Genodermatoses with malignant potential.

Abstract:

PURPOSE OF REVIEW:The delineation of syndromes carrying a predisposition to malignancy has led to great insights into the molecular biology of malignancy. Many such syndromes have cutaneous findings which can precede the development of neoplasia. Early recognition of the cutaneous stigmata of the genodermatoses with malignant potential can lead to early diagnosis and initiation of proper screening and treatment when indicated. RECENT FINDINGS:This article reviews 'classic' genodermatoses with malignant potential and highlights recent recommendations for screening and treatment. Additionally more recently delineated syndromes and their cutaneous findings are discussed. SUMMARY:Certain inherited syndromes with a risk of neoplasia exhibit characteristic cutaneous findings. Recognition of these findings by the astute practitioner can lead to early intervention which can impact the course of these rare diseases.

journal_name

Curr Opin Pediatr

authors

Holman JD,Dyer JA

doi

10.1097/MOP.0b013e3282495939

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

446-54

issue

4

eissn

1040-8703

issn

1531-698X

pii

00008480-200708000-00012

journal_volume

19

pub_type

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