Nongenomic regulation of gene expression.

Abstract:

PURPOSE OF REVIEW:The purpose of this review is to highlight the recent advances in epigenetic regulation and chromatin biology for a better understanding of gene regulation related to human disease. RECENT FINDINGS:Alterations to chromatin influence genomic function, including gene transcription. At its most simple level, this involves DNA methylation and posttranscriptional histone modifications. However, recent developments in biochemical and molecular techniques have revealed that transcriptional regulation is far more complex, involving combinations of histone modifications and discriminating transcription factor binding, and long-range chromatin loops with enhancers, to generate a multifaceted code. Here, we describe the most recent advances, culminating in the example of genomic imprinting, the parent-of-origin monoallelic expression that utilizes the majority of these mechanisms to attain one active and one repressed allele. SUMMARY:It is becoming increasingly evident that epigenetic mechanisms work in unison to maintain tight control of gene expression and genome function. With the wealth of knowledge gained from recent molecular studies, future goals should focus on the application of this information in deciphering their role in developmental diseases.

journal_name

Curr Opin Pediatr

authors

Iglesias-Platas I,Monk D

doi

10.1097/MOP.0000000000000365

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

521-8

issue

4

eissn

1040-8703

issn

1531-698X

journal_volume

28

pub_type

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