzi P,Oostra BA

    更新日期:2000-12-01 00:00:00

  • Endocrine disorders and orthopedic problems in children.

    abstract::Endocrine excesses or deficiencies frequently result in alterations of height as compared with age-matched children. Less clinically obvious are significant alterations in bone metabolism leading to osteoporosis, which can affect the child and may affect the patient as an adult. Slipped capital femoral epiphysis appea...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199602000-00015

    authors: Mann DC

    更新日期:1996-02-01 00:00:00

  • Superior mesenteric artery syndrome in a 16-year-old with bilious emesis.

    abstract::Superior mesenteric artery (SMA) syndrome describes vascular compression of the third portion of the duodenum and presents with nausea, postprandial vomiting, and epigastric abdominal pain. The syndrome is rare and may be missed if appropriate radiologic studies are not performed or the clinical presentation is atypic...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章

    doi:10.1097/MOP.0b013e32833c4947

    authors: Kurbegov A,Grabb B,Bealer J

    更新日期:2010-10-01 00:00:00

  • Therapeutic drug monitoring in inflammatory bowel disease.

    abstract:PURPOSE OF REVIEW:There are an expanding number of therapies available to treat pediatric inflammatory bowel disease (IBD). As pediatric gastroenterologists attempt to achieve complete intestinal mucosal healing for their patients, it has become more important to gain an understanding of how to maximize the efficacy of...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000393

    authors: Jossen J,Dubinsky M

    更新日期:2016-10-01 00:00:00

  • What is new in the biology and treatment of pediatric rhabdomyosarcoma?

    abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight some of the advances in the way we think about rhabdomyosarcoma (RMS). Recent outcome and biological analyses have shifted the risk stratification and treatment paradigms for pediatric RMS. RECENT FINDINGS:The presence or absence of the FOXO1 translocation i...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000041

    authors: Hawkins DS,Gupta AA,Rudzinski ER

    更新日期:2014-02-01 00:00:00

  • Atopic dermatitis update.

    abstract:PURPOSE OF REVIEW:Atopic dermatitis, one of the most common chronic illnesses of childhood, is encountered routinely by all providers of health care to children. RECENT FINDINGS:In recent years there has been a dramatic rise in the prevalence of atopic dermatitis and therefore a rapid increase in the number of studies...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/01.mop.0000133632.33920.dd

    authors: Sturgill S,Bernard LA

    更新日期:2004-08-01 00:00:00

  • 2014 update on atopic dermatitis in children.

    abstract:PURPOSE OF REVIEW:The prevalence of pediatric atopic dermatitis (AD) has increased throughout the world, now ranging from 10 to 20% in developed countries. Pediatric patients with AD make up a substantial proportion of patients seen by general pediatricians, allergists, dermatologists, and other specialists. As such, t...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0000000000000109

    authors: Totri CR,Diaz L,Eichenfield LF

    更新日期:2014-08-01 00:00:00

  • Preimplantation genetic diagnosis.

    abstract::Preimplantation genetic diagnosis now represents an alternative reproductive option for parents at high risk of having offspring affected with certain genetic diseases. Progress in the past year has included increasing reliability in embryo sexing by both polymerase chain reaction and fluorescent in situ hybridization...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/00008480-199412000-00018

    authors: Black SH

    更新日期:1994-12-01 00:00:00

  • Blunt abdominal trauma in children.

    abstract:PURPOSE OF REVIEW:This review will examine the current evidence regarding pediatric blunt abdominal trauma and the physical exam findings, laboratory values, and radiographic imaging associated with the diagnosis of intra-abdominal injuries (IAI), as well as review the current literature on pediatric hollow viscus inju...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e328352de97

    authors: Schonfeld D,Lee LK

    更新日期:2012-06-01 00:00:00

  • Lower extremity stress fractures in pediatric and adolescent athletes.

    abstract:PURPOSE OF REVIEW:To familiarize primary care pediatricians with basic detection and treatment strategies of lower extremity stress fractures, while highlighting new research related to improving diagnosis and management approaches for pediatric and adolescent athletes. RECENT FINDINGS:Young age appears to be a risk f...

    journal_title:Current opinion in pediatrics

    pub_type: 杂志文章,评审

    doi:10.1097/MOP.0b013e3282f370c0

    authors: Heyworth BE,Green DW

    更新日期:2008-02-01 00:00:00